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更新日期：2018年9月3日 姓 名 张学武 性 别 男 出生年月 1963年5月 籍贯 湖南宁乡市 民 族 汉族 政治面貌 中国共产党党员 最后学历 博士研究生 最后学位 理学博士 技术职称 教授 导师类别 博、硕导 行政职务 Email xuewu@scut.edu.cn 工作单位 食品科学与工程学院 邮政编码 510640 通讯地址 13208 单位电话 13022089007 个人简介 张学武教授在生物活性肽与多糖以及组学技术（蛋白质组学，转录组学，代谢组学）领域有扎实的基础。具体工作简介如下：1 超声耦合亚临界水提取螺旋藻活性多肽及降血糖活性研究2 螺旋藻水解物对小鼠肝-脑轴的调控作用与抗肥胖活性研究3 罗非鱼皮胶原肽在小鼠中的抗氧化和降血糖作用4 扁竹根抗糖尿病多肽的制备5 基于iTRAQ的蛋白质组学探索螺旋藻抗衰老肽的机理6 螺旋藻的抗肿瘤肽研究7 金钱龟抗肿瘤肽的分离与纳米包埋研究8 小球藻的抗肿瘤肽研究9 铁皮石斛的抗肿瘤肽研究10 坛紫菜多肽的分离纯化及其抗肿瘤活性研究11 基于蛋白质组学技术的香菇多糖L2对小鼠肠道蛋白质改变的影响12香菇多糖影响衰老小鼠的代谢组学分析13 香菇多糖改变小鼠肠道菌群的空间结构研究14 磁性纳米粒固相萃取结合HPLC-MS/MS测定4种工业染料的研究15 小球藻的抗衰老肽与抗肥胖肽研究16 黑茶的抗肥胖肽与降血糖肽研究17 海洋低值鱼的降血压肽研究 工作经历 2005-现在，华南理工大学, 食品科学与工程学院, 教授.2003-2005，香港大学, 医学院巴斯德研究中心, 研究助理教授.2001-2002，美国加州大学洛杉矶分校(University of California at Los Angeles), 医学系, 博士后研究员.2000-2001，加拿大马尼托巴大学(University of Manitoba), 数学系, 博士后研究员.1999-2000，加拿大不列颠哥伦比亚大学(University of British Columbia), 数学系/生物技术研究室, 博士后研究员.1998-1999, 香港大学, 植物系, 博士后研究员.1993-1999，中山大学, 食品工程研究中心, 副研究员. 教育经历 1990 - 1993，中山大学，生物学，博士1987 - 1990，中山大学，生物学，硕士 1979 - 1983，湖南师范大学，数学，学士 获奖、荣誉称号 2014年广东省优秀硕士生论文指导老师奖 社会、学会及学术兼职 《现代食品科技》副主编 研究领域 食品营养，功能食品，组学技术（蛋白质组学，代谢组学，转录组学，宏基因组学） 科研项目 1.   国家高技术研究发展计划(863 计划)子课题：微藻抗肿瘤肽的制备与活性评估，2014AA0220042.   广东省海洋与渔业局研究与开发项目：螺旋藻抗皮肤衰老、抗肥胖和抗骨质疏松活性肽的制备技术，A201401C083. 广州市产学研协同创新重大专项：基于纳米净化-非靶标分析策略的食品中非法添加色素筛查平台建设和关键技术研究，201704020024 发表论文 近5年发表的主要SCI论文(通讯作者)：[34] Fan XD,Cui YJ,Zhang RL,Zhang XW* Purification and identification of anti-obesity peptides derived from Spirulina platensis. Journal of Functional Foods (In press). IF=3.1,1区.[33] Zhang RL, Chen J, Zhang XW* Extraction of intracellular protein from Chlorella pyrenoidosa using a combination of ethanol soaking, enzyme digest, ultrasonication and homogenization techniques. Bioresource Technology 2018, 267-272. IF=5.65,1区。[32] Mao XL, Bai L, Fan XD, Zhang XW* Anti-proliferation peptides from protein hydrolysates of Pyropia haitanensis. Journal of Applied Phycology 2017, 29 (3): 1623-1633. IF=2.372.[31] Xu XF, Yang JG, Ning ZX, Zhang XW* 1H NMR-based metabolic investigation of the effect of Lentinula edodes-derived polysaccharides on aged mice. Journal of Food Biochemistry 2018 68, 207-216. IF=0.832.[30] Mao XL, He SJ, Zhang T, Guo XL, Ge YZ, Ma CW, Zhang XW* Isolation and characterization of antiproliferative peptides from Chinese three-striped box turtle (Cuora trifasciata).Biotechnology and Applied Biochemistry 2017 (In press). IF=1.429.[29] Wang ZJ, Zhang XW* Isolation and identification of anti-proliferative peptides from Spirulina platensis using three-step hydrolysis. Journal of The Science of Food and Agriculture 2017, 97 (3): 918-922. IF=2.076.[28] Wang ZJ, Zhang XW* Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth. Food & Function 2016, 7,781–788. IF=2.9.[27] Xu XF, Yang JG, Ning ZX, Zhang XW* Proteomic analysis of intestinal tissues from mice fed with Lentinula edodes-derived polysaccharide. Food & Function 2016,7(1):250-61. IF=2.9.[26] Qi P, Liang ZA, Wang Y, Xiao J, Liu J, Zhou QQ, Zheng CH, Luo LN, Lin ZH, Zhu F, Zhang XW* Mixed hemimicelles solid-phase extraction based on sodium dodecyl sulfate-coated nano-magnets for selective adsorption and enrichment of illegal cationic dyes in food matrices prior to high-performance liquid chromatography-diode array detection detection. Journal of Chromatography A, 2016, 1437: 25-36. IF=3.926.[25] Zhang RL, Chen J, Jiang XW, Yin LS, Zhang XW* Antioxidant and ,hypoglycaemic effects of tilapia skin collagen peptide in mice. International Journal of Food Science and Technology，2016, 51: 2157-2163. IF=1.5.[24] He SJ, Mao XL, Zhang T, Guo XL, Ge YZ, Ma CW, Zhang XW* Separation and nanoencapsulation of antitumor peptides from Chinese three-striped box turtle (Cuora trifasciata), Journal of Microencapsulation, 2016, 33(4): 344-354. IF=1.631.[23] Wang ZJ, Zhang XW* Characterization and antitumor activity of protein hydrolysates from Arthrospira platensis (Spirulina platensis) using two-step hydrolysis. Journal of Applied Phycology 2016, 28:3379–3385. IF=2.372.[22] Liu XF, Cao SQ, Zhang XW* Modulation of gut microbiota-brain axis by probiotics, prebiotics and diets. Journal Of Agricultural And Food Chemistry 2015,63, 7885-7895. IF=2.912.[21] Cui YJ, Yan HD, Zhang XW* Preparation of Lentinula edodes polysaccharide-calcium complex and its immunoactivity. Bioscience, Biotechnology, and Biochemistry 2015, 79, 1619-1623. IF=1.29.[20] Xu XF, Yang JG, Ning ZX, Zhang XW* Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota. Food & Function 2015, 6: 2653-2663. IF=2.9.[19] Xu PP, Zhang T, Guo XL, CW Ma, Zhang XW* Purification, Characterization, and Biological Activities of Broccolini Lectin. Biotechnology Progress 2015, 31(3): 736-743. IF=2.178.[18] Xu XF, Yang JG, Lu Z, Zhang XW* Lentinula edodes-derived polysaccharide enhances systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice. Food & Function 2015,6: 2068-2080. IF=2.9.[17] Zheng QP, Qiu DS, Liu XJ, Zhang L, Cai SK, Zhang XW* Antiproliferative effect of Dendrobium catenatum Lindley polypeptides against human liver, gastric and breast cancer cell lines. Food & Function 2015, 6(5): 1489-95. IF=2.9.[16] Qi P, Lin ZH, Chen GY, Xiao J, Liang ZA, Luo LN, Zhou J, Zhang XW* Fast and simultaneous determination of eleven synthetic color additives in flour and meat products by liquid chromatography coupled with diode-array detector and tandem mass spectrometry. Food Chemistry 2015, 181: 101-110. IF=3.3.[15] Xu XF, Wang ZJ, Zhang XW* The human microbiota associated with overall health. Critical Reviews in Biotechnology 2015, 35(1): 129-140. IF=6.472.[14] Xu XF, Zhang XW* Lentinula edodes-derived polysaccharide alters the spatial structure of gut microbiota in mice. PLOS ONE 2015, 10: e0115037. IF=4.4.[13] Xu XF, Zhang XW* Effects of cyclophosphamide on immune system and gut microbiota in mice. Microbiological Research 2015, 171: 97-106. IF=1.9.[12] Liu XF, Zhang XW* Aptamer-based technology for food analysis. Applied Biochemistry and Biotechnology 2015, 175: 603-624. IF=1.6.[11] Fan XD, Bai L, Zhu L, Yang L, Zhang XW* Marine algae-derived bioactive peptides for human nutrition and health. Journal Of Agricultural And Food Chemistry 2014, 62, 9211-9222. IF=2.912.[10] Qi P, Lin,ZH, Li JX, Wang CL, Meng WW, Hong H, Zhang XW* Development of a rapid, simple and sensitive HPLC-FLD method for determination of rhodamine B in chili-containing products. Food Chemistry 2014, 164, 98-103. IF=3.3.[9] Xu XF, Yan HD, Tang J, Chen J, Zhang XW* Polysaccharides in Lentinus edodes : Isolation, Structure, Immuno-modulating activity and future prospective. Critical Reviews in Food Science and Nutrition 2014, 54: 474-487. IF=3.725.[8] Xu XF, He SJ, Zhang XW* New food safety concerns associated with gut microbiota. Trends in Food Science and Technology 2013, 34: 62-66. IF=3.71.[7] Zhang BC, Zhang XW* Separation and nanoencapsulation of antitumor polypeptide from Spirulina platensis. Biotechnology Progress 2013, 29, 1230-1238. IF=2.178.[6] Wang XQ, Zhang XW* Separation, antitumor activities and encapsulation of polypeptide from Chlorella pyrenoidosa. Biotechnology Progress 2013, 29, 681-687. IF=2.178.[5] Zhang XW* A combination of epitope prediction and molecular docking allows for good identification of MHC class I restricted T-cell epitopes. Computational Biology and Chemistry, 2013, 45, 30-35. IF=1.28.[4] Xu XF, Xu PP, Ma CW, Tang J, Zhang XW* Gut microbiota, host health, and polysaccharides. Biotechnology Advances 2013, 31, 318-337. IF=8.25.[3] Wang XQ, Zhang XW* Optimal extraction and hydrolysis of Chlorella pyrenoidosa proteins. Bioresource Technology 2012, 126: 307-13. 1 区, IF=4.494.[2] Xu XF, Yan HD, Zhang XW* Structure and Immuno-Stimulating Activities of a New Heteropolysaccharide from Lentinula edodes. Journal Of Agricultural And Food Chemistry 2012, 60 (46): 11560-11566. IF=2.912.[1] Liao XX, Zhang XW*  Preparation, characterization and cytotoxicity of carbon nanotube-chitosan-phycocyanin complex. Nanotechnology 2012 , 23(3), DOI: 10.1088/0957-4484/23/3/035101. IF=3.446. 出版专著和教材 1. Zhang XW* (Editor), Omics Technologies in Cancer Biomarker Discovery.  Landes Bioscience, USA, 2011. 2. Chen G and Zhang XW* Proteomics in food biotechnologies. In: Benkeblia N (Ed.), “OMICs Technologies: Tools for Food Science”, Taylor & Francis, 2011. 3. Zhang XW* et al. Translational medicine: application of omics for drug target discovery and validation. pp 235-246. In: Cho WC (Ed.), “An Omics Prospective on Cancer Research”, Springer, 2010. 4. Zhang XW* et al. Novel Omics Technologies in Nutraceutical and Functional Food Research. pp 11-22. In: Bagchi D (Ed.), “Genomics, Proteomics & Metabolomics in Nutraceuticals & Functional Foods”, Creighton University, USA, Wiley-Blackwell, 2010. 科研创新 已授权的发明专利:(15) 张学武，曾巧辉，一种十肽及其应用，中国专利号ZL201510634074.5，授权日2018.2.23.(14) 张学武，何胜洁，一种金钱龟抗肿瘤多肽的制备方法，中国专利号ZL201510029499.3，授权日2018.1.5.(13) 张学武，戚平，肖剑，王宇，刘佳，梁智安，刘冬豪，一种维生素B12分子印迹固相萃取磁性材料及其制备方法和应用，中国专利号ZL201510671139.3，授权日2017.10.20.(12) 张学武，郑秋平，铁皮石斛抗肿瘤多肽的制备方法及其应用，中国专利号ZL201410466768.8，授权日2017.10.20.(11)张学武，戚平，白露，郑秋平, 扁竹根抗糖尿病多肽的制备方法, 中国专利号ZL201510031380.X，授权日2016.6.22.(10)张学武，戚平，林子豪，罗丽妮，郑春浩, 一种肉或肉制品中11种食用合成色素的HPLC-MS/MS检测方法, 中国专利号ZL201510031380.X，授权日2016.6.22.(9)张学武，许平平, 西兰苔凝集素的制备方法与应用, 中国专利号ZL201410149248.4，授权日2016.8.17.(8)张学武，曾巧辉，王敬敬, 一种小鼠背部辐射方形铁丝网固定装置, 中国专利号ZL201521143892.7，授权日2016.10.5.(7)张学武，张博超，螺旋藻多肽-壳聚糖纳米粒的制备方法，中国专利号ZL 2012 1 0318051.X，授权日2015.3.11.(6)张学武，王晓琴，小球藻多肽-壳聚糖纳米粒的制备方法，中国专利号ZL 2012 1 0318093.3, 授权日2014.4.2.(5)张学武，王晓琴，小球藻抗肿瘤多肽的制备方法，中国专利号ZL 2012 1 0318091.4, 授权日2014.7.30.(4)张学武，王晓琴，小球藻多肽微胶囊的制备方法，中国专利号ZL 2012 1 0318076.X, 授权日2014.7.30.(3)张学武，许平平，张博超，一种螺旋藻抗肿瘤多肽的制备方法，中国专利号ZL 2012 1 0318087.8，2014.11.12.(2)张学武，廖晓霞，碳纳米管-壳聚糖-藻蓝蛋白纳米粒的制备方法，中国专利号ZL 2011 1 0197971.6, 授权日2012.12.5(1)张学武，廖晓霞，一种从螺旋藻中分离高纯度藻蓝蛋白的方法，中国专利号ZL 2010 1 0224910.X, 授权日2013.5.8.