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孙名安 267 个人信息Personal Information 正高级 博士生导师 硕士生导师 教师拼音名称：Sun Ming An 电子邮箱： mingansun@yzu.edu.cn 入职时间：2019-09-26 所在单位：兽医学院 办公地点：扬州大学荷花池校区逸夫楼205室 联系方式：微信: mingansun 学科：兽医学其他专业预防兽医学 其他联系方式Other Contact Information 邮编 : 225009 通讯/办公地址 : 扬州大学荷花池校区逸夫楼205室 邮箱 : mingansun@yzu.edu.cn 同专业博导 同专业硕导 个人简介Personal Profile 孙名安，教授，博士生导师，江苏“特聘教授”。长期从事转录组、表观组和生物信息学相关研究，在内源性逆转录病毒和表观遗传修饰相关领域取得了一系列成果，以第一/通讯作者在Science Advances (2024)、PNAS（2018）、Genome Research（2014, 2023）、Nucleic Acids Research（2023, 2篇）、Mol Biol Evol（2021）等经典期刊发表SCI论文十余篇，此外有多项合作成果发表在Cell、Science等顶刊，引用累计超过2500次。受邀担任Nature Communications, PNAS, Genome Research、Mol Biol Evol、Nucleic Acids Research等经典期刊审稿人，国自然面上项目和英国Wellcome基金评审专家。主持国自然面上项目、青年项目、科技部外专项目和多项省级课题。 本课题组以人、小鼠、猪为主要研究对象，综合应用分子生物学、高通量组学、生物信息学的方法，重点开展三个方面的研究：1）胎盘的发育、进化、感染、免疫、疾病等相关机制；2）内源性逆转录病毒的调控机制与功能进化原理；3）内源性逆转录病毒在发育与免疫进化过程中的功能。 具体信息见本课题组英文主页：https://sun-lab.yzu.edu.cn。欢迎志同道合的你加入！ 代表性论文： Brown JL, Zhang L, Rocha PP, Kassis JA*, Sun MA*. (2024). Polycomb protein binding and looping in the ON transcriptional state. Sci Adv 10, eadn1837. Du C, Jiang J, Li Y, Yu M, Jin J, Chen S, Fan H, Macfarlan TS, Cao B*, Sun MA*. (2023). Regulation of endogenous retrovirus-derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells. Genome Res 33, 197-207. Yu M, Hu XQ, Pan ZH, Du C, Jiang J, Zheng WS, Cai H, Wang YA, Deng WB, Wang HB, Lu JH, Sun MA*, Cao B*. (2023). Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization. Nucleic Acids Res 51, 4745-4759. Erokhin M, Brown JL, Lomaev D, Vorobyeva NE, Zhang L, Fab LV, Mazina MY, Kulakovskiy IV, Ziganshin RH, Schedl P, Georgiev P, Sun MA*, Kassis JA*, Chetverina D*. (2023). Crol contributes to PRE-mediated repression and Polycomb group proteins recruitment in Drosophila. Nucleic Acids Res 51, 6087-6100. Li Y, Fan H, Qin W, Wang Y, Chen S, Bao W, Sun MA*. (2023). Regulation of the three-dimensional chromatin organization by transposable elements in pig spleen. Comput Struct Biotechnol J 21, 4580-4588. Sun MA*, Wolf G, Wang Y, Senft AD, Ralls S, Jin J, Dunn-Fletcher CE, Muglia LJ, Macfarlan TS*. (2021). Endogenous Retroviruses Drive Lineage-Specific Regulatory Evolution across Primate and Rodent Placentae. Mol Biol Evol 38, 4992-5004. Brown JL#, Sun MA#, Kassis JA*. (2018). Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho. Proc Natl Acad Sci U S A 115, E1839-E1848. Sun MA, Wang Y, Zhang Q, Xia Y, Ge W, Guo D. (2017). Prediction of reversible disulfide based on features from local structural signatures. BMC Genomics 18, 279. Zhao# L, Sun MA#, Li Z#, Bai X, Yu M, Wang M, Liang L, Shao X, Arnovitz S, Wang Q, He C, Lu X*, Chen J*, Xie H*. (2014). The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation. Genome Res 24, 1296-1307. Sun MA, Wang Y, Cheng H, Zhang Q, Ge W, Guo D. (2012). RedoxDB--a curated database for experimentally verified protein oxidative modification. Bioinformatics 28, 2551-2552. 合作发表论文 Wolf G, de Iaco A, Sun MA, Bruno M, Tinkham M, Hoang D, Mitra A, Ralls S, Trono D, Macfarlan TS. (2020). KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage. Elife 9. Chen C, Sun MA, Warzecha C, Bachu M, Dey A, Wu T, Adams PD, Macfarlan T, Love P, Ozato K. (2020). HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis. Cell Rep 30, 2136-2149 e2134. Sun Z, Xu X, He J, Murray A, Sun MA, Wei X, Wang X, McCoig E, Xie E, Jiang X, et al. (2019). EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity. Nat Commun 10, 3892. De S, Cheng Y, Sun MA, Gehred ND, Kassis JA. (2019). Structure and function of an ectopic Polycomb chromatin domain. Sci Adv 5, eaau9739. Huang Y, Mao K, Chen X, Sun MA, Kawabe T, Li W, Usher N, Zhu J, Urban JF, Jr, Paul WE, et al. (2018). S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. Science 359, 114-119. Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, et al. (2018). DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Cell 173, 221-233 e212. Yang P, Wang Y, Hoang D, Tinkham M, Patel A, Sun MA, Wolf G, Baker M, Chien HC, Lai KN, et al. (2017). A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568. Science 356, 757-759. Sharif J, Endo TA, Nakayama M, Karimi MM, Shimada M, Katsuyama K, Goyal P, Brind'Amour J, Sun MA, Sun Z, et al. (2016). Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA. Cell Stem Cell 19, 81-94. 教育经历Education Background 工作经历Work Experience 2009.8 2012.12 香港中文大学 生物 理学博士学位 2005.9 2008.7 中国科学院海洋研究所 海洋生物学 理学硕士学位 2001.9 2005.7 曲阜师范大学 生物科学 理学学士学位 2008.8 2009.7 北京华大基因研究院 2016.1 2019.9 美国国立卫生研究院 2015.9 2015.12 香港中文大学 2012.12 2015.6 弗吉尼亚理工大学 研究方向Research Focus 社会兼职Social Affiliations 内源性逆转录病毒、表观遗传学、先天性免疫 Frontiers in Genetics和Frontiers in Cell and Developmental Biology审稿编辑。 团队成员Research Group 团队名称：动物生殖与免疫调控研究团队 陈帅