教师主页移动版

个人经历 Personal experience 工作经历 教育经历 2022/06 - 至今               西北工业大学生命学院            副教授 ，硕导2016/07 - 2022/06         西北工业大学生命学院           助理教授  2007/09 - 2011/07      中国农业大学食品科学与营养工程学院       工学学士2011/09 - 2016/07      清华大学生命科学学院                                理学博士

教育教学

教育教学 Education and teaching 教育教学 本科生课程：《Genetics》、《生命科学导论》研究生课程：《细胞培养技术》、《航天医学工程》、《细胞工程》Undergraduate Courses：《Genetics》、《Introduction to Life Science》Graduate Courses：《Cell Culture Technology》、《Aerospace Medical Engineering》、《Cell Engineering》硕士研究生招生：具有生物学、医学、生物医学工程背景的本科生Graduate enrollment：undergraduate students with a background in biology, medicine or biomedical engineering

荣誉获奖

科学研究 Scientific Research 国家自然基金青年基金，2018/01-2020/12，21万元，项目负责人陕西省重点研发计划，2021/01-2022/12, 5万元，项目负责人中国博士后科研基金，2017/01-2018/12，5万元，项目负责人陕西省自然科学基金青年项目，2018/01-2019/12，3万元，项目负责人中央高校基本科研业务费，2019/01-2020/12，20万元，项目负责人中央高校基本科研业务费，2017/01-2019/12，15万元，项目负责人

科学研究

学术成果 Academic Achievements 学术论文：Lin X, Xu F, Zhang KW, Qiu WX, Zhang H, Hao Q, Li M, Deng XN, Tian Y*, Chen ZH*, Qian AR*，Acacetin Prevents Bone Loss by Disrupting Osteoclast Formation and Promoting Type H Vessel Formation in Ovariectomy-Induced Osteoporosis, Front Cell Dev Biol, 2022, 10, 796227. doi: 10.3389/fcell.2022.796227Lin X#, Xiao YY#, Zhang KW, Yang D, Miao ZP, Deng XN, Qian AR*, Knockdown of MACF1 inhibits the migration and cytoskeletal arrangement of pre-osteoclasts induced by simulated microgravity, Acta Astronaut, 2022, 190:149-159. doi: 10.1016/j.actaastro.2021.10.010Ma JH#, Lin X#, Chen C, Li SY, Zhang SS, Chen ZH, Li DJ, Zhao F, Yang CF, Yin C, Qiu WX, Xiao YY, Zhang KW, Miao ZP, Yang TM*, Qian AR*, Circulating miR-181c-5p and miR-497-5p are potential biomarkers for prognosis and diagnosis of osteoporosis, J Clin Endocrinol Metab, 2020, 105(5). doi: 10.1210/clinem/dgz300Cao FJ, Wang L, Feng CL, Lin X*, Feng H*, Synthesis of polyurethane-derived nitrogen-doped carbon dots for a high-performance fluorescence bioimaging probe, Rsc Advances, 2021, 11(54). doi: 10.1039/d1ra06334k  Qiu WX#, Ma XL#, Lin X#, Zhao F, Li DJ, Chen ZH, Zhang KW, Zhang R, Wang P, Xiao YY, Miao ZP, Dang K, Wu XY, Qian AR*, Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway, J Cell Mol Med, 2020, 24(1):317-327. doi: 10.1111/jcmm.14729Lin X#, Chen Q#, Xiao YY, Gao YG, Ifty Ahmed, Li M, Li H, Zhang KW, Qiu WX, Liu XH, Aldo R. Boccaccini, Qian AR*, Phosphate glass fibers facilitate proliferation and osteogenesis through Runx2 transcription in murine osteoblastic cells, J Biomed Mater Res A, 2020, 108(2): 316-326. doi: 10.1002/jbm.a.36818Lin X#, Suryaji Patil#, Gao YG*, Qian AR*, The bone extracellular matrix in bone formation and regeneration, Front Pharmacol, 2020, 11: 757. doi: 10.3389/fphar.2020.00757（ESI高被引论文）Lin X, Zhang KW, Wei DX, Tian Y, Gao YG, Chen ZH, Qian AR*, The impact of spaceflight and simulated microgravity on cell adhesion. Int J Mol Sci, 2020, 21(9). doi: 10.3390/ijms21093031Lin X, Xiao YY, Chen ZH, Ma JH, Qiu WX, Zhang KW, Xu F, Dang K, Qian AR*, Microtubule actin crosslinking factor 1 (MACF1) knockdown inhibits RANKL-induced osteoclastogenesis via Akt/GSK3β/NFATc1 signalling pathway, Mol Cell Endocrinol, 2019, 494:110494. doi: 10.1016/j.mce.2019.110494 Suryaji Patil#, Gao YG#, Lin X#, Li Y, Dang K, Tian Y, Zhang WJ, Jiang SF, Abdul Qadir, Qian AR*. The development of functional non-viral vectors for gene delivery. Int J Mol Sci, 2019, 20(21), pii:E5491. doi: 10.3390/ijms20215491Chen ZH#, Zhao F#, Liang C#, Hu LF#, Li DJ, Zhang Y, Yin C, Chen L, Wang LY, Lin X, Su PH, Ma JH, Yang CF, Tian Y, Zhang WJ, Li Y, Peng SL*, Chen WY*, Zhang G*, Qian AR*. Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli. Theranostics, 2020, 10(26):12263–12278. doi: 10.7150/thno.53009Ma XL, Su PH, Yin C, Lin X, Wang X, Gao YG, Suryaji Patil, Abdul Rouf War, Abdul Qadir, Tian Y*, Qian AR*, The roles of FoxO transcription factors in regulation of bone cells function, Int J Mol Sci, 2020, 21(3): 692. doi: 10.3390/ijms21030692Chen ZH#, Zhang Y#, Zhao F, Yin C, Yang CF, Wang X, Wu ZX, Liang SJ, Li DJ, Lin X, Tian Y, Hu LF*, Li Y*, Qian AR*. Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression. Int J Mol Sci, 2020, 21(4):1259. doi: 10.3390/ijms21041259Dang K#, Zhang WJ#, Jiang SF, Lin X, Qian AR*, Application of lectin microarrays for biomarker discovery. ChemistryOpen, 2020, 9(3):285-300. doi: 10.1002/open.201900326Gao YG, Liu FL, Suryaji Patil, Li DJ, Abdul Qadir, Lin X, Tian Y, Li Y, Qian AR*, 1,8-Naphthalimide-based multifunctional compounds as Cu2+ probes, lysosome staining agents, and non-viral vectors, Front Chem, 2019, 7:616. doi: 10.3389/fchem.2019.00616Abdul Qadir#, Gao YG#, Patil Suryaji, Tian Y, Lin X, Dang K, Jiang SF, Li Y, Miao ZP, Qian AR*. Non-Viral Delivery System and Targeted Bone Disease Therapy. Int J Mol Sci, 2019, 20(3), pii:E565. doi: 10.3390/ijms20030565Gao YG, Lin X, Dang K, Jiang SF, Tian Y, Liu FL, Li DJ, Li Y, Miao ZP, Qian AR*. Structure-activity relationship of novel low-generation dendrimers for gene delivery. Org Biomol Chem, 2018, 16(42):7833-7842. doi: 10.1039/c8ob01767kLin X, He Y, Hou X, Zhang ZM, Wang R, Wu Q*, Endothelial cells can regulate smooth muscle cells in contractile phenotype through the miR-206/ARF6&NCX1/exosome axis, PLoS One, 2016, 11(3):e0152959. doi: 10.1371/journal.pone.0152959Lin X, Wu L, Zhang ZM, Yang RH, Guan Q, Hou XF, Wu Q*, MiR-335-5p promotes chondrogenesis in mouse mesenchymal stem cells and is regulated through two positive feedback loops, J Bone Miner Res, 2014, 29(7):1575-1585. doi: 10.1002/jbmr.2163Wang Y#, Jiang XL#, Yang SC, Lin X, He Y, Yan C, Wu L, Chen GQ, Wang ZY, Wu Q*, MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern, Biomaterials, 2011, 32(35):9207-9217. doi: 10.1016/j.biomaterials.2011.08.058Wang Y#, Gao R#, Wang PP, Jian J, Jiang XL, Yan C, Lin X, Wu L, Chen GQ, Wu Q*, The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARgamma signaling, Biomaterials, 2012, 32(2):485-493. doi: 10.1016/j.biomaterials.2011.09.089申请发明专利： 骞爱荣，高永光，蔺枭，胡丽芳，张文娟，罗晓庆，赵欣，李迪杰，骨靶向肽与萘酰亚胺修饰的树形高分子转基因载体、其制备方法及应用[P]，申请号：201810620827.0骞爱荣，田野，王雪，蔺枭，裴佳伟，苏佩红，印崇，谭慎行，赵欣，一种治疗骨质疏松的组合物，申请号：201910855234.7会议报告： Xiao Lin, Chao Yan, Yang Wang, Qiong Wu*. MicroRNA Regulating Cell Differentiation on PHA materials, The 13th International Symposium on Biopolymers, Cairns, Australia, 7 - 10 October 2012 Xiao Lin, et al. Microtubule actin crosslinking factor 1 (MACF1) positively controls osteoclastogenesis by regulating cell migration and fusion, 第九届国际骨质疏松和骨矿盐疾病学术会议（IOCBR 2018），优秀论文奖，2018.10Xiao Lin, et al. Microtubule actin crosslinking factor 1 (MACF1) positively controls osteoclastogenesis and bone resorption activity，陕西省细胞生物学学会2018年年会，优秀墙报奖，2018.11Xiao Lin, et al. Microtubule actin crosslinking factor 1 (MACF1) knockdown inhibits RANKL-induced osteoclastogenesis via Akt/GSK3β/NFATc1 signalling pathway. 2019 ASBMR Annual meeting.  Olando, USA, 19 - 23 September 2019 (poster)

学术成果

荣誉获奖 Awards Information （2015）博士研究生国家奖学金（2011）北京市优秀毕业生；校级优秀毕业生，校级优秀党员；院级优秀毕业论文；中国农业大学食品学院本科生科技创新二等奖（2010）校长奖学金（学校最高荣誉）；国家奖学金；中国农业大学学习优秀一等奖；校级三好学生；中国农业大学第二届“挑战杯”创业计划竞赛一等奖；中国农业大学第二届“兴农杯”创意大赛三等奖（2009）国家奖学金；中国农业大学学习优秀一等奖；校级三好学生；校级优秀团干部（2008）国家奖学金；中国农业大学学习优秀一等奖；校级优秀团员

综合介绍