杨小蓉
时间:2024-05-03 22:57 来源: 作者: 点击:次
更新日期：2023年6月20日 姓 名 杨小蓉 性 别 女 出生年月 籍贯 民 族 政治面貌 最后学历 最后学位 理学博士 技术职称 副教授 导师类别 硕导 行政职务 Email 工作单位 邮政编码 通讯地址 华南理工大学南校区 单位电话 工作经历 2014.10—目前 副教授，华南理工大学 生物科学与工程学院 2008.8—2014.9 Research Scientist，美国宾州州立大学（Penn State University) 化学系 2006.5—2007.2 教学助理，德国斯图加特大学 (Stuttgart University) 物理化学研究所 1996.7—2000.5 技术员，中国重庆三峡油漆股份有限公司 教育经历 2003.5—2007.2 德国斯图加特大学 (Stuttgart University) 物理化学所 物理化学 博士 2000.9—2003.3 中国科学院北京化学所 分析化学 硕士 1992.9—1996.6 重庆大学 化工学院 精细化工 本科 研究领域 生物大分子与小分子化合物相互作用；酶学与酶工程；生物分子相分离；生物物理等 科研项目 主持国家自然科学基金面上项目、广东省自然科学基金面上项目、广州市科学研究一般专项、国家重点研发计划子课题等 发表论文 [1] Qunyang Chen, Yiping Wu, Zhuojun Dai, Zhuqing Zhang, Xiaorong Yang*. Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates, International Journal of Biological Macromolecules, 2023, 230, 123221. [2] Zhuojun Dai, Guoli Li, Qunyang Chen, Xiaorong Yang* . Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates, BBA - Gene Regulatory Mechanisms, 2022, 1865, 194827. [3] Jiangbo Zhan, Hengsong Sun, Zhuojun Dai, Yi Zhang, Xiaorong Yang* . Loops constructing the substrate-binding site controlled the catalytic efficiency of Thermus thermophilus SG0.5JP17-16 laccase, Biochimie, 2022, 200, 60-67. [4] Yi Zhang, Zhuojun Dai, Shumin Zhang, Xiaorong Yang*, The catalytic properties of Thermus thermophilus SG0.5JP17-16 laccase were regulated by the conformational dynamics of pocket loop 6, BBA-Gen Subjects, 2021, 1865, 129872. [5] Yanyun Zhu, Jiangbo Zhan, Yi Zhang, Ying Lin, Xiaorong Yang*, The K428 residue from Thermus thermophilus SG0.5JP17-16 laccase plays the substantial role in substrate binding and oxidation, J Biomol Struct Dyn, 2021, 39(4), 1312-1320. [6] Xiaorong Yang*, Chenguang Gu, Ying Lin, A novel fungal laccase from Sordaria macrospora k-hell: expression, characterization, and application for lignin degradation, Bioprocess Biosyst Eng, 2020, 43(7), 1133-1139. [7] Yanyun Zhu, Yi Zhang, Jiangbo Zhan, Ying Lin, Xiaorong Yang*, Axial bonds at the T1 Cu site of Thermus thermophiles SG0.5JP17-16 laccase influence enzymatic properties, FEBS Open Bio, 2019, 9(5), 986-995.[8] Jingjing shi, Jacob M Perryman, Xiaorong Yang, Xinran Liu, Derek M Musser, Alyson K Boehr, Ibrahim M Moustafa, Jamie J Arnold, Craig E Cameron, David D Boehr, Rational control of poliovirus RNA-dependent RNA polymerase fidelity by modulating motif D loop conformational dynamics, Biochemistry, 2019, 58(36), 3735-3743.[9] Huiping Liu, Yanyun Zhu, Xiaorong Yang*, Ying Lin*, Four second-sphere residues of Thermus thermophilus SG0.5JP17-16 laccase tune the catalysis by hydrogen-bonding networks, Appl Microbiol Biotechnol, 2018, 102(9), 4049-4061.[10] Xiaorong Yang*, Conformational dynamics play important roles upon the function of N-acetyl glutamate kinase, Appl Microbiol Biotechnol, 2017, 101(9), 3485-3492.[11] Xiaorong Yang, Xinran Liu, Derek M. Musser, Ibrahim M Moustafa, Jamie J. Arnold, Craig E. Cameron and David D. Boehr, Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases, J Biol Chem. 2017, 292(9), 3810-3826.[12] Yuanyuan Huang, Cheng Li, Hao Zhang, Shuli Liang, Shuangyan Han, Ying Lin, Xiaorong Yang*, Suiping Zheng*, Monomeric Corynebacterium glutamicum N-acetyl glutamate kinase maintains sensitivity to L-arginine but has a lower intrinsic catalytic activity, Appl Microbiol Biotechnol, 2016, 100(4), 1789-1798.[13] Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron and David D. Boehr, Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase, Viruses, 2015, 7, 5571-5586.[14] Ibrahim M Moustafa, Victoria S Korneeva, Jamie J Arnold, Eric D Smidansky, Laura L Marcotte, David W Gohara, Xiaorong Yang, Maria A Sánchez-Farrán, David Filman, Janna K Maranas, David D Boehr, James M Hogle, Coray M Colina, Craig E Cameron, Structural Dynamics as a Contributor to Error-prone Replication by a RNA-dependent RNA Polymerase, J Biol Chem. 2014, 289, 36229-36248. [15] David D Boehr, Xinran Liu, Xiaorong Yang, Targeting structural dynamics of the RNA-dependent RNA polymerase for anti-viral strategies. Curr Opin Virol. 2014, 9, 194-200. [16] Xinran Liu, Xiaorong Yang (共同第一作), Cheri A. Lee, Ibrahim M. Moustafa, Eric D. Smidansky, David Lum, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity, J Biol. Chem. 2013, 288, 32753-65. [17] Xiaorong Yang, Eric D. Smidansky, Kenneth R. Maksimchuk, David Lum, Jesse L. Welch, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition, Structure, 2012, 20, 1519-1527. [18] Xiaorong Yang*, Klaus Müller, The guest ordering and dynamics in urea inclusion compounds studied by solid state 1H and 13C MAS NMR spectroscopy, J. Mol. Struct. 2011, 1006, 113-120. [19] Xiaorong Yang*, Klaus Müller, The structural and dynamic properties of 1-bromodecane in urea inclusion compounds investigated by solid state 1H, 13C and 2H NMR spectroscopy, Magn. Reson. Chem. 2011, 49, 514-522. [20] Xiaorong Yang, Jesse L. Welch, Jamie J. Arnold, David D. Boehr, Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance, Biochemistry, 2010, 49, 9361-9371.（* 代表通讯作者） 科研创新 1. 一种基于相分离研究磷酸化p53稳定性以及细胞内定位的方法。杨小蓉，戴卓君，专利号：CN114527054A. 2. 一种提高染料脱色效率的漆酶突变体及其制备方法与应用。杨小蓉，祝艳云，林影，刘慧平，专利号: CN108374000-A. 教学活动 主讲本科生课程《生物药剂学》、《大学化学》、《无机化学》和《免疫学》等，参与讲授研究生课程《酶学与酶工程》； |