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Home People Research Research Publications Teaching Protocol Sharing News Center for Pain Medicine Research Brief Info Software Alumni Join us Contact us associate professor associate professor |School of Medicine, Department of Biochemistry Jia, Ning is an associate professor in School of Medicine, SUSTech. Ning got her PhD degree in biochemistry and molecular biology at University of Science and Technology of China in 2016. Then she started her postdoctoral training in Dinshaw J. Patel lab at Memorial Sloan Kettering Cancer Center. Ning joined SUSTech on May, 2021. Ning has focused on elucidating the mechanisms underlying the mysteries of the arms race between microorganisms and their host immune systems. In the past few years, Ning has published 10 research papers as first author or corresponding author (Science, 2020; Nature Reviews Molecular Cell biology, 2021； Molecular Cell, 2019a, 2019b, 2019c; Nature Communications, 2022; Cell Research, 2020，2022; PNAS, 2019; EMBO reports, 2016). The paper Nature Communications, 2022 is recommended by Faculty Opinions; Besides, as first author and co-corresponding author, Ning has been invited to write a review published on Nature Reviews Molecular Cell Biology. In recognition of her scientific excellence, Ning became the sole recipient of 2020 Blavatnik Regional Awards for Young Scientists in Chemistry and was elected as MIT Technology Review Innovators Under 35 Asia Pacific 2022.  EDUCATION: 2006-2010 Ocean University of China, BS in Marine biology. 2010-2016 University of Science and Technology of China, PhD in Biology. Advisor: Zhou, Cong-Zhao/ Chen, Yuxing  WOKRING EXPERIENCE: 2021.06-present, Associate Professor，School of Medicine, Southern University of Science and Technology（SUStech） 2021.05-2022.05, Assistant Professor，School of Medicine, Southern University of Science and Technology（SUStech） 2017-2021 Research Fellow, Memorial Sloan Kettering Cancer Center, New York, USA  HONORS AND AWARDS: 2022 MIT Technology Review Innovators Under 35 Asia Pacific 2022. 2021 Shenzhen overseas high-level talents 2020 Blavatnik Regional Awards for Young Scientists, Winner in Chemistry. 2016 Caisi-Zebrafish Research Award 2010 Outstanding Graduate in Shandong Province 2007,2009 National Scholarship Personal Profile Personal Profile Research 1）Elucidating the mechanism of the arm race between microorganisms and their host immune systems, particularly the prokaryotic immune systems that defend against the invading phages and plasmids. 2）Developing biotechnological tools, including gene editing tools based on CRISPR-Cas systems, to advance our ability to understand and manipulate biological systems. Publications Read More （# co-first author;   *co-corresponding author ） Cui, N.#, Zhang, J.T.#, Li, Y., Liu, Y., Liu, X.Y., Wang, C., Huang, H.*, and Jia, N.* (2023). Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment. Molecular cell, in press. Ning Cui#, Jun-Tao Zhang# Zhuolin Li, Xiao-Yu Liu, Chongyuan Wang, Hongda Huang* and Ning Jia*（2022）Structural basis for the non-self RNA-activated protease activity of Craspase during type III-E CRISPR-Cas immunity. Nature Communications 13, 7549. Dinshaw J. Patel*, You Yu and Ning Jia (2022) Bacterial origins of cyclic nucleotide-activated antiviral immune signaling. Molecular Cell 82, 4591-4610. Jia, N*., & Patel, D. J.* (2022). Structure-based evolutionary relationship between IscB and Cas9. Cell Research 32, 875-877. Jia, N.*, Patel. D. J.*. (2021) Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins. Nature Reviews Molecular Cell Biology，22, 563-579. Meeske A. J.#, Jia, N.#, Cassel A.K., Kozlova A., Liao J., Wiedmann   M., Patel D. J.*, Marraffini L. A.*. (2020) A phage-encoded anti-CRISPR   enables complete evasion of type VI-A CRISPR-Cas immunity. Science   369, 54-59.  Jia, N.*, Xie, W., De La Cruz, J.M.,   Eng, E.T., Patel, D.J.* (2020) Structure-function insights into the initial   step of DNA integration by a CRISPR-Cas-Transposon complex. Cell   research 30,   182-184.  Jia, N.*, Jones, R., Yang, G., Ouerfelli, O., Patel,   D.J.* (2019). CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering   Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity. Molecular   cell 75, 944-956 e946. Jia, N.*, Jones, R., Sukenick, G., Patel, D.J.* (2019)   Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type   III-A CRISPR-Cas Csm Complex and Its Release Path. Molecular cell 75, 933-943   e936. Jia, N.*, Mo, C.Y., Wang, C., Eng, E.T., Marraffini,   L.A., Patel, D.J.* (2019). Type III-A CRISPR-Cas Csm Complexes: Assembly,   Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Molecular   cell 73, 264-277 e265. Jia,   N.#, Unciuleac, M.#, Xue C., Greene   E.C., Patel, D.J.*, Shuman, S.* (2019) Structures and single-molecule   analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA   double-strand break resection. Proceedings   of the National Academy of Sciences of the United States of America 116, 24507-24516. Chen,   L.L., Xie, J., Cao, D.D., Jia, N.,   Li, Y.J., Sun, H., Li, W.F., Hu, B., Chen, Y., Zhou, C.Z. (2018). The   pore-forming protein Aep1 is an innate immune molecule that prevents   zebrafish from bacterial infection. Dev Comp Immunol 82, 49-54.  Jia, N., Liu, N., Cheng, W., Jiang, Y.L., Sun, H.,   Chen, L.L., Peng, J., Zhang, Y., Ding, Y.H., Zhang, Z.H., et al. (2016).   Structural basis for receptor recognition and pore formation of a zebrafish   aerolysin-like protein. EMBO reports 17, 235-248. Zhou, K., Jia, N., Hu, C., Jiang,   Y.L., Yang, J.P., Chen, Y., Li, S., Li, W.F., Zhou, C.Z. (2014). Crystal   structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx   mori. Proteins 82, 3224-3229.  Song, N., Jia, N., Yanagimoto, T.,   Lin, L., Gao, T. (2013). Genetic differentiation of Trachurus japonicus from   the Northwestern Pacific based on the mitochondrial DNA control region. Mitochondrial   DNA 24, 705-712. He, Y.X., Zhang, N.N., Li, W.F., Jia,   N., Chen, B.Y., Zhou, K., Zhang, J., Chen, Y., Zhou, C.Z. (2012).   N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in   response to pH decrease. Journal of molecular biology 418, 197-207.   Join us Read More Contact Us Contact Address 1088 Xueyuan Avenue, Shenzhen 518055, P.R. China Office Phone 88010071 Email jian@sustech.edu.cn