教师主页移动版

更新日期：2022年12月26日 姓 名 颜金武 性 别 男 出生年月 1985年8月 籍贯 湖南醴陵市 民 族 汉族 政治面貌 中国共产党党员 最后学历 博士研究生 最后学位 理学博士 技术职称 副教授 导师类别 硕导 行政职务 Email yjw@scut.edu.cn 工作单位 生物科学与工程学院 邮政编码 通讯地址 广州大学城华南理工大学生物科学与工程学院B6-401办公室 单位电话 个人简介 新型药物分子设计、合成及活性研究；荧光探针、诊断试剂的设计、合成及其在生物成像及诊断中的应用等。例如，阿尔茨海默病领域的小分子药物及诊断试剂的研发。作为第一或通讯作者，在Anal. Chem., Chem. Eng. J., J. Med. Chem., Chem. Commun., Sensor. Actuat. B-Chem., Anal. Chim. Acta, Talanta, Bioorg. Med. Chem.等期刊发表40余篇研究论文以及授权10余项发明专利，论文被引用1000余次，并受邀担任多个高水平期刊的审稿人以及客座编辑。 工作经历 2017.09至今  华南理工大学 生物科学与工程学院，副教授2013.08-2017.09  华南理工大学 生物科学与工程学院，讲师 教育经历 2008.09-2013.06 中山大学药学院，获药物化学博士学位；2004.09-2008.06 中山大学化学与化学工程学院，获学士学位； 获奖、荣誉称号 4、2017年度本科教学优秀奖“科技创新优秀指导教师”一等奖；3、2017-2018学年度本科生班主任工作考核优秀；2、2017年被评为华南理工大学本科毕业设计（论文）优秀指导教师奖；1、2016年被评为华南理工大学本科毕业设计（论文）优秀指导教师奖； 社会、学会及学术兼职 受邀担任多个高水平期刊的审稿人以及客座编辑。 研究领域 新型药物分子设计、合成及活性研究；荧光探针、诊断试剂的设计、合成及其在生物成像及诊断中的应用等。例如，阿尔茨海默病领域的小分子药物及诊断试剂的研发。 科研项目 11、光敏剂的开发、设计和合成（20220400），企事业单位委托技术开发与合作项目，2022.03-2024.03。10、GFP发色团类荧光探针的构建及其对视网膜Aβ寡聚体的成像研究（2019A1515010137），广东省自然科学基金面上项目，2019.10-2022.09。9、GFP发色团类Aβ寡聚体荧光探针的构建及其对脑部和眼部视网膜Aβ寡聚体的成像研究（(D2191260），中央高校基本科研业务费重点项目，2019.1-2020.12。8、基于部花菁骨架的Aβ蛋白荧光探针分子库的构建及评价（A2019029），广东省医学科研基金项目面上基金，2019.7-2021.6。7、基于非对称芳叉酮骨架的阿尔茨海默症诊疗试剂的设计、合成及评价（A2018080），广东省医学科研基金项目青年基金，2018.7-2020.6。6、基于非对称苄叉酮骨架的阿尔茨海默症诊疗试剂的设计、合成及评价（2017MS079），中央高校基本科研业务费面上项目，2017.1-2018.12。5、双芳叉类双光子荧光探针的设计、合成及其在Aβ斑块成像中的应用（21502056），国家自然科学基金-青年科学基金项目，2016.1-2018.12。4、靶向Aβ斑块的双光子荧光探针的设计、合成及其在阿尔兹海默症早期诊断中的应用（2016A030310463），广东省自然科学基金-博士启动项目，2016.6-2019.06。3、香豆素-查尔酮轭合物的设计、合成及抗痴呆活性研究（2011A060901014-001），广东省新药设计与评价重点实验室开放基金科研项目，2014.2-2015.12。2、多靶点抗老年痴呆药物：香豆素-查尔酮轭合物的设计、合成及活性研究（2014ZB0002），中央高校基本科研业务费博士启动项目，2014.1-2015.12。1、与R-bambuterol结构或功能相关的新化合物的合成（x2swD9132350），企业合作项目， 2013.8-2016.8。 发表论文 40、Jinrong Yang, Weijie Chi,* Wen-Jing Shi, Lei Zhang and Jin-wu Yan,*  An in situ-triggered and chemi-excited photooxygenation system for Aβ aggregates. Chem. Eng. J., 456, 140998, 2022.39、Jinrong Yang, Xin Wang, Jinsheng Liu, Weijie Chi, Lei Zhang, Lehui Xiao* and Jin-wu Yan,* Near-infrared Photooxygenation Theranostics Used for the Specific Mapping and Modulating of Amyloid- Aggregation. Anal. Chem., 94, 15902–15907, 2022.38、Wen-Jing Shi, * Ru Chen, Jinrong Yang, Yong-Feng Wei, Yuhui Guo, Zi-Zhou Wang, Jin-wu Yan,* and Li Niu, Novel Meso-Benzothiazole-Substituted BODIPY-Based AIE Fluorescent Rotor for Imaging Lysosomal Viscosity and Monitoring Autophagy. Anal. Chem., 94, 14707–14715, 2022.37、Yuhui Guo, Huaxiang Leng, Qingxiu Chen, Junyi Su, Wen-jingShi, Chunli Xia*, Lei Zhang* and Jin-wu Yan,* Development of Novel Near-infrared GFP Chromophore-based Fluorescent Probes for Imaging of Amyloid-β Plaque and Viscosity. Sens. Actuat B-Chem., 372, 132648, 2022.36、Yuhui Guo, Huaxiang Leng, Yuxuan Wang, Wen-Jing Shi*, Lei Zhang*, and Jin-wu Yan,* A novel H2O2-activated NIR fluorescent probe for imaging β-amyloid fibrils and mitochondrial viscosity. Dyes Pigments, 206, 110665, 2022.35、Yuxuan Wang, Jinrong Yang, Qingxiu Chen, Junyi Su, Wen-Jing Shi*, Lei Zhang, Chunli Xia*, and Jin-wu Yan,* Rotor-Tuning Boron Dipyrromethenes for Dual-Functional Imaging of Aβ Oligomers and Viscosity. ACS Appl. Bio Mater., 5, 6, 3049–3056, 2022.34、Huaxiang Leng, Yuxuan Wang, Juan Wang, Han Sun, Anyang Sun*, Marco Pistolozzi, Lei Zhang*, and Jin-wu Yan,* Dual-Emission GFP Chromophore-Based Derivative for Imaging and Discriminating Aβ Oligomers and Aggregates. Anal. Chem., 94, 4, 1999–2006, 2022.33、Wen-Jing Shi, * Yong-Feng Wei, Jinrong Yang, Hui-Zhi Li, Qing-Hui Wan, Yuxuan Wang, Huaxiang Leng, Kun Chen and Jin-wu Yan,* Novel meso-trifluoromethyl BODIPY-based near-infrared-emitting fluorescent probes for organelle-specific imaging of cellular viscosity. Sens. Actuat B-Chem, 359, 131594, 2022.32、Wen-Jing Shi,* Jinrong Yang, Yong-Feng Wei, Xiao-Tong Li, Xu-Hui Yan, Yuxuan Wang, Huaxiang Leng, Liyao Zheng and Jin-wu Yan,* Novel cationic meso-CF3 BODIPY-based AIE fluorescent rotors for imaging viscosity in mitochondria. Chem. Commun, 58, 1930-1933, 2022.31、Yang Li, Jia-Jia Li, Qing Zhang, Jian-Yong Zhang, Na Zhang, * Yong-Zheng Fang, Jin-wu Yan,* and Qinfei Ke. * The multifunctional BODIPY@Eu-MOF nanosheets as bioimaging platform: a ratiometric fluorescencent sensor for highly efficient detection of F-, H2O2 and glucose. Sens. Actuat B-Chem, 354, 131140, 2022.30、Fantao, Sun, Jinsheng Liu, Yanan Huang, Xinyin Zhu, Yu Liu, Lei Zhang and Jin-wu Yan,* A quinoline derived D-A-D type fluorescent probe for sensing tetrameric transthyretin. Bioorg. Med. Chem.Lett., 52, 128408, 2021.29、Jinsheng Liu, Yinghong Xiong, Yanan Huang, Xinyin Zhu, Yu Liu, Lei Zhang and Jin-wu Yan,* A quinoline-benzothiazole hybrid as the first near-infrared fluorescent probe for transthyretin. New J. Chem., 45 (39), 18453-18458, 2021.28、Jinrong Yang, Yuhui Guo, Marco Pistolozzi,* Jin-wu Yan,* Research progress of multi-functional fluorescent probes for Alzheimer's disease monitoring (Review). Dyes Pigments, 193, 109466, 2021.27、Wen-Jing Shi*, Yong-Feng Wei, Chun-Feng Li, Han Sun, Liu-Xia Feng, Shi Pang, Fenggang Liu*, Liyao Zheng, Jin-wu Yan,* A novel near-infrared-emitting aza-boron-dipyrromethene-based remarkable fluorescent probe for Hg2+ in living cells. Spectrochim Acta A., 119207, 248, 2020.26、Yuxuan Wang, Yutai Qiu, Anyang Sun*, Yinghong Xiong, Huiya Tan, Yuqi Shi, Pan Yu, Gaurab Roy, and Lei Zhang* and Jin-wu Yan*. Dual-functional AIE fluorescent probes for imaging β-amyloid plaques and lipid droplets. Anal. Chim. Acta, 1133, 109-118, 2020.25、Han Sun, Hua-xiang Leng, Jin-sheng Liu, Gaurab Roy, Jin-wu Yan,* and Lei Zhang*. A novel fluorescent protein chromophore analogue to simultaneously probe lysosome viscosity and β-amyloid fibrils. Sens. Actuat B-Chem, 305, 127509, 2020.24、Wen-Jing Shi,* Chun-Feng Li, Yan Huang, Hui-ya Tan, Yong-Feng Wei, Fenggang Liu,* Liu-Xia Feng, Liyao Zheng, Guo-Shu Chen, Jin-wu Yan,* A remarkable colorimetric probe for fluorescent ratiometric and ONOFF discriminative detection of Hg2+ and Cu2+ by double-channel imaging in living cells. Dyes Pigments, 171, 107782, 2019.23、Hui-ya Tan, Kai-xiang Zhou, Han Sun, Jin-wu Yan,* Meng-chao Cui* and Lei Zhang*. Dual-functional red-emitting fluorescent probes for imaging beta-amyloid plaques and viscosity. Sens. Actuat B-Chem, 298, 126903, 2019.22、Hui-ya Tan, Yu-tai Qiu, Han Sun, Jin-wu Yan,* and Lei Zhang*. A lysosome-targeting dual-functional fluorescent probe for imaging intracellular viscosity and beta-amyloid. Chem. Commun., 55, 2688-2691, 2019.21、Yan Huang, Chun-Feng Li, Wen-Jing Shi,* Hui-Ya Tan, Zhi-Zhou He, Liyao Zheng, Fenggang Liu and Jin-wu Yan*. A near-infrared BODIPY-based fluorescent probe for ratiometric and discriminative detection of Hg2+ and Cu2+ ions in living cells. Talanta, 198, 390-397, 2019.20、Zi-ying Wu, Zhong-yong Xu, Hui-ya Tan, Xue Li, Jinwu Yan,* Chang-zhi Dong and Lei Zhang*. Two novel rhodamine-based fluorescent probes for the rapid and sensitive detection of Fe3+: experimental and DFT studies. Spectrochim Acta A., 213, 167-175, 2019.19、Weiguo Wang, Rongkai Du, Changzhi Dong, Jinwu Yan,* and Lei Zhang*. A modified sensitive ELISA based on dual catalysis of Pd@Pt porous nanoparticles and horseradish peroxidase. Sens. Actuat B-Chem, 284, 475-484, 2019.18、Zi-ying Wu,  Zhong-yong Xu, Jin-wu Yan,* Yafang Li, Qiuye Kou, and Lei Zhang*. Development of rhodamine-based fluorescent probes for sensitive detection of Fe3+ in water: Spectroscopic and computational investigations. New J. Chem, 43, 1725-1732, 2018.17、Weiguo Wang, Junmin Li, Changzhi Dong, Yafang Li, Qiuye Kou, Jin-wu Yan,* and Lei Zhang*. Ultrasensitive ELISA for the detection of hCG based on assembled gold nanoparticles induced by functional polyamidoamine dendrimers. Anal. Chim. Acta, 1042, 116-124, 2018.16、Zhong-yong Xu, Zi-ying Wu, Hui-ya Tan, Jin-wu Yan,* Xiao-lin Liu, Jia-ying Li, Zi-yan Xu, Chang-zhi Dong and Lei Zhang. Piperazine-tuned NBD-based colorimetric and fluorescent turn-off probes for hydrogen sulfide. Anal. Methods, 10, 3375-3379, 2018.15、Xiaohong Yang, Han Sun, Xiao Zhang, Xujin He, Jin-wu Yan,* and Rongbiao Pi*. Discovery of multi-functional carbazole-rivastigmine hybrids as enhancers of neural stem cell proliferation in C17.2 cells. J.Pharm. Res., 2018, 37(1).14、Yong-jun Wang, Jing-gong Liu, Hui-ya Tan, Jin-wu Yan* and Lei Zhang*. A colorimetric and far-red fluorescent probe for the highly sensitive detection of silver(I). RSC Adv., 7, 55567-55570, 2017.13、Jin-Wu Yan, Jia-ying Zhu, Kai-xiang Zhou, Jin-sheng Wang, Hui-ya Tan, Zhong-yong Xu, Shuo-bin Chen, Yu-ting Lu, Meng-chao Cui* and Lei Zhang*. Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques. Chem. Commun., 53, 9910-9913, 2017.12、Jin-wu Yan, Xiao-lin Wang, Lin-fu Zhou and Lei Zhang*, CV-APC, a colorimetric and red-emitting fluorescent dual probe for the highly sensitive detection of palladium. RSC Adv., 7, 20369-20372, 2017.11、Chan Shan†, Jin-wu Yan†, Yu-Qing Wang, Tong Che, Zhou-Li Huang, Ai-Chun Chen, Pei-Fen Yao, Jia-Heng Tan, Ding Li, Tian-Miao Ou*, Lian-Quan Gu, and Zhi-Shu Huang*, Design, Synthesis and Evaluation of Isaindigotone Derivatives to Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex. J. Med. Chem., 60, 1292–1308, 2017.10、Jia-ying Zhu, Lin-fu Zhou, Yu-kun Li, Shuo-bin Chen, Jin-wu Yan* and Lei Zhang*, In Vivo Near-Infrared Fluorescence Imaging of Amyloid-β Plaques with a Dicyanoisophorone-based Probe. Anal. Chim. Acta, 961, 112-118, 2017.9、Hui-ya Tan, Jing-gong Liu, Lin-fu Zhou, Yu-kun Li, Jin-wu Yan* and Lei Zhang*, A smart NIR fluorescent probe for the highly selective detection of palladium. RSC Adv., 7, 6583-6586, 2017.8、Jin-wu Yan, Jia-ying Zhu, Qi-feng Tan, Lin-fu Zhou, Pei-fen Yao, Yu-ting Lu, Jia-Heng Tan and Lei Zhang*, Development of a colorimetric and NIR fluorescent dual probe for carbon monoxide. RSC Adv., 6, 65373-65376, 2016.7、Zhongyong Xu, JinWu Yan*, Jing Li, Pei-fen Yao, Jia-Heng Tan and Lei Zhang*, A colorimetric and fluorescent turn-on probe for carbon monoxide and imaging in living cells. Tetrahedron Lett., 57, 2927-2930, 2016.6、Zhong-yong Xu, Xiao-lin Wang, Jin-wu Yan,* Jing Li, Su Guan and Lei Zhang,* A colorimetric and fluorometric NBD-based chemosensor for highly selective recognition of palladium(II) cations. RSC Adv., 6, 43539-43542, 2016.5、Jin-Wu Yan, Xiao-lin Wang, Qi-feng Tan, Pei-fen Yao, Jia-Heng Tan and Lei Zhang*, A colorimetric and fluorescent dual probe for palladium in aqueous medium and living cell imaging. Analyst, 141, 2376-9, 2016.4、Jin-wu Yan*, Yi-guang Tian, Jia-heng Tan and Zhi-shu Huang. Colorimetric and fluorescence detection of G-quadruplex nucleic acids with a coumarin-benzothiazole probe. Analyst, 140, 7146-7149, 2015.3、Jin-Wu Yan, Shuo-Bin Chen, Wen-Jie Ye, Tian-Miao Ou, Jia-Heng Tan, * Ding Li, Lian-Quan Gu, Zhi-Shu Huang*. Development of a New Colorimetric and Red-Emitting Fluorescent Dual Probe for G-Quadruplex Nucleic Acids. Chem. Commun., 50, 6927-6930, 2014.2、Jin-Wu Yan, Wen-Jie Ye, Shuo-Bin Chen, Wei-Bin Wu, Jin-Qiang Hou, Tian-Miao Ou, Jia-Heng Tan*, Ding Li, Lian-Quan Gu, and Zhi-Shu Huang*. Development of a universal colorimetric indicator for g-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton. Anal. Chem., 84, 6288, 2012.1、Jin-Wu Yan, Yan-Ping Li, Wen-Jie Ye, Shuo-Bin Chen, Jin-Qiang Hou, Jia-Heng Tan*, Tian-Miao Ou, Ding Li, Lian-Quan Gu, and Zhi-Shu Huang*. Design, Synthesis and Evaluation of Isaindigotone Derivatives as Dual Inhibitors for Acetylcholinesterase and Amyloid Beta Aggregation. Bioorg. Med. Chem., 20, 2527, 2012. 科研创新 20、颜金武，刘金胜，张雷，李晶，一种近红外荧光探针及制备以及其在检测转甲状腺素四聚体蛋白中的应用。中国发明专利，202110090019.X, 已授权（2022.02.14）。19、颜金武，刘金胜，张雷，李晶，一种靶向β淀粉样蛋白的荧光探针及制备以及其在阿尔兹海默症中的应用。中国发明专利，2021100899370，已授权。18、颜金武，王宇轩，张雷，李晶，一种检测Aβ寡聚体的荧光探针及其制备方法和应用。中国发明专利，202011631168.4, 已授权（2021.08.04）。17、颜金武，冷花香，孙涵，张雷，李晶，一种用于检测β-淀粉样蛋白斑块的双发射荧光探针及其制备方法和应用。中国发明专利，202011634952.0。16、颜金武，孙繁涛，刘金胜，张雷，李晶，一种具有AIE性质的荧光探针及制备以及其在检测转甲状腺素四聚体蛋白中的应用。中国发明专利，202011634267.8，，已授权（2022.04.06）。15、颜金武，张雷，谭慧雅，李晶，一种部花菁类荧光化合物及其制备方法和应用。中国发明专利，201811022803.1，已授权（2021.03.22）。14、颜金武，张雷，吴紫盈，李晶，一种检测三价铁离子的荧光探针及其制备方法。中国发明专利，201811022822.4。13、颜金武，张雷，吴紫盈，李晶，一种检测铁离子的荧光探针及制备与应用。中国发明专利，201811023210.7。12、颜金武，张雷，朱佳莹，李晶，一种与Aβ斑块具有亲和力的荧光化合物及制备与应用。中国发明专利，201710347238.5，已授权（2019.08.29）。11、张雷，王勇军，颜金武，李晶，欧松; 张和平，一种3α,7α-二羟基-6α-乙基胆烷酸的制备方法。中国发明专利，201610856803.6，已授权（2019.01.18）。10、皮荣标，颜金武，杨晓红，陈紫薇，王胜男，陈景考，咔唑‑利凡斯的明二联体及其药物组合物和应用。中国发明专利，201610385701.0，已授权（2018.11.16）。9、颜金武，张雷，谭慧雅，李晶，一种检测零价钯的近红外荧光探针及其制备方法。中国发明专利，201610874700.2。8、颜金武，张雷，李晶，一种检测零价钯的有机小分子探针及其制备方法。中国发明专利，201610880558.2。7、颜金武，张雷，朱佳莹，李晶，一种荧光化合物在Aβ斑块显像制剂中的应用。中国发明专利，201610808146.8。6、颜金武，张雷，李晶，一种有机小分子探针及其制备方法和应用。中国发明专利，201610264523.6, 已授权（2018.04.13）。5、张雷，颜金武，李晶，一种检测零价钯的有机小分子探针及其制备方法。中国发明专利， 201610143331.X。4、张雷，徐忠勇，李晶，颜金武，一种CO探针及其制备方法和应用。中国发明专利，201510997205.6, 已授权（2017.10.20）。3、黄志纾，古练权，谭嘉恒，颜金武，候金强，一种喹唑酮衍生物及其制备方法和作为抗癌药物的用途。中国发明专利，201010186371.5, 已授权（2012.11.21）。2、黄志纾，古练权，谭嘉恒，颜金武，叶文杰，一种染料及其制备方法与在检测特殊DNA二级结构中的应用。201110273189.8, 已授权（2014.04.23）。1、黄志纾，古练权，谭嘉恒，颜金武，叶文杰，一种双功能探针及其制备方法与在检测G-四链体结构中的应用。201210207279.1，已授权（2014.07.02）。 教学活动 讲授本科生课程《有机化学》、《有机化学实验》、《药物化学》、《生物医药与健康》。讲授研究生课程《有机波谱解析》 指导学生情况 学硕：生物学（医药生物学）专硕：药学 我的团队 医药生物学团队