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俞琰垒

个人简介   俞琰垒,博士,朝晖特聘副研究员,研究主要包括三个方面:(1)活性天然产物筛选和天然产物数据库构建;(2)基于液质联用的代谢组学研究;(3)岩藻多糖的结构鉴定和构效关系研究,已在J. Am. Chem. Soc, Carbohyd. Polym等国际权威期刊上发表40余篇SCI论文。教育经历(1)2015.09-2017.09 伦斯勒理工学院,生化及跨学科研究中心,联合培养博士,合作导师:Robert J. Linhardt(2)2013.09-2018.01 浙江工商大学,食品科学,工学博士,导师:张虹(3)2010.09-2013.01 浙江工商大学,食品质量与工程,工学硕士,导师:张虹(4)2006.09-2010.06 浙江中医药大学,生物科学,理学学士工作经历(1)2020.12-至今,浙江工业大学,绿色制药协同创新中心,朝晖特聘副研究员(2)2018.03-2020.08,美国伦斯勒理工学院,生化及跨学科研究中心,博士后,合作导师:Robert J. Linhardt 教学与课程 主讲《现代仪器分析》 留学生辅讲《高等药物分析》 研究生《药用植物学与生药学》 留学生《药物分析实验》 本科生《药物分析》 本科生 科研项目 1. 国家自然科学基金委员会,青年科学基金项目,82204272,基于结构糖组学的低分子量岩藻聚糖硫酸酯治疗代谢综合征的构效关系研究,2023-01-01至2025-12-31,30万元,在研,主持2. 国家自然科学基金委员会,面上项目,42276137,基于PSMPA技术的深海微生物抗细菌耐药性次级代谢产物多样性的研究,2023-01-01至2026-12-31,56万元,在研,参与 科研成果 1. Yu. Y., Fu, L., He, P., Xia, K., Varghese, S., Dordick, J., Wang, H., Zhang, F., Linhardt, R. J. Enzymatic synthesis of low molecular weight heparins from N-sulfo heparosan depolymerized by heparanase or heparin lyase. Carbohyd. Polym. 2022, 295, 1198252. Yu, Y., Fu, L., He, P., Xia, K., Varghese, S., Wang, H., Zhang, F., Dordick, J., Linhardt, R. J. Chemobiocatalytic synthesis of a low-molecular-weight heparin. ACS Chem. Biol. 2022, 17, 637-646.3. Yu. Y., Zhang, F., Renois-Predelus, G., Amster, I. J., Linhardt, R. J. Filter-entrapment pull-down assay for glycosaminoglycan structural characterization and protein interaction. Carbohyd. Polym. 2020, 245, 116623. 4. Yu, Y., Bruzdoski, K., Kostousov, V., Hensch, L., Linhardt, R. J. Structural characterization of a clinically described heparin-like substance in plasma causing bleeding. Carbohyd. Polym. 2020, 244, 116443. 5. Yu, Y., Williams, A.,  Zhang, X., Fu, L., Xia, K., Xu, Y., Zhang, F., Liu, J., Koffas, M., Linhardt, R. J. Specificity and action pattern of hepararanse Bp, a β-glucuronidase from Burkholderia pseudomallei. Glycobiology. 2019, 27, 57-63.6. Yu, Y., Zhang, F., Colon, W., Linhardt, R. J., Xia, K. Glycosaminoglycans in human cerebrospinal fluid determined by LC-MS/MS MRM. Anal. Biochem. 2019, 567, 82-84.7. Yu. Y., Linhardt, R. J. Xylosyltransferase 1 and the GAG attachement site. Structure. 2018, 26, 797-799.8. Yu, Y., Duan, J., Leach III, F. E., Toida, T., Higashi, K., Zhang, H., Zhang, F., Amster, I. J., Linhardt, R. J. Sequencing the dermatan sulfate chain of decorin. J. Am. Chem. Soc. 2017, 139, 16986-16995.9. Yu, Y., Chen, Y., Mikael, P., Zhang, F., Stalcup, A. M., German, R. Z., Gould, F., Ohlemacher, J., Zhang, H., Linhardt, R. J. Suprising absence of heparin in the intestinal mucosa of baby pigs. Glycobiology. 2017, 27, 57-63.8. Yu, Y., Hirakane, M., Mori, D., Lin, L., Zhang, F., Zhang, H., Linhardt, R. J. Structural and activity variability of fractions with different charge density and chain length from pharmaceutical heparins. Glycoconjugate. J. 2017, 34, 545-552.9. Yu, Y., Zhang, F., Lu, D., Zhang, H. Selenium bioavailability from shrimps (Penaeus vannamei Boone) and its effect on the metabolism of phospholipid and cholesterol ester. J. Funct. Foods. 2014, 6, 186-195.