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Home People Research Research Publications Teaching Protocol Sharing News Center for Pain Medicine Research Brief Info Software Alumni Join us Contact us Chun-Yu Ho Professor Department of Chemistry Personal Profile 何振宇 何振宇博士，南方科技大学化学系青年教师，Grubbs 研究院双聘教授，广东省突出贡献人员专业技术资格有机化学研究员，广东省高校化学类专业指导委员会委员，马萨诸塞州理工学院(MIT)博士后，在交叉氢烯基化、N-杂环卡宾Ni(II)H催化剂、催化合成支链和偕二取代烯烃、 N-杂环卡宾-过渡金属不对称催化的远程电子效应技术上建立了比较良好的国际声誉，是我国乃至全世界目前在“NHC-Ni” 和“Hydroalkenylation”领域中最优秀的化学家之一，他积极申请各种研究经费，紧追国际前沿，科技创新能力和组织管理效果情况良好。 Personal Profile Research 1. Catalytic organic synthesis (Gem-Olefins); 2. Sustainable organic/hybrid materials preparations and applications; 3. Phosphonylation and cyanation to access important biological compounds and their subsequent SAR studies; 4. Olefin polymerization for functional Materials (poly(IB) derivatives) 5. Bioresponsive Heterocycles Library Preparation 6. Organometallic Chemistry (NHC ligand effects) 7. Photochemical activation of carbene transition metal complexes and application 8. Acetylcholinesterase inhibitor design and applications (with School of Pharmacy, CUHK) 9. Mechanistic investigation of NHC-transition metal catalysis (with UCLA) Publications Read More  Publications： （35）. (NHC)Ni(II) directed insertions and higher olefin synthesis from olefins. Zhang, Z. F; Chen. Y; Gu, X;Ho, C.-Y.* Acc. Chem. Res. 2023, 56, 1087.   （34）. Our Voyage from Catalytic Cross-Hydroalkenylation to Transfer-Dehydroaromatization of Cyclic pi-Systems: Reactivity and Selectivity Changes Enabled by NHC-Ni and NHC-Pd Hydride Equivalents. Chen, Y.;Chen. W.;Gu, X.;Ho, C.-Y.* Synlett. 2023, 34, 1639.   （33）. Unsymmetric N-Aryl Substituent Effects on Chiral NHC-Cu: Enantioselectivity and Reactivity Enhancement by Ortho-H and Syn-Configuration. Xi, J.; Ng, E. W. H.; Ho, C.-Y.* ACS Catal. 2023, 13, 407. Highlighted in X-mol.   （32）. (NHC)Pd(II) hydride-catalyzed dehydroaromatization by Olefin Chain-Walking Isomerization and Transfer-Dehydrogenation. Chen. W.; Chen, Y.; Gu, X.; Chen, Z.; Ho, C.-Y.* Nat. Commun. 2022, 13, 5507. Highlighted in X-mol & Chemstation. （31）. NHC-Ni(II)-Catalyzed Cyclopropene-Isocyanide [5+1] Benzannulation. Huang, J.-Q.; Yu, M.; Yong, X.; Ho, C.-Y.* Nat. Commun. 2022, 13, 4145. Highlighted in X-mol. （30）. Diastereodivergent Hydrosilylative Enyne Cyclization Catalyzed by N-Heterocyclic Carbene-Ni(0). Yu, M.; Yong, X.; Gao, W.; Ho, C.-Y.* Chin. J. Chem. 2021, 39, 1587. (Special Issue: SUSTech 10th Anniversary/南科大化学系十周年纪念专辑) （29）. NHC/Nickel(II)-Catalyzed [3+2] Cross-Dimerization of Unactivated Olefins and Methylenecyclopropanes. Huang, J.-Q.; Ho, C.- Y.* Angew. Chem. Int. Ed. 2020, 59, 5288. Highlighted in X-mol. （28）. NHC-Ni catalyzed enantioselective synthesis of 1,4-dienes by cross-hydroalkenylation of cyclic 1,3-dienes and heterosubstituted terminal olefins. Chen, Y.; Dang, L.; Ho, C.- Y.* Nat. Commun. 2020, 11 , 2269. （27）. NHC-Ni catalyzed 1,3- and 1,4-diastereodivergent heterocycle synthesis from hetero-substituted enyne. Yong, X.; Gao, W.; Lin, X.; Ho, C.- Y.* Comm. Chem. 2020, 3 , 50. （26）. NHC-Ni(0) Catalyzed Diastereodivergent Hydroacylative Enyne Cyclization: Synthesis of Heterocycles bearing gamma-Enone. Yong, X.; Ng, E.; Zhen, Z.; Lin, X.; Gao, W.; Ho, C.-Y.* Adv. Synth. Cat. 2020, 362 , 4164. （25）. Applications of (NHC)Ni(II) Catalyzed [3+2] Hydroalkenylation-Rearrangement Cascades. Yong, X.; Huang, J.-Q., Ho, C.- Y.* Chin. J. Org. Chem. 2020, 40, 3327. (Special Issue: Professor Henry N. C. Wong on the occasion of his 70th birthday) （24）. [(NHC)Ni(II)H]-Catalyzed Cross-Hydroalkenylation of Cyclopropenes with Alkynes: Cyclopentadiene Synthesis by [(NHC)Ni(II)]-Assisted C-C Rearrangement. Huang, J.-Q.; Ho, C.-Y.* Angew. Chem. Int. Ed. 2019, 58, 5702. Featured as Inside Cover in Angew. Chem. Int. Ed. 2019, 58, 5466. （23）. Electronic Effects on Chiral NHC–Transition-Metal. Yong, X., Thurston, R. & Ho, C.-Y.* Synthesis. 2019, 51, 2058. （22）. Synthesis and Study of Au(III)-Indolizine Derivatives: Turn-on Luminescence by Photo-induced Control Release. Yang, J.; Zhu, Y.; Tse, A. K.-W.; Zhou, X.; Chen, Y.; Tse, Y. C.;* Wong, K. M.-C.;* Ho, C.-Y.* Chem. Commun. 2019, 55, 4471. （21）. Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer’s disease. Qian, S.; He, .; Wang, Q.; Wong, Y. C.; Mak, M.; Ho, C.-Y.*; Han, Y.*; Zuo, Z*. Life Sciences 2018, 207, 428. （20）. (NHC)NiH-Catalyzed Regiodivergent Cross-Hydroalkenylation of Vinyl Ether with α-Olefin: 1,2- and 1,3-Disubstituted Allyl Ether Syntheses. Chen, W.; Li, Y.; Chen, Y.; Ho, C.-Y.* Angew. Chem. Int. Ed. 2018, 57, 2677. Highlighted in X-mol & Chin. J. Org.Chem. （19）. (NHC)NiH-Catalyzed Intermolecular Regio- and Diastereoselective Cross-Hydroalkenylation of Endocyclic Dienes with α-Olefins. Lian, X.; Chen, W.; Dang, L.; Li, Y.; Ho, C.-Y.* Angew. Chem. Int. Ed. 2017, 56, 9048. Highlighted in X-mol. （18）. Mechanism and Regioselectivities of (NHC)Nickel(II)hydride-Catalyzed Cycloisomerization of Dienes: A Computational Study. Gao, Y.; Houk, K. N.; Ho, C.-Y.*; Hong, X.* Org. Biomol. Chem. 2017, 15, 7131. Themed Collections: Mechanistic Aspects of Organic Synthesis （17）. Catalytic Asymmetric Hydroalkenylation of Vinylarenes: Electronic Effects of Substrates and Chiral N-Heterocyclic Carbene Ligands Ho, C.-Y.*; Chan, C.-W.; He, L. Angew. Chem. Int. Ed. 2015, 54, 4512. Featured as Front Cover & VIP (Very Important Paper), in Angew. Chem. Int. Ed. 2015, 54 (15), 4403. in ChemCatChem 2015, 7, 1639 by Prof. Gerhard Hilt & in ChemInform (preparative org. chem.) & in X-Mol. （16）. Substituted 1,3-cyclohexadiene synthesis by NHC-Nickel(0) catalyzed [2+2+2] cycloaddition of 1,n-Enyne”. Zhao, J.-P.; Chan, S.-C.; Ho, C.-Y.* Tetrahedron 2015, 71, 4426. Invited Special Symposium-in-Print: Progress in organic synthesis: New reactions, strategies and targets. （15）. Computational Exploration of Mechanism and Selectivities of NHC-Ni(II)hydride Catalyzed Hydroalkenylations of Styrene with a-Olefins. Hong, X.; Wang, J.; Yang, Y.-F.; He, L.; Ho, C.-Y.*; Houk, K. N.* ACS Catal. 2015, 5, 5545. （14）. Nitrate-Enhanced NHC-NiH Catalyzed Tail-to-Tail Vinyl Ether Dimerization. He, L.; Ho, C.-Y.* Synlett 2014, 25, 2738. Invited Special Issue: Catalysis with Sustainable Metals. （13）. Medium-Sized Heterocycle Synthesis by the Use of Synergistic Effects of Ni-NHC and γ Coordination in Cycloisomerization. Ho, C.-Y.*; He, L. J. Org. Chem. 2014, 79, 11873. Highlighted thrice: in SynFacts 2014, 10, 913 (by Prof. V. Snieckus) in ChemInform (preparative org. chem.) in Organic Chemistry Highlights, 2015(by Prof. D. F. Taber)“C-O Ring Construction” （12）. Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors. Qian, S.; He, L.; Mak, M.; Han, Y.*; Ho, C.-Y.*; Zuo, Z.* Int. J. Pharmaceutics, 2014, 477, 442. （11）. Shuffle off the Classic b-Si Elimination by Ni-NHC Cooperation: Implication for C-C Forming Reactions Involving Ni-Alkyl-β-Silanes. Ho, C.-Y.*; He, L. Chem. Commun. 2012, 48, 1481. Highlighted twice: in Novo Nordisk & in ChemInform (Organoelement compounds) （10）. Catalytic Intermolecular Tail-to-Tail Hydroalkenylation of Styrenes with alpha Olefins: Regioselective Migratory Insertion Controlled by a Nickel/N-Heterocyclic Carbene. Ho, C.-Y.*; He, L. Angew. Chem. Int. Ed. 2010, 49, 9182. Highlighted thrice: in SynForm 2011, issue 2, A15-16 & as Cover (by Prof. M. Zanda); in SynFacts 2011, issue 3, 310 (by Prof. P. Knochel); in Organic Chemistry Highlights, 2011 Functionalization & Homologation of Alkenes (by Prof. D. F. Taber) （9）. Cyanative Alkene-Aldehyde Coupling: Ni(0)-NHC-Et2AlCN Mediated Chromanols Synthesis with High cis-Selectivity at room temperature. Ho, C.-Y.* Chem. Commun. 2010, 46, 466. （8）. Nitrile assisted, Bronsted acid catalyzed regio and stereoselective diarylphosphonylation of allyl silyl ethers. Ho, C.-Y.*; Chan, C.-W.; Wo, S.-K.; Zuo, Z.; Chan, L.-Y. Biomol. Chem. 2010, 8, 3480. Highlighted in ChemInform (organoelement compounds) （7）. Alpha Olefins as Alkenylmetal Equivalents in Catalytic Conjugate Addition Reactions. Ho, C.-Y.; Ohmiya, H.; Jamison, T. F.* Angew. Chem. Int. Ed. 2008, 47, 1893. （6）. Highly Chemoselective Reductive Amination of Carbonyl Compounds Promoted by InCl3/Et3SiH/MeOH System. Lee, O.-Y.; Law, K.-L.; Ho, C.-Y.; Yang, D.* J. Org. Chem. 2008, 73, 8829. （5）. Highly Selective Coupling of Alkenes and Aldehydes Catalyzed by NHC–Ni–P(OPh)3: Synergy Between a Strong σ-Donor and a Strong π-Acceptor. Ho, C.-Y.; Jamison, T. F.* Angew. Chem. Int. Ed. 2007, 46, 782. Highlighted twice: in Angew. Chem. Int. Ed. as Hot Paper in ChemInform (isocyclic compounds) （4）. Nickel-Catalyzed Coupling of Alkenes, Aldehydes, and Silyl Triflates. Ng, S.-S.; Ho, C.-Y.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 11513. （3）. Nickel-Catalyzed, Carbonyl-Ene-Type Reactions: Selective for Alpha Olefins and More Efficient with Electron-Rich Aldehydes. Ho, C.-Y.; Ng, S.-S.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 5326. Highlighted in ChemInform (isocyclic compounds) （2）. Fluorinated Chiral Secondary Amines as Catalysts for Epoxidation of Olefins with Oxone. Ho, C.-Y.; Chen, Y.-C.; Wong, M.-K.; Yang, D.* J. Org. Chem. 2005, 70, 898. （1）. Asymmetric epoxidation of olefins catalyzed by chiral iminium salts generated in-situ from chiral amines and aldehydes. Wong, M.-K.; Ho, L.-M.; Zheng, Y.-S.; Ho, C.-Y.; Yang, D.* Org. Lett. 2001, 3, 2587.   People Read More PrevNext UpDown Join us Welcome to join us! 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