教师主页移动版

个人经历 personal experience 工作经历 教育经历 2013/12~2015/12，西北工业大学生命学院，博士后2016/01~2019/12，西北工业大学生命学院，助理教授2019/12~今，西北工业大学生命学院，副教授 2009/4~2013/12：西北工业大学，人机与环境工程，工学博士 2006/9~2009/3：西北工业大学，生物医学工程，工学硕士 2002/9~2006/6：陕西师范大学，生物学（基地班），理学学士

教育教学

教育教学 Education and teaching 教育教学 招生信息 1. 授课：    本科生课程：    干细胞生物学（英），分子生物学，生命科学导论      研究生课程：    细胞工程，细胞培养技术2. 指导5名本科生完成毕业设计，1名学生获得西北工业大学本科优秀毕业论文3. 指导研究生创意创新种子基金1项，指导大学生创新训练项目6项 博士研究生招生专业：生物医学工程硕士研究生招生专业：生物学，生物医学工程，生物技术与工程

荣誉获奖

荣誉获奖 Awards Information 2018年：西北工业大学“优秀青年教师奖”2018年：陕西省细胞生物学学会“青年优秀论文奖”2016年：陕西省细胞生物学学会“优秀青年论文鼓励奖”2014年：陕西省细胞生物学学会“优秀青年论文三等奖”2014年：国际空间研究委员会（COSPAR）“青年科学家杰出论文奖（Outstanding Paper Award for Young Scientists）”

科学研究

科学研究 Scientific Research 研究方向：骨代谢疾病，细胞衰老，生物力学主持科研项目：1. 国家自然科学基金面上项目，MACF1结合CDK12参与模拟失重抑制骨形成的作用及机制，81772017，2018.1-2021.12 2. 国家自然科学基金青年项目，MACF1通过Wnt/β-catenin信号通路参与模拟失重抑制成骨细胞分化的机制研究，31400725, 2015.1-2017.123. 陕西省自然科学基金面上项目，MACF1调控Sclerostin表达在骨细胞感知与响应失重环境中的作用及机制，2023-JC-YB-163，2023.1-2024.124. 陕西省自然科学基金面上项目，MACF1调节细胞骨架重排在成骨细胞感知与响应失重环境的作用，2018JM3040, 2018.1-2019.125. 陕西省高校科协青年人才托举计划项目，MACF1结合CDK12参与老年性骨质疏松症发生的作用及机制，20170401，2018.1-2019.126. 陕西省博士后基金，MACF1调节细胞骨架重排参与老年性骨质疏松症发生的作用研究，2017.1-2018.127. 中国博士后科学基金特别资助项目，miR-138-5p在模拟失重抑制骨形成中的作用及机制，2015T81051, 2015.9-2017.98. 中国博士后科学基金面上项目，MACF1分子参与模拟失重条件抑制骨形成的作用研究，2014M562450, 2014.7-2015.129. 陕西省自然科学基金青年人才项目，MACF1参与模拟失重条件影响前成骨细胞迁移的作用及机制研究，2015JQ3076, 2015.1-2016.1210. 中央高校基本科研业务费资助项目，一种新的非编码RNA调控MACF1参与骨形成的分子机制研究，3102016ZY037，2016.1-2017.1211. 中央高校基本科研业务费资助项目，前成骨细胞向骨形成表面迁移的分子机制研究，3102014JKY15007, 2014.5-2016.512. 西北工业大学基本科研费，非编码RNA通过调节MACF1参与成骨细胞分化与骨形成的机制研究，3102016QD015，2016.1-2017.12

学术成果

学术成果 Academic Achievements 代表性论文：(1) Zixiang Wu#, Lifang Hu#,*, Kang Ru, Wenjuan Zhang, Xia Xu, Shuyu Liu, Hua Liu, Yunxia Jia, Shujing Liang, Zhihao Chen, Airong Qian*. Ellagic acid inhibits CDK12 to increase osteoblast differentiation and alleviate osteoporosis in hindlimb-unloaded and ovariectomized mice. Phytomedicine, 2023, 114: 154745.(2) Lifang Hu#, Chong Yin#, Dong Chen#, Zixiang Wu, Shujing Liang, Yu Zhang, Zizhan Huang, Shuyu Liu, Xia Xu, Zhihao Chen, Yi Zhang*, Airong Qian*. MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm. Cell Death and Differentiation, 2021, 28(7):2160-2178.(3) Xia Xu#, Shuyu Liu#, Hua Liu, Kang Ru, Yunxian Jia, Zixiang Wu, Shujing Liang, Zarnaz Khan, Zhihao Chen, Airong Qian*, Lifang Hu*. Piezo channels: awesome mechanosensitive structures in cellular mechanotransduction and their role in bone. International Journal of Molecular Sciences, 2021, 22: 6429.(4) Zhihao Chen, Yan Zhang, Fan Zhao, Chong Yin, Chaofei Yang, Ying Huai, Shujing Liang, Shuyu Liu, Xia Xu, Zixiang Wu, Ye Tian, Yu Li, Lifang Hu*, Airong Qian*. miR-138-5p negatively regulates osteoblast differentiation through inhibiting β-catenin under simulated microgravity in MC3T3-E1 cells. Acta Astronautica. 2021, (182), 240-250.(5) Zhihao Chen#, Fan Zhao#, Chao Liang#, Lifang Hu#, Dijie Li, Yan Zhang, Chong Yin, Lei Chen, Luyao Wang, Xiao Lin, Peihong Su, Jianhua Ma, Chaofei Yang, Ye Tian, Wenjuan Zhang, Yu Li, Songlin Peng*, Weiyi Chen*, Ge Zhang*, Airong Qian*. Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli. Theranostics, 2020, 10(26): 12263-12278.(6) Shuyu Liu#, Xia Xu#, Shujing Liang#, Zhihao Chen, Yan Zhang, Airong Qian*, Lifang Hu*. The Application of MSCs-Derived Extracellular Vesicles in Bone Disorders: Novel Cell-Free Therapeutic Strategy. Frontiers in Cell and Developmental Biology. 2020, 8: 619.(7) Shujing Liang#, Lifang Hu#, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian*. CDK12: A Potent Target and Biomarker for Human Cancer Therapy. Cells. 2020, 9(6): 1483.(8) Zhihao Chen#, Yan Zhang#, Fan Zhao, Chong Yin, Chaofei Yang, Xue Wang, Zixiang Wu, Shujing Liang, Dijie Li, Xiao Lin, Ye Tian, Lifang Hu*, Yu Li, Airong Qian*. Recombinant irisin prevents the reduction of osteoblast differentiation induced by simulated microgravity through increasing β-catenin expression. International Journal of Molecular Science, 2020, 21(4), 1259.(9) Abdul Qadir, Shujing Liang, Zixiang Wu, Zhihao Chen, Lifang Hu*, Airong Qian*. Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells. International Journal of Molecular Science, 2020, 21(1): 349.(10) Zixiang Wu, Shujing Liang, Wenyu Kuai, Lifang Hu*, Airong Qian*. MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells. RSC Advances, 2019, 9, 37300–37311.(11) Lifang Hu, Zizhan Huang, Zixiang Wu, Arshad Ali, Airong Qian*. Mammalian plakins, giant cytolinkers: versatile biological functions and roles in cancer. International Journal of Molecular Science. 2018, 19(4): 974(12) Lifang Hu, Chong Yin, Fan Zhao, Arshad Ali, Jianhua Ma, Airong Qian*. Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment. International Journal of Molecular Science. 2018, 19(2): 360.(13) Lifang Hu, Peihong Su, Chong Yin, Runzhi Li, Kun Yan, Zhihao Chen, Dijie Li, Ge Zhang, Liping Wang, Zhiping Miao*, Airong Qian*, Cory J. Xian. Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis. Journal of Cellular Physiology. 2018, 233(2): 1574-1584.(14) Lifang Hu, Yunyun Xiao, Zhipeng Xiong, Fan Zhao, Chong Yin, Yan Zhang, Peihong Su, Dijie Li, Zhihao Chen, Xiaoli Ma, Ge Zhang, Airong Qian*. MACF1, versatility in tissue-specific function and in human disease. Seminars in Cell & Developmental Biology. 2017, 69: 3-8.(15) Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Yan Zhang, Peng Shang, Tuanmin Yang, Airong Qian*. Isoforms, structures, and functions of versatile spectraplakin MACF1. BMB Reports. 2016, 49(1): 37-44.(16) Lifang Hu, Peihong Su, Runzhi Li, Kun Yan, Zhihao Chen, Peng Shang, Airong Qian*. Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells. BMB Reports. 2015, 48(10): 583-588.(17) Lifang Hu, Jingbao Li, Airong Qian, Fei Wang, Peng Shang*. Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition. Cell Biology International. 2015, 39(4): 364-372.(18) Lifang Hu, Runzhi Li, Peihong Su, Yasir Arfat, Ge Zhang, Peng Shang, Airong Qian*. Response and adaptation of bone cells to simulated microgravity. Acta Astronautica, 2014, 104(1): 396-408. (19) Lifang Hu, Airong Qian, Yang Wang, Shengmeng Di, Peng Shang*. Inhibitory effect of simulated microgravity on differentiating preosteoblasts. Advances in Space Research, 2013, 51(1), 107-114. (20) Airong Qian, Lifang Hu. Spectraplakins, versatile roles in physiology and pathology. Seminars in Cell & Developmental Biology. 2017, 69: 1-2.(21) Yan Zhang#, Chong Yin#, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang*, Airong Qian*, Cory J. Xian. MACF1 overexpression by transfecting the 21-kbp large plasmid PEGFP-C1A-ACF7 promotes osteoblast differentiation and bone formation. Human Gene Therapy. 2018, 29(2):259-270.(22) Chong Yin#, Yan Zhang#, Lifang Hu, Ye Tian, Zhihao Chen, Dijie Li, Fan Zhao, Peihong Su, Xiaoli Ma, Ge Zhang, Zhiping Miao, Liping Wang*, Airong Qian*, Cory J. Xian. Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation. Journal of Cellular Physiology. 2018, 233(7):5405-5419.(23) 胡丽芳，吴自祥，丛晓岚，Mitchel Alioscha-Perez，王哲，蒋冬梅*，骞爱荣*, Hichem Sahli. MACF1对成骨细胞微丝骨架和细胞力学性能的调节作用. 陕西师范大学学报. 2020, 48(5): 98-104.(24) 胡丽芳，骞爱荣，李迪杰，李京宝，商澎*.不同分化阶段的成骨细胞对强磁重力环境的响应.中国细胞生物学学报. 2013, 35(7): 950-957. (25) 胡丽芳，骞爱荣，商澎*. 骨硬化蛋白与骨代谢.生命的化学. 2011, 31(5): 613-618.(26) 胡丽芳，骞爱荣，商澎*. Vinculin在细胞响应力学刺激中的作用.中国生物化学与分子生物学报. 2009, 25(9): 805-810.(27)胡丽芳，骞爱荣，杨鹏飞，张维，谢丽，商澎*. 中等强度静磁场对白血病细胞增殖和细胞周期的影响.第四军医大学学报. 2009, 30(5): 397-400. 专利：(1) 骞爱荣，商澎，胡丽芳，李润芝，苏佩红，印崇，闫琨，陈志浩，戚依朵，孙瑜隆. 抑制小鼠MACF1基因表达的shRNA序列及其应用。专利号：ZL 201410631379.6(2) 骞爱荣，胡丽芳，印崇，赵帆，陈志浩，张琰，马剑华，苏佩红，李迪杰，仇伍霞，马小莉，王牌。MACF1基因及其表达产物在制备诊断和治疗骨质疏松症药物中的应用。公开号：CN106148520A(3) 骞爱荣，胡丽芳，印崇，张琰，马剑华，赵帆，陈志浩，李迪杰，李思宇，马小莉，仇伍霞，杨超飞，王牌，苏佩红。miR-489-3p在制备诊断和治疗人骨质疏松症药物中的应用。公开号：CN106011264A(4) 骞爱荣，胡丽芳，马剑华，李思宇，赵帆，陈志浩，李迪杰，陈楚，杨团民，印崇，苏佩红，马小莉，张琰，仇伍霞，张茹，王牌，杨超飞。老年骨质疏松性骨折的血清microRNA诊断标志物及其诊断试剂盒。公开号：CN106591487A(5) 骞爱荣，胡丽芳，王牌，马小莉，赵帆，仇伍霞，张茹，陈蕾，印崇，李迪杰，苏佩红，陈志浩，张琰，杨超飞，李思宇。MACF1定点转基因小鼠模型构建方法，发明专利，公开号：CN107446950A(6) 骞爱荣，胡丽芳，仇伍霞，马小莉，赵帆，张茹，王牌，陈蕾，印崇，陈志浩，苏佩红，李迪杰，张琰，李思宇，杨超飞。MACF1基因在成骨细胞中条件性敲除的小鼠模型的构建及应用。发明专利，公开号：CN107114311A(7) 骞爱荣，马小莉，胡丽芳，赵帆，张茹，仇伍霞，王牌，苏佩红，陈志浩，李迪杰，印崇，苗治平，陈蕾。间充质干细胞中MACF1基因条件性敲除小鼠模型的建立及其应用，发明专利，公开号：CN107047452A(8) 骞爱荣，印崇，苗治平，张琰，胡丽芳，陈志浩，赵帆，李迪杰，马剑华，苏佩红，马小莉，仇伍霞，杨超飞，李思宇，王牌。长链非编码RNA Lnc-DIF的应用。公开号：CN106676177A(9) 骞爱荣，陈志浩，Yasir Arfat，印崇，胡丽芳，赵帆，李迪杰，张琰，李润芝，苏佩红，马小莉，仇伍霞。力学敏感的miR-138-5p 作为药物靶点在骨骼肌肉系统疾病中应用。公开号：CN105169411A(10) 骞爱荣，马剑华，赵帆，陈志浩，胡丽芳，李迪杰，印崇，马小莉，苏佩红。与老年性骨质疏松相关微小RNA的寡核苷酸化合物的应用。公开号：CN106167824

综合介绍

社会兼职 Social Appointments 担任BMC Musculoskeletal Disorders期刊编委担任Frontiers in Physiology期刊Review Editor担任Seminars in Cell and Developmental Biology、Frontiers in Cell and Developmental Biology期刊Guest Editor担任Advanced Science，Astrobiology，Journal of Cellular Biochemistry等期刊审稿人美国骨矿盐学会(American Society of Bone and Mineral Research)会员国际华人骨研学会(International Chinese Musculoskeletal Research Society)会员中国空间科学学会会员中国生物力学学会会员中国细胞生物学学会会员陕西省细胞生物学学会会员