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个人简介 Personal Profile 郑加麟，医学博士，特聘教授，博士生导师，现任同济大学医学院院长，曾任美国内布拉斯加医学中心协理副校长。教育部脑衰老相关疾病医药创新基础研究中心主任，上海市麻醉与脑功能调控重点实验室和催化医学前沿研究基地主任，国际脑计划中方代表，“国际医学校院协会(AAHCI)”领导委员会委员。国家海外高层次人才，科技部重大科学研究计划首席科学家，主持国家自然科学基金重点项目与重大研究计划。同时担任中国高等教育学会医学教育专业委员会常务理事、上海市衰老与退行性疾病学会副理事长、上海市医学会常务理事、中国神经科学会神经退行性疾病分会副主委。长期致力于中枢神经退行性疾病发病机制研究与治疗策略研发，已发表200余篇研究论著，引用次数9600余次，H-index指数58，i10指数135。 研究方向Research Directions 神经病学,神经免疫学 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 科研项目 近五年负责的课题：1.国家自然科学基金项目（重大研究项目）（205万）神经干细胞与胶质细胞释放的外泌体在介导衰老与神经退行性病变中的作用及其分子机制研究2.科技部 国家重大科学研究计划（1500万）诱导性前脑神经祖细胞体内微环境的组分解析、条件优化和功能模拟3.国家自然科学基金委员会（海外及港澳学者合作研究基金）220万巨噬细胞及神经小胶质细胞在中枢神经退行性疾病中的作用及机制 (1-2)中脑多巴胺神经元前体细胞的转分化及其治疗帕金森疾病的研究 (3-6)4.国家自然科学基金委员会（重点项目）（293万）谷氨酰胺酶C亚型介导的小胶质细胞激活在阿尔兹海默病神经炎症的机制解析5.课题组国家自然科学基金项目15项 研究成果 学术论文：(总引用次数:9600余次; h-index: 58; i10-index: 135)20221.   Yuan Pǂ, Li Jǂ, Liu J, Liu H, Gong S,Wang L, Liu J, Li C, Wang Y,Xia X,Zheng JC* (2022). Cognitive dysfunction inpatients with pulmonary hypertension. Am J Resp Crit Care. 2022; Accepted.(IF=30.528)2.   XiaX, Wang Y, Qin Y, Zhao S, Zheng JC* (2022).Exosome: a novel neurotransmission modulator or non-canonical neurotransmitter?Ageing Research Reviews. doi:10.1016/j.arr.2022:74: 101558 3.   Fu S, Chen H, Yang W, Xia X*, Zhao S,Xu, X, Ai P, Cai Q, Li X, Wang Y, Zhu J, Zhang B*, Zheng JC* (2022).ROS-targeted Depression Therapy via BSA-incubated Ceria Nanocluster. NanoLetters. 2022; May 18. doi:10.1021/acs.nanolett.2c01334. Online ahead of print. PMID: 355835184.   Fu Sǂ, Chen Hǂ, Zhao Sǂ, Yang W, XiaX*, Xu, X, Liang Z, Feng X, Wang Z, Ai P, Ding L, Cai Q, Wang Y, Zhang Y, ZhuJ, Zhang B*, Zheng JC* (2022). Insulin-incubated palladium clusterspromote recovery after brain injury. J Nanobiotechnology. 2022; (In Press). 5.   Ding Lǂ, Wu H, Wang Y, Li Y, Xia X*, ZhengJC* (2022). m6A reader Igf2bp1 regulates the inflammatory responses ofmicroglia by stabilizing Gbp11 and Cp mRNAs. Front. Immunol. 2022; 2022 Apr 29;13:872252. doi: 10.3389/fimmu.2022.872252. eCollection2022.PMID: 355725756.   Ma Z, Zheng JC, Li T, Xie Z, Kang L (2022). Janus KinaseMediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesiain the Migratory Locusts. Front Physiol. 2022 Mar 30;13:806746. doi: 10.3389/fphys.2022.806746.eCollection 2022.PMID: 354319997.   Gao Gǂ,Li Cǂ, Zhu Jǂ, Sheng S, Liang Z, Fu S, Li X, Sun Y, Wang Y, Feng X, Xia X*, ZhengJC* (2022). Induced neural stem/progenitor cell-derived extracellularvesicles promote recovery post stroke. Clinical and Translational Medicine;(In press).  8.   Sun Yǂ,Xia Xǂ, Basnet D, Zheng JC*, Huang J*, Liu J* (2022). Mechanisms offerroptosis and emerging links to the pathology of neurodegenerative diseases. FrontAging Neurosci. 2022; (In press).                                                                                                                                                                          9.   Liu Jǂ, Feng Xǂ, Wang Y, Xia X*, Zheng JC*(2022). Astrocytes: GABAceptive and GABAergic cells in the brain. Front CellNeurosci. 2022; (In press).                                   10. LiuJ, Ding L, Yang X, Liu Y, Wang Y, Li C, Gao G, Zhao S, Sheng S, Xia X*, ZhengJC* (2022). Exosomes mediate APP dysregulation via APP-miR-185-5p axis. Frontiersin Cell and Developmental Biology. doi: 10.3389/fcell.2022.79338811. XiaX*, Wang Y, Zheng JC* (2022). The microRNA-17~92 family as a keyregulator of neurogenesis and potential regenerative therapeutics ofneurological disorders. Stem Cell Review & Report.doi: 10.1007/s12015-020-10050-5.    12.Sun X, Zhang M, Lu Z, Zhang Z, Zheng JC,Cheng L, Zeng L, Qian Y, Huang L (2022). Turnover intention andrelated factors among resident physicians in China under the standardisedresidency training programme: a cross-sectional survey. BMJ Open. 2022 Apr 11;12(4):e061922. doi:10.1136/bmjopen-2022-061922.PMID: 3541094113. PanJ, Sheng S, Ye L, Xu X, Ma Y, Feng X, Qiu L, Fan Z, Wang Y*, Xia X*, ZhengJC* (2022).  Extracellular vesiclesderived from glioblastoma promote proliferation and migration of neuralprogenitor cells via PI3K-Akt pathway. Cell Communication & Signaling.2022; 20:7  doi:10.1186/s12964-021-00760-9 202114. Zheng X, Wang X, Zhang W, Li R,Liu M, Xu FY, Li YX*, Zheng JC*, Nie ZY* (2021). ExtendedApplication of Digital Clock Drawing Test in the Evaluation of Alzheimer’sDisease Based on Artificial intelligence and the Neural Basis. Current AlzheimerResearch. doi: 10.2174/1567205018666211210150808.15. Ji C, Tang Y, Zhang Y, Li C,Liang H, Ding L, Xia X, Xiong L, Qi XR*, Zheng JC* (2021). Microglialglutaminase 1 deficiency mitigates neuroinflammation associated depression. BrainBehavior and Immunity. doi:10.1016/j.bbi.2021.10.009.16. Wang J, Zhang W, Zheng X, NieZ, Li YX*, Zheng JC* (2021). Exploration and progress of new cognitiveassessment techniques in the diagnosis of dementia. Journal of ChongqingMedical University. doi:10.13406/j.cnki.cyxb.002927.(in Chinese)17. Ma Y, Xu X, Li C, Wang Y, ZhuJ, Xia X*, Zheng JC*(2021). Inducedneural progenitor cell-derived extracellular vesicles promote neural progenitorcell survival via extracellular signal- regulated kinase pathway. CNSNeuroscience and Therapeutics. doi: 10.1111/cns.13744.18. Liu J, Ai P, Sun Y, Yang X,Li C, Liu Y, Xia X, Zheng JC*. Propofol inhibits microglial activationvia miR-106b/Pi3k/Akt axis. Front. Cell. Neurosci.2021; In Press.19. Liu M, Nie Z, Li R, Zhang W,Huang L, Wang J, Xiao W, Zheng JC*, Li Y*(2021).Neural Mechanism of Repeated Transcranial Magnetic Stimulation to EnhanceVisual Working Memory in Elderly Individuals With Subjective Cognitive Decline.Front. Neurol.  2021; 12:1106.doi:10.3389/fneur.2021.665218. 20. Yuan P, Ding L, Chen H, WangY, Li C, Zhao S, Yang X, Ma Y, Zhu J, Qi X, Zhang Y, Xia X*, Zheng JC* (2021). Neural stem cell-derived exosomes regulateneural stem cell differentiation through miR-9-Hes1 axis. Front. Cell Dev.Biol. 2021; 9:601600. doi: 10.3389/fcell.2021.601600. 21.Liu S, Müller S, Dolan RJ, Zhao X, Zheng JC, Heinz A.(2021). Opportunities, risks and challenges in global mental health andpopulation neuroscience: a case of Sino-German cooperation Eur ArchPsychiatry Clin Neurosci. 2021 Sep;271(6):1027-1034. doi:10.1007/s00406-020-01176-1. Epub 2020 Jul 29.PMID: 32729097 22. Xia X*, Wang Y, Zheng JC* (2021). COVID-19 and Alzheimer's disease: how onecrisis worsens the other. Transl. 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Safety, Tolerability, and Immunogenicity ofCOVID-19 Vaccines: A Systematic Review and Meta-Analysis. medRxiv. doi:10.1101/2020.11.03.20224998. 28. Ding L ,Xu X, Li C , Wang Y*, Xia X*, Zheng JC* (2020). Glutaminase inmicroglia: a novel regulator of neuroinflammation. Brain Behav Immun.doi:10.1016/j.bbi.2020.11.038. 29. Dalfo D, Ding Y,Liang Q, Fong A, Cipriani PG, Piano F, Zheng JC, Qin Z, Hubbard EJA*.A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused byElevated GLP-1/Notch Signaling in Caenorhabditis elegans. G3 (Bethesda).doi:10.1534/g3.120.401632. 30. Qiu L, Zhang M, Zhang S, TangY,  Zhang Y, Li C, Wang Y, Jiang L* and Zheng JC*(2020).  Activation of CXCR7 promotes endothelial repair and reduces the carotid atherosclerotic lesionsthrough inhibition of pyroptosis signaling pathways. Aging Cell.doi:10.1111/acel.13205. 31. 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LiuS, Müller S, Dolan RJ, Zhao X, Zheng JC, Andreas Heinz.(2020). Opportunities, risks and challenges in global mental health andpopulation neuroscience: a case of Sino-German cooperation. Eur ArchPsychiatry Clin Neurosci. doi:10.1007/s00406-020-01176-1. 38. Fu S, Wang Y, XiaX*, Zheng JC* (2020). Exosomeengineering: current progress in cargo loading and targeted delivery. NanoImpact. doi:10.1016/j.impact.2020.100261. 39. Liu Z , ZhengJC,Tang W. Special Issue on Advanced Diagnosis and Therapy for Major Diseases andInjuries. Nano LIFE. 2020:2002001. doi: 10.1142/S1793984420020018.   主要科技奖励：1. 2008年，美国内布拉斯加州立大学医学中心杰出科学家奖（UNMC Outstanding Scientist Award）2. 2005年，美国内布拉斯加州立大学医学中心约瑟夫·吉尔摩(青年)科学家奖（UNMC Joseph P. Gilmore Outstanding Investigator Award） 主要专利：获国际专利1项，国内专利2项：1. “U.S. Application No. 15/503,649 - Methods and Compositions forSelective Generation of Dopaminergic Precursors (VP 160351-010300)”2.A method for detectingaxon growth orientation of cortical neurons and its application 3. 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