教师主页移动版

更新日期：2021年9月22日 姓 名 曾伟 性 别 男 出生年月 1971年10月 籍贯 重庆梁平县 民 族 汉族 政治面貌 中国共产党党员 最后学历 博士研究生 最后学位 理学博士 技术职称 教授 导师类别 博、硕导 行政职务 Email zengwei@scut.edu.cn 工作单位 华南理工大学 邮政编码 510641 通讯地址 化学与化工学院 单位电话 个人主页 http://www2.scut.edu.cn/zengw/ 个人简介 曾伟教授先后在四川大学获得学士、硕士和博士学位。2003年获得博士学位后, 曾在香港大学、美国北卡州立大学和纽约州立大学 (布法罗分校) 从事博士后研究工作。2008年底回国后受聘为华南理工大学“百人计划”杰出青年教师，2010年入选“教育部新世纪优秀人才支持计划”。目前的研究兴趣主要涉及发展新型过渡金属催化C-C和C-hetero atom bond 的形成反应来构建生物活性及功能分子的核心骨架；在过渡金属催化酰亚胺的烷基化、不对称芳基化; 过渡金属催化、功能基导向的Csp2-H 及Csp3-H功能化以及过渡金属催化烯烃的分子内不对称双胺化反应等方面已有系列原创性的研究工作，自独立开展研究工作以来, 曾伟教授先后在化学类国际主流期刊上Nat. Commun., Angew. Chem., Int. Ed.; Chem. Sci.; ACS Catal.; Chem. Commun.; Org. Lett.已发表高水平学术论文近50篇。先后承担和参加了国家自然科学基金面上项目、科技部国家重点研发计划、教育部新世纪人才支持计划 、中科院“西部之光”人才培养计划“联合学者”基金及广州市科技计划等项目。 工作经历 工作经历:1994 /07 ~ 1997 /09: 中国工程物理研究院化工材料研究所, 助理工程师2004 /02 ~ 2005 /02: 香港, Dept. of Chemistry, The Univ. of Hong Kong, 研究助理2005 /02 ~ 2006 /10: 美国, Dept. of Chemistry, North Carolina State Univ., 博士后2006 /11 ~ 2008 /10: 美国, Dept. of Chemistry, Univ. at Buffalo, The State Univ. of New York, 博士后2008 /11 ~ 至今: 华南理工大学化学与化工学院, 教授/博士生导师, “百人计划”杰出青年教师,   2010年入选“教育部新世纪优秀人才支持计划” 教育经历 教育经历:1990 /09 ~ 1994 /07:  四川大学化学学院, 获学士学位1997 /09 ~ 2003 /07:  四川大学化学学院, 获理学硕士和博士学位 社会、学会及学术兼职 现任广东省功能分子工程重点实验室副主任，兼任广东省突发事件应急管理专家。 研究领域 主要研究兴趣:1. 发展新型有机及过渡金属络合催化反应, 实现复杂杂环化合物的快速而有效构建，进而探索其在天然产物全合成中的应用2. 不对称催化与合成3. 药物分子的设计合成及其生物活性研究 科研项目 科研项目：1. 华南理工大学“百人计划”科研启动基金项目，2008/11- 2011/11, 项目负责人2. 教育部新世纪优秀人才支持计划(No. NCET-10-0371), 2010/1- 2012/12, 项目负责人3. 国家自然科学基金(No. 21072063), 2011/1- 2013/12, 项目负责人4. 教育部留学回国人员科研启动基金, 2011/1- 2013/12, 项目负责人5. 教育部高等学校博士学科点科研基金(No. 20100172120020), 2011/1- 2013/12, 项目负责人6. 中国科学院“西部之光”人才培养计划“联合学者”基金（No.Y3C1011100）, 2013/1-2016/1, 项目负责人7. 国家自然科学基金(No. 21372085), 2014/1- 2017/12, 项目负责人8. 广州市科技计划项目(No. 156300075), 2015/5- 2017/6, 项目负责人9. 国家重点研究计划项目(No. 2016YFA0602900), 2016/5- 2021/6, 项目参加人 发表论文 Publications54. Chen, F. J.; Shao, Y. X.; Li, M.K.; Yang, C.; Su, S. J*.; Jiang, H. F.; Ke, Z. F*.; Zeng, W*. “Photocatalyzed Cycloaromatization of Vinylsilanes with Arylsulfonyl Azides”. Nat. Commun. 2021, 12, 3304.53. Liu, Z, P.; Hu, X. W.; Yang,C.; Xie, H. S.; Jiang,H. F.; Jiang,F. B.; Zeng, W*.“Rh(III)-Catalyzed Csp2-Csp3 Bond Cleavage/Carbonylethylation of alpha-Indolyl Alcohols”. Adv. Synth. Catal. 2021, 363, 1672.52. Hu, X. W.; Tan, Z.; Liu, Z. P.; Liu, Z. P.; Chen, F. J.; Jiang, H. F.; Zeng, W*.  "Rh(III)-catalyzed sulfonylamination of alpha-indolyl alcohols via Csp2-Csp3 bond cleavage". Org. Chem. Front. 2021, 8, 983. 51. Hu, X. W.; Shao, Y. X.; Xie, H. S.; Chen, X.; Chen, F. J.; Ke, Z. F.; Jiang, H. F.; Zeng, W*. “Direct Carbon-Carbon sigma Bond Amination of Unstrained Arylalkylketones”. ACS Catal. 2020, 10, 8402.50. Chen, F, J.; Yang, C.; Hu, X. W.; Zhang, X. Q.; Xie, H. S.; Jiang, H. F.; Jiang, F. B.; Zeng, W*. “Photocatalyzed Formal Carbooxygenation of Terminal Alkynes”. Org. Chem. Front. 2020, 7, 1600.49. Gui, J.; Xie, H. S.; Chen, F. J.; Liu, Z. P.; Zhang, X. Q.; Jiang, F. B.; Zeng, W,* “Bronsted Acid/ Visible- Light- Promoted Markovnikov Hydroamination of Vinylarenes with Arylamines”. Org. Biomol. Chem. 2020, 18, 956.48. Huang, J. M.; Hu, X. W.; Chen, F. J.; Gui, J.; Zeng, W*. "Rhodium(I)-Catalyzed Vinylation/[2+1] Carbocyclization of 1,6-Enynes with -Diazocarbonyl Compounds". Org. Biomol. Chem. 2019, 17, 7042.47. Xie, H.; Shao, Y.; Gui, J.; Lan, J.; Liu, Z.; Ke, Z.; Deng, Y.; Jiang, H.; Zeng, W*. "Co(II)-Catalyzed Regioselective Pyridine C–H Coupling with Diazoacetates". Org. Lett. 2019, 21, 3427.46. Gui, J.; Xie, H.; Jiang, H.; Zeng, W*. "Visible-Light-Mediated Sulfonylimination of Tertiary Amines with Sulfonylazides Involving Csp3–Csp3 Bond Cleavage". Org. Lett. 2019, 21, 2804.45. Yang, H, H.; An, B. B.; Li, X. S*.; Zeng, W*. “Evaluation of 4-Phenylamino-Substituted Naphthalene-1,2-Diones as Tubulin Polymerization Inhibitors”. Bioorg. Med. Chem. Lett. 2018, 28, 3057.44. Hu, X. W.; Chen, F. J.; Deng, Y. F.; Jiang, H. F.; Zeng, W*.  “Zn(OAc)2-Catalyzed C3-Carbonylacetylation of Indoles with α-Diazoketones Involving Wolff  Rearrangement”. Org. Lett. 2018, 20, 6140.43. Xie, H. S.; Lan, J. Y.; Gui, J.; Chen, F. J.; Jiang, H. F.; Zeng. W*. “Ru (II)-Catalyzed Coupling-Cyclization of Sulfoximines with alpha-Carbonyl Sulfoxonium Ylides as an Approach to 1,2-Benzothiazines”, Adv. Synth. Catal. 2018, 360, 3534.42. Chen, Z. Y.; Hu, X. W.; Huang, J. M.; Zeng, W*. “Rhodium(I)-Catalyzed Coupling-Cyclization of C=O Bonds with alpha-Diazoketones”, Org. Lett. 2018, 20, 3980.41. Hu, X. W.; Chen, X.; Shao, Y.; Xie, H. S.; Deng, Y. F.; Ke, Z. F*.; Jiang, H. F.; Zeng, W*. “Co(III)-Catalyzed Coupling-Cyclization of Aryl C-H Bonds with -Diazoketones Involving Wolff Rearrangement”. ACS Catal. 2018, 8, 1308.40. Xie, H. S.; Ye, Z. R.; Ke, Z. F.;* Lan. J. Y.; Jiang, H. F.;* Zeng, W*. “Rh(III)-Catalyzed Regioselective Intermolecular N-Methylene Csp3-H Bond Carbenoid Insertion”. Chem. Sci. 2018, 9, 985.39. Lan, JY.; Xie, HS.; Lu, XX.; Deng, YF.; Jiang, HF.; Zeng, W*. “Co(II)-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Aryl C-H Bonds with Carboxylic Acids”. Org. Lett. 2017, 19, 4279.38. Hu, X. W.; Chen, X.; Zhu, Y.; Deng, Y. F.; Zeng, H. Q.; Jiang, H. F.; Zeng, W*. “Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp2-H/Csp3-Csp3 Activation”, Org. Lett. 2017. 19, 3474.37. Zhang, Z. H.; Liu, K. K.; Xun Chen, X.; Su, S. J.;* Deng, Y. F.; Zeng, W*. “Rhodium(III)-Catalyzed Indole-Directed Carbenoid Aryl C-H Insertion/Cyclization: Access to 1, 2-Benzocarbazoles”, RSC. Adv. 2017, 7, 30554.36. Bai, S. Y.; Chen, X.; Hu, X. W.; Deng, Y. F.; Jiang, H. F.; Zeng, W*. “Ir(III)-Catalyzed Aryl C-H Bond Carbenoid Functionalization Cascade: Access to 1,3-Dihydroindole-2-Ones”, Org. Biomol. Chem. 2017, 15, 3638.35. Huang, F. S.; Chen, X.; Xie, Y.; Zeng, W*. “Progress in the Transition Metal-Catalyzed C(sp2)-H Bond Functionalization of Azoarenes”, Chin. J. Org. Chem. 2017, 37, 31.34. Chen, X.; Hu, X. W.; Deng, Y.; Jiang, H. F.; Zeng, W*. “A [4 + 1] Cyclative Capture Access to Indolizines via Cobalt(III)-Catalyzed Csp2-H Bond Functionalization”, Org. Lett. 2016. 18, 4742.33．Xiao, X. S.; Hou, C.; Zhang, Z. H.; Ke, Z. F*.; Lan, J. Y.; Jiang, H. F.; Zeng, W*. “Ir(III)-Catalyzed Regioselective Intermolecular Unactivated Secondary Csp3-H Bond Amidation”, Angew. Chem., Int. Ed. 2016, 55, 11897.32．Xiao, X. S.; Zhang, W.; Lu, X. X.; Deng, Y. F.; Jiang, H. F.; Zeng, W*. “Copper-Catalyzed Addition of Alkylboranes to Iminoacetates: Access to alpha-Alkyl Branched alpha-Amino Acids”, Adv. Synth. Catal. 2016, 358, 2497.31．Chen, TF.; Chen, X.; Wei, J.; Lin D.; Xie. Y.; Zeng, W*. “Copper-Catalyzed Cascade Cycloamination of α-Csp3–H Bond of N-Aryl Ketimines with Azides: Access to Quinoxalines”, Org. Lett. 2016, 18, 2078.30. Xie, Y.; Chen, X.; Liu, X.; Su, S. –J.; Li, J.; Zeng, W*. “Rh(III)-Catalyzed Relay Carbenoid Functionalization of Aromatic C-H Bonds: Access to π-Conjugated Fused Heteroarenes”, Chem. Commun. 2016, 52, 5856. 29. Wei, J.; Jiang, J.; Xiao, X.; Lin, D *.; Deng, Y.; Ke, Z *.; Jiang, H.; Zeng, W*. “Copper-Catalyzed Regioselective C-H Sulfonylation of 8-Aminoquinolines”, J. Org. Chem. 2016, 81, 946.28. Chen, X.; Hu, X. W.; Bai, S. Y.; Deng, Y.; Jiang, H. F.; Zeng, W*. “Rh(III)-Catalyzed [4 + 2] Annulation of Indoles with Diazo Compounds: Access to Pyrimido[1,6-a]indole-1(2H)-ones”, Org. Lett. 2016, 18, 192.27. Chen, X.; Xie, Y.; Xiao, X.; Li, G.; Deng, Y.; Jiang, H.; Zeng, W*. “Rh(III)-Catalyzed Chelation-Assisted Intermolecular Carbenoid Functionaliztion of -Imino Csp3-H Bonds”, Chem. Commun. 2015, 51, 15328. 26. Xiao, X.; Xie, Y.; Bai, S.; Deng, Y.; Jiang, H.; Zeng, W*. “Transition-Metal-Free Tandem Chlorocyclization of Amines with Carboxylic Acids: Access to Chloroimidazo[1,2-]pyridines”, Org. Lett. 2015, 17, 3998.25. Xie, Y,; Chen, T. F.; Fu, S. M.; Jiang, H. F.; Zeng, W*. “Pd-Catalyzed Carbonylative Cycloamidation of Ketoimines for Synthesis of Pyrido [1, 2-a] Pyrimidin-4-Ones”, Chem. Commun. 2015, 51, 9377.24. Zhang, W.; Wei, J.; Fu, S. M.; Lin, D.; * Jiang, H.; Zeng, W*. “Highly Steroselective Ruthenium(II)-Catalyzed Direct C2-Syn-Alkenylation of Indoles with Alkynes”, Org. Lett. 2015, 17, 1349. 23. Liu, J. Z.; Xie, Y.; Zeng, W *.; Lin, D.; Deng, Y.; Lu, X*. “Pd(II)-Catalyzed Pyridine N-Oxide-Directed Arylation of Unactivated Csp3-H bonds ”. J. Org. Chem. 2015, 80, 4618. 22. Fu, S. M.; Yang, H. H.; Li, G. Q.; Deng, Y. F.; Jiang, H. F.; Zeng, W*. “Copper(II)-Catalyzed Enantioselective Intramolecular Cyclization of N-Alkenyl Ureas”. Org. Lett. 2015, 17, 1018.21. Li, M. Y.; Xie, Y.; Ye, Y*.; Zou, Y.; Jiang, H. F.; Zeng, W*. “Cu(I)-Catalyzed Transannulation of N-Heteroaryl Aldehydes or Ketones with Alkylamines via C(sp3)-H Amination”, Org. Lett., 2014, 16, 6232.20. Liang, L. B.; Fu, S. M.; Lin, D.; Zhang, X. Q.; Deng, Y. F.; Jiang, H. F.; Zeng, W*. “Ruthenium(II)- Catalyzed Direct Addition of Indole/Pyrrole C2-H Bonds to Alkynes”. J. Org. Chem. 2014, 79, 9472.19. Fu, M. Q.; Lin, D. E.; Deng, Y. F.; Zhang, X. Q.; Liu, Y. C.; Lai, C. S.; Zeng, W*. “Pd-Catalyzed Tandem Homocupling- Adol- Dehydration of ortho-Acylphenyl Iodides”, RSC Adv. 2014, 4, 23595.18. Qian, C.; Lin, D. E.; Deng, Y. F.; Zhang, X. Q.; Jiang, . HF.; Miao, G.; Tang, X. H.; Zeng, W*. “Palladium-catalyzed ortho-Functionalization of Azoarenes with Aryl Acylperoxides”, Org. Biomol. Chem. 2014, 12, 5866. 17. Xie, Y.; Chen, T. F.; Fu, S. M.; Li, X. S.; Deng, Y. F.; Jiang, H. F.; Zeng, W*. “Pd-Catalyzed [3 + 2] Cycloaddition of Ketoimines with Alkynes via Directed sp3 C-H Bond Activations”, Chem. Commun. 2014, 50, 10699. 16. Dang, L.; Liang, L. B.; Qian, C.; Fu, M. Q.; Ma, T. M*.; Xu, D. G*.; Jiang, H. F.; Zeng, W*. “Cu(OAc)2-Promoted Cascade Carboamination/Oxidative Cyclization of C-Acylimines with Alkenes”. J. Org. Chem. 2014, 79, 769.15. Tang, H.; Qian, C.; Lin, D. E*.; Jiang, H. F.; Zeng, W*. “Palladium-Catalyzed Direct Oxidative C-H Cross-Coupling of Azoarenes with Alcohols”. Adv. Synth. Catal. 2014, 356, 519.14. Xiong, F.; Qian, C.; Lin, D. E.; Zeng, W*.; Lu, X. X*. “Palladium-Catalyzed Cascade Oxidation/ sp2 C-H Acylation of Azoarenes with Aryl Methanes”. Org. Lett. 2013, 15, 5444.13. Qian, C.; Chen, J. Y.; Fu, M. Q.; Zhu, S. Y.; Chen, W. H.; Jiang, H. F.; Zeng, W*. “An Unusual 1, 2-Aryl Shift in Palladium-Catalyzed Cross-Coupling Ethoxycarbonylation of Arylboronic Acids with -Iminoesters”. Org. Biomol. Chem., 2013, 11, 6013.12. Zhu, S. J.; Lu, X. X.; Luo, YT.; Zhang, W.; Jiang, H. F.; Yan, M.; Zeng. W*. “Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of α-Imino Esters with Dienes”. Org. Lett. 2013, 15, 1440.11. Luo, Y. T.; Lu, X. X.; Ye, Y*.; Guo, Y.; Jiang, H. F.; Zeng, W*. “Pd-Catalyzed Tandem Cyclization of Ethyl Glyoxalate and Amines: Rapid Assembly of Highly Substituted Cyclic Dehydro-α-Amino Acid Derivatives”. Org. Lett. 2012, 14, 5640.10. Chen, J. Y.; Lu, X. X.; Lou, W. Y.; Ye, Y.; Jiang, H. F.; Zeng, W*. “Pd(II)-Catalyzed Enantioselective Arylation of -Imino Esters”. J. Org. Chem. 2012, 77, 8541.9. Fu, S. M.; Jiang, H. F.; Deng, Y. F.; Zeng, W*. “Palladium-Catalyzed Intramolecular Sulfonamidation/Oxidation of  Imine: Access to Multifunctional Benzimidazoles”. Adv. Synth. Catal. 2011, 353, 2795.8. Zhu, S. J.; Dong, J.; Fu, S. M.; Jiang, H. F.; Zeng, W*. “Cu(II)-Catalyzed Intermolecular Amidation of C-Acylimine: A Convenient Access to gem-Diamino Acid Derivatives”. Org. Lett. 2011, 13, 4914.7. Zeng W.; Chemler, S. R*. “Total Synthesis of S-(+)-Tylophorine via Enantioselective Intramolecular Alkene Carboamination”. J. Org. Chem. 2008, 73, 6045. 6. Zeng W.; Chemler, S. R*. “Copper (II)-Catalyzed Enantioselective Intramolecular Carboamination of Alkenes”. J. Am. Chem. Soc. 2007, 129, 12948. 5. Huigens III, R. W.; Richards, J. J.; Parise, G.; Ballard, T. E.; Zeng W.; Deora, R.; Melander C*. “Inhibition of Pseudomonas aeruginosa Biofilm Formation with Bromoageliferin Analogues”. J. Am. Chem. Soc. 2007, 129, 6966. 4. Zeng W.; Ballard T. E.; Melander C*. “Mimicking the DNA Cleavage Activity of Kinamycin D with Electronically Tuned Diazofluorene analogs”. Bioorg. Med. Chem. Lett. 2006, 16, 5148.3. Zeng W.; Ballard T. E.; Melander C*. “Tuning the Oxidation Properties of Vanadium (V) through Ligand Stoichiometry”. Tetrahedron Lett. 2006, 47(33), 5929.2. Zeng W, Li J. Z, Mao Z. H, Hong Z, Qin S. Y*. “Synthesis, Oxygenation and Catalytic Oxidation Performance of Crown Ether Containing Schiff Base Transition - metal Complexes”. Adv. Synth. Catal. 2004, 346, 1385-1391.1. Zeng W, Mao Z. H, Li J. Z, Qin S. Y*. “Synthesis of Novel Crowned Salicylaldimine Schiff Bases”. Synthesis 2004, 7, 1011. 教学活动 曾伟教授先后主讲本科生课程《有机化学》和研究生课程《不对称催化与合成》。教学过程中注重培养学生的创新精神和实践能力，教学效果良好，深受师生好评。 指导学生情况 至今已指导博士研究生11人，硕士研究生25人。 我的团队 曾伟教授课题组信息，请浏览课题组网页：http://www2.scut.edu.cn/zengw/