教师主页移动版

个人经历 Personal experience 工作经历 教育经历 2020年7月-至今             西北工业大学生命学院，硕士生导师2017年7月-2020年7月     西北工业大学生命学院，博士后2017年1月-至今               西北工业大学生命学院 助理教授Jul 2017-Jul 2020     Postdoctor, School of Life Sciences, Northwestern Polytechnical UniversityJul 2020 -now           Master’s Supervisor, School of Life Sciences, Northwestern Polytechnical UniversityJan 2017-now           Assistant Professor, School of Life Sciences, Northwestern Polytechnical University 2012/09-2016/12   西北农林科技大学 生物信息学 理学 博士2009/09-2012/06   西北农林科技大学  环境工程    工学 硕士2012/09-2016/12，PhD, Bioinformatics, Northwest A&F University2009/09-2012/06,  Master, Environmental Engineering, Northwest A&F University

教育教学

教育教学 Education and teaching 教育教学 招生信息 本科生全英文课程 《Zoology》（动物学）和《Genetics》（遗传学）本科生综合素养课程《生命科学导论》研究生课程 《航天医学工程》Undergraduate Courses：《Zoology》、《Genetics》Undergraduate Courses：《Introduction of Life Sciences》Graduate Courses：《Aerospace Medical Engineering》 每年招收对生物信息学、医学大数据分析、骨代谢研究和系统生物学等方向感兴趣的硕士研究生。欢迎数学、生物、计算机等相关专业的同学加入合作，可先邮件联系：wenjuan_zhang2017@nwpu.edu.cn

荣誉获奖

科学研究 Scientific Research 1. 主持国家自然基金（青年项目），81901917，CD40L参与模拟失重促进破骨细胞分化的骨免疫机制研究，2020.01-2022.12，20万元；2. 主持“一带一路”及校际重要合作伙伴科技合作种子基金，D5000210746，失重性骨质流失的骨免疫机制及防护研究，2021.01-2022.12，20万元；3. 主持陕西省重点研发计划（一般项目），2022SF-295，骨质疏松症病的骨免疫机制研究及其药食同源药物开发，2022.01-2023.12，6万元；4. 主持中国博士后科学基金（面上项目），2017M623249，基于网络药理学探讨黄芪心脑同治的物质基础和作用机制，2017.10-2019.10，5万元；5. 主持中央高校基本科研业务专项资金资助（科研启动费），3102017OQD050，黄芪多靶协同心脑同治的物质基础和分子机制，2017.01-2018.12，15万元.6. 参与国家自然科学基金（面上项目），81772017，MACF1结合CDK12参与模拟失重抑制骨形成的作用及机制，2018/01-2021/12，55万元 Fundings1. National Natural Science Foundation of China (Grant No. 81901917). 2020.01-2022.12, RMB 2000002. The Fundamental Research Funds for the Central Universities under  (Grant No. D5000210746). 2021.01-2022.12,RMB 2000003. Key Research and Development Project of Shaanxi Province (Grant No. 2022SF-295). 2022.01-2023.12,RMB 60000 4. China Postdoctoral Science Foundation (Grant No.2017M623249). 2017.10-2019.10, RMB 500005. The Fundamental Research Funds for the Central Universities (Grant No. 3102017OQD050). 2017.01-2018.12, RMB 1500006. National Natural Science Foundation of China (Grant No. 81772017). 2018.01-2021.12, RMB 550000

科学研究

学术成果 Academic Achievements (1) Xiaoli Ma , Ye Tian, Kaiyue Xue, Ying Huai, Suryaji Patil, Xiaoni Deng, Qiang Hao, Danming Li, Zhiping Miao, Wenjuan Zhang*, Airong Qian*. Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway.Eur J Pharmacol. 2021, 15;911:174555.(2) Ying Huai#, Wen juan Zhang#, Wei Wang, Kai Dang, Shan-feng Jiang, Dan-ming Li,Meng Li, Qiang Hao e, Zhi-ping Miao, Yu Li*, Ai-rong Qian*. Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment. Chinese Herbal Medicines, 2021, 13(3): 313-331.(3) Hong Wang#, Wenjuan Zhang#, Jinren Liu, Junhong Gao, Le Fang, Zhiyong Liu, Baoqing Xia, Xiaolin Fan, Cunzhi Li, Qing Lu, Airong Qian*. NF-κB and FosB mediate inflammation and oxidative stress in the blast lung injury of rats exposed to shock waves. Acta Biochim Biophys Sin. 2021, 53: 283–293.(4) Wenjuan Zhang#, Ying Huai#, Kai Dang#, Airong Qian*. Osteoimmunology: the regulatory roles of T lymphocytes in osteoporosis. Frontiers in Endocrinology. 2020,11:465.(5) Ying Huai#, Wenjuan Zhang#, Zhihao Chen, Fan Zhao, Wei Wang, Kai Dang, Kaiyue Xue, Yongguang Gao, Shanfeng Jiang, Zhiping Miao, Meng Li, Qiang Hao, Chu Chen*, Airong Qian*. A Comprehensive Analysis of MicroRNAs in Human Osteoporosis. Frontiers in Endocrinology. 2020,11:116213.(6) Hong Wang, WenJuan Zhang, JunHong Gao, JinRen Liu, ZhiYong Liu, BaoQing Xia, XiaoLin Fan, CunZhi Li, AiRong Qian*. Global gene expression profiling of blast lung injury of goats exposed to shock wave. Chinese Journal of Traumatology. 2020, 23 (5) , 249-257.(7) Wenjuan Zhang, Ying Huai, Zhiping Miao, Airong Qian*, Yonghua Wang*. Systems Pharmacology for Investigation of the Mechanisms of action of Traditional Chinese Medicine in Drug Discovery. Frontiers in Pharmacology, 2019 July 11, 10:743. (8) Wenjuan Zhang#, Kaiyue Xue#, Yongguang Gao#, Ying Huai, Wang Wei, Miao Zhiping, Dang Kai, Jiang Shanfeng, Qian Airong*. Systems pharmacology dissection of action mechanisms of Dipsaci Radix for osteoporosis. Life sciences, 2019, Aug 30, 235:116820.(9) Wenjuan Zhang, Ying Huai, Zhiping Miao, Chu Chen, Mohamed Shahen, Siddiq Ur Rahman, Mahmoud Alagawany, Mohamed E. Abd El-Hack*, Heping Zhao*, Airong Qian*. Systems pharmacology approach to investigate the molecular mechanisms of herb Rhodiola rosea L. radix. Drug Development Industrial Pharmacology, 2018 Nov 17:1-9. (10) Wenjuan Zhang#, Ying Huai#, Wei Wang, Kaiyue Xue, Lei Chen, Chu Chen*, Airong Qian*. A Retrospective Cohort Study on the Risk Factors of Deep Vein Thrombosis (DVT) for Traumatic Fracture Patients at Honghui Hospital. BMJ Open, 2019 Mar 3; 9(3):e024247. (11) Wenjuan Zhang, Qin Tao, Zihu Guo, Yingxue Fu, Xuetong Chen, Piar Ali Shar, Mohamed Shahen, Jinglin Zhu, Jun Xue, Yaofei Bai, Zhezhong Wang, Wei Xiao*, Yonghua Wang*. Systems Pharmacology Dissection of the Integrated Treatment for Co-Occurring Disorders by Chinese medicine: Cardiovascular and Gastrointestinal Disorders. Scientific Reports, 2016 Sep 6; 6:32400.(12) Wenjuan Zhang, Yaofei Bai, Yonghua Wang*, Wei Xiao*. Polypharmacology in drug discovery: a review from systems pharmacology perspective. Current Pharmaceutical Design, 2016 22(21):3171-81.(13) Haixing Yang#, Wenjuan Zhang#, Chao Huang, Wei Zhou, Yao Yao, Zhenzhong Wang, Yan Li, Wei Xiao, Yonghua Wang*. A novel systems pharmacology model for herbal medicine injection: a case using reduning injection. BMC Complement Alternative Medicine. 2014 Nov 4; 14:430.(14)   张文娟, 王永华*. 系统药理学原理、方法及在中医药中的应用.世界中医药. 2015, 10(2): 280-286. (15)  Jianling Liu#, Ke Sun#, Chuli Zheng, Xuetong Chen, Wenjuan Zhang, Zhenzhong Wang, Piar Ali Shar, Wei Xiao, Yonghua Wang*. Pathway as a Pharmacological Target for Herbal Medicines: An Investigation from Reduning Injection. PLOS ONE. 2015 Apr 1; 10(4): e0123109. (16) Yuan Wang, Zihu Guo, Xuetong Chen, Wenjuan Zhang, Aiping Lu, Yonghua Wang*. Multi-scale modeling of cell survival and death mediated by p53 network: A Systems Pharmacology Framework. Molecular BioSystems. 2015 Nov 11(11):3011-21.(17) Piar Ali Shar, Weiyang Tao, Shuo Gao, Chao Huang, Bohui Li, Wenjuan Zhang, Mohamed Shahen, Chunli Zheng, Yaofei Bai, Yonghua Wang*. Pred-binding: large-scale protein–ligand binding affinity prediction. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016, Feb 18:1-8. (18)  Weiyang Tao#, Bohui Li#, Shuo Gao, Yaofei Bai, Piar Ali Shar, Wenjuan Zhang, Zihu Guo, Ke Sun, Yingxue Fu, Chao Huang, Chunli Zheng, Jiexin Mu, Tianli Pei,Yuan Wang, Yan Li, Yonghua Wang*. CancerHSP: anticancer herbs database of systems pharmacology. Scientific Reports. 2015 Jun 15; 5:11481. (19) Peng Li#, Chao Huang#, Yingxue Fu#, Jinan Wang#, Ziyin Wu, Jinlong Ru, Chunli Zheng, Zihu Guo, Xuetong Chen, Wei Zhou, Wenjuan Zhang, Yan Li, Jianxin Chen, Aiping Lu, Yonghua Wang*. Large-scale exploration and analysis of drug combinations. Bioinformatics. 2015 Jun 15; 31(12):2007-16. (20) Bo Zhang#, Yingxue Fu#, Chao Huang#, Chunli Zheng#, Ziyin Wu#, Wenjuan Zhang, Xiaoyan Yang, Fukai Gong, Yuerong Li, Xiaoyu Chen, Shuo Gao, Xuetong Chen, Yan Li, Aiping Lu, Yonghua Wang*. New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Scientific Reports. 2016 Feb 25; 6:21872. (21)  Mohamed Shahen#, Zihu Guo#, Akhtar Hussain Shar#, Reham Ebaid, Qin Tao, Wenjuan Zhang, Ziyin Wu, Yaofei Bai, Yingxue Fu, Chunli Zheng, He Wang, Piar Ali Shar, Jianling Liu, Zhenzhong Wang, Wei Xiao*, Yonghua Wang*. Dengue virus causes changes of MicroRNA genes regulatory network revealing potential targets for antiviral drugs. BMC Systems Biology. 2018 12

学术成果

综合介绍