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导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名： 周庆华 部门： 生命科学技术学院 直属机构： 生命科学技术学院 性别： 男 职务： 院长 职称： 教授 学位： 博士 毕业院校： 美国科罗拉多大学 电子邮箱： gene@email.jnu.edu.cn 办公地址： 广东省广州市天河区暨南大学生命科学技术学院705 通讯地址： 广东省广州市天河区暨南大学生命科学技术学院 荣誉奖励： 万人计划领军人才,国家级青年人才 联系方式 个人简介 周庆华，海外青年人才引进计划和国家科技领军人才入选者。现任暨南大学生命科学技术学院院长，教授，博士生导师。于2003、2006和2012年分别获南开大学学士、清华大学硕士和美国科罗拉多大学博士学位，后赴耶鲁大学从事博士后研究。2015年回国，在暨南大学任教至今。以第一或通讯作者在Science、Nature Communications、Science Advances、Cell Research等杂志发表多篇论文，主持了多项国家级和省部级的科研项目。曾于2021-2023年担任国家自然科学基金委流动项目主任。研究方向包括线粒体遗传、抗衰老药物开发、细胞自噬、抗肿瘤药物药理研究等。 学习经历 1999.09-2003.07 南开大学生物技术系，学士学位 （指导老师：刘方教授）2003.09-2006.07 清华大学生物系，硕士学位 （指导老师：隋森芳院士）2006.08-2013.06 美国科罗拉多大学分子细胞发育生物学系,博士学位（PI: Dr. Ding Xue）2013.07-2015.07 美国耶鲁大学遗传学医学遗传分部，博士后 （PI: Dr. Peining Li） 工作经历 2015.07-2016.09   暨南大学生物医学转化研究院, 副研究员2016.10-2023.10   暨南大学生物医学转化研究院, 研究员、教授、博士生导师（其中2021-2023在国家自然科学基金委担任流动项目主任）2023.10至今      暨南大学生命科学技术学院， 院长，教授、博士生导师 研究方向 科研方向：利用线虫、细胞、小鼠和临床标本为研究对象：1. 筛选具有抗衰老和缓解阿兹海默症的天然代谢产物及其分子机制研究；2. 研究非孟德尔式遗传中的跨代表观遗传分子机制；3. 线粒体自噬、细胞自噬与衰老的分子机制的研究。 主要论文 1) Wenjun Wang#*, Junyang Tan#, Xiaomin Liu, Wenqi Guo, Mengmeng Li, Xinjie Liu, Yanyan Liu, Wenyu Dai, Liubing Hu, Yimin Wang, Qiuxia Lu, Wen Xing Lee, Hong-Wen Tang & Qinghua Zhou*. Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress. Nat Commun. 2023 Oct 4;14(1):6201.2) Wenjun Wang#, Jianshuang Li#, Qinghua Zhou* The biological function of cytoplasm-translocated ENDOG (endonuclease G). Autophagy . 2023 Oct 27:1-3.3) Qin-Li Wan#, Xiao Meng#, Chongyang Wang, Wenyu Dai, Zhenhuan Luo, Zhinan Yin, Zhenyu Ju, Xiaodie Fu, Jing Yang, Qunshan Ye, Zhanhui Zhang, Zhou, Qinghua Zhou*. Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans，Nature Communications, 2022, 13(1): 1-14.4) Yu Ruan, Jiaqiao Hu, Yaping Che, Yanyan Liu, Zhenhuan Luo, Jin Cheng, Qi Han, He He*& Qinghua Zhou*. CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response. Cell Death Dis. 2022;13(2):156.5) Wenjun Wang#, Jianshuang Li#, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G. Basnakian, Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou*; Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response, Nature Communications, 2021, 12: 476–490.6) Jianshuang Li#，Wenjun Wang, Qinghua Zhou*, Conserved role of ENDOG in promoting autophagy, Autophagy ,2021,17(4):1061-10627) Qin-Li Wan#, Xiao Meng, Wenyu Dai, Zhenhuan Luo, Chongyang Wang, Xiaodie Fu, Jing Yang, Qunshan Ye, Qinghua Zhou*; N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress, Science Advances, 2021, 7(1): 3026–3039.8) Liumin He *#, Zhongqing Sun#, Jianshuang Li#, Rong Zhu, Ben Niu, Ka Long Tam, Qiao Xiao, Jun Li, Wenjun Wang, Chi Ying Tsui, Vincent Wing Hong Lee, Kwok-Fai So, Ying Xu, Seeram Ramakrishna, Qinghua Zhou*, Kin Chiu*; Electrical stimulation at nanoscale topography boosts neural stem cell neurogenesis through the enhancement of autophagy signaling, Biomaterials, 2021, 268:1-16.9) Xin Zhang, Sihan Lv, Zhenhuan Luo, Yongfei Hu, Xin Peng, Jie Lv,Shanshan Zhao, Jianqi Feng, Guanjie Huang, Qin-Li Wan, Jun Liu, Hongxin Huang,Bing Luan, Dong Wang, Xiaoyang Zhao, Ying Lin, Qinghua Zhou*,Zhen-Ning Zhang,* and Zhili Rong*, MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo, Nucleic Acids Research, 2021，49（7）：4171-418510) Qin-Li Wan#, Xiaodie Fu#, Wenyu Dai, Jing Yang, Zhenhuan Luo, Xiao Meng, Xiao Liu, Ruowei Zhong, Hengwen Yang*, Qinghua Zhou*;  Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2, Aging, 2020，12(3): 2840–2856.11) Qin-Li Wan#, Xiaodie Fu, Xiao Meng, Zhenhuan Luo, Wenyu Dai, Jing Yang, Chongyang Wang, Hao Wang, Qinghua Zhou*; Hypotaurine promotes longevity and stress tolerance via the stress response factors DAF-16/FOXO and SKN-1/NRF2 in Caenorhabditis elegans, Food & Function, 2020，11:347-357.12) Huajian Tian, Wenjun Wang, Xiao Meng, Miaomiao Wang, Junyang Tan,Wenjuan Jia, Peining Li, Jianshuang Li* and Qinghua Zhou*；ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell, Frontiers in Cell and Developmental Biology, 2020, 7(375):1-9.13) Xingkun Yang #, Qinghua Zhou #, Wanjun Zhou, Mei Zhong, Xiaoling Guo, Xiaofeng Wang, Xin Fan, Shanhuo Yan, Liyan Li, Yunli Lai, Yongli Wang, Jin Huang, Yuhua Ye, Huaping Zeng, Jun Chuan, Yuanping Du, Chouxian Ma, Peining Li, Zhuo Song*, Xiangmin Xu*; Cell-free DNA Barcode-Enabled Single-Molecule Test for Noninvasive Prenatal Diagnosis of Monogenic Disorders: Application to β-Thalassemia, Advanced Science, 2019, 6:1802332. 14) Qin-Li Wan, Xiao Meng, Xiaodie Fu, Bohui Chen, Jing Yang, Hengwen Yang*, Qinghua Zhou*. Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals, Aging, 2019, 11:e1-18.15) Xiujun Zhao #, Qinli Wan #, Xiaodie Fu, Xiao Meng, Xianfeng Ou, Ruowei Zhong, Qinghua Zhou*, Mingxian Liu*; Toxicity evaluation of one-dimensional Nanoparticles using Caenorhabditis elegans: a comparative study of Halloysite Nanotubes and Chitin Nanocrystals, ACS Sustainable Chemistry and Engineering, 2019, 7(23):18965-18975.16) Jianming Luo, Jiamei Qi, Wenjun Wang, Zhenhuan Luo, Liu Liu, Guangwen Zhang, Qinghua Zhou*, Jiesheng Liu*, and Xichun Peng*; Antiobesity Effect of Flaxseed Polysaccharide via Inducing Satiety due to Leptin Resistance Removal and Promoting Lipid Metabolism through the AMP-Activated Protein Kinase (AMPK) Signaling Pathway, Journal of Agricultural and Food Chemistry, 2019, 67(25):7040-7049.17) Wenjun Wang #, Miaomiao Wang #, Yu Ruan, Junyang Tan, Hao Wang, Tao Yang, Jianshuang Li*, Qinghua Zhou*; Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy. Journal of agricultural and food chemistry, 2019, 67(36), 10097-10106.18) Qinghua Zhou