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个人经历 Personal experience 工作经历 教育经历 2016.04-至今        西北工业大学生命学院  副教授2015.03-2016.03  香港中文大学药剂学院  访问学者2014.03-2016.03  西北工业大学生命学院  讲师2012.02-2014.02  西北工业大学生命学院  博士后2011.01-2012.01  香港中文大学药剂学院  科研助理 2010年毕业于香港中文大学药剂学院，药剂学专业，获博士学位；2007年毕业于四川大学华西药学院，临床药学专业，获硕士学位；2004年毕业于四川大学华西药学院，药学专业，获学士学位。

教育教学

教育教学 Education and teaching 教育教学 本科生专业课：《人体解剖生理学》、《生理学》（全英文）、《生物药剂与药物动力学》、《生物药剂与药物动力学》（全英文）研究生专业课：《药物设计、合成与生物活性》、《药物代谢与药物分析》

荣誉获奖

科学研究 Scientific Research 主要从事中药药理学方面的研究，目前的研究重点为代谢性疾病（骨质疏松及动脉粥样硬化）的发生机制及其天然药物防护；中药药动学研究及中西药联用的相互作用

科学研究

学术成果 Academic Achievements 主持项目1. 国家自然科学基金青年科学基金项目，模拟微重力条件下黄芩苷通过β-catenin和Cx43促进骨髓间充质干细胞成骨分化的研究（No. 81502980），2016.01–2018.12；2. 陕西省自然科学基金青年人才项目，黄芩苷对原发性和继发性骨质疏松防治作用及其机制研究（No. 2015JQ8289），2015.01–2017.12；3. 科技部973计划前期研究专项子课题，结/直肠癌发病机制与化学预防的实验研究，2011.05-2012.12；4. 中国博士后科学基金面上项目，黄芩内黄酮单体抗废用性骨质疏松活性及其机制研究（No. 2012M521806），2012.09-2014.09；5. 中央高校基础研究基金，杜仲总环烯醚萜抗失重性骨质流失活性及其分子机制研究（No. 3102014JCQ15009），2014.05-2016.05发表学术论文20余篇，其中发表在Life Sciences上的文章为ESI高被引论文。代表性论文：Li CR, Wang Z, Wang Q, Ka Yan Ho RL, Huang Y, Chow MSS, Kei Lam CW, Zuo Z. Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination-in vitro and in vivo investigation using a taxane-resistant prostate cancer model. Oncotarget. 9(3): 3338-3352, 2017Li CR, Wang Q, Ren TJ, Zhang YF, Lam CWK, Chow MSS, Zuo Z. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. Journal of Pharmaceutical and Biomedical Analysis. 128: 286-293, 2016Li CR, Li Q, Mei QB, Lu TL. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii. Life Sciences. 126: 57-68, 2015（ESI高被引文章）李晨睿, 孟志远, 牛银波,翟远坤, 潘亚磊, 谢丽, 梅其炳. 黄芩苷通过Wnt/β-catenin信号通路对大鼠骨髓间充质干细胞成骨分化的促进作用. 中国药理学通报. 31(7): 919-924,2015Li CR, Li Q, Liu RJ, Niu YB, Pan YL, Zhai YK, Mei QB. Medicinal herbs in the prevention and treatment of osteoporosis. American Journal of Chinese Medicine. 42(1):1-22, 2014Li CR, Zhang GW, Niu YB, Pan YL, Zhai YK, Mei QB. Antiosteoporosis effect of Radix Scutellariae extract on density and microstructure of lone bones in tail-suspended Sprague-Dawley rats. Evidence-Based Complementary and Alternative Medicine. DOI: 10.1155/2013/753703Li CR, Fong YK Sophia, Mei QB, Lin G, Zuo Z. Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. Pharmaceutical Biology. 52(3): 291-297, 2014李晨睿, 牛银波, 潘亚磊, 翟远坤, 武祥龙, 范於菟, 梅其炳. 黄芩药动学研究进展. 中国药理学通报. 29(8): 1048-1053,2013Li CR, Zhang L, Zhou LM, Wo SK, Zhou L, Lin G, Zuo Z. Pharmacokinetic interactions among major bioactive components in Radix Scutellariae via metabolic competition. Biopharmaceutics & Drug Disposition. 33(9): 487-500,2012 Li CR, Zhang L, Zhou LM, Wo SK, Lin G, Zuo Z. Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. AAPS Journal. 14(1): 23-34,2012 Li CR, Lin G, Zuo Z. Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. Biopharmaceutics & Drug Disposition. 32(8): 427-445, 2011Li CR, Zhang L, Lin G, Zuo Z. Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix Scutellariae product. Journal of Pharmaceutical and Biomedical Analysis. 54(4): 750-758, 2011Li CR, Zhou L, Lin G, Zuo Z. Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of Radix Scutellariae. Journal of Pharmaceutical and Biomedical Analysis. 50(3): 298-306, 2009Zhang GW, Li CR, Zhu NH, Chen YL, Yu Q, Liu EQ, Wang R. Sex differences in the formation of atherosclerosis lesion in apoE-/- mice and the effect of 17β-estrodiol on protein S-nitrosylation. Biomedical Pharmacotherapy. 99: 1014-1021, 2018Fong SYK, Li CR, Ho YC, Li R, Wang Q, Wong YC, Xue H, Zuo Z. Brain uptake of bioactive flavones in Scutellariae Radix and its relationship to anxiolytic effect in mice. Molecular Pharmaceutics. 14(9): 2908-2916, 2017Zhang GW, Li CR, Niu YB, Yu Q, Chen YL, Liu EQ. Osteoprotective effect of Radix Scutellariae in female hindlimb-suspended Sprague-Dawley rats and the osteogenic differentiation effect of its major constituent. Molecules. 22(7): E1044, 2017Ren TJ, Wang Q, Li CR, Yang MB, Zuo Z. Efficient brain uptake of piperine and its pharmacokinetics characterization after oral administration. Xenobiotica. 28: 1-9, 2017Qian S, Li CR, Zuo Z. Pharmacokinetics and disposition of various drug loaded liposomes. Current Drug Metabolism. 13(4): 372-395,2012

学术成果

社会兼职 Social Appointments 陕西省实验动物学会理事国际华人骨研学会（International Chinese Musculoskeletal Research Society Membership, ICMRS）会员美国药学家协会（American Association of Pharmaceutical Scientists）会员

综合介绍