教师主页移动版

个人经历 Personal experience 工作经历 教育经历 2011.07- 2012.01  德国Max Planck Institute of Microstructure Physics, 博士后 2012.02-2016.05   西班牙CIC纳米研究中心,  博士后  2016.06                西北工业大学，生命学院，教授 1996.09-2000.07   郑州大学,   商用英语,   文学学士2000.09-2007.07   德国哈勒维滕贝格大学,   生物化学,   Diplom2007.09-2011.07   德国斯图加特大学,   生物化学,   博士

教育教学

教育教学 Education and teaching 教育教学 本科生课程： 生物科学Plus，纳米酶学, 细胞生物学前沿（英文） 本科全英文专业课程：Botany， Neuroscience研究生课程：纳米酶学

荣誉获奖

荣誉获奖 Awards Information 2010国家优秀自费留学生奖学金 欧洲材料研究学会（European Materials Research Society）2010 Young Scientist Award

科学研究

科学研究 Scientific Research 主要研究方向：纳米酶；新型功能纳米材料生物医学应用；生物内源分子纳米修饰与仿生；微纳仿生电光效应；生物催化剂分子改造及构效关系分析。主持科研项目：国家自然科学基金面上项目（31971315) 2020-2023国家自然科学基金面上项目（31771577) 2018-2019陕西省自然科学基金面上项目(2018JM3027)陕西省留学人员科技活动择优资助项目（2017044）代表性论文：1. Fan Yang, Mikel Abadia, Chaoqiu Chen, Weike Wang, Le Li, Lianbing Zhang*, Celia Rogero, Andrey Chuvilin, Mato Knez* Design of active and stable oxygen reduction reaction catalysts by embedding CoxOy nanoparticles into nitrogen-doped carbon. Nano Research 2017,10,97-107. 2. Le Li, Lianbing Zhang*, Mato Knez* Comparison of two endogenous delivery agents in cancer therapy: Exosomes and ferritin. Pharmacological Research 2016，110,1-9.3. Le Li, Maider Mu？oz-Culla, Unai Carmona, Maria Paz Lopez, Fan Yang, Cesar Trigueros, David Otaegui, Lianbing Zhang*, Mato Knez* Ferritin-mediated siRNA delivery and gene silencing in human tumor and primary cells. Biomaterials 2016，98, 143-151.4. Lianbing Zhang, Le Li, Di Penta, A.; Carmona, U.; Yang, F.; Sch？ps, R.; Brandsch, M.; Zugaza, JL.; Knez, M.* H-Chain Ferritin: A Natural Nuclei Targeting and Bioactive Delivery Nanovector. Advanced Healthcare Materials 2015，4, 1305-1310. 5. Unai Carmona, Le Li, Lianbing Zhang*, Mato Knez* Ferritin light-chain subunits: key elements for the electron transfer across the protein cage. Chem. Commun. 2014，50, 15358-15361. 6. Le Li, Lianbing Zhang*, Unai Carmona, Mato Knez* Semi-Artificial and Bioactive Ferroxidase with Nanoparticles as the Active Sites. Chem. Commun. 2014，50, 8021-8023. 7. Unai Carmona, Lianbing Zhang*, Le Li, Mato Knez* Tuning, Inhibiting and Restoring the Enzyme Mimetic Activities of Pt-Apoferritin. Chem. Commun. 2014，50, 701-703.8. ZhangZhang, Lianbing Zhang*, Stephan Senz, Mato Knez, Immobilization of Apoferritin-Templated Seeds for Si Nanowire Growth. Chem. Vapor Deposition, 2011，17, 149-154. 9. Lianbing Zhang*, Wiebek Fischer, Eckhard Pippel, Gerd Hause, Matthias Brandsch, Mato Knez* Receptor-Mediated Cellular Uptake of Nanoparticles: a Switchable Delivery System. Small2011，7, 1538-1541. 10. Zhang, LB.*; Laug, L.; Münchgesang, W.; Pippel, E.; G？sele, U.; Brandsch, M.; Knez, M.* Reducing Stress on Cells with Apoferritin-Encapsulated Platinum Nanoparticles. Nano Lett. 2010,10, 219-223.11. Zhang, LB.*; Patil, A. J.; Li, L.; Schierhorn, A.; G？sele, U.; Knez, M.* Chemical Infiltration during Atomic Layer Deposition: Metalation of Porphyrins as Model Substrates. Angew. Chem. Int. Ed. 2009,48, 4892-4895.

学术成果

社会兼职 Social Appointments 中国生物物理学会 纳米酶分会 副会长（任期 2019.08-2021.08；2021.08-2025.08）Frontiers in Chemictry，Reviewer Editor

综合介绍

团队信息 Team Information  纳米生物医学先进诊疗技术实验室Laboratory of Advanced Nano-Biomedical Theranostic Technology       本课题组的研究领域是纳米生物材料与纳米医学，是跨越材料、化学、生物医学的新兴交叉学科。我们的目标是开发新型功能纳米材料，通过结构设计、可控合成、合理的表面修饰、利用纳米材料独特的物理与化学性质得到功能丰富的生物仿生纳米材料，研究其在生命体系中的行为，挖掘在生物医学领域的应用潜力。 主要研究方向：    纳米酶；新型功能纳米材料生物医学应用、生物内源分子纳米修饰与仿生、微纳仿生电光效应、生物催化剂分子改造及构效关系分析 课题组成员:陈 耀 助理教授:毕业于中国科学院山西煤炭化学研究所，获材料物理与化学博士学位。主要研究方向为基于原子层沉积的纳米生物检测和传感材料设计，仿生材料及生物电化学分析。博士后：杨迎春  研究生：田庆、杨荣、杨陆秋、杨珂、韩瑞婷、邓芳清、孟钰琪、张瑞凯、杨光昊、侯静、皇甫帅奇、牛锦云毕业生：尉迟庆潇、杨雄、李阳、王婷、杨迎春  课题组科研项目： 2项 国家自然科学基金面上项目: 31771577, 319713154项 国家自然科学基金青年项目: 31700700；21804109；31900984；221021305项 国家博士后科学基金: 2017M623232；2018M631197；2018M633561；2018M633566；2018M6335811项 陕西省自然科学基金面上项目: 2018JM30274项 陕西省自然科学基金青年项目：2018JQ2038；2019JQ-034；2019JQ-231；2020JQ-1451项 深圳市科创委计划项目(基础研究—自由探索类): JCYJ201708151544182071项 陕西省留学人员择优资助项目: Nr. 20170444项 陕西省博士后科学基金 课题组研究成果： 2022Yao Chen, Qing Tian, Haoyu Wang, Ruonan Ma, Ruiting Han, Yu Wang, Huibin Ge, Yujing Ren, Rong Yang, Huimin Yang, Yinjuan Chen, Xuezhi Duan, Lianbing Zhang*, Jie Gao*, Lizeng Gao*, Xiyun Yan, Yong Qin*, Manganese based metal-organic framework as cold-adapted nanozyme. Advanced Materials 2022, 202206421                               (IF 32.086)Ziqi Xu, Tianyi Wang, Yixiao Li, Mengyao Wen, Kangqiang Liang, Chenlong Ruan, Lianbing Zhang, Yumeng Xue,* and Li Shang*, Nanozyme-engineered bioglass through supercharged interface for enhanced anti-Infection and fibroblast regulation. Advanced Functional Materials 2022, 2209438.                  (IF 19.924)Yixiao Li, Shaohua Qu, Yumeng Xue, Lianbing Zhang, Li Shang*, Cationic antibacterial metal nanoclusters with traceable capability for fluorescent imaging the nano-bio interactions. Nano Research 2022, DOI:10.1007/s12274-022-4837-x      (IF 10.269)Miao Sun, Xi Zhou*, Yi Quan, Lianbing Zhang, Yanbo Xie, Highly flexible elastomer microfluidic chip for single cell manipulation. Biomicrofluidics 2022, 16:024104    (IF 3.258)Yang Li, Qiutang Wang, Siyi Wei,Kai Chen*, Shuqi Wu*, Lianbing Zhang, A novel fluoro-pyrazine-bridged donor-accepter-donor fluorescent probe for lipid droplet-specific imaging in diverse cells and superoxide anion generation. Pharmaceutical Research 2022, 39(6), 1205-1214           (IF 4.58)2021Qing Tian, Yingchun Yang, Aipeng Li, Yao Chen, Yixiao Li, Leming Sun, Li Shang, Lizeng Gao*, Lianbing Zhang*, Ferrihydrite nanoparticles as the photosensitizer augment microbial infected wound healing with blue light. Nanoscale 2021, 13(45), 19123-19132.    (IF 7.79)Rehmat Islam, Leming Sun*, Lianbing Zhang, Biomedical applications of chinese herb-synthesized silver nanoparticles by phytonanotechnology. Nanomaterials 2021, 11(10), 2757.      (IF 5.076)Aipeng Li, Ting Wang, Ke Yang, Xuanshuo Zhang, Dongming Yin, Yong Qin, Lianbing Zhang*, Engineering a carbonyl reductase as a potential tool for the synthesis of chiral α‐tetralinols. ChemCatChem 2021, 13, 4625-4633.    (IF 5.686)Ting Wang, Ke Yang, Qing Tian, Ruiting Han, Xuanshuo Zhang, Aipeng Li*, Lianbing Zhang, Acetoacetyl-CoA reductase PhaB as an excellent anti-Prelog biocatalyst for the synthesis of chiral β-hydroxyl ester and the molecular basis of its catalytic performance. Molecular Catalysis 2021, 514:111854.   (IF 5.062)Weifeng Lin, Yingchun Yang, Yang Lei, Feifei An, Leming Sun*, Yong Qin, Lianbing Zhang*, Self-assembly of anti-tumor dipeptide induced near-infrared fluorescence and improved stability for theranostics applications. ACS Applied Materials & Interfaces 2021, 13(28), 32799.   (IF 9.229)Yao Chen, Xiaomei Shen, Unai Carmona, Fan Yang, Xingfa Gao*, Mato Knez*, Lianbing Zhang*, Yong Qin, Control of stepwise Hg2+ reduction on gold to selectively tune its peroxidase and catalase-like activities and the mechanism. Advanced Materials Interfaces 2021, 8, 2100086.  (IF 6.147)Yingchun Yang, Qing Tian, Shuqi Wu, Yixiao Li, Ke Yang, Yi Yan, Li Shang, Aipeng Li, Lianbing Zhang*, Blue light-triggered Fe2+-release from monodispersed ferrihydrite nanoparticles for cancer iron therapy. Biomaterials 2021, 271, 120739.     (IF 12.479)Aipeng Li, Ting Wang, Qing Tian, Xiaohong Yang, Dongming Yin, Yong Qin, Lianbing Zhang*, Single point mutant inverts stereoselectivity of a carbonyl reductase toward β-ketoesters with enhanced activity. Chemistry-A European Journal 2021, 27, 6283.  (IF 5.236)Dingchang Liu, Dongjie Fu, Lianbing Zhang, Leming Sun*, Detection of amyloid-beta by Fmoc-KLVFF self-assembled fluorescent nanoparticles for Alzheimer’s disease diagnosis. Chinese Chemical Letters 2021, 32, 1066.  (IF 6.779)Leming Sun*, Dingchang Liu, Dongjie Fu, Tao Yue, Douglas Scharre, Lianbing Zhang*, Fluorescent peptide nanoparticles to detect amyloid-beta aggregation in cerebrospinal fluid and serum for Alzheimer's disease diagnosis and progression monitoring. Chemical Engineering Journal 2021, 405, 126733. (IF 13.273)Shuqi Wu, Yang Li, Ruofei Zhang, Kelong Fan, Weihang Ding, Letong Xu, Lianbing Zhang*, Persistent luminescence-polypyrrole nanocomposite for dual-modal imaging and photothermal therapy of mammary cancer. Talanta 2021, 221, 121435. (IF 6.057)2020Dongjie Fu, Dingchang Liu, Lianbing Zhang, Leming Sun*, Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications. Chinese Chemical Letters 2020, 31(12), 3195-3199.  (IF 4.632)Yingchun Yang, Tao Li, Yong Qin, Lianbing Zhang, Yao Chen*, Construct of carbon nanotube-supported Fe2O3 hybrid nanozyme by atomic layer deposition for highly efficient dopamine sensing. Frontiers in Chemistry 2020, 8:564968. (IF 3.693)Shuqi Wu, Zihan Qiao, Yang Li, Sunpei Hu, Yuan Ma, Siyi Wei, Lianbing Zhang*, Persistent luminescence nanoplatform with Fenton-like catalytic activity for tumor multimodal imaging and photoenhanced combination therapy. ACS Applied Materials & Interfaces 2020, 12(23), 25572-25580. (IF 8.758).Aipeng Li, Xue Li, Wei Pang, Qing Tian, Ting Wang, Lianbing Zhang*, Fine-tuning of the substrate binding mode to enhance the catalytic efficiency of an ortho-haloacetophenone-specific carbonyl reductase. Catalysis Science & Technology 2020, 10, 2462-2472.  (IF 5.721)Shuqi Wu, Yang Li, Weihang Ding, Letong Xu, Yuan Ma, Lianbing Zhang*, Recent advances of persistent luminescence nanoparticles in bioapplications. Nano-Micro Letters 2020, 12, 70. (IF 12.264).Yao Chen, Qingxiao Yuchi, Tao Li, Guanghao Yang, Jiaojiao Miao, Chenyang Huang, Jingyi Liu, Aipeng Li, Yong Qin*, Lianbing Zhang*, Precise engineering of ultra-thin Fe2O3 decorated Pt-based nanozymes via atomic layer deposition to switch off undesired activity for enhanced sensing performance. Sensors and Actuators B: Chemical 2020, 305, 127436.  (IF 7.1)Jiaojiao Miao, Xue Teng, Rui Zhang*, Pengfei Guo, Yao Chen, Xuehua Zhou, Hongqiang Wang*, Xiangnan Sun*, Lianbing Zhang*, "Carbohydrate-universal" electrolyzer for energy-saving hydrogen production with Co3FePx@NF as bifunctional  electrocatalysts. Applied Catalysis B: Environmental 2020, 263,118109.  (IF 16.683)2019Aipeng Li, Qingxiao Yuchi, Xue Li, Wei Pang, Bin Li, Feng Xue*, Lianbing Zhang*, Discovery of a novel ortho-haloacetophenones-specific carbonyl reductase from Bacillus aryabhattai and insight into the molecular basis for its catalytic performance. International Journal of Biological Macromolecules 2019, 138, 781-790. (IF 5.162)Leming Sun, Aipeng Li, Yanzi Hu, Yang Li, Li Shang, Lianbing Zhang*, Self-assembled fluorescent and antibacterial GHK-Cu nanoparticles for wound healing applications. Particle & Particle Systems Characterization 2019, 36(4), 1800420. (IF 4.384)2018Leming Sun*, Yanzi Hu, Lianbing Zhang*, Recent trends in nanocrystals for pharmaceutical applications. Current Pharmaceutical Design 2018, 24(21), 2394-2402. (IF 2.757)Aipeng Li, Qingxiao Yuchi, Lianbing Zhang*, Ferritin: A powerful platform for nanozymes. Progress in Biochemistry and Biophysics 2018, 45(2), 193-203. (IF 0.463)2017Fan Yang, Mikel Abadia, Chaoqiu Chen, Weike Wang, Le Li, Lianbing Zhang*, Celia Rogero, Andrey Chuvilin, Mato Knez*, Design of active and stable oxygen reduction reaction catalysts by embedding CoxOy nanoparticles into nitrogen-doped carbon. Nano Research 2017, 10, 97-107. (IF 8.893)2016Le Li, Maider Mu？oz-Culla, Unai Carmona, Maria Paz Lopez, Fan Yang, Cesar Trigueros, David Otaegui, Lianbing Zhang*, Mato Knez*, Ferritin-mediated siRNA delivery and gene silencing in human tumor and primary cells. Biomaterials 2016, 98, 143-151. (IF 10.317)Le Li, Lianbing Zhang*, Mato Knez*, Comparison of two endogenous delivery agents in cancer therapy: Exosomes and ferritin. Pharmacological Research 2016, 110, 1-9. （IF 5.893）