程祝宽
时间:2024-05-03 00:31 来源: 作者: 点击:次
个人简介 研究员，博士生导师 E-mail: chengzk@yzu.edu.cn 1987年获扬州大学农学系农学学士，1990年获扬州大学农学系作物遗传育种硕士，1999年获中国科学院遗传研究所理学博士，1999年至2002年在美国Wisconsin-Madison大学从事博士后研究。2002年10月来中科院遗传发育所工作，任创新研究组组长，研究员，博士生导师。同年入选中国科学院“百人计划”，终期考核优秀。2003年获国家杰出青年基金资助，担任过Chromosome Research、Frontiers in Plant Science、JGG、PLoS One等杂志编委。 主要研究方向——植物减数分裂的遗传调控机制 减数分裂是真核生物有性生殖过程中发生的核心事件，对于有性生殖有着极其重要的意义。一方面，减数分裂产生染色体数目减半的配子，它们通过雌雄配子受精结合，维系了亲代与子代之间染色体数目的恒定。另一方面，减数分裂过程中同源染色体的非姊妹染色单体间发生交换，以及非同源染色体间的自由组合，使得遗传物质在双亲之间充分交流，增加了杂交后代的遗传多样性，亦为自然或人工选择提供丰富的基础材料。 水稻是重要的粮食作物，同时也是单子叶植物分子生物学研究的模式生物。其基因组只有430 Mb，是粮食作物中最小的。加之成熟的遗传转化体系、相对完善的基因组信息以及适中的染色体大小和数目，水稻已日渐成为减数分裂研究的理想材料。到目前为止，我们以水稻为模式植物，克隆了30多个参与减数分裂起始、同源染色体配对、联会、重组、分离等关键事件的功能基因，初步构建了水稻减数分裂遗传调控的基因网络。与酵母、哺乳动物以及拟南芥相比，水稻减数分裂基因功能具有很强的保守性，但有些基因也会有明显的功能分化。例如水稻联会复合体横丝蛋白基因ZEP1，该基因突变导致重组频率显著提高，这与其它物种相比有很大差别。另外，水稻SDS基因参与了DSB的形成，而在拟南芥中SDS并不参与DSB的形成，说明物种之间减数分裂调控机制可能存在一定的差异。 对减数分裂调控机制研究的深入，便可能通过基因工程手段实现对减数分裂过程的遗传调控，更好地服务于育种实践。例如，通过增加重组频率，更容易打破遗传累赘，缩短育种周期，提高育种效率。随着基因编辑手段在减数分裂突变体创制中的应用，以及减数分裂相关蛋白生化功能研究的深入，结合超高分辨显微技术、活体成像技术、单细胞测序技术等，对减数分裂调控机制的解析将愈加深入，相应遗传工程应用也会更有成效。 出版专著 顾铭洪，程祝宽 (2020).《水稻起源、分化与细胞遗传》，科学出版社，第1-345页。 责任作者文章 1. Yang H, Li YF, Cao YW, Shi WQ, Xie E, Mu N, Du GJ, Shen Y, Tang D, Cheng ZK (2022). Nitrogen nutrition contributes to plant fertility by affecting meiosis initiation. Nature Comm. 13: 485. 2. Yang SY, Zhang C, Cao YW, Du GJ, Tang D, Li YF, Shen Y, Yu HX, Cheng ZK (2022). FIGNL1 inhibits non-homologous chromosome association and crossover formation. Front. Plant Sci. 13: 1220. 3. Ren LJ, Zhao T, Zhao YZ, Du GJ, Yang SY, Mu N, Tang D, Shen Y, Li YF, Cheng ZK (2021). The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis. Cell Rep. 37: 109941. 4. Miao YJ, Shi WQ, Wang HJ, Xue ZH, You HL, Zhang FF, Du GJ, Tang D, Li YF, Shen Y, and Cheng ZK (2021). Replication protein A large subunit (RPA1a) limits chiasma formation during rice meiosis. Plant Physiol. 187: 1605-1618. 5. Zhao TT, Ren LJ, Zhao YZ, You HL, Zhou Y, Tang D, Du G, Shen Y, Li YF, Cheng ZK (2021). Reproductive cells and peripheral parietal cells collaboratively participate in meiotic fate acquisition in rice anthers. Plant J. 108: 661-671. 6. Shi WQ, Ji JH, Xue ZH, Zhang FF, Miao YJ, Yang H, Tang D, Du GJ, Li YF, Shen Y, Cheng ZK (2021). PRD1, a homologous recombination initiation factor, is involved in spindle assembly in rice meiosis. New Phytol 230: 585–600. 7. Jiang PF, Lian B, Liu CZ, Fu ZY, Shen Y, Cheng ZK, Qi YJ (2020). 21-nt phasiRNAs direct target mRNA cleavage in rice male germ cells. Nat Commun 11: 5191 8. Liu CZ, Shen Y, Qin BX, Wen H, Cheng J, Mao F, Shi WQ, Tang D, Du GJ, Li YF, Wu YF, Cheng ZK (2020). Oryza sativa RNA-dependent RNA polymerase 6 contributes to double-strand break formation in meiosis. Plant Cell 32: 3273-3289. 9. Zhang FF, Shen Y, Miao CB, Cao YW, Shi WQ, Du GJ, Tang D, Li YF, Luo Q, Cheng ZK (2020). OsRAD51D promotes homologous pairing and recombination by preventing nonhomologous interactions in rice meiosis. New Phytol 227: 824-839. 10. 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Fast assignment of DNA sequences to individual chromosome arms based on dosage effects from a set of rice telotrisomics, Acta Botanica Sinica 42: 708-711. 研究方向 社会兼职 暂无内容 暂无内容 教育经历 工作经历 1996.9-----1999.7 中国科学院研究生院 | 遗传学 | 博士研究生毕业 | 农学博士学位 暂无内容 团队成员 暂无内容 返回顶部 +130 程祝宽 个人信息 正高级 博士生导师 教师拼音名称：CZK 出生日期：1966-05-11 入职时间：2022-05-01 所在单位：农学院 学历：博士研究生毕业 性别：男 学位：农学博士学位 职称：正高级 在职信息：在岗 毕业院校：中国科学院研究生院 最后更新时间：2024-4-26 访问量：00006625 手机版 扬州大学官网 扬州大学 版权所有 苏ICP备 12022580号-1 地址：中国·江苏·扬州市大学南路88号 电话(TEL):86-0514-87991201 苏公网安备 32100302010246号 |