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Home People Research Research Publications Teaching Protocol Sharing News Center for Pain Medicine Research Brief Info Software Alumni Join us Contact us Wenfei Jin Google Scholar ResearcherID Associate Professor |School of Life Sciences, Department of Biology Dr. Wenfei Jin is an Associate Professor (PI) in Department of Biology in Southern University of Science and Technology (SUSTech). He has worked on genomics, particular developed singe cell technologies, including scDNase-seq (Nature 2015), scPolyA-seq (PNAS 2022), CCI (Cell Discov 2021) and kssd (Genome Biol 2021), to study tumor. He has published >40 articles, including first author and corresponding author articles on Nature, Nat Methods, PNAS, Genome Res, AJHG and Genome Biol. Dr. Jin is interested in: 1) single cell sequencing and its applications in cancer biology; 2) bioinformatics and identifying genetic/epigenetic changes that drive oncogenesis; 3) developing cancer prediction and treatment model for precision medicine. Dr. Wenfei Jin received his bachelor’s degree from Zhengzhou University in 2006. He received his Ph.D. in Computational biology from Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB) with Prof. Li Jin (CAS member) and Prof. Shuhua Xu in 2012. Dr. Jin completed his Postdoc Fellow in systems biology in National Institutes of Health (NIH) with Dr. Keji Zhao in 2017. Dr. Jin is the recipient of many honors and awards including National young Talent, Pearl River young Talent, SUSTech Excellent Postgraduate Supervisor Award, Springer Theses, CAS Excellent Doctoral Dissertation and NHLBI Orloff Award. Personal Profile Dr. Wenfei Jin is an Associate Professor (PI; PhD supervisor;Tenure Track) in Department of Biology in Southern University of Science and Technology (SUSTech). Dr. Jin received his bachelor's degree from Zhengzhou University in 2006. He received his Ph.D. in Computational biology from Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB) with Prof. Li Jin (CAS member) and Prof. Shuhua Xu in 2012. Dr. Jin completed his Postdoc Fellow in systems biology at National Institutes of Health (NIH) with Dr. Keji Zhao in 2017. He joined in Southern University of Science and Technology (SUSTech) in 2017. Dr. Jin works on population genetics and precision medicine related field since his Ph.D. program. He has published >20 research articles and book chapters, including first/co-fist author articles on Nature, AJHG, Genome Res, Genome Biol and HMG. Dr. Jin and his colleagues developed single cell DNase-seq (scDNase-seq) that could provide key regulatory information for precision medicine (Jin, et.al, 2015 Nature). Dr. Jin is the recipient of many honors and awards including Springer Theses, CAS Excellent Doctoral Dissertation and NHLBI Orloff Award. Dr. Jin is especially interested in promoting the applications of single cell sequencing in clinical diagnosis and medical consultation. Research interests Dr. Jin’s lab is interested in identifying genetic/epigenetic changes that drive oncogenesis, and developing disease risk prediction model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies. Professional Experience Mar.2017-present        Associate Professor, Southern University of Science and Technology Jan.2013-Mar.2017     Postdoc fellow, National Institutes of Health (NIH)                               Mentor: Dr. Keji Zhao Jan.2012-Dec.2012      Assistant researcher, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB), SIBS, CAS Education Sept.2006-Dec.2011    Ph.D. in Computational Biology, PICB and University of Chinese Academies of Sciences Supervisors: Prof. Felix Li Jin (CAS member) and Dr. Shuhua Xu Feb.2006-April.2006   Intern, Institute of Biochemistry and Cell Biology, SIBS, CAS Mentors: Prof. Mofang Liu and Prof. Enduo Wang (CAS member) Sept.2001-July.2006    B.Sc. in Biotechnology, Zhengzhou University, China Awards and Honors 2022    Excellent Postgraduate Supervisor Award, SUSTech 2022    Excellent Postgraduate "Mentor and Friend", Graduate School of SUSTech 2019    Pearl River Youth Talents, Guangdong 2018    Outstanding Advisor of College, Zhixin College, SUSTech 2018    National level leading expert, Shenzhen 2017    Shenzhen Peacock Plan B 2017     Distinguished Scientist Award, NIH-CSSA 2016    Orloff innovation Awards, NHLBI, USA 2016     Fellows Award for Research Excellence (FARE), NIH, USA 2014    Springer Theses, Springer 2013    Excellent Doctoral Dissertation, Chinese Academy of Sciences 2012    First-author Awards, PICB                                                   2012    Outstanding Graduate Award, University of Chinese Academy of Sciences 2012    SIBS-Eli Lilly Outstanding Ph.D. Thesis Awards, Eli Lilly 2011    Travel Awards, 12th International Congress of Human Genetics (ICHG)/61th ASHG 2011    Pfizer Awards, Shanghai Institutes for Biological Sciences 2010    Di’ao scholarship Awards, Chinese Academy of Sciences Personal Profile Research The long-term goal of Jin lab is developing precision diagnosis and treatment for cancers. Currently, our lab mainly works on designing single cell multi-omics approaches to address questions in development and medicine, particularly focus on: 1) Developing single cell sequencing to study tumor microenvironment and model tumor development 2) Investigating the cellular heterogeneity and its mechanism via single cell technology Teaching Courses: Computational Biology Bioinformatics Genomics Data Analysis Publications Read More Selected Representative Publications from 50 papers (#equal contribution; * corresponding author) 20. Huang C#, Wang X#, Wang Y#, Feng Y, Wang X, Chen S, Yan P, Liao J, Zhang Q, Mao C, Li Y, Wang L, Wang X, Yi W, Cai W, Chen S, Hong N*, He W*, Chen J*, Jin W*. Sirpα restrains antitumour immunity by modulating the tumour immune microenvironment. Nat Cancer (Accepted) 19.  Yi H#*, Lin Y#, Chang Q, Jin W*. (2023) A fast and globally optimal solution for RNA-seq quantification. Brief Bioinform. https://doi.org/10.1093/bib/bbad298 18. Li H#, Liu H#, Liu Y#, Wang X, Yu S, Huang H, Shen X, Zhang Q, Hong N, Jin W* (2023) Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq. iScience 26: 107588. https://doi.org/10.1016/j.isci.2023.107588 17. Zhou J#, Chen G#, Wang J#, Zhou B, Sun X, Wang J, Tang S, Xing X, Hu X, Zhao Y, Peng Y, Shi W, Zhao T, Wu Y, Zhong H, Hong N, Ruan Z*, Zhang Y*, Jin W*. (2023)  Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer. Oncogenesis 12:22  https://doi.org/10.1038/s41389-023-00468-0 16. Wang J#, Chen W#, Yue W, Hou W, Rao F, Zhong H, Qi Y*, Hong N*, Ni T*, Jin W*. (2022) Comprehensive mapping of alternative polyadenylation site usage and its dynamics at single cell resolution. PNAS  119:e2113504119.  https://doi.org/10.1073/pnas.2113504119 15. Xu W#,Yang W#, Zhang Y, Chen Y, Hong N, Zhang Q, Wang X, Hu Y, Song K, Jin W*, Chen X*. (2022) ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells.  Nat Methods 19:1243-1249. doi: 10.1038/s41592-022-01601-4 14. Wang X#, Shen X#, Chen S, Liu H, Hong N, Zhong H, Chen X, Jin W*. (2022) Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing. J Immunol. 208(2):396-406. https://doi.org/10.4049/jimmunol.2100581 13. Yi G, Lin Y, Lin C, Jin W*. (2021) Kssd: sequence dimensionality reduction by k-mer substring space sampling enables real-time large-scale datasets analysis. Genome Biol. 22:84. doi: 10.1186/s13059-021-02303-4 12. Qin P#, Pang Y#, Hou W#, Fu R#, Zhang Y#, Wang X#, Meng G, Liu Q, Zhu X, Hong N*, Cheng T* and Jin W* (2021) Integrated decoding hematopoiesis and leukemogenesis using single cell sequencing and its medical implication. Cell Discov. 7:2. doi: 10.1038/s41421-020-00223-4 11. Han Z, Cui K, Placek K, Hong N, Lin C, Chen W, Zhao K*, Jin W*, (2020) Diploid genome architecture revealed by multi-omic data of hybrid mice. Genome Res. 30:1097-1106. 10. Wang W, Ren G, Hong N*, Jin W*. (2019) Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq. BMC Genomics. 20:1015. doi: 10.1186/s12864-019-6379-5. 9. Lai B#, Tang Q#, Jin W#, Hu G#, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. (2018). Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 15:741-747. 8. Lai B, Gao W, Cui K, Xie W, Tang Q, Jin W, Hu G, Ni B, Zhao K. (2018) Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing. Nature. 562:281-285 7. Ren G#, Jin W#, Cui K, Rodrigez J, Hu G, Zhang Z, Larson DR, Zhao K. (2017). CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression. Mol Cell 67: 1049-1058. 6. Jin W#, Tang Q#, Wan M, Cui K, Zhang Y, Ren G, Ni B, Sklar J, Przytycka T, Childs R, Levens D, Zhao K. (2015) Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples. Nature. 528:142-146 5. Jin W#, Li R#, Zhou Y, Xu S. (2014) Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping. Euro J Hum Genet. 22:930-937. 4. Kraushaar DC#, Jin W#, Maunakea A, Abraham B, Ha M, Zhao K. (2013) Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol. 14:R121. 3. Jin W, Wang S, Wang H, Jin L, Xu S. (2012) Exploring population admixture dynamics via empirical and simulated genome-wide distribution of ancestral chromosomal segments. Am J Hum Genet. 91:849-862. 2. Jin W, Qin P, Lou H, Jin L, Xu S. (2012) A systematic characterization of genes underlying both complex and Mendelian diseases. Hum Mol Genet. 21: 1611-1624. 1. Jin W, Xu S, Wang H, Yu Y, Shen Y, Wu B, Jin L. (2012) Genome-wide detection of natural selection in African Americans pre- and post-admixture. Genome Res. 22:519-527.   News More Researchers discover that switch of PolyA site usage plays important role in cell cycle regulation through development of single-cell polyA sequencing 2022-12-19 Researchers develop technology for characterisation of cell types 2022-10-11 SUSTech scholars develops data sketching technique for genomic big data 2021-03-19 People Read More PrevNext UpDown Join us We are seeking highly motivated postdoctoral fellows, PhD students, graduate students and interns with interesting in single cell sequencing and precision medicine to join our lab. Dr. Wenfei Jin’s lab in the Southern University of Science and Technology is interested in 1) single cell sequencing and its applications in cancer biology; 2) identifying genetic/epigenetic changes that drive oncogenesis; 3) developing cancer prediction and treatment model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies. The lab is well funded by multiple programs including "National Key R&D Program" and "National Science Foundation of China (NSFC)". Postdoc’s annual total salary usually is about 330,000 RMB(48,000 USD) per year,  (Applicants should have a track-record of high quality publications). Scholarship is highly competitive (about >80,000 RMB per year for PhD student; about >40,000 RMB per year for graduate student) Stipends for intern will depends on applicant’s performance.ContactIf you are interested in joining Dr. Jin’s lab, please send your C.V. and the names of 2-3 references to Dr. Jin (jinwf@sustech.edu.cn). We look forward to hearing from you! Read More Contact Us Contact Address 1088 Xueyuan Avenue # Faculty Research Building NO.1, Room 206 Office Phone (+86) 0755-88018478 Email jinwf@@sustech.edu.cn