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导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名： 李弘剑 部门： 药学院 直属机构： 药学院 性别： 女 职务： 院党委书记、副院长 职称： 教授 学位： 博士 毕业院校： 华南理工大学 联系电话： 02085226360 电子邮箱： tlihj@jnu.edu.cn 办公地址： 暨南大学 生命科学技术学院505 邮编： 510632 联系方式 学习经历 1991/09 - 1994/07，华南理工大学，发酵工程，博士 1988/09 - 1991/07，华南理工大学，发酵工程，硕士 1984/09 - 1988/07，华南理工大学，生物化工，学士 工作经历 1994/07 - 至今，暨南大学，生命科学技术学院，历任讲师、副教授、教授1995/10 - 1996/10，日本大阪大学，生物工学国际交流中心，访问学者2003/08 - 2005/08，美国加州大学伯克利分校，公共卫生学院，访问学者 主要论文 代表性研究成果 1.Feng L, Sheng J, Vu GP, Liu Y, Foo C, Wu S, Trang P, Paliza-Carre M, Ran Y, Yang X, Sun X, Deng Z, Zhou T, Lu S, Li H（通讯作者）, Liu F.Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein.PLoS Pathog. 2018 Jan 29;14(1):e1006867. doi: 10.1371 2018 Jan2.Liu MY,Liu J,Lai W,Luo J,Liu Y,Vu GP,Yang Z,Trang P,Li H（通讯作者）,Wu J. Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012. Sci Rep.2016 Dec 12;6:38451. doi: 10.1038/srep384513.Liu H, Wang X, Liu S,Li H, Yuan X, Feng B, Bai H, Zhao B,Chu Y,Li H. Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy.Int J Biochem Cell Biol. 2016 Jan;70:149-604.Li H（通讯作者）, Ma Y, Chen Y, Sang Y, Zhou T, Qiu M, Huang X, Zhou C, Su Z.A protease-based strategy for the controlled release of therapeutic peptides.Angew Chem Int Ed Engl. 2010 Jul 5;49(29):4930-35.Li H , Zhou CX, Su Z . Protease-resistant glucagon like peptide-1 analogs with long-term anti-diabetes type 2 activity.Adv Exp Med Biol. 2009;611:475-6.6.Li H Li Y, Ni F, Su Z Inhibition of pathogenically-related morphologic transition in Candida albicans by disrupting Cdc42 binding to its effectors.Adv Exp Med Biol. 2009;611:471-2. 7.Li H, Zhou CX, Su JZChemical ligation and cleavage on solid support facilitate recombinant peptide purification.Protein Expr Purif. 2006 Dec;50(2):238-46. Epub 2006 Sep 12.8.Li H, Trang P, Kim K, Zhou T, Umamoto S, Liu F.Effective inhibition of human cytomegalovirus gene expression and growth by intracellular expression of external Q1 guide sequence2006 RNA Vol.12 No.1 63-729.Wang K, Li Y, Zhao G, Wu Y, Zhang X, Li H, Zhou T. Inhibition of human cytomegalovirus DNA replication by small interfering RNAs targeted to UL49.ActaBiochim Biophys Sin (Shanghai). 2013 May;45(5):401-710..Bai Y, Gong H, Li H, Vu GP, Lu S, Liu F.Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice.Proc Natl Acad Sci U S A. 2011 Feb 7 22;108(8):3222-711.Bai Y, Li H, Vu GP, Gong H, Umamoto S, Zhou T, Lu S, Liu F. Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells.Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7269-7412.Zhang W, Li H, Li Y, Zeng Z, Li S, Zhang X, Zou Y, Zhou T.Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P.Virol J. 2010 May 18;7:100 13.Zeng Z, Li H, Li Y, Cui Y, Zhou Q, Zou Y, Yang G, Zhou T.Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences.Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):389-9814.Zhou T, Xiao X, Xu B, Li H, Zou Y.Overexpression of SSTR2 inhibited the growth of SSTR2-positive tumors via multiple signaling pathways.Acta Oncol. 2009;48(3):401-10.15.Bai Y, Trang P, Li H ,Kim K, Zhou T, Liu F. Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31) :10919-24. 16.Su ZD , Li HJ , Li Y and Ni F, Inhibition of pathogenically-related morphological transition in Candida albicans through intervening interactions of Cdc42 with its effectors: Impact on signal transduction therapy ,Chemistry & Biology (Cell Press), 2007，Nov.14(11):1273-8217.Guo F, Huang X, Li S, Sun L, Li Y, Li H, Zhou Y, Chu Y, Zhou T.Identification of prosaposin as a novel interaction partner for Rhox5.J Genet Genomics. 2007 May;34(5):392-918.Yang YH,Li H, Zhou T, Kim K, Liu F Engineered external guide sequences are highly effective in inducing RNase P for inhibition of gene expression and replication of human cytomegalovirus Nucleic Acids Research,2006, Vol. 34, No.2575-58319.Zhang WJ, Li HJ , Li YQ, He HK, Tang DS, Zhang X, Zhou TH.Construction of An Effective M1GS Ribozyme Targeting HCMV UL97 mRNA Segment in Vitro.Acta Genetica Sinica, November 2005,32(11),1205-121220.Su YZ, Li HJ, Li YQ, Chen HJ, Tang DS, Zhang X, Jiang H, Zhou TH. In Vitro Construction of Effective M1GS Ribozymes Targeting HCMV UL54 RNA Segments. Acta Biochimica et Biophysica Sinica, 2005, 37(3):210-21  会议论文 1. Li Hongjian*（通讯作者） Linyuan Feng , Chingman Foo ,Songbin Wu,Yanhong Ran, Xiaoping Yang, Zemin Deng , Tianhong Zhou. Human cytomegalovirus UL23 protein regulates transcription of interferon-γ stimulated genes