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Home People Research Research Publications Teaching Protocol Sharing News Center for Pain Medicine Research Brief Info Software Alumni Join us Contact us Zhongmin Liu Assistant Professor Department of Immunology and Microbiology Dr. Liu obtained his Bachelor's degree in Medicine from Nanchang University in 2009, finished his Ph.D. at Peking University in 2015, then joined Hongwei Wang's group as a postdoc at Tsinghua University. Since 2020, Dr. Liu has been employed at the School of Life Sciences at Southern University of Science and Technology; Dr. Liu was honored as Shenzhen Pengcheng Peacock Scholar and the Pearl River Talents (Young Top Talent) of Guangdong Province. As the first author or corresponding author, he has published several works in top journals, including Cell, Nature Chemical Biology, Nature Communications, PNAS、Protein&Cell, and other authoritative international journals. Personal Profile Personal Profile Research Our group applies multidisciplinary techniques such as cryo-Electron Microscopy, liquid-liquid separation, biochemistry, molecular biology, and cell biology to do cutting-edge biomedical research. Our lab has two main research directions: (1) The homeostasis of Stress Granules and their functions in innate immunity: the stress granules will be formed after cells suffer from variant stimulators, such as drugs, viruses, heat, cold, and other factors. The stress granule is identified as a nonmembrane organelle comprising a large amount of ribonucleoprotein, RNA, and other molecules that are liquid-liquid phase separated in the cytosol. We will explore the structures and functions of proteins and RNAs in stress granules and reveal their impact on SG homeostasis and finally determine their roles in innate immunity. (2) The working mechanism of transmembrane transporters: Membrane transporters translocate numerous substrates, such as cytokines, amino acids, nucleotides, inorganic ions, and drugs, across the membrane through hydrolyzing ATP moles; thus, membrane transporters are potential targets for drug development. The unique structural features of each membrane transporter directly specify its substrate. We will study the working mechanisms of disease-related membrane transporters, providing a structural basis for subsequent drug design. Publications Read More   Lulu Guo#; Yumu Zhang#; Guoxing Fang#; Lu Tie#; Yuming Zhuang#; Chenyang Xue#; Qi Liu; Minghui Zhang; Kongkai Zhu; Chongzhao You; Peiyu Xu; Qingning Yuan; Chao Zhang; Lei Liu; Naikang Rong; Shengxuan Peng; Yuan Liu; Chuanzheng Wang; Xin Luo; Zongyao Lv; Dongwei Kang; Xiao Yu; Cheng Zhang; Yi Jiang; Xinzhong Dong*; Jiuyao Zhou*; Zhongmin Liu*; Fan Yang*; Eric Xu*; Jin-Peng Sun*; Ligand recognition and G protein coupling of the human itch receptor MRGPRX1, Nature Communications, 2023, 14(5004). (期刊论文) （共同通讯作者） Shen-Ming Huang#; Meng-Yao Xiong#; Lei Liu#; Jianqiang Mu#; Ming-Wei Wang#; Ying-Li Jia#; Kui Cai#; Lu Tie; Chao Zhang; Sheng Cao; Xin Wen; Xiaoyan Zhang*; Zhongmin Liu*; Bao-Xue Yang*; Yang Du*; Jin-Peng Sun*; Single hormone or synthetic agonist induce Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths, proceedings of the national academy of sciences of the united states of America （PNAS）, 2023, 120(30): e2216329120. (期刊论文)（共同通讯作者） Mengqi Wu#; Cang Wu#; Tiefeng Song#; Kewu Pan; Yong Wang*; Zhongmin Liu*; Structure and transport mechanism of the human calcium pump SPCA1, Cell Research, 2023, 33(7): 533-545. (期刊论文) （共同通讯作者） Huang Ying#; Xue Chenyang#; Wang Liangdong; Bu Ruiqian; Mu Jianqiang; Wang Yong*; Liu Zhongmin*; Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4., Communications Biology, 2023, 6(1). (期刊论文) （共同通讯作者） Mu Jianqiang#; Xue Chenyang#; Fu Lei#; Yu Zongjun; Nie Minhan; Wu Mengqi; Chen Xinmeng; Liu Kun; Bu Ruiqian; Huang Ying; Yang Baisheng; Han Jianming; Jiang Qianru; Chan Kevin C; Zhou Ruhong; Li Huilin; Huang Ancheng; Wang Yong*; Liu Zhongmin*; Conformational cycle of human polyamine transporter ATP13A2., Nature Communications, 2023, 14(1). (期刊论文) （共同通讯作者） Zheng, Liming; Liu, Nan*; Gao, Xiaoyin; Zhu, Wenqing; Liu, Kun; Wu, Cang; Yan, Rui; Zhang, Jincan; Gao, Xin; Yao, Yating; Deng, Bing; Xu, Jie; Lu, Ye; Liu, Zhongmin; Li, Mengsen; Wei, Xiaoding*; Wang, Hong-Wei*; Peng, Hailin*; Uniform thin ice on ultraflat graphene for high-resolution cryo-EM, Nature Methods, 2023, 20(1): 123-+. (期刊论文) Lin, Hui; Xiao, Peng; Bu, Rui-Qian; Guo, Shengchao; Yang, Zhao; Yuan, Daopeng; Zhu, Zhong-Liang; Zhang, Chuan-Xin; He, Qing-Tao; Zhang, Chao; Ping, Yu-Qi; Zhao, Ru-Jia; Ma, Chuan-Shun; Liu, Chang-Hao; Zhang, Xiao-Ning; Jiang, Dan; Huang, Shaohui; Xi, Yue-Tong; Zhang, Dao-Lai; Xue, Chen-Yang; Yang, Bai-Sheng; Li, Jian-Yuan; Lin, Hao-Cheng; Zeng, Xu-Hui; Zhao, Han; Xu, Wen-Ming; Yi, Fan*; Liu, Zhongmin*; Sun, Jin-Peng*; Yu, Xiao*; Structures of the ADGRG2-G(s) complex in apo and ligand-bound forms, Nature Chemical Biology, 2022, 18(11): 1196-+. (期刊论文) （共同通讯作者） Yuan, Daopeng#; Liu, Zhongmin#; Kaindl, Jonas; Maeda, Shoji; Zhao, Jiawei; Sun, Xiaoou; Xu, Jun; Gmeiner, Peter*; Wang, Hong-Wei*; Kobilka, Brian K.*; Activation of the alpha(2B) adrenoceptor by the sedative sympatholytic dexmedetomidine, Nature Chemical Biology, 2020, 16(5): 507-+. (期刊论文) （共同第一作者） Liu, Zhongmin#; Wang, Jia#; Cheng, Hang#; Ke, Xin#; Sun, Lei; Zhang, Qiangfeng Cliff; Wang, Hong-Wei*; Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate, Cell, 2018, 173(5): 1191-+. (期刊论文) （共同第一作者） Guan Zhe; Cai Tiantian; Liu Zhongmin; Dou Yunfeng; Hu Xuesong; Zhang Peng; Sun Xin; Li Hongwei; Kuang Yao; Zhai Qiran; Ruan Hao; Li Xuanxuan; Li Zeyang; Zhu Qihui; Mai Jingeng; Wang Qining; Lai Luhua; Ji Jianguo; Liu Haiguang; Xia Bin; Jiang Taijiao; Luo Shu Jin; Wang Hong Wei; Xie Can*; Origin of the Reflectin Gene and Hierarchical Assembly of Its Protein, Current Biology, 2017, 27(18): 2833-+. (期刊论文) Qin, Siying#; Yin, Hang#; Yang, Celi; Dou, Yunfeng; Liu, Zhongmin; Zhang, Peng; Yu, He; Huang, Yulong; Feng, Jing; Hao, Junfeng; Hao, Jia; Deng, Lizong; Yan, Xiyun; Dong, Xiaoli; Zhao, Zhongxian; Jiang, Taijiao; Wang, Hong-Wei; Luo, Shu-Jin; Xie, Can*; A magnetic protein biocompass, Nature Materials, 2016, 15(2): 217. (期刊论文) Liu Zhongmin#; Wang Jia; Li Gang*; Wang Hong Wei*; Structure of precursor microRNA’s terminal loop regulates human Dicer’s dicing activity by switching DExH/D domain, Protein & Cell, 2015, 6(3): 185-193. (期刊论文) （第一作者） Li Chaoying#; Wang Shanshan; Jiang Wei; Li Hui; Liu Zhongmin; Zhang Chao; McNutt Michael A; Li Gang*; Impact of intracellular alpha fetoprotein on retinoic acid receptors-mediated expression of GADD153 in human hepatoma cell lines, International Journal of Cancer, 2012, 130(4): 754-764. (期刊论文) Wang Shanshan; Jiang Wei; Chen Xiangmei; Zhang Chao; Li Hui; Hou Wenting; Liu Zhongmin; McNutt Michael A; Lu Fengmin*; Li Gang*; Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma, Journal of Hepatology, 2012, 57(2): 322-329. (期刊论文) Li, Mengsen; Li, Hui; Li, Chaoying; Wang, Shanshan; Jiang, Wei; Liu, Zhongmin; Zhou, Sheng; Liu, Xinhua; McNutt, Michael A.; Li, Gang*; Alpha-fetoprotein: a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cell lines, International Journal of Cancer, 2011, 128(3): 524-532. (期刊论文)   Join us Read More Contact Us Contact Address Office Phone 0755-88018667 Email liuzm@sustech.edu.cn