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个人简介 Personal Profile         本人担任同济大学附属第十人民医院药学部副主任，主任药师/博导，从事药理学/临床药学领域研究工作。近十年来，围绕脂肪肝、糖脂代谢异常等代谢疾病患者易患心血管疾病并逐渐成为“共病”这一临床重要问题，针对过度炎症反应在这类慢性疾病发生发展中的作用，在国自然面上（3项）、国自然青年等8个项目资助下，从肝脏、血管、血清等临床样本入手，发现多个新功能因子通过精准调控靶器官内的慢性炎症反应，在代谢紊乱与心血管疾病“互扰、互促”过程中起到重要的保护作用。基于这些靶点，开发潜在药物化合物，提出基于“精准调控炎症”的药物干预策略。        近年来以第一作者或通讯作者在高水平学术期刊上发表SCI 文章共 33篇，其中9篇IF2022> 10，最高IF为39.4，包括：国际心血管领域Top 1期刊European Heart Journal、中国药学Top 1期刊Acta Pharm Sin B、国际松果体Top 1期刊J Pineal Res、国际环境/公共卫生知名期刊Biological Trace Element Research、国际药理学经典期刊British Journal of Pharmacology、美国心脏学会经典期刊ATVB及Hypertension等。本人还担任中国药理学会心血管药理专业委员会委员、中国药理学会生化与分子药理专业委员会委员等学术兼职。 研究方向Research Directions 心血管代谢药理学 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 科研项目 1.      国家自然科学基金面上项目：GSDME介导的非传统细胞焦亡在药物性肝损伤中的作用及分子机制(No. 82274030)，52万元，2023.01-2026.122.      国家自然科学基金面上项目：Caspase-3/GSDME介导的新型细胞焦亡在血管衰老中的作用及分子机制(No. 81971306)，55万元，2020.01-2023.123.      国家自然科学基金面上项目：代谢调控新因子Irisin延缓血管衰老的作用及机制研究(No.81773719)，55万元，2018.01-2021.124.       国家自然科学基金青年项目：α7nAChR在血管损伤后新生内膜增生中的作用及机制(No.81300081)，23万元，项目负责人，2014.01-2016.125.      上海市人力资源和社会保障局：上海市人才发展资金（No.2020091），30万元，2020.11-2023.106.       上海市自然科学基金青年项目：血管损伤后新生内膜增生的胆碱能受体作用及机制(No.13ZR1459300)，15万元， 2013.10-2015.097.       上海市卫健委“医苑新星”青年医学人才培养资助计划（No.20191011），10万元，2019.10-2022.098.        同济大学“中央高校基本科研业务费专项资金”自主原创项目：GSDME介导的新型细胞焦亡在药物性肝损伤中的作用及分子机制，10万元，2021.07-2022.129.        同济大学“中央高校基本科研业务费专项资金”学科交叉项目：血管损伤后平滑肌细胞表型转换的表观遗传调控网络研究，10万元，2015.07-2016.0710.      同济大学优秀青年人才培养计划：5万元，2015.01-2016.12 研究成果 按通讯作者和第一作者分开，并以IF降序排列：通讯作者1.        Chen Chi, Hui Fu, Yong-HuaLi, Guo-Yan Zhang, Fei-Yan Zeng, Qing-Xin Ji, Qi-Rui Shen, Xu-Jie Wang, Zi-ChenLi, Can-Can Zhou, Di-Yang Sun, Jiang-Tao Fu, Wen-Bin Wu, Ping-Ping Zhang,Jia-Bao Zhang, Jian Liu, Fu-Ming Shen*, Dong-Jie Li*, Pei Wang*. Exerkine fibronectin type-III domain-containing protein5/irisin-enriched extracellular vesicles delay vascular ageing by increasingSIRT6 stability. Eur Heart J. 2022 ; ehac431. IF=35.8552.        Jie Tong, Xiu-Ting Lan, ZhenZhang, Yi Liu, Di-Yang Sun, Xu-Jie Wang, Shen-Xi Ou-Yang, Chun-Lin Zhuang,Fu-Ming Shen, Pei Wang*, Dong-Jie Li*.Ferroptosis inhibitor liproxstatin-1 alleviates metabolicdysfunction-associated fatty liver disease in mice: potential involvement ofPANoptosis. Acta Pharmacologica Sinica. 2022, Online ahead ofprint. IF=7.1693.        Hui Fu, Ji-Kuai Chen, Wen-Jie Lu,Yu-Jie Jiang, Yuan-Yuan Wang, Dong-Jie Li*, Fu-Ming Shen*.Inflammasome-Independent NALP3 Contributes to High-Salt Induced EndothelialDysfunction. Front Pharmacol. 2018; 9:968. IF=5.9884.        Jian-Jin Wu, Jie Jin, Yong-Hua Li, Chao Wang, Jun Bai,Qing-Jun Jiang, Tian-Xiao He, Shao-Jie Nie, Dong-Jie Li*, Le-Feng Qu*.LncRNA FGF7-5 and lncRNA GLRX3 together inhibits the formation of carotidplaque via regulating the miR-2681-5p/ERCC4 axis in atherosclerosis. Cell Cycle. 2022 Sep 7;1-18.IF=5.1735.        Can-Can Zhou, Yu-Qiong He,Yu-Shuang Qiu, Chen-Xu Ni, Fu-Ming Shen, Dong-Jie Li*. Zincsupplementation ameliorates sorafenib-induced cognitive impairment throughROS/JNK signaling pathway. Biol TraceElem Res. 2022 Feb 7. Online ahead of print. IF=4.0816.        Can-Can Zhou, Xu-Jie Wang,Zi-Chen Li, Wen-Jie Lu, Yun-Ting Zhang, Fu-Ming Shen, Dong-Jie Li*. Leadexposure in developmental ages promotes Aβ accumulation by disturbing Aβ transportationin blood-cerebrospinal fluid barrier/blood-brain barriers and impairing Aβ clearancein the liver. Biol Trace Elem Res. 2022;200(8):3702-3711. IF=4.0817.        Fang Huang, Min-Ni, Jing-MingZhang, Dong-Jie Li*, Fu-Ming Shen*, TRPM8 downregulation by angiotensinIIin vascular smooth muscle cell is involved in hypertension. Mol Med Rep, 2017, 15(5): 31-35. IF=3.4238.        Yu-Gang Zhuang, Yuan-ZhuoChen, Shu-Qin Zhou, Hu Peng, Yan-Qing Chen, Dong-Jie Li*. High plasma levels of pro-inflammatoryfactors interleukin-17 and interleukin-23 are associated with poor outcome of cardiac-arrestpatients: a single center experience. BMCCardiovasc Disord. 2020; 20:170. IF=2.1749.        Di-Yang Sun, Jiang-Tao Fu, Guo-QiangLi, Wen-Jie Zhang, Fei-Yan Zeng, Jie Tong, Chao-Yu Miao, Dong-Jie Li*, PeiWang*. iTRAQ- and LC-MS/MS-based quantitative proteomics reveals Pqlc2 as apotential regulator of hepatic glucose metabolism and insulin signallingpathway during fasting. Clin ExpPharmacol Physiol. 2021 Feb; 48(2):238-249. IF=2.56第一作者1.        Dong-Jie Li, Jie Tong, Yong-Hua Li, Hong-Bo Meng, Qing-Xin Ji, Guo-Yan Zhang, Jia-HuiZhu, Wen-Jie Zhang, Fei-Yan Zeng, Gang Huang, Xia Hua, Fu-Ming Shen*, Pei Wang*.Melatonin safeguards againstfatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination andstabilization in a β-arrestin-1 dependent manner. J Pineal Res.2019;67(4): e12611. IF=14.22.        Dong-Jie Li, Jian Liu, Xia Hua, Hui Fu, Fang Huang, Yi-Bo Fei, Wen-JieLu, Fu-Ming Shen*, Pei Wang*. Nicotinic acetylcholine receptor alpha7 subunitimproves energy homeostasis and inhibits inflammation in nonalcoholic fattyliver disease. Metabolism, 2018; 79:52-63. IF=13.9343.        Dong-Jie Li, Hui Fu, Ting-Zhao, Min-Ni, Fu-Ming Shen*.Exercise-stimulated FGF23 promotes exercise performance via controlling theexcess reactive oxygen species production and enhancing mitochondrial functionin skeletal muscle. Metabolism, 2016, 65(5) :747-756. IF=13.9344.        Dong-Jie Li, Yong-Hua Li, Hong-Bin Yuan, Le-Feng Qu, Pei-Wang*, Thenovel exercise-induced hormone irisin protects against neuronal injury viaactivation of the Akt and ERK1/2 signaling pathways and contributes to theneuroprotection of physical exercise in cerebral ischemia. Metabolism, 2017, 68: 31-42. IF=13.9345.        Dong-Jie Li, Si-Jia Sun,Jiang-Tao Fu, Shen-Xi Ou-Yang, Qin-Jie Zhao, Li Su, Qing-Xin Ji, Di-Yang Sun,Jia-Hui Zhu, Guo-Yan Zhang, Jia-Wei Ma, Xiu-Ting Lan, Yi Zhao, Jie Tong,Fu-Ming Shen, Pei Wang*. NAD+-boosting therapy alleviatesnonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. Theranostics,2021;11(9):4381-4404. IF=11. 6006.        Dong-Jie Li, Hui Fu, Jie Tong, Yong-HuaLi, Lei-Feng Qu, Pei Wang, Fu-Ming Shen*. Cholinergic anti-inflammatory pathwayinhibits neointimal hyperplasia by suppressing inflammation and oxidativestress. Redox Biol, 2018; 15: 22-33. IF=10.787 7.        Dong-Jie Li, Fang Huang, Min-Ni, Hui Fu, Liang-Sheng Zhang, Fu-MingShen*. Alpha7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II-InducedSenescence in Vascular Smooth Muscle Cells by Raising Nicotinamide AdenineDinucleotide-Dependent SIRT1 Activity. ArteriosclerThromb Vasc Biol, 2016, 36 (8):1566-1576. IF=10.5148.        Jie Tong#, Dong-Jie Li#, Hong-Bo Meng, Di-Yang Sun, Xiu-Ting Lan, Min Ni, Jia-Wei Ma,Fei-Yan Zeng, Si-Jia Sun, Jiang-Tao Fu, Guo-Qiang Li, Qing-Xin Ji, Guo-YanZhang, Qi-Rui Shen, Yuan-Yuan Wang, Jia-Hui Zhu, Yi Zhao, Xu-Jie Wang, Yi Liu,Shen-Xi Ou-Yang, Chun-Quan Sheng, Fu-MingShen*, Pei Wang*. Targetinga novel inducible GPX4 alternative isoform to alleviate ferroptosis and treatmetabolic-associated fatty liver disease. Acta PharmaceuticaSinica B. 2022 Sep; 12(9):3650-3666. IF=14.9039.        Dong-Jie Li, Roger G Evans, Zhong-Wei Yang, Shu-Wei Song, Pei Wang, Xiu-Juan Ma,Chong Liu, Xi Tao, Ding-Feng Su, Fu-Ming Shen*. Dysfunction of the cholinergicanti-inflammatory pathway mediates organ damage in hypertension. Hypertension. 2011;57(2):298-307. IF=9.89710.    Dong-Jie Li, Jie Tong,Fei-Yan Zeng, Meng-Qi Guo, Yong-Hua Li, Hong-Bo Wang*, Pei Wang*. Nicotinic ACh receptor α7 inhibitsPDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3. British Journal of Pharmacology, 2019;176:4388-4401. IF=9.47311.    Dong-Jie Li, Fang Huang, Wen-Jie Lu, Guo-Jun Jiang, Ya-Ping Deng, Fu-MingShen*, Metformin promotes irisin release from murine skeletal muscleindependently of AMP-activated protein kinase activation. Acta Physiol, 2015, 213(3): 711-721. IF=7.523 12.     Zhong-Wei Yang#, Dong-Jie Li#, Chong Liu, PingHan, Yi-Li Yang, Ding-Feng Su, Fu-Ming Shen*. Role of vascular K(ATP) channelsin blood pressure variability after sinoaortic denervation in rats. Acta Pharmacologica Sinica.2011;32(2):194-200. IF=7.16913.    Dong-Jie Li, Qiu Tang, Fu-Ming Shen, Ding-Feng Su, Jun-Li Duan, Xi Tao*.Overexpressed alpha7 nicotinic acetylcholine receptor inhibited proinflammatorycytokine release in NIH3T3 cells. JBiosci Bioeng. 2009;108(2):85-91.IF=3.185 学生信息 研究生 童洁 欧阳沈玺 张振 信如娟 张妍 尹航 学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份