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个人简介 Personal Profile 田志新，同济大学教授，国家青年千人计划获得者。2003年于中国科学院化学研究所获得化学博士学位。2004-2011年先后在美国明尼苏达大学和太平洋西北国家实验室从事合作研究。2011年被聘为中国科学院大连化学物理研究所研究员，高分辨质谱技术研究组组长。2013年被聘为同济大学化学科学与工程学院教授、博士生导师。目前主要研究领域是基于生物质谱的蛋白质组学与糖基化修饰组学。发明了生物质谱原位解析算法iMEF，并基于iMEF发展了一系列蛋白质及翻译后修饰搜索引擎；开展了癌症、癌症干细胞潜在N-糖蛋白质标志物发现等研究工作。在JACS、Angew、PNAS、Chemical Reviews、Chemical Communications、Analytical Chemistry等刊物上发表论文90多篇。现任中国质谱学会理事，中国生物化学与分子生物学会糖复合物专业委员会委员、蛋白质组学专业委员会委员，中国生物物理学会糖生物学分会委员。 研究方向Research Directions 生物质谱与蛋白质组学 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 团队展示 目前主要致力于生物分子修饰糖链及游离多糖定性定量新技术新方法的研发及应用研究；在样本制备、液相色谱分离、串级质谱分析及生物信息学数据解析等环节发展糖链结构特异分析方法；应用于疾病潜在早诊标志物、预后标志物、药物靶点的发现，以及蛋白类药物的表征。 项目情况 § 国家自然科学基金面上项目（22074105，基于烷基酰胺化衍生反应和链接组合数据库搜索的唾液酸链接特异N-糖蛋白质组学的研发与应用研究），2021-2024，负责人，在研§ 2020年国家重点研发计划“科技冬奥”重点专项-冬季项目运动训练与比赛关键技术，2021-2022，项目骨干，在研§ 国家自然科学基金面上项目（21775110，基于近同重二甲基标记和同位素轮廓指纹比对的完整N-糖肽定性定量分析研究），2018-2021，负责人，已结题§ 国家自然科学基金面上项目（21575104，基于同位素轮廓指纹比对和同重二甲基标记的整体蛋白质组定量研究），2016-2019，负责人，已结题§ 国家重点基础研究发展（973）计划（2013CB911203，修饰蛋白质规模化分离鉴定新技术新方法），2013-2017，项目骨干，已结题§ 同济大学“千人和引进人才计划”，2013，负责人，已结题§ 国家“青年千人计划”，2012-2014，负责人，已结题 科研项目 § 国家自然科学基金面上项目（22074105，基于烷基酰胺化衍生反应和链接组合数据库搜索的唾液酸链接特异N-糖蛋白质组学的研发与应用研究），2021-2024，负责人，在研§ 2020年国家重点研发计划“科技冬奥”重点专项-冬季项目运动训练与比赛关键技术，2021-2022，项目骨干，在研§ 国家自然科学基金面上项目（21775110，基于近同重二甲基标记和同位素轮廓指纹比对的完整N-糖肽定性定量分析研究），2018-2021，负责人，已结题§ 国家自然科学基金面上项目（21575104，基于同位素轮廓指纹比对和同重二甲基标记的整体蛋白质组定量研究），2016-2019，负责人，已结题§ 国家重点基础研究发展（973）计划（2013CB911203，修饰蛋白质规模化分离鉴定新技术新方法），2013-2017，项目骨干，已结题§ 同济大学“千人和引进人才计划”，2013，负责人，已结题§ 国家“青年千人计划”，2012-2014，负责人，已结题 研究成果 1.     Suideng Qin,Zhixin Tian*. Gain-of-glycosylation in breast multi-drug-resistant MCF-7adenocarcinoma cells and cancer stem cells characterized by site- andstructure-specific N-glycoproteomics. Analytica Chimica Acta, 2023, 10.1016/j.aca.2023.341029.2.     2023-02-20_HailunYang, Feifei Xu, Yun Chen*, Zhixin Tian*. Structural N-glycoproteomicscharacterization of cell-surface N-glycosylation of  MCF-7/ADR cancer stem cells. Journal ofChromatography B, 2023, 1219, 123647 (DOI: 10.1016/j.jchromb.2023.123647).3.     2022-09-16_HailunYang, Zhixin Tian*. Sialic acid linkage-specific quantitative N-glycoproteomicsusing selective alkylamidation and multiplex TMT-labeling. Analytica ChimicaActa, 2022, 1230, 340391 (DOI: 10.1016/j.aca.2022.340391). 4.     2022-08-05_ShanshanQin, Suideng Qin, Zhixin Tian*. Progresses in mass spectrometry-based plantN-glycomics and N-glycoproteomics. International Journal of Mass Spectrometry(invited article in memory of Prof. Pengyuan Yang). 2022, 481, 116917 (DOI: 10.1016/j.ijms.2022.116917).5.    2022-06-04_Suideng Qin and Zhixin Tian*. Proteoform Identification withintact protein database search engine ProteinGoggle. Methods in molecularbiology (Clifton, N.J.), 2022, 2500, 131-144 (DOI: 10.1007/978-1-0716-2325-1_10).6.     2022-05-04_ZihanZhang, Hua Xu* and Zhixin Tian*. Exploration of quantitative site-specificserum O-glycoproteomics with isobaric labelling for the discovery of putativeO-glycoprotein biomarkers. Proteomics-Clinical Applications, 2022, e2100095 (DOI:10.1002/prca.202100095).7.    2022-04-01_Shanshan Qin, Suideng Qin, Zhixin Tian*. Comprehensive site-and structure-specific characterization of N-glycosylation in model plantArabidopsis using mass-spectrometry-based N-glycoproteomics. Journal ofChromatography B, 2022, 1198, 123234 (DOI: 10.1016/j.jchromb.2022.123234).8.     2022-03-29_MingBi, Bing Bai*, Zhixin Tian*. Structure-specific N-glycoproteomicscharacterization of NIST monoclonal antibody reference material 8671. Journalof Proteome Research, 2022, 21, 1276−1284 (DOI: 10.1021/acs.jproteome.2c00027).9.    2021-12-26_Lehua Lu, Menghui Xiang, haoran Lu, Zhixin Tian* and YihanGao*. Progresses on quantification of nicotine content and form distribution inelectronic cigarette liquids and aerosols. Analytical Methods, 2022, 14(4),359-377 (DOI: 10.1039/d1ay01679b).10.  2021-09_毕明，田志新*。结构特异N-糖蛋白质组学研究进展。质谱学报(邀请综述), 2021, 42 (5), 897-913 (DOI:10.7538/zpxb.2021.0122, Funding N/A).11.  2021-11-15_YanqiuGong#, Suidong Qin#, Lunzhi Dai*, Zhixin Tian*. Theglycosylation in SARS-CoV-2 and its receptor ACE2. Signal Transduction andTargeted Therapy (invited review), 2021, 6 (1), 396 (DOI:10.1038/s41392-021-00809-8; Funded by NSFC 21775110 (6th)  and 22074105 (7th), non-first).12.  2021-10-28_ Hailun Yang,Feifei Xu, Kaijie Xiao, Yun Chen*, Zhixin Tian*. N‑Glycoproteomics Study of Putative N‑Glycoprotein Biomarkers of Drug Resistance in MCF‑7/ADR Cells. Phenomics, 2021, 1, 269–284 (DOI: 10.1007/s43657-021-00029-8.(Funded by NSFC 21775110 and 22074105)13.  2021-10-26_ Yang Su, JianhuiLi, Wenting Zhang, Jinjing Ni, Rui Huang, Zuoqiang Wang, Sen Cheng, Yue Wang,Zhixin Tian, Qiuxiang Zhou, Donghai Lin, Wenjuan Wu, Christoph M. Tang, XiaoyunLiu, Jie Lu, Yu-Feng Yao. Methylation of PhoP by CheR Regulates SalmonellaVirulence. mBio, 2021, 12(5), e0209921 (DOI: 10.1128/mBio.02099-21).14.  2021-09-20_Suideng Qin, Zhixin Tian*. Chapter 5: Analytical Softwareand Databases in N-glycoproteomics. PP 131-166 in “Mass Spectrometry–BasedGlycoproteomics and Its Clinic Application” (Ed. Prof. Haojie Lu, Taylor &Francis Books, Inc., ISBN 978-1-0320-2861-3).15.  2021-04-30_Hailun Yang,Feifei Xu, Kaijie Xiao, Yun Chen*, Zhixin Tian*. PutativeN-glycoprotein markers of MCF-7/ADR cancer stem cells from N-glycoproteomicscharacterization of the whole cell lysate. Talanta, 2021, 232, 122437 (DOI:10.1016/j.talanta.2021.122437; Funded by NSFC 21775110 and 22074105)16.  2021-04-09_HaoranLu, Kaijie Xiao, Zhixin Tian*. Benchmark of site- and structure-specificquantitative tissue N-glycoproteomics for discovery of potential N-glycoproteinmarkers: a case study of pancreatic cancer. Glycoconjugate Journal, 2021, 38(2),213–231 (DOI: 10.1007/s10719-021-09994-8; Funded by NSFC 21775110 and 22074105).17.  2020-12-08_SvetlanaRezinciuc, Zhixin Tian, Si Wu, Shawna Hengel, Ljiljana Pasa-Tolic and HeatherS. Smallwood*. Mapping Influenza-Induced Posttranslational Modifications onHistones from CD8+ T Cells. Viruses, 2020, 12 (12), 1409 (DOI:10.3390/v12121409).18.  2020-09-23_YunShen Kaijie Xiao Zhixin Tian. Site- and structure-specific characterization ofhuman urinary N‐glycoproteome withsite‐determining andstructure‐diagnostic productions. Rapid Communications in Mass Spectrometry, 2021, 35 (1), e8952 (DOI:10.1002/rcm.8952).19.  2020-7-29_JingyunYang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi, Linlin Bao,Fei Mo, Xue Li, Yong Huang, Weiqi Hong, Yun Yang, Yuan Zhao, Fei Ye, Sheng Lin,Wei Deng,Hua Chen, Hong Lei, Ziqi Zhang, Min Luo, Hong Gao, Yue Zheng, Yanqiu Gong,Xiaohua Jiang,Yanfeng Xu, Qi Lv, Dan Li, Manni Wang, Fengdi Li, Shunyi Wang,Guanpeng Wang, Pin Yu,Yajin Qu, Li Yang, Hongxin Deng, Aiping Tong, Jiong Li,Zhenling Wang, Jinliang Yang,Guobo Shen, Zhiwei Zhao, Yuhua Li, Jingwen Luo,Hongqi Liu, Wenhai Yu, Mengli Yang,Jingwen Xu, Junbin Wang, Haiyan Li, HaixuanWang, Dexuan Kuang, Panpan Lin,Zhengtao Hu, Wei Guo, Wei Cheng, Yanlin He,Xiangrong Song, Chong Chen, Zhihong Xue,Shaohua Yao, Lu Chen, Xuelei Ma, SiyuanChen, Maling Gou, Weijin Huang, Youchun Wang,Changfa Fan, Zhixin Tian, MingShi, Fu-Sheng Wang, Lunzhi Dai, Min Wu, Gen Li,Guangyu Wang, Yong Peng, ZhiyongQian, Canhua Huang, Johnson Yiu-Nam Lau,Zhenglin Yang, Yuquan Wei, Xiaobo Cen,Xiaozhong Peng, Chuan Qin, Kang Zhang*, Guangwen Lu*& Xiawei Wei*. A vaccine targeting the RBD of the S protein of SARS-CoV-2induces protective immunity. Nature, 2020,586 (7830), 572–577 (DOI: 10.1038/s41586-020-2599-8, Funding N/A).20.  2020-06-19_杜钰莹，王悦，赖治臻，田志新*，李智立*。肺癌与肺良性疾病特异血清免疫炎性蛋白质Ｎ-糖基化修饰差异。基础医学与临床，2020，40 (8), 1096-1102(DOI: １００１-６３２５(２０２０)０８-１０９６-０７, Funding N/A)。21.  2020-05-27_Yue Wang, Kaijie Xiao, Zhixin Tian*.Quantitative N-glycoproteomics using stable isotopic diethyl labeling. Talanta,2020, 219, 121359 (DOI: 10.1016/j.talanta.2020.121359, Funded by NSFC21775110 and 22074105).22.  2020-02-07_Yue Wang#, Feifei Xu#,Yun Chen*, Zhixin Tian*. Quantitative N-glycoproteomics study of cell-surfaceN-glycoprotein markers of MCF-7/ADR cancer stem cells. Analytical and Bioanalytical Chemistry, 2020, 412,2423–2432 (DOI: 10.1007/s00216-020-02453-7, Funded by NSFC21775110 and 22074105).23.  2020-02-05_Feifei Xu#, Yue Wang#, KaijieXiao, Yechen, Hu, Zhixin Tian*, Yun Chen*. Quantitative site- andstructure-specific N-glycoproteomics characterization of differentialN-glycosylation in MCF-7/ADR cancer stem cells. Clinical Proteomics, 2020, 17,3 (DOI: 10.1186/s12014-020-9268-7, Funded by NSFC 21775110 and 22074105). 24.  2020-01-22_Yue Wang, Zhixin Tian*. New Energy Setup Strategy for Intact N‑Glycopeptides Characterization UsingHigher-Energy Collisional Dissociation. Journal of the American Society for MassSpectrometry, 2020, 2020, 31, 651−657 (DOI: 10.1021/jasms.9b00089, , Funded by NSFC 21775110 and 22074105).25.  2019-11-20_Bingbing Xue, Kaijie Xiao, YueWang, Zhixin Tian*.  Site- and structure-specificquantitative N-glycoproteomics study of differential N-glycosylation in MCF-7cancer cells. Journal of Proteomics, 2020, 212, 103594 (DOI:10.1016/j.jprot.2019.103594).26.  2019-10-28_Dapeng Zhou*, Kaijie Xiao, ZhixinTian*. Separation and detection of minimal length isomeric glycopeptideneoantigen epitopes centering GSTA region of MUC1 by LC-MS. RapidCommunications in Mass Spectrometry, 2019, 34, e8622 (DOI: 10.1002/rcm.8622). 27.  2019-10-14_Kaijie Xiao, Yuyin Han, HailunYang, Haoran Lu, Zhixin Tian*. Mass spectrometry-based qualitative andquantitative N-glycomics: an update of 2017-2018. Analytica Chimica Acta (invited review), 2019, 1091, 1-21 (DOI: 10.1016/j.aca.2019.10.007).28.  2019-08-23_Kaijie Xiao, Zhixin Tian*. Site-and structure-specific quantitative N-glycoproteomics using RPLC-pentaHILICseparation and intact N-glycopeptide search engine GPSeeker. Current Protocolsin Protein Science, invited protocol, 2019, 97, e94 (DOI:10.1002/cpps.94). 29.  2019-06-12_Yue Wang#, Feifei Xu#, Kaijie Xiao, Yun Chen* andZhixin Tian*. Site- andstructure-specific characterization of N-glycoprotein markers of MCF-7 cancerstem cells using isotopic-labeling quantitative N-glycoproteomics. Chemical Communications, 2019, 55, 7934-7937(DOI:10.1039/c9cc04114a).30.  2019-05-22_KaijieXiao, Zhixin Tian*. GPSeeker enables quantitativestructural N-glycoproteomics for site- and structure-specific characterizationof differentially expressed N-glycosylation in hepatocellular carcinoma.Journal of Proteome Research, 2019, 18, 2885-2895 (DOI: 10.1021/acs.jproteome.9b00191)31.  Yun Shen#, Yiwen You#, Kaijie Xiao, YunChen*, Zhixin Tian*. Large-scale identification and fragmentation pathwaysanalysis of N-glycans from mouse brain. Journal of American Society for Mass Spectrometry,2019, 30(7), 1254-1261 (DOI:10.1007/s13361-019-02181-y).32.  BingbingXue, Kaijie Xiao, Zhixin Tian*. Top-down characterization of mouse corehistones. Journal of Mass Spectrometry,2019, 54, 258-265 (DOI: 10.1002/jms.4339).33.  2018-10-21_YuyinHan, Kaijie Xiao, Zhixin Tian*. Comparative glycomics study of cell-surfaceN-glycomes of HepG2 versus LO2 cell lines. Journal of Proteome Research,2019, 18(1), 372-378 (DOI:10.1021/acs.jproteome.8b00655).34. 2018-09-14_HaoWang, Zhixin Tian*. Facile synthesis of titanium (IV) ion immobilizedpoly-glycidyl methacrylate microparticles functionalized with polyethylenimineand adenosine triphosphate for highly specific intact phosphoproteinsenrichment. Journal of Separation Science, 2018, 41, 4194-4202 (DOI: 10.1002/jssc.201800689).35. 2018-08-21_ShashaLi#, Kaijie Xiao#, Yue Zhou#, Jing Li*, Zhixin Tian*. Selective fragmentationof the N-glycan moiety and protein backbone of ribonuclease B on an OrbitrapFusion Lumos Tribrid Mass Spectrometer. Rapid Communications in MassSpectrometry, 2018, 32, 2031-2039(DOI: 10.1002/rcm.8273).36. 2018-06-20_HaoWu, Kaijie Xiao, Zhixin Tian*. Top-down characterization of chicken corehistones. Journal of Proteomics, 2018, 184, 34-38 (DOI:10.1016/j.jprot.2018.06.007).37. 2018-06-06_HaoWang, Zhixin Tian*. Facile synthesis of titanium (IV) ion immobilized adenosinetriphosphate functionalized silica nanoparticles for highly specific enrichmentand analysis of intact phosphoproteins. Journal of Chromatography A, 2018, 1564, 69-75 (DOI: 10.1016/j.chroma.2018.06.013).38. 2018-05-03_KaijieXiao, Yuyin Han, Zhixin Tian*. Large-scale identification and visualization ofhuman liver N-glycome enriched from LO2 cells. Analytical and Bioanalytical Chemistry, 2018,410 (17), 4195–4202 (DOI: 10.1007/s00216-018-1070-2).39. 2017-12-16_HaoWang, Jinqiang Zhong, Kaijie Xiao, Zhixin Tian*. Enrichment of intactphosphoproteins using immobilized titanium (IV) affinity chromatographymicrospheres. Separation Science Plus, 2018, 1(2), 93-99 (DOI: 10.1002/sscp.201700008). 40. 2017-10-20_KaijieXiao, Yue Wang, Yun Shen, Yuyin Han, Zhixin Tian*. Large-scale identificationand visualization of N-glycans with primary structures using GlySeeker. RapidCommunications in Mass Spectrometry, 2018, 32, 142-148 (DOI: 10.1002/rcm.8023).41. 2017-10-17_KaijieXiao, Yun Shen, Shasha Li, Zhixin Tian*. Accurate Phosphorylation SiteLocalization Using Phospho-brackets. Analytica Chimica Acta, 2017, 996, 38-47(DOI: 10.1016/j.aca.2017.09.043).42. 2017-03-21_KaijieXiao, Fan Yu, Houqin Fang, Bingbing Xue, Yan Liu, Yunhui Li, and Zhixin Tian*.Are neutral loss and internal product ions useful for top-down proteinidentification? Journal of Proteomics, 2017, 160, 21-27(DOI:10.1016/j.jprot.2017.03.011).43.2017-02-01_肖开捷，田志新*。整体蛋白质电喷雾质谱原位解析。生命的化学，2017，37(1),16-21。44.2016-12-01_Kaijie Xiao, Zhixin Tian*.Top-down Characterizationof Histone H4 Proteoforms with ProteinGoggle 2.0. Chinese Journal ofChromatography, 2016, 34(12),1254-1262 (DOI: 10.3724/SP.J.1123.2016.09012).45. 2016-10-27_KaijieXiao, Fan Yu, Zhixin Tian*. Top-down Protein Identification Using IsotopicEnvelope Fingerprinting. Journal of Proteomics, 2017, 152, 41-47 (DOI:10.1016/j.jprot.2016.10.010).46. 2016-06-30_HouqinFang#, Kaijie Xiao#, Yunhui Li, Fan Yu, Yan Liu, BingbingXue, Zhixin Tian*. Intact ProteinQuantitation Using Pseudo-isobaric Dimethyl labeling. Analytical Chemistry,2016, 88, 7198−7205 (DOI: 10.1021/acs.analchem.6b01388).47. 2016-03-20_FanYu, Houqin Fang, Kaijie Xiao, Yan Liu, Bingbing Xue, Zhixin Tian*. Mass Measurement Accuracy of the Orbitrap inIntact Proteome Analysis. Rapid communications in Mass Spectrometry. 2016, 30, 1391-1397 (DOI:10.1002/rcm.7574).48. 2015-10-06_KaijieXiao, Fan Yu, Houqin Fang, Bingbing Xue, Yan Liu, Zhixin Tian*. Accurate and Efficient Resolution ofOverlapping Isotopic Envelopes in Protein Tandem Mass Spectra. Scientific Reports, 2015, 5, 14755 (DOI: 10.1038/srep14755).49. 2014-05-09_ZhixinTian*, Dana. R. Reed, Steven R. Kass*. H/D Exchange Pathways: Flip-flop andRelay Processes. International Journal of Mass Spectrometry, 2015, 377, 130-138(DOI: 10.1016/j.ijms.2014.04.020).50.  2013-11-18_Zhixin Tian*, Lev Lis, Steven R.Kass*. Carbon–Hydrogen Bond Dissociation Energies: The Curious Case ofCyclopropene. Journal of Organic Chemistry, 2013, 78(24), 12650-12653 (DOI: 10.1021/jo402263v).51.  2013-08-16_Zhixin Tian*, Steven R. Kass*. Carbanions in the Gas Phase. ChemicalReviews, 2013, 113(9), 6986–7010 (DOI: 10.1021/cr4000896).52.  2013-03-09_Zhixin Tian*, et al. Interpreting Raw Biological Mass Spectra UsingIsotopic Mass-to-charge Ratio and Envelope Fingerprinting. Rapid communicationsin Mass Spectrometry, 2013, 27(11), 1267-1277 (DOI: 10.1002/rcm.6565). 学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份