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个人简介 Personal Profile 同济大学附属第十人民医院病理主管技师，同济大学医学院讲师、高研院副研究员、硕士生导师，上海市预防医学会微生态专业委员会委员。聚焦结直肠癌等疾病中肠道菌群与宿主互作机制，致力于精准解析肠道细菌促进肿瘤等疾病发生发展的遗传基础及分子作用机制，探索新型诊疗靶点及策略。目前在相关领域发表SCI论文33篇，其中以第一/通讯作者在Nature Communications、Nucleic Acids Research、Signal Transduction and Targeted Therapy等期刊发表15篇；他引合计超1500次。主持国家自然科学基金2项，入选上海市“医苑新星”青年医学人才培养计划；获7项发明专利授权；参编中英文专著各1部、科普书籍1部；作为参与人获上海市科技进步一等奖。 研究方向Research Directions 肠道微生态与分子病理 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 科研项目 1. 国家自然科学基金（National Natural Science Foundation of China），82072236，2021/01-2024/12，主持2. 国家自然科学基金（National Natural Science Foundation of China），81702037，2018/01-2020/12，主持3. 上海市“医苑新星”青年医学人才培养资助计划（Shanghai “Rising Stars of Medical Talent” Youth Development Program），20204. 同济大学附属第十人民医院攀登人才计划（Pandeng Research Foundation of Shanghai Tenth People’s Hospital），2018SYPDRC015，2018/09-2020/08 研究成果 发表论文/Publication1.   Song F, Zhang Y, Chen Q, Bi D, Yang M, Lu L, Li M, Zhu H, Liu Y, Wei Q, Qin H, Li J. Mast cells inhibit colorectal cancer development by inducing ER stress through secreting Cystatin C. Oncogene, 2023, 42: 209-223.2.   Viardot-Foucault V, Zhou J, Bi D, Takinami Y, Chan JKY, Lee YH. Dehydroepiandrosterone supplementation and the impact of follicular fluid metabolome and cytokinomeprofiles in poor ovarian responders. Journal of Ovarian Research. 2023, 16:107.3.  Wang J, Cao Y, Hou W, Bi D, Yin F, Gao Y, Huang D, Li Y, Cao Z, Yan Y, Zhao J, Kong D, Lv X, Huang L, Zhong H, Wu C, Chen Q, Yang R, Wei Q, Qin H. Fecal microbiota transplantation improves VPA-induced ASD mice by modulating the serotonergic and glutamatergic synapse signaling pathways. Translational Psychiatry. 2023, 13:17.4.  Bi D*, Zhu Y, Gao Y, Li H, Zhu X, Wei R, Xie R, Cai C, Wei Q, Qin H. Profiling Fusobacterium infection at high taxonomic resolution reveals lineage-specific correlations in colorectal cancer. Nature Communications. 2022, 13:3336.5.  Zhu H#, Bi D#, Zhang Y#, Kong C#, Du J, Wu X, Wei Q, Qin H. Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations. Signal Transduction and Targeted Therapy, 2022, 7:11. (Review; # joint-first author)6.  Wang D, Wang L, Bi D, Song J, Wang G, Gao Y, Tang KFJ, Meng F, Xie J, Zhang F, Huang J, Li J, Dong X. Conjugative transfer of acute hepatopancreatic necrosis disease-causing pVA1-type plasmid is mediated by a novel self-encoded type IV secretion system. Microbiology Spectrum, 2022, 10: e0170222.7.  Bi D, Zhu Y, Gao Y, Li H, Zhu X, Wei R, Xie R, Wei Q, Qin H. A newly developed PCR-based method revealed distinct Fusobacterium nucleatum subspecies infection patterns in colorectal cancer. Microbial Biotechnology, 2021, 14:2176-2186.8.  Gao Y#, Bi D#, Xie R#, Li M, Guo J, Liu H, Guo X, Fang J, Ding T, Zhu H, Cao Y, Xing M, Zheng J, Xu Qing, Xu Qian, Wei Q, Qin H. Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade incolorectal cancer. Signal Transduction and Targeted Therapy, 2021, 6:398. (# joint-first author)9.  Cai C#, Bi D#, Bick G#, Wei Q, Liu H, Lu L, Zhang X, Qin H. HNF1A serves as a potential regulator in shaping super-enhancer landscape in colorectal cancer liver metastasis. FEBS Letters, 2021, 595:3056–3071. (# joint-first author)10. Bi D, Zheng J, Xie R, Zhu Y, Wei R, Ou HY, Wei Q, Qin H. Comparative analysis of AbaR-type genomic islands reveals distinct patterns of genetic features in elements with different backbones. mSphere, 2020, 5: e00349-20.11. Mao S, Wu Y, Wang R, Guo Y, Bi D, Ma W, Zhang W, Zhang J, Yan Y, Yao X. Overexpression of GAS6 promotes cell proliferation and invasion in bladder cancer by activation of the PI3K/AKTpathway. OncoTargets and Therapy, 2020, 13: 4813-4824.12. Huang X, Yan Y, Wei R, Liu Hu, Zhu X, Bi D, Wei Q, Yao X. Centrosome protein 78 is overexpressed in muscle-invasive bladder cancer and associated with tumour molecular subtypes and mutation signatures. 2020, Medical Science Monitor, 2020, 26:e925197.13. Bi D, Xie R, Zheng J, Yang H, Ou HY,Wei Q. Large-scale identification of AbaR-type genomic islands in Acinetobacter baumannii reveals diverse insertion sites and clonal lineage-specific antimicrobial resistance gene profiles. Antimicrobial Agents and Chemotherapy, 2019, 63: e02526-18.14. Lu L, Xie R, Wei R, Cai C, Bi D, Yin D, Zheng J, Song F, Gao Y, Zhang Y, Tan L, Liu H, Wei Q, Qin H.Integrin α5 subunit is required for tumor supportive role of fibroblasts in colorectal adenocarcinoma and serves as a potential stroma prognostic marker. Molecular Oncology, 2019, 13: 2697-2714. (Cover article)15. Yang Y, Misra BB, Liang L, Bi D, Weng W, Wu W, Cai S, Qin H, Goel A, Li X, Ma Y. Integrated microbiome and metabolome analysis reveals a novel interplay between commensal bacteria and metabolites in colorectal cancer. Theranostics, 2019, 9: 4101-4114.16. Zhao W, Yang J, Ni B, Bi D, Sun Y, Xu M, Zhu X, Li C, Jin L, Gao P, Wang P, Hua Y, Li M. Towards automatic prediction of EGFR mutation status in pulmonary adenocarcinomawith 3D deep learning. Cancer Medicine, 2019, 8: 3532–3543.(Cover article)17. Gao Y, Yan Y, Guo J, Zhang Q, Bi D, Wang F, Chang Z, Lu Ling, Yao X, Wei Q. HNF-4α downregulation promotes tumor migration and invasion via regulating E-cadherin in renal cell carcinoma. Oncology Reports, 2019, 42: 1066-1074.18. Liu M, Li X, Xie Y, Bi D, Sun J, Li J, Tai C, Deng Z, Ou HY. ICEberg 2.0: an updated database of bacterial integrative and conjugative elements. Nucleic Acids Research, 2019, 47: D660-D665.19. Wu X, Tan G, Gao R, Yao L, Bi D, Guo Y, Yu F, Fan L. Assessment of the Xpert MTB/RIF Ultra assay on rapid diagnosis of extrapulmonary tuberculosis. International Journal of Infectious Diseases,2019, 81: 91-96.20. Dong X, Song J, Chen J, Bi D, Wang W, Ren Y, Wang H, Tang KFJ, Wang X, Huang J. Conjugative transferof the pVA1-type plasmid carrying the pirABvp genes results in the formation of new AHPND-causing Vibrio. Frontiers in Cellular and Infection Microbiology, 2019, 9: 195.21. Bi D, Zheng J, Li JJ, Sheng ZK, Zhu X, Ou HY, Li Q, Wei Q. In silico typing and comparative genomic analysis of IncFIIK plasmids and insights into the evolution of replicons, plasmid backbones and resistance determinant profiles. Antimicrobial Agents and Chemotherapy, 2018, 62: e00764-18.22. Bai F, Wei C, Zhang P, Bi D, Ge M, Chen Q, Jia Y, Lu Y, Wu K. Use of peripheral lymphocytes and support vector machine for survival prediction in breast cancer patients. Translational Cancer Research, 2018,7: 978-987.23. Dong X#, Bi D#, Wang H, Zou P, Xie G, Wan X, Yang Q, Zhu Y, Chen M, Guo C, Liu Z,Wang W, Huang J. pirABvp-Bearing Vibrio parahaemolyticus and Vibrio campbellii pathogens isolated from the same AHPND-affected pond possess highly similar pathogenic plasmids. Frontiers in Microbiology, 2017, 8: 1859.(# joint-first author)24. Wei Y, Bi D, Wei D, Ou HY. Prediction of type II toxin-antitoxin loci in Klebsiella pneumoniae genome sequences. Interdisciplinary Sciences:Computational Life Sciences, 2016, 8: 143-149.25. Bi D, Jiang X, Sheng ZK, Tai C, Wang M, Deng Z, Rajakumar K, Ou HY. Mapping the resistance-associated mobilome of a carbapenem-resistant Klebsiella pneumoniae strain reveals insights into factors shaping these regions and facilitates generation of a ‘resistance-disarmed’ model organism. Journal of Antimicrobial Chemotherapy, 2015, 70: 2770-2774.26. Li G#, Zhang Y#, Bi D#, Shen P, AiF, Liu H, Tian Y, Ma Y, Wang B, Rajakumar K, Ou HY, Jiang X. Firstreport of a clinical, multidrug-resistant Enterobacteriaceae isolate coharboring fosfomycin resistance gene fosA3 and cabarpenemase gene blaKPC-2 on the same transposon,Tn1721. Antimicrobial Agents and Chemotherapy, 2015, 59: 338-343.(# joint-first author)27. Bi D, Liu L, Tai C, Deng Z, Rajakumar K, Ou HY. SecReT4: a web-based bacterial typeIV secretion system resource. Nucleic Acids Research, 2013, 41: D660-D665.28. Bi D, Xu Z, Harrison EM, Tai C, Wei Y, He X, Jia S, Deng Z, Rajakumar K, Ou HY. ICEberg:a web-based resource for integrative and conjugative elements found in Bacteria. Nucleic Acids Research, 2012, 40:D621-D626.29. Liu P, Li P, Jiang X, Bi D, XieY, Tai C, Deng Z, Rajakumar K, Ou HY. Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae HS11286, a multidrug-resistant strain isolated from human sputum. Journal of Bacteriology, 2012, 194: 1841-1842.30. Shao Y, Harrison EM, Bi D, Tai C, He X, Ou HY, Rajakumar K, Deng Z. TADB: a web-based resource for Type 2 toxin-antitoxin loci in Bacteria and Archaea. Nucleic Acids Research, 2011, 39:D606-D611.31. Bi D, Chu D, Zhu P, Lu C, Fan C, Zhang J, Bao J. Utilization of dry distiller's grain and solubles as nutrient supplement in the simultaneous saccharification and ethanolfermentation at high solids loading of corn stover. Biotechnology Letters, 2011, 33: 273-276.  学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份