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个人经历 personal experience 工作经历 教育经历 2018/07-至今： 西北工业大学，医学研究院，副教授，博/硕士生导师 2015/09-2018/06  重庆大学，生物医学工程专业，博士，导师：蔡开勇2012/09-2015/06  重庆大学，生物学专业，硕士，导师：蔡开勇

教育教学

教育教学 Education and teaching 招生信息 招生专业：博士研究生：生物医学工程硕士研究生：药学、生物与医药研究方向：1）纳米药物递送系统的构建与抗肿瘤效应评价；2）功能纳米控释系统肿瘤生物/免疫治疗的机制研究；3）肿瘤微环境的分子调控及代谢干预策略。*欢迎具有材料、化学、高分子、医学、生物学等背景的同学报考研究生！

荣誉获奖

科学研究 Scientific Research 戴亮亮教授（ORCID ID：0000-0002-2041-9357）一直从事构建生物功能性纳米药物递送系统肿瘤免疫及代谢治疗的研究。近 5 年，在Nature Communications, Advanced Functional Materials, ACS Nano, Nano Today, Advanced Science, Small, Biomaterials, Chemistry of Materials等本领域TOP期刊发表SCI论文50余篇。影响因子IF大于10的17篇，大于5的22篇，ESI高被引用论文及热点论文3篇，H指数30，SCI引用2300余次。在功能性药控系统的构建与抗肿瘤疗效评价等研究领域具有一定的工作基础，担任Asian Journal of Pharmaceutical Sciences 青年编委、Frontiers in Bioengineering and Biotechnology（IF 6.064）副主编、BME Horizons编委以及中国抗癌协会肿瘤基因诊断专业青年委员会委员。

科学研究

荣誉获奖 Awards Information 2022年，陕西省第十五届自然科学优秀论文奖2022年，入选西北工业大学人才培育支持计划2021年，入选西北工业大学“翱翔新星”2020年，入选陕西省高校科协青年人才托举计划

学术成果

学术成果 Academic Achievements 代表性论文：2024年[25] Siyu Meng, Huiping Du, Liangliang Dai *, etc al. An Adjuvant Micelle-Based Multifunctional Nanosystem for Tumor Immunotherapy by Remodeling Three Types of Immunosuppressive Cells. ACS Nano. 2024, 18, 3134. (IF 17.1)[24] Pan Zhao, Liyang Gong Li, Liangliang Dai *, etc al. Multifunctional Fe-based coordination polymer nano-bomb modifed with β-lapachone and CaO2 for targeted tumor dual chemodynamic therapy with enhanced ferroptosis and H2O2 self-supply. Journal of Nanobiotechnology. 2024, 22, 3. (IF 10.2)2023年[23] Huiping Du, Siyu Meng, Liangliang Dai *, etc al. Detachable MOF-based core/shell nanoreactor for cancer dual-starvation therapy with reversing glucose and glutamine metabolisms. Small. 2023, 2303253. (IF 15.153，Hot Paper)[22] Zhang Yuan,* Jianshuang Wu, Liangliang Dai *, etc al. A Photo-therapeutic nanocomposite with bio-responsive oxygen self-supplying combats biofilm infections and inflammation from drug-resistant bacteria. Advanced Functional Materials. 2023, 33, 2302908. (IF 19.924)[21] Liangliang Dai *, etc al. Editorial: Advances in the development of functional biomaterial nanosystem in tumor therapy and tissue regeneration. Front Bioeng Biotech. 2023, 11, 1195089. (IF 6.064)[20] Beining Yang, Fanze Meng, Liangliang Dai *, etc al. Engineered drug delivery nanosystems for tumor microenvironment normalization therapy. Nano Today. 2023, 49, 101766. (IF 18.962)[19] Xinming Zheng, Xiang Li, Liangliang Dai *, etc al. Cascade amplification of tumor chemodynamic therapy and starvation with re-educated TAMs via Fe-MOF based functional nanosystem. Journal of Nanobiotechnology. 2023, 21, 127. (IF 10.2)2022年[18] Zhenxiang Fu, Huiping Du, Liangliang Dai *, etc al. Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES. Materials Today Bio. 2022, 16, 100449. (IF 10.761)[17] Liangliang Dai, Mengjiao Yao, Zhenxiang Fu, etc al. Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2,3-dioxygenase-blockade tumor immunotherapy. Nature Communications. 2022, 13, 2688. (IF 17.694)[16] Zhang Yuan, Jianshuang Wu, Liangliang Dai*, etc al. Polydopamine-mediated interfacial functionalization of implants for accelerating infected bone repair through light-activatable antibiosis and carbon monoxide gas regulated macrophage polarization. Advanced Functional Materials. 2022, 32，2200374. (IF 19.924)2021年[15] Liangliang Dai, Xiang Li, Xinmin Zheng, etc al. TGF-β blockade-improved chemo-immunotherapy with pH/ROS cascade-responsive micelle via tumor microenvironment remodeling. Biomaterials. 2021, 276, 121010. (IF 15.304)[14] Xinmin Zheng, Pan Zhang, Liangliang Dai*, etc al. Applications of nanomaterials in tissue engineering. RSC Adv. 2021, 11, 19041–19058. (IF 4.036)[13] Zhang Yuan, Chuanchuan Lin, Liangliang Dai*, etc al. Near‐infrared light‐activatable dual‐action nanoparticle combats the established biofilms of methicillin‐resistant staphylococcus aureus and its accompanying inflammation. Small. 2021, 17, 2007522. (IF 15.153)2020年[12] Liangliang Dai, Xiang Li, Mengjiao Yao, etc al. Programmable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy. Biomaterials. 2020, 241, 119901. (IF 15.304) [11] Ke Li, Lu Lu, Liangliang Dai*, etc al*. Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo. Nanoscale. 2020, 12, 130-144. (IF 8.307，HCP)2019年[10] Liangliang Dai, Xiang Li, Xianglong Duan, etc al. A pH/ROS cascade-responsive charge-reversal nanosystem with self-amplified drug release for synergistic oxidation-chemotherapy. Advanced Science. 2019, 6, 1801807. (IF 17.521)[9] 戴亮亮，等。响应性纳米药物递送系统构建及肿瘤治疗研究[J]，医用生物力学，2019年S1期2018年[8] Liangliang Dai, Ke Li, Menghuan Li, etc al. Size/Charge changeable acidity‐responsive micelleplex for photodynamic‐improved PD‐L1 immunotherapy with enhanced tumor penetration. Advanced Functional Materials. 2018, 28, 1707249. (IF 19.924)2017年[7] Liangliang Dai, Ruisi Cai, Menghuan Li, etc al. Dual-targeted cascade-responsive prodrug micelle system for tumor therapy in vivo. Chemistry of Materials. 2017, 29, 6976-6992. (IF 10.508)2016年[6] Liangliang Dai, Yonglin Yu, Zhong Luo, etc al. Photosensitizer enhanced disassembly of amphiphilic micelle for ROS-response targeted tumor therapy in vivo. Biomaterials. 2016, 104, 1-17. (IF 15.304)[5] Liangliang Dai, Junjie Liu, Zhong Luo, etc al. Tumor therapy: Targeted drug delivery systems. Journal of Materials Chemistry B. 2016, 4. 6758-6772. (IF 7.571) [4] Liangliang Dai, Qingfeng Zhang, Xinkun Shen, etc al. A pH-responsive nanocontainer based on hydrazone-bearing hollow silica nanoparticles for targeted tumor therapy. Journal of Materials Chemistry B. 2016, 4, 4594-4604. (IF 7.571)2015年以前[3] Liangliang Dai, Qingfeng Zhang, Jinghua Li, etc al. Dendrimerlike mesoporous silica nanoparticles as pH-responsive nanocontainers for targeted drug delivery and bioimaging. ACS Applied Materials & Interfaces. 2015, 7, 7357-7372. (IF 10.383)[2] Liangliang Dai, Qingfeng Zhang, Hao Gu, etc al. Facile synthesis of yolk-shell silica nanoparticles for targeted tumor therapy. Journal of Materials Chemistry B. 2015, 3, 8303-8313. (IF 7.571, Hot Paper)[1] Liangliang Dai, Jinghua Li, Beilu Zhang, etc al. Redox-responsive nanocarrier based on heparin end-capped mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo. Langmuir. 2014, 3, 7867-7877.  (IF 4.331)代表性项目：1）主持国家自然科学基金面上项目，2024.01-2027.12；2）主持国家自然科学基金青年科学基金项目，2021.01-2023.12；3）主持陕西省重点研发计划项目，2022.01-2023.12；4）主持陕西省高校科协青年人才托举计划，2021.01-2022.12；5）主持陕西省自然科学基金青年项目，2019.01-2020.12；6）主持中央高校基本科研业务费，2018.01-2020.12；

综合介绍