靳明亮
时间:2024-04-23 15:59 来源: 作者: 点击:次
个人简介 靳明亮，浙江大学“百人计划”研究员，国家自然科学基金优秀青年科学基金获得者。2006年于南京农业大学获农学学士学位，2011年于浙江大学获博士学位。2011-2019年于西北工业大学任讲师、副教授；2015-2017年加拿大阿尔伯塔大学访问学者。2019年5月至今浙江大学研究员。主要围绕猪消化道微生物与碳水化合物代谢，开展系列应用基础研究，构建了日粮纤维体外微生物厌氧发酵体系，阐明了肠道微生物通过发酵日粮纤维及生物活性多糖等碳水化合物产生短链脂肪酸进而影响宿主健康；围绕肠道微生态，研发了生物活性多糖、阿拉伯木聚糖等碳水化合物及生物发酵饲料等生猪健康养殖营养调控技术。承担国家自然科学基金优秀青年科学基金、浙江省自然科学基金重点项目、国际科学基金、中国博士后科学基金特别资助等项目或课题10余项。在Microbiome、Journal of Allergy and Clinical Immunology、Carbohydrate Polymers等期刊发表SCI论文70余篇，以第一作者/通讯作者（含共同）共发表SCI论文26篇，其中IF>5.0的SCI论文19篇，总被引用2390余次，2篇合作文章入选ESI高被引论文。荣获陕西省科技进步二等奖1项，获中国畜牧兽医学会“第四届井冈新秀”荣誉称号及动物营养学分会青年学者论坛优秀奖。同时担任中国畜牧兽医学会动物营养学分会理事及副秘书长。1. 教育经历2006.09-2011.06: 博士研究生，浙江大学，动物营养与饲料科学2002.09-2006.06: 学士，南京农业大学，动物科学2. 工作经历2020.08-至今: 百人计划研究员，浙江大学2019.05-2020.07: 特聘研究员，浙江大学2014.05-2019.04: 副教授，西北工业大学2018.07-2018.08: 访问学者，加拿大阿尔伯塔大学2015.09-2017.02: 访问学者，加拿大阿尔伯塔大学2013.07-2014.04: 讲师，西北工业大学2011.07-2013.06: 博士后，西北工业大学2011.07-2011.08: 访问学者，美国密苏里州立大学哥伦比亚分校 教学与课程 1. 慕课课程：猪文化与人类健康2. 研究生课程：分子生物学实验3. 研究生课程：现代农业创新与乡村振兴战略 研究与成果 1. 国家自然科学基金优秀青年科学基金：猪消化道微生物与碳水化合物代谢，2021-2023，主持。2. 国家自然科学基金青年基金：白术多糖对断奶应激诱导肠粘膜屏障损伤的调控作用及机制研究，2018-2020，主持。3. 浙江省自然科学基金重点项目：基于益生活性的仔猪结肠菌群对不同类型膳食纤维的动态响应机制研究，2020-2023，主持。4. 浙江大学基本科研业务费专项资金青年科研创新专项：肠道菌群在木耳多糖干预高脂诱导肥胖中的作用及机制研究，2020-2021，主持。5. 浙江大学“以民促J”基础培育计划项目：****对肠道屏障功能的影响及肠道微生物机制研究，2021.3-2021.12，主持。6. 浙江大学百人计划科研启动经费，2021-2025，主持。7. 横向课题：断奶幼龄动物肠道菌群的营养调控研究，2021-2022，主持。8. 陕西省自然科学基金面上项目： 基于微生物区系研究模拟失重对肠黏膜屏障功能的影响，2017-2018，主持。9. 国际科学基金：Preparation, structural characterization and antiviral activities of sulfated polysaccharides from Astragalus membranaceus，2012-2014，主持。10. 中国博士后科学基金特别资助项目：基于Toll样受体通路研究模拟失重对肠道免疫功能的影响，2013-2014，主持。11. 中国博士后科学基金面上项目：模拟微重力环境下灵芝多糖硫酸酯化衍生物对肠道免疫功能的调控及其机理研究，2011-2013，主持。12. 中央高校基本科研业务费科研资助项目：白术多糖对模拟失重诱导肠黏膜屏障功能障碍的调控作用及机制研究，2017-2018，主持。13. 中央高校基本科研业务费科研资助项目：肠道微生态在模拟失重诱导肠黏膜损伤中的作用及机制研究，2014-2016，主持。 发表论文 发表学术论文:[1]. Wang, C., Wei, S.Y., Chen, N.N., Xiang, Y., Wang, Y.Z., Jin, M.L.* Characteristics of gut microbiota in pigs with different breeds, growth periods and genders. Microbial Biotechnology. 2021, 1-12. (IF=5.813)[2]. Zong, X., Cheng, Y.Z., Xiao, X., Fu, J., Wang, F.Q., Lu, Z.Q., Wang, Y.Z., Jin, M.L.* Protective effects of sulfated polysaccharide from Enterobacter cloacae Z0206 against DSS-induced intestinal injury via DNA methylation. International Journal of Biological Macromolecules. 2021, 183: 861-869. (IF=6.953)[3]. Zong, X., Xiao, X., Kai, L.X., Cheng, Y.Z., Fu, J., Xu, W., Wang, Y.Z., Zhao, K., Jin, M.L.* Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1. International Journal of Biological Macromolecules. 2021, 167: 76-84. (IF=6.953)[4]. Su, W., Jiang, Z.P, Hao, L.H., Li, W.T., Gong, T., Zhang, Y., Wang, C., Lu, Z.Q.*, Jin, M.L.*, Wang, Y.Z.* Variations of soybean meal and corn mixed substrates in physicochemical characteristics and microbiota during two-stage solid-state fermentation. Frontiers in Microbiology. 2021, 12: 1856. (IF=5.64)[5]. Xu, B.C., Fu, J., Qiao, Y., Cao, J.P., Deehan, E.C., Li, Z., Jin, M.L.*, Wang, X.X.*, Wang, Y.Z.* Higher intake of microbiota-accessible carbohydrates and improved cardiometabolic risk factors: a meta-analysis and umbrella review of dietary management in patients with type 2 diabetes. American Journal of Clinical Nutrition. 2021, 113(6): 1515-1530. (IF=7.045)[6]. Zong, X., Fu, J., Xu, B.C., Wang, Y.Z., Jin, M.L.* Interplay between gut microbiota and antimicrobial peptides. Animal Nutrition. 2020, 6: 389-396. (IF=6.383)[7]. Chen, N.N.#, Zhang, H. #, Zong, X., Li, S.Y., Wang, J.J., Wang, Y.Z., Jin, M.L.* Polysaccharides from Auricularia auricula: Preparation, structural features and biological activities.Carbohydrate Polymers. 2020, 247: 116750. (IF=9.381)[8]. Chen, N.N.#, Zhao, X.Y.#, Wang, F.Q., Lu, Z.Q., Wang, Y.Z., Jin, M.L.* Proteomic study of sulfated polysaccharide from Enterobacter cloacae Z0206 against H2O2-induced oxidative damage in murine macrophages.Carbohydrate Polymers. 2020, 237: 116147.(IF=9.381)[9]. Xu, B.C., Fu, J., Zhu, L.Y., Li, Z., Wang, Y.Z., Jin, M.L.* Overall assessment of antimicrobial peptides in piglets: a set of meta-analyses. Animal. 2020, 1-9.[10].Xu, B.C., Zhu, L.Y., Fu, J., Li, Z., Wang, Y.Z., Jin, M.L.* Overall assessment of fermented feed for pigs: a series of meta-analyses. Journal of Animal Science. 2019, 12: 4810-4821.[11].Jin, M.L., Wang, J.J., Zhang, H., Zhou, H.B., Zhao, K.* Simulated weightlessness perturbs the intestinal metabolomic profile of rats. Frontiers in Physiology, 2019, 10: 1279.[12].Jin, M.L., Kalainy, S., Baskota, N., Chiang, D., Deehan, E.D., McDougall, C., Tandon, P., Martínez, I., Cervera, C., Walter, J.*, Abraldes, J.G.* Faecal microbiota from patients with cirrhosis has a low capacity to ferment non-digestible carbohydrates into short chain fatty acids. Liver International. 2019, 39: 1437-1447. (IF=5.828)[13].Jin, M.L., Zhang, H., Wang, J.J., Shao, D.Y., Yang, H., Huang, Q.S., Shi, J.L., Xu, C.L.*, Zhao, K.* Response of intestinal metabolome to polysaccharides from mycelia of Ganoderma lucidum. International Journal of Biological Macromolecules. 2019, 122: 723-731.(IF=6.953)[14].Jin, M.L., Zhang, H., Zhao, K., Xu, C.L., Shao, D. Y., Huang, Q.S., Shi, J.L., Yang, H.* Responses of intestinal mucosal barrier functions of rats to simulated weightlessness. Frontiers in Physiology. 2018, 9: 729.[15].Jin, M.L.*, Zhu, Y.M., Shao, D.Y., Zhao, K., Xu, C.L., Li, Q., Yang, H., Huang, Q.S., Shi, J.L. Effects of polysaccharide from mycelia of Ganoderma lucidum on intestinal barrier functions of rats. International Journal of Biological Macromolecules. 2017, 94: 1-9. (IF=6.953)[16].Xu, C.L.*, Guo, Y., Qiao, X.J., Shang, X.Y., Niu, W.N., Jin, M.L.* Design, recombinant fusion expression and biological evaluation of vasoactive intestinal peptide analogue as novel antimicrobial agent. Molecules. 2017, 22: 1963.[17].Zhao, K.#, Jin, M.L.#, Chen, Q., Zheng, P.S.* Polysaccharides produced by Enterobacter cloacae induce apoptosis in cervical cancer cells. International Journal of Biological Macromolecules. 2015, 72: 960-964. (IF=6.953)[18].Jin, M.L., Wang, Y.M., Huang, M., Lu, Z.Q., Wang, Y.Z.* Sulphation can enhance the antioxidant activity of polysaccharides produced by Enterobacter cloacae Z0206. Carbohydrate Polymers. 2014, 99: 624-629. 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(IF=9.381)[23].Jin, M.L., Lu, Z.Q., Huang, M., Wang, Y.M., Wang, Y.Z.* Effect of Se-enriched polysaccharides produced by Enterobacter cloacae Z0206 on alloxan-induced diabetic mice. International Journal of Biological Macromolecules. 2012, 50: 348-352. (IF=6.953)[24].Jin, M.L., Lu, Z.Q., Huang, M., Wang, Y.M., Wang, Y.Z.* Sulfated modification and antioxidant activity of exopolysaccahrides produced by Enterobacter cloacae Z0206. International Journal of Biological Macromolecules. 2011, 48: 607-612. (IF=6.953)[25].Jin, M.L., Wang, Y.M., Huang, M., Lu, Z.Q., Wang, Y.Z.* Optimization of culture medium for exo-polysaccharide production by Enterobacter cloacae Z0206 using response surface methodology. Asian Journal of Chemistry. 2011, 23: 3799-3802.[26].Jin, M.L., Wang, Y.M., Xu, C.L., Lu, Z.Q., Huang, M., Wang, Y.Z.* Preparation and biological activities of an exopolysaccharide produced by Enterobacter cloacae Z0206. Carbohydrate Polymers. 2010, 81: 607-611. 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Applied Microbiology and Biotechnology. 2021, 105(4): 1657-1668.[33].Zhang, Z.H., Jin, M.L., Wang, K.M., Zhang, N., Zhang, Q., Tao, X., Wei, H.* Short-term intake of Lactiplantibacillus plantarum ZDY2013 fermented milk promotes homoeostasis of gut microbiota under enterotoxigenic Bacillus cereuschallenge. Food & Function. 2021.[34].Xu, B.C., Cao, J.P., Fu, J., Li, Z., Jin, M.L., Wang, X.X. Wang, Y.Z.* The effects of nondigestible fermentable carbohydrates on adults with overweight or obesity: a meta-analysis of randomized controlled trials. Nutrition Reviews. 2021.[35].Xu, B.C., Fu, J., Zhu, L.Y., Li, Z., Jin, M.L., Wang, Y.Z.* Overall assessment of antibiotic substitutes for pigs: a set of meta-analyses. Journal of Animal Science and Biotechnology. 2021, 12(1): 1-15.[36].Wang, C., Wei, S.Y., Xu, B.C., Hao, L.H., Su, W.F., Jin, M.L., Wang, Y.Z.* Bacillus subtilis and Enterococcus faecium co‐fermented feed regulates lactating sow's performance, immune status and gut microbiota. Microbial Biotechnology. 2021, 14(2): 614-627.[37].Nguyen, N.K., Deehan, E.C., Zhang, Z., Jin, M.L., Baskota, N., Perez-Muñoz, M.E., Cole, J., Tuncil, Y.E., Seethaler, B., Wang, T., Laville, M. Delzenne, N.M., Bischoff, S.C., Hamaker, B.R., Martínez, I., Knights, D., Bakal, J.A., Prado, C. M., Walter, J.* Gut microbiota modulation with long-chain corn bran arabinoxylan in adults with overweight and obesity is linked to an individualized temporal increase in fecal propionate. Microbiome. 2020, 8(1): 1-21.[38].Wang, C., Shi, C., Su, W., Jin, M.L., Xu, B., Hao, L., Zhang, Y., Lu, Z., Wang, F., Wang, Y., Du, H. Dynamics of the physicochemical characteristics, microbiota, and metabolic functions of soybean meal and corn mixed substrates during two-stage solid-state fermentation. mSystems. 2020, 11:5(1).[39].Jing, N., Liu, X., Jin, M.L., Yang, X., Hu, X., Li, C. Zhao, K*. Fubrick tea attenuates high-fat diet induced fat deposition and metabolic disorder by regulating gut microbiota and caffeine metabolism. Food & Function. 2020.[40].Lian, Z., Zhu, B., Lei, C., Zhao, W., Huang, Q., Jiang, C., Jin, M.L., Shi, J. Shao, D.* Reverse cholesterol transport-related miRNAs and their regulation by natural functional compounds. Current Protein and Peptide Science. 2019, 20(10): 1004-1011.[41].Rajoka, M.S.R., Zhao, H., Mehwish, H.M., Li, N., Lu, Y., Lian, Z., Shao, D., Jin, M.L., Li, Q., Zhao, L., Shi, J.* Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk. Food Research International. 2019, 123: 286-297.[42].Lei, S., Zhao, H., Pang, B., Qu, R., Lian, Z., Jiang, C., Shao, D., Huang, Q., Jin, M.L., Shi, J.* Capability of iturin from Bacillus subtilis to inhibit Candida albicans in vitro and in vivo. 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Production of bioproducts by endophytic fungi: chemical ecology, biotechnological applications, bottlenecks, and solutions. Applied Microbiology and Biotechnology. 2018,105:6279-6298.[50].Riaz Rajoka, M.S., Jin, M.L., Zhao, H., Li, Q., Shao, D., Huang, Q., Shi, J.* Impact of dietary compounds on cancer-related gut microbiota and microRNA. Applied Microbiology and Biotechnology. 2018, 102: 4291-4303.[51].Riaz Rajok, M.S., Jin, M.L., Zhao, H., Li, Q., Shao, D., Jiang, C., Huang, Q., Yang, H., Shi, J.*, Hussain, N. Functional characterization and biotechnological potential of exopolysaccharide produced by Lactobacillus rhamnosus strains isolated from human breast milk. LWT-Food Science and Technology. 2018, 89: 638-647.[52].Riaz Rajoka, M.S., Zhao, H., Lu, Y., Lian, Z., Li, N., Hussain, N., Shao, D., Jin, M.L., Li, Q., Shi, J.* Anticancer potential against cervix cancer (HeLa) cell line of probiotic Lactobacillus casei and Lactobacillus paracasei strains isolated from human breast milk. 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Applied Microbiology and Biotechnology. 2016, 100: 7407-7421.[61].Xie, J.H., Tang, W., Jin, M.L., Li, J.E., Xie, M.Y.* Recent advances in bioactive polysaccharides from Lycium barbarum L., Zizyphus jujuba Mill, Plantago spp., and Morus spp.: Structures and functionalities. Food Hydrocolloid. 2016, 60: 148-160.[62].Xie, J.H., Jin, M.L., Morris, G.A., Zha, X.Q., Chen, H.Q., Yi, Y., Li, J.E., Wang, Z.J., Gao, J., Nie, S.P., Shang, P., Xie, M.Y.* Advances on bioactive polysaccharides from medicinal plants. Critical Reviews in Food Science and Nutrition. 2016, 56(S1): S60-S84.[63].Yang, H.*, Tang, R.H., Li, J., Liu, Y.X., Ye, L.J., Shao, D.Y., Jin, M.L., Huang, Q.S., Shi, J.L. A new Ex Vivo method for effective expansion and activation of human natural killer cells for anti-tumor immunotherapy. Cell Biochemistry and Biophysics. 2015, 73: 723-729.[64].Yang, H.*, Liu, Y.X., Tang, R.H., Shao, D.Y., Li, J., Ye, L.J., Jin, M.L., Huang, Q.S., Shi, J.L. Cell signaling in the interaction between pathogenic bacteria and immune cells. Frontiers in Bioscience-Landmark. 2015, 20: 1029-1035.[65].Yang, H.*, Tang, R.H., Li, J., Li, J., Liu, Y.X., Ye, L.J., Shao, D.Y., Jin, M.L., Huang, Q.S., Shi, J.L. Changes of cytoskeleton affect T cell biological behaviors. Frontiers in Bioscience-Landmark. 2015, 20: 829-837.[66].Yang, H.*, Li, J., Tang, R.H., Li, J., Liu, Y.X., Ye, L.J., Shao, D.Y., Jin, M.L., Huang, Q.S., Shi, J.L. The aspartyl (asparaginyl) beta-hydroxylase in carcinomas. Frontiers in Bioscience-Landmark. 2015, 20: 902-909.[67].Huyan, T., Li, Q., Yang, H., Jin, M.L., Zhang, M.J., Ye, L.J., Li, J., Huang, Q.S., Yin, D.C.* Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells. Carbohydrate Polymers. 2014, 101: 819-827.[68].Lu, Z.Q., Jin, M.L., Huang, M., Wang, Y.M., Wang, Y.Z.* Bioactivity of selenium-enriched exopolysaccharides produced by Enterobacter cloacae Z0206 in broilers. Carbohydrate Polymers. 2013, 96: 131-136.[69].Xu, C.L., Wang, Y.Z.*, Jin, M.L., Yang, X.Q. Preparation, characterization and immunomodulatory activity of selenium-enriched exopolysaccharide produced by bacterium Enterobacter cloacae Z0206. Bioresource Technology. 2009, 100: 2095-2097. 发表会议论文或摘要：[1]. Jin, M.L., Deehan, E., Baskota, N., Kalainy, S., Chiang, D., McDougall, C., Tandon, P., Cervera, C., Martinez, I., Walter, J.*, Abraldes, J.G.* Fecal microbiotas from patients with cirrhosis show a low capacity for short chain fatty acids production. Hepatology. 2018, 68: 143A-144.[2]. Jin, M.L., Shang, P. Effects of simulated weightlessness on the intestinal mucosal barrier functions of rats. Proceeding of the 19th International Academy of Astronautics (IAA) Humans in Space. Jul. 2013. Cologne, Germany.[3]. Jin, M.L., Wang, Y.M., Lu, Z.Q., Huang, M., Xu, C.L., Wang, Y.Z. Isolation, characterization and antioxidant activity of an exopolysaccharide produced by Enterobacter cloacae Z0206. Proceedings of ADSA-CSAS-ASAS Joint Annual Meeting. Jul. 2010. Denver, USA.[4]. Jin, M.L., Wang, Y.Z., Yang, X.Q., Xu, C.L., Lu, Z.Q. Protective effect of polysaccharide produced by Enterobacter cloacae Z0206 on cyclophosphamide-induced suppression of immune functions in mice. Proceedings of ADSA-CSAS-ASAS Joint Annual Meeting. Jul. 2009. Montreal, Canada.[5]. Jin, M.L., Wang, Y.Z., Xu, C.L., Yang, X.Q. Effect of enriched-Selenium exopolysaccharide and exopolysaccharide produced by Enterobacter cloacae Z0206 on immune function of immunosuppressed mice. Proceeding of the 13th Animal Science Congress of the Asian-Australasian Association of Animal Production Societies. Sep. 2008. Hanoi, Vietnam. 参编著作：[1]. 《动物分子营养学》，浙江大学出版社，2020，参编。[2]. Deehan, E.C., Duar, R.M., Armet, A.M., Perez-Muñoz, M.E., Jin, M., Walter, J. Chapter 20: Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health. Bugs as Drugs: Therapeutic Microbes for the Prevention and Treatment of Disease. ASM Press, 2018. |