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Home People Research Research Publications Teaching Protocol Sharing News Center for Pain Medicine Research Brief Info Software Alumni Join us Contact us Sheng-Jian Ji Associate Professor with Tenure |School of Life Sciences, Department of Neuroscience Dr. Ji is currently an associate professor with tenure at Department of Neuroscience, School of Life Sciences. He also serves as Associate Dean for Academic Affairs at Shude College. Dr. Ji has been primarily focusing on developmental neurobiology. He is primarily interested in elucidating different posttranscriptional mechanisms regulating neuronal development, including local protein synthesis in axons and mRNA modification during neuronal development. His lab has become (one of) the most important group(s) studying mRNA modification in regulation of neuronal development and functions in the world. He has also made progresses on studying the roles of retrograde signals derived from target tissues of axon. Personal Profile Personal Profile Research Novel mechanisms regulating neural development and functions: ◆ mRNA modification ◆ Local mRNA translation in axons ◆ Retrograde signaling from axonal terminal to soma Teaching Neurobiology (Undergraduate) Cellular and Molecular Neurobiology (Graduate) Publications Read More Selected publications (*corresponding author；#equal contribution） Xin-Tai Wang#, Lin Zhou#, Bin-Bin Dong#, Fang-Xiao Xu, De-Juan Wang, En-Wei Shen, Xin-Yu Cai, Yin Wang, Na Wang, Sheng-Jian Ji, Wei Chen, Martijn Schonewille, J Julius Zhu*, Chris I De Zeeuw*, Ying Shen*. cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning. eLife 2023, 12: e80875. DOI: https://doi.org/10.7554/eLife.80875. Published online April 26, 2023 Zhuoxuan Yang#, Jun Yu#, Jian Zhang#, Huixue Song#, Haixia Ye#, Jianhui Liu#, Nijia Wang#, Pengfei Che, Gaoxin Long, Yunxuan Wang, Jaewon Park*, Sheng-Jian Ji*. Facilitation of axonal transcriptome analysis with quantitative microfluidic devices. Lab on a Chip 2023. DOI: https://doi.org/10.1039/D2LC01183B. Published on April 5, 2023. Mengru Zhuang#, Xiaoqi Geng#, Peng Han#, Pengfei Che#, Fanghao Liang#, Chao Liu#, Lixin Yang, Jun Yu, Zhuxia Zhang, Wei Dong*, Sheng-Jian Ji*. YTHDF2 in dentate gyrus is the m6A reader mediating m6A modification in hippocampus-dependent learning and memory. Molecular Psychiatry 2023. DOI: https://doi.org/10.1038/s41380-023-01953-z. Peng Han#, Yuanchu She#, Zhuoxuan Yang, Mengru Zhuang, Qingjun Wang, Xiaopeng Luo, Chaoqun Yin, Junda Zhu, Samie R. Jaffrey*, Sheng-Jian Ji*. Cbln1 regulates axon growth and guidance in multiple neural regions. PLOS Biology 2022, 20(11): e3001853. DOI: 10.1371/journal.pbio.3001853. Published Nov 17, 2022. Tian Zhou, Yuxin Li, Xiaoyu Li, Fanzhuo Zeng, Yanxia Rao, Yang He, Yafei Wang, Meizhen Liu, Dali Li, Zhen Xu, Xin Zhou, Siling Du, Fugui Niu, Jiyun Peng, Xifan Mei, Sheng-Jian Ji, Yousheng Shu, Wei Lu, Feifan Guo, Tianzhun Wu, Ti-Fei Yuan, Ying Mao, Bo Peng*. Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nature Communications 2022, 13(1): 6233. DOI: 10.1038/s41467-022-33932-3. Published Oct 24, 2022. Fugui Niu#, Pengfei Che#, Zhuoxuan Yang, Jian Zhang, Lixin Yang, Mengru Zhuang, Xijun Ou*, Sheng-Jian Ji*. m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs. iScience 2022, 25(9): 104908. DOI: https://doi.org/10.1016/j.isci.2022.104908. Published Sep 16, 2022 (online August 10, 2022).  Fugui Niu, Peng Han, Jian Zhang, Yuanchu She, Lixin Yang, Jun Yu, Mengru Zhuang, Kezhen Tang, Yuwei Shi, Baisheng Yang, Chunqiao Liu, Bo Peng*, Sheng-Jian Ji*. The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells. eLife 2022, 11: e75827. DOI: 10.7554/eLife.75827 (online Feb 18, 2022). Hengjun Huang, Gaopu Zhang, Gui-Xin Ruan, Yuxing Li, Wenjing Chen, Jia Zou, Rui Zhang, Jing Wang, Sheng-Jian Ji*, Shengli Xu, Xijun Ou*. Mettl14-mediated m6A modification is essential for germinal center B cell response. Journal of Immunology 2022, 208(8): 1924-1936. Published online April 1, 2022. Lichao Li#, Jun Yu#, Sheng-Jian Ji*. Axonal mRNA localization and translation: local events with broad roles. Cellular and Molecular Life Sciences (In press) Jun Yu#, Yuanchu She#, Lixin Yang#, Mengru Zhuang, Peng Han, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen, Chunxuan Jiang, Yujia Zhang, Yujing Yuan, Sheng-Jian Ji*. The m6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons. Advanced Science 2021, doi:10.1002/advs.202101329. Published Oct 12, 2021. Jun Yu, Yuanchu She, Sheng-Jian Ji*. m6A modification in mammalian nervous system development, functions, disorders and injuries. Frontiers in Cell and Developmental Biology 2021, 9: 679662. Mengru Zhuang, Xinbei Li, Junda Zhu, Jian Zhang, Fugui Niu, Fanghao Liang, Mengxian Chen, Duo Li, Peng Han, Sheng-Jian Ji*. The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Research 2019, 47(9): 4765-4777. Published online Mar 7, 2019. Jun Yu#, Mengxian Chen#, Haijiao Huang#, Junda Zhu, Huixue Song, Jian Zhu, Jaewon Park, Sheng-Jian Ji*. Dynamic m6A modification regulates local translation of mRNA in axons. Nucleic Acids Research 2018, 46(3): 1412-1423. Published online Nov 23, 2017. Sheng-Jian Ji, Samie R. Jaffrey*. Axonal transcription factors: Novel regulators of growth cone-to-nucleus signaling. Developmental Neurobiology 2014, 74(3): 245-258.  Dilek Colak, Sheng-Jian Ji, Bo Torben Porse, Samie R. Jaffrey*. Regulation of axon guidance by nonsense-mediated mRNA decay. Cell 2013, 153(6): 1252-1265.  Sheng-Jian Ji, Samie R. Jaffrey*. Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification. Neuron 2012, 74(1): 95-107.  Breset A. Walker#, Sheng-Jian Ji#, Samie R. Jaffrey*. Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG. Journal of Neuroscience 2012, 32(41): 14442-14447.  Sheng-Jian Ji, Goran Periz, Shanthini Sockanathan*. Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities. Development 2009, 136 (2): 231-240. Sheng-Jian Ji#, Binquan Zhuang#, Crystal Falco, André Schneider, Karin Schuster-Gossler, Achim Gossler, Shanthini Sockanathan*. Mesodermal and neuronal retinoids regulate the induction and maintenance of forelimb spinal motor neuron subtype identity. Developmental Biology 2006, 297(1): 249-261.  Sheng-Jian Ji, Ying-Chun Lu, Jian-Xun Feng, Gang Wei, Jun Li, Yong-Hui Shi, Qiang Fu, Di Liu, Jing-Chu Luo, Yu-Xian Zhu*. Isolation and analyses of genes preferentially expressed during early cotton fiber development by subtractive PCR and cDNA array. Nucleic Acids Research 2003, 31(10): 2534-2543. Sheng Jian Ji, Feng Liu, Er Qiu Li, Yu Xian Zhu*. Recombinant scorpion insectotoxin AaIT kills specifically insect cells but not human cells. Cell Research 2002, 12(2): 143-150. Shengjian Ji, Yingchun Lu, Jun Li, Gang Wei, Xiujuan Liang, Yuxian Zhu*. A b-tubulin-like cDNA expressed specifically in elongating cotton fibers induces longitudinal growth of fission yeast. Biochemical and Biophysical Research Communications 2002, 296(5): 1245-1250. News More Yanbo got offers from Stanford, NYU, UNC... Congratulations! 2024-03-15 SMART Symposium 2023-10-31 Celebrate the National Teachers' Day and welcome the new lab members! 2023-09-10 People Read More PrevNext UpDown Join us Currently we seek motivated candidates to apply for the postdoc and PhD fellowships in the lab. Please send your detailed CV (with complete education and publication records) to jisj#sustech.edu.cn.     Read More Contact Us Contact Address Room 343, Research Building 1, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong,China Office Phone 0755-88018498 Email jisj@sustech.edu.cn