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更新日期：2024年3月18日 姓 名 竺传乐 性 别 男 出生年月 1987年11月 籍贯 湖南华容县 民 族 汉族 政治面貌 中国共产党党员 最后学历 博士研究生 最后学位 理学博士 技术职称 教授 导师类别 博、硕导 行政职务 Email cechlzhu@scut.edu.cn 工作单位 化学与化工学院 邮政编码 510640 通讯地址 天河区五山路381号华南理工大学15号楼414室 单位电话 13544551560 个人主页 http://www2.scut.edu.cn/ce/2017/0927/c2422a210832/page.htm 个人简介 基于绿色化学理念，通过有机小分子催化不对称合成及过渡金属催化碳氢活化等策略，利用化学键选择性断裂与可控性重组等手段，围绕杂环、小环及含氟分子的高效合成与转化开展研究工作。近年来主持了国家自然科学基金青年项目、国家重点研发计划项目课题等国家级、省部级科研项目8项，发表SCI论文33篇，其中以第一或通讯作者在Angew. Chem. Int. Ed., Org. Lett., Chem. Commun.等上发表SCI研究论文24篇（15篇IF > 5.4），SCI他引350次；申请发明专利8项，授权发明专利4项，出版英文专著1部。 工作经历 2020.9-至今， 华南理工大学化学与化工学院，教授，博士生导师；2017.4-2020.8， 华南理工大学化学与化工学院，副教授，硕士生导师；2020.2-2021.1，美国斯坦福大学化学系，访问学者，合作导师：Barry M. Trost 院士；2015.3-2017.3，华南理工大学化学与化工学院，有机化学，师资类博士后，助理研究员，合作导师：江焕峰教授； 教育经历 2009.9-2015.1，天津大学，有机化学，博士，导师：马军安教授；2011.9-2012.7，法国国立应用科学学院鲁昂分院，有机化学，博士交流生，导师:Dominique Cahard教授；2005.9-2009.7，天津大学，化学，学士。 获奖、荣誉称号 2011年，法国外交部埃菲尔博士研究生奖学金（全球35人/年）；2012年，教育部2012年度博士研究生学术新人奖；2012年，教育部2012年度博士研究生国家奖学金；2012年，天津大学2012年度优博基金；2013年，中国航天科技集团一等奖学金；2018年，广州市2018年度珠江科技新星；2020年，广东省杰出青年科学基金获得者。 研究领域 碳氢活化、有机氟化学、绿色有机合成化学、催化不对称合成 科研项目 [1] 国家自然科学基金面上项目，主持；[2] 国家自然科学基金青年项目，主持；[3] 国家重点研发计划项目课题，主持；[4] 广东省自然科学基金博士启动项目，主持；[5] 广州市科技计划项目-珠江科技新星专题，主持；[6] 中国博士后基金特别资助项目，主持；[7] 中国博士后基金面上项目（一等），主持；[8] 制浆造纸国家重点实验室开放基金，主持；[9] 华南理工大学中央高校重点项目，主持。[10] 华南理工大学中央高校面上项目，主持。 发表论文 202250. Hao Zeng, Hengyuan Li, Chengxi Li, Huanfeng Jiang, Chuanle Zhu. Bond Energy Enabled Amine Distinguishing Strategy: Chemo-, Regioselective 1,3-Diamination of (Trifluoromethyl)alkenes with Different Amines by Two C(sp3)-F Bond Cleavages. Org. Chem. Front. 2022, 9, DOI: 10.1039/d1qo01849c.49. Hao Zeng, Hengyuan Li, Huanfeng Jiang, Chuanle Zhu.* Steric-switched defluorofunctionalization selectivity: controlled synthesis of monofluoroalkene-masked medium-sized heterocyclic lactams and lactones. Sci. China Chem, 2022, 65, 554–56248. Yingying Cai, Chi Liu, Guangying Liu, Chengxi Li, Huanfeng Jiang, Chuanle Zhu,* Access to α,α-difluoro(arylthio)methyl oxetanes from α,α-difluoro(arylthio)methyl ketones and trimethylsulfoxonium halides: scope, mechanism and applications. Org. Biomol. Chem., 2022, 20, 1500–150947. Yingying Cai, Huanfeng Jiang, Chuanle Zhu,* α‑Trifluoromethyl Carbanion-catalyzed Intermolecular Stetter Reaction of Aromatic Aldehydes with 2‑Bromo-3,3,3-trifluoropropene: Synthesis of β‑Alkoxyl-β-trifluoromethylated Ketones. Org. Lett. 2022, 24, 33−37202146. Chuanle Zhu,* Yingying Cai, Huanfeng Jiang.* Recent advances for the synthesis of chiral sulfones with the sulfone moiety directly connected to the chiral center. Org. Chem. Front., 2021, 8, 5574–558945. Hengyuan Li, Chuanle Zhu.* Dual Roles of TBHP Enabled Regioselective Hydroetherification of (Trifluoromethyl)alkenes with Boronic Acids: Access to α-Trifluoromethyl β-Aryloxy Tertiary Alcohols. Synthesis, 2021, DOI: 10.1055/a-1481-2023.44. Chi Liu, Chuanle Zhu,* Yingying Cai, Huanfeng Jiang.* Solvent-Switched Oxidation Selectivities with O2: Controlled Synthesis of α-Difluoro(thio)methylated Alcohols and Ketones. Angew. Chem. Int. Ed. 2021, Doi:anie.20201727143. Barry M. Trost,* Chuanle Zhu,# Chloe Christine Ence.#Pd-Catalyzed Regio-, Diastereo-, and Enantioselective [3 + 2] Cycloaddition Reactions: Access to Chiral Cyclopentyl Sulfones. Org. Lett. 2021, doi.org/10.1021/acs.orglett.1c00384 (# equal contribution)42. Hao Zeng, Xiaojie Fang, Zhiyi Yang, Chuanle Zhu,* Huanfeng Jiang, Regioselective Synthesis of 5‑Trifluoromethylpyrazoles by [3 + 2] Cycloaddition of Nitrile Imines and 2‑Bromo-3,3,3-trifluoropropene. J. Org. Chem. 2021, doi: org/10.1021/acs.joc.0c0276541. Hao Zeng, Yingying Cai, Huanfeng Jiang, Chuanle Zhu.* Two C(sp3)-F Bonds Activation in a CF3 Group: ipso-Defluorinative Amination Triggered 1,3-Diamination of (Trifluoromethyl)alkenes with Indoles, Carbazoles, Pyrroles, and Sulfonamides. Org. Lett. 2021, DOI: org/10.1021/acs.orglett.0c03708. 202040. Barry M. Trost,* Chuanle Zhu. Zn-ProPhenol Catalyzed Enantioselective Mannich Reaction of 2H-Azirines with Alkynyl Ketones. Org. Lett. 2020, doi.org/10.1021/acs.orglett.0c03737.39. Chi Liu, Hao Zeng, Chuanle Zhu,* Huanfeng Jiang.*Recent advances in three-component difunctionalization of gem-difluoroalkenes, Chem. Commun. 2020, DOI: 10.1039/d0cc04318d.38. Yingying Cai#, Hao Zeng#, Chuanle Zhu,* Chi Liu, Guangying Liu and Huanfeng Jiang.* Double allylic defluorinative alkylation of 1,1-bisnucleophiles with (trifluoromethyl)alkenes: construction of all-carbon quaternary centers. Org. Chem. Front. 2020, DOI: 10.1039/d0qo00121j.(equal contribution).37.Hao Zeng, Chuanle Zhu,* Chi Liu, Yingying Cai, Fulin Chen and Huanfeng Jiang*Three component hydroxyletherification and hydroxylazidation of (trifluoromethyl)alkenes: access to a-trifluoromethyl b-heteroatom substituted tertiaryalcohols. Chem. Commun. 2020, DOI: 10.1039/d0cc02550j.36. Chuanle Zhu,* Hao Zeng, Chi Liu, Yingying Cai, Xiaojie Fang, and Huanfeng Jiang*. Regioselective Synthesis of 3-Trifluoromethylpyrazole by Coupling of Aldehydes, Sulfonyl Hydrazides, and 2-Bromo-3,3,3-Trifluoropropene. Org. Lett. 2020, DOI: 10.1021/acs.orglett.9b04228.35. Chi Liu, Chuanle Zhu* Yingying Cai, Zhiyi Yang, Hao Zeng, Fulin Chen, Huanfeng Jiang*. Fluorohalogenation of gem-Difluoroalkenes: Synthesis and Applications of α-Trifluoromethyl Halides. Chem. Eur. J. 2020, DOI:10.1002/chem.201905445.201934. Chuanle Zhu* Hao Zeng,  Fulin Chen, Chi Liu, Huanfeng Jiang*. Copper-Catalyzed Cyclization of Aryl Amines and Aryldiazonium Salts under Air: Access to N-2-Aryl-Naphthotriazoles. Adv. Synth. Catal. 2019, 361, 5149-5159.33. Chuanle Zhu*, Hao Zeng, Chi Liu, Fulin Chen, Huanfeng Jiang*. Copper-Catalyzed Intermolecular [4 + 2] Annulation Enabled by Internal Oxidant-Promoted C(sp3)–H Functionalization: Access to 3-Trifluoromethylated 3-Hydroxy-cyclohexan-1-ones. Org. Lett. 2019, 21,4900.32. Chuanle Zhu*, Chi Liu, Hao Zeng, Fulin Chen, Huanfeng Jiang*. Transition-Metal Free Selective C(α)-C(β) Bond Cleavage of Trifluoromethyl Ketones with Amidines under Air: Facile Access to 5-Trifluoromethylated Imidazol-4-ones. Org. Chem. Front. 2019, 6, 858.31. Hao Zeng, Chuanle Zhu*, Huanfeng Jiang*. Single C(sp3)-F Bond Activation in a CF3 Group: Ipso-Defluorooxylation of (Trifluoromethyl)alkenes with Oximes. Org. Lett. 2019, 21, 1130.201830. Chuanle Zhu*, Hao Zeng, Fulin Chen, Zhiyi Yang, Yingying Cai, Huanfeng Jiang*. Intermolecular C(sp3)-H Amination Promoted by Internal Oxidants: Synthesis of Trifluoroacylated Hydrazones. Angew. Chem. Int. Ed. 2018, 57, 17215.29. Chuanle Zhu, Fulin Chen, Hao Zeng, Chi Liu, Zhiyi Yang, Wanqing Wu, Huanfeng Jiang*. Copper-Catalyzed Unstrained C-C Single Bond Cleavage of Acyclic Oxime Acetates Using Air: An Internal Oxidants Triggered Strategy toward Nitriles and Ketones. J. Org. Chem. 2018, 83, 1471328. Huanfeng Jiang*, Fulin Chen, Chuanle Zhu*, Rui Zhu, Hao Zeng, Chi Liu, Wanqing Wu. Two C-O Bond Formations on a Carbenic Carbon: Palladium-Catalyzed Coupling of N-Tosylhydrazones and Benzo-1,2-quinones To Construct Benzodioxoles. Org. Lett. 2018, 20, 3166.27. Chuanle Zhu, Hao Zeng, Fulin Chen, Chi Liu, Rui Zhu, Wanqing Wu, Huanfeng Jiang*. Copper-Catalyzed Coupling of Oxime Acetates and Aryldiazonium salts: an Azide-Free Strategy Toward N-2-Aryl-1,2,3-Triazoles. Org. Chem. Front. 2018, 5, 571.26. Huanfeng Jiang*, Rui, Zhu, Chuanle Zhu*, Fulin Chen, Wanqing Wu. Nucleophilic trifluoromethylthiolation of bromoalkynones with AgSCF3: C(sp)-SCF3 bond formation towards ynonyl trifluoromethyl sulfides. Org. Biomol. Chem. 2018, 16, 1646.25. Wei Huang, Chuanle Zhu, Minke Li, Wanqing Wu, Zhengchao Tu*, Huanfeng Jiang*. TBAI or KI-Promoted Oxidative Coupling of Enamines and N-Tosylhydrazine: An Unconventional Method toward 1,5-and 1,4,5-Substituted 1,2,3-Triazoles. Adv. Synth. Catal. 2018, 360, 3117.201724. Chuanle Zhu, Rui Zhu, Hao Zeng, Fulin Chen, Chi Liu, Wanqing Wu, Huanfeng Jiang*. Copper-Catalyzed Csp3-H/Csp3-H Cross-Dehydrogenative Coupling with Internal Oxidants: Synthesis of 2-Trifluoromethyl Dihydropyrro-2-ols, Angew. Chem. Int. Ed. 2017, 56, 13324-13328.23. Chuanle Zhu, Rui Zhu, Pengquan Chen, Wanqing Wu*, Huanfeng Jiang*. Carbonyl Ylides Derived from Palladium Carbenes: The Impressive Fluorine Effect, Adv. Synth. Catal. 2017, 359, 3154.22. Chuanle Zhu, Pengquan Chen, Rui, Zhu, Guangbin Jiang, Zhiming Lin, Wanqing Wu*, Huanfeng Jiang*. Conversion of Triple Bonds into Single Bonds in a Domino Carbopalladation with Norbornene, Chem. Asian J. 2017, 12, 2991.21. Pengquan Chen, Chuanle Zhu*, Rui Zhu, Wanqing Wu, Huanfeng Jiang*. MnO2-Promoted Oxidative Radical Sulfonylation of Haloalkynes with Sulfonyl Hydrazides: C(sp)-S Bond Formation towards Alkynyl Sulfones, Chem. Asian J. 2017, 12, 1875.20. Chuanle Zhu, Pengquan Chen, Rui Zhu, Zhiming Lin, Wanqing Wu*, Huanfeng Jiang*. C=N Bond Formation via Palladium-Catalyzed Carbene Insertion into N=N Bonds: Inhibiting the General 1,2-Migration Process of Ylide Intermediates. Chem. Commun. 2017, 53, 2697.19. Guangbin Jiang, Chuanle Zhu, Jianxiao Li, Wanqing Wu*, Huanfeng Jiang*. Silver-Catalyzed Regio- and Stereoselective Thiocyanation of Haloalkynes: Access to (Z)-Vinyl Thiocyanates, Adv. Synth. Catal. 2017, 359, 1208.18. Guangbin Jiang, Jianxiao Li, Chuanle Zhu, Wanqing Wu*, Huanfeng Jiang*. Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids To Construct Functionalized Isocoumarins, Org. Lett. 2017, 19, 4440.17. Jianhua Liao, Lianfeng Fan, Wei Guo, Zhenming Zhang, Jiawei Li, Chuanle Zhu, Yanwei Ren, Wanqing Wu*, Huanfeng Jiang*. Palladium-Catalyzed Fluoroalkylative Cyclization of Olefins, Org. Lett. 2017, 19, 1008.16. Yubing Huang, Yue Yu, Zhongzhi Zhu, Chuanle Zhu, Jinghe Chen, Xianwei Li, Wanqing Wu*, Huanfeng Jiang*. Copper-Catalyzed Cyanation of N-Tosylhydrazones with Thiocyanate Salt as the “CN” Source, J. Org. Chem. 2017, 82, 7621.15. Jiangwen Peng, Yan Gao, Chuanle Zhu, Bifu Liu, Yinlan Gao, Miao Hu, Wanqing Wu, Huanfeng Jiang*. Synthesis of Polysubstituted 3-Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction, J. Org. Chem. 2017, 82, 3581.14. Pengquan Chen#, Chuanle Zhu#, Rui Zhu, Zhiming Lin, Wanqing Wu*, Huanfeng Jiang*. Synthesis of 3-Azabicyclo[3.1.0]hexane Derivatives via Palladium-Catalyzed Cyclopropanation of Maleimides with N-Tosylhydrazones: Practical and Facile Access to CP-866,087. Org. Biomol. Chem. 2017, 15, 1228 (equal contribution).201613. Huanfeng Jiang, Chuanle Zhu, Wanqing Wu. Haloalkyne Chemistry, Springer, 2016 .12. Chuanle Zhu, Pengquan Chen, Wanqing Wu*, Chaorong Qi, Yanwei Ren, Huanfeng Jiang*. Transition-Metal-Free Diastereoselective Epoxidation of Trifluoromethylketones with N-Tosylhydrazones: Access to Tetrasubstituted Trifluoromethylated Oxiranes. Org. Lett. 2016, 18, 4008.11. Chuanle Zhu, Jiawei Li, Pengquan Chen, Wanqing Wu*, Yanwei Ren, Huanfeng Jiang*. Transition-Metal-Free Cyclopropanation of 2-Aminoacrylates with N-Tosylhydrazones: A General Route to Cyclopropane α-Amino Acid with Contiguous Quaternary Carbon Centers. Org. Lett. 2016, 18, 1470.10. Yue Ye, Songjian Yi, Chuanle Zhu, Weigao Hu, Bingjie Gao, Yang Chen, Wanqing Wu*, Huanfeng Jiang*. Csp3-P versus Csp2-P Bond Formation: Catalyst-Controlled Highly Regioselective Tandem Reaction of Ene-Yne-Ketones with H-Phosphonates, Org. Lett. 2016, 18, 400.9. Yubing Huang, Xianwei Li, Yue Yu, Chuanle Zhu, Wanqing Wu, Huanfeng Jiang*. Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5- Trisubstituted Furans, J. Org. Chem. 2016, 81, 5014.8. Chuanle Zhu, Jun-An Ma*, Dominique Cahard*. Trifluorodiazoethane (CF3CHN2) in the Uncatalyzed Cyclopropanation of 3-Arylmethylenebenzofuran-2(3H)-one. Asian J. Org. Chem. 2016, 5, 66.Before 20157.Chuanle Zhu#, Lijun Yang#, Shen, Li, Yan Zheng, Jun-An Ma*. Brine-Stabilized 2,2,2-Trifluorodiazoethane and Its Application in the Synthesis of CF3-Substituted Cyclopropane α-Amino Acids. Org. Lett. 2015, 17, 3442 (equal contribution).6. Chuanle Zhu, Mayaka Maeno, Fa-Guang Zhang, Taiki Shigehiro, Takumi Kagawa, Kosuke Kawada, Norio Shibata*, Jun-An Ma*, and Dominique Cahard*. Chiral N-Fluorodibenzenesulfonimide Analogues for Enantioselective Electrophilic Fluorination and Oxidative Fluorination. Eur. J. Org. Chem. 2013, 69, 6501.5. Chuanle Zhu, Xiao-Yun Fu, Ai-Jia Wei, Dominique Cahard*, Jun-An Ma*. P-Spiro Phosphonium Salts Catalyzed Asymmetric Fluorination of 3-Substituted Benzofuran-2-(3H)-ones. J. Fluorine Chem. 2013, 150, 60.4. Chuanle Zhu, Li-Jun Yang, Jing Nie, Yan Zheng, Jun-An Ma*. Organocatalytic Asymmetric Branching Sequence of MBH Carbonates: Access to Chiral Benzofuran-2(3H)-one Derivatives with Three Stereocenters. Chin. J. Chem. 2012, 30, 2693.3. Chuanle Zhu, Fa-Guang Zhang, Wei Meng, Jing Nie, Dominique Cahard, Jun-An Ma*. Enantioselective Base-Free Electrophilic Amination of Benzofuran-2(3H)-ones: Catalysis by Binol-Derived P-Spiro Quaternary Phosphonium Salts. Angew. Chem. Int. Ed. 2011, 50, 5869. 2. Lian Wang, Wei Meng, Chuanle Zhu, Yan Zheng, Jing Nie, Jun-An Ma*. The Long-Arm Effect: Influence of Axially Chiral Phosphoramidite Ligands on the Diastereo- and Enantioselectivity of the Tandem 1,4-Addition/Fluorination, Angew. Chem. Int. Ed. 2011, 50, 9442.1. Hai Ma, Kun Liu, Faguang Zhang, Chuanle Zhu, Jing Nie, Jun-An Ma. Chiral Bifunctional Thiourea-Catalyzed Enantioselective Michael Addition of Ketones to Nitrodienes, J. Org. Chem. 2010, 75, 1402. 出版专著和教材 Huanfeng Jiang, Chuanle Zhu, Wanqing Wu. Haloalkyne Chemistry; Springer: Verlag GmbH Berlin Heidelberg, 2016. 科研创新 [1] 江焕峰，竺传乐，伍婉卿；一种含连续季碳中心环丙烷α-氨基酸衍生物及合成方法；专利授权号：ZL201510287859.X [2] 江焕峰，竺传乐，伍婉卿，陈鹏全；一种含三氟甲基取代连续季碳中心环氧丙烷衍生物及合成方法；专利授权号：ZL201510401572.5[3] 江焕峰，竺传乐，伍婉卿，陈鹏全；一种含N,N-二酰胺基取代腙衍生物及合成方法；专利授权号：ZL201610560893.4[4] 马军安，竺传乐，崔汉峰，聂晶，王腾；含联萘轴手性螺环季膦盐相转移催化剂及其制备方法，专利授权号：ZL200910068429.3[5] 江焕峰，陈鹏全，竺传乐；一种氮杂五并三环药物分子中间体的合成方法；专利授权号：ZL201510834743.3[6] 江焕峰，竺传乐；一种构建N-2-芳基取代-1,2,3-三氮唑的方法；专利申请号：201710640957.6 [7] 江焕峰，竺传乐；一种三氟甲基修饰Ab-42抑制剂结构类似物的合成方法；专利申请号：201710594989.7 [8] 伍婉卿，林芝铭，竺传乐；含连续季碳中心环丙烷氨基磷酸酯类化合物的合成方法；申请专利号：201611101322.0 教学活动 讲授本科生《有机化学》、《有机化学实验》、《大学化学》、《学科前言讲座》等课程；讲授研究生《有机波谱分析》课程 指导学生情况 博士：1、龙旭婧（2023级博士）2、1个2024年博士指标，期待你加盟。硕士1、曾浩（2018级硕士）：获2018-2019年度研究生“新宙邦创新力奖学金”，2020年度研究生国家奖学金，2021广东省研究生阶段优秀毕业生。2、刘炽（2018级硕士，与江焕峰教授共同指导）：获2020年度研究生国家奖学金。3、蔡莹莹（2020级硕士）：获2022年度研究生国家奖学金4、李恒源（2021级硕士）、李钰琪（2021级硕士）、聂佳（2021级硕士）5、龙旭婧（2022级硕士）、李涵（2022级硕士）6、陈炜（2023级硕士）、周慧婷（2023级硕士）7、彭荣斌（2024级硕士）、2个2024级硕士指标，期待你的加盟