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个人经历 personal experience 教育经历 工作经历 2009.9—2012.7：河北医科大学，分子药理学，博士，导师：张海林 2006.9—2009.7：河北医科大学，分子药理学，硕士，导师：张海林2002.9—2006.7：兰州大学，药学，学士 2019.03—至今      西北工业大学医学研究院2019.03—2020.08  军事医学研究院毒物药物研究所2017.07—2018.11   Indiana University School of Medicine, Assistant Research Professor,2015.09—2017.06    Indiana University School of Medicine，Research Associate;2012.08—2015.08    Indiana University School of Medicine，博士后，合作导师： Alexander Obukhov

教育教学

教育教学 Education and teaching 招生信息 招生专业：硕士研究生：分子药理学、基础药理学* 欢迎具有基础医学、药学、分子生物学等学习背景的同学和从业者报考硕士研究生。

荣誉获奖

科学研究 Scientific Research 研究方向 ：   1. TRP通道门控机制研究；2. 钙离子通道调控细胞钙稳态在疾病发生中的机制研究；3. 靶向钙离子通道的药物研究。主持承担科研项目：1. 国家自然科学基金青年基金：TRPC通道与创伤性脑损伤促进动脉粥样硬化的关系研究，81900402，2020-1-1 至 2022-12-312. 陕西省自然科学基金青年项目：肾上腺嗜铬细胞中TRPC1对TRPC5和VGCCs的调节作用，S2020-JC-QN-1940，2020-1至2021-123. 中央高校基本科研业务费：TRPV1和TRPA1通道相关的雌激素在痛觉减退DPN中保护DRG神经元的作用及机制研究  31020190QD001, 2019-1 至2021-12

科学研究

学术成果 Academic Achievements 发表学术论文情况（发表时间）：2024年1. Song H#, Yang S#, Wu S, Qin X, Wang Y, Ma X, Gong J, Wei M, Wang A, Wang M, Lan K, Guo J, Liu M, Chen X*, Li Y* and Lv K*. Identification of dihydroquinolizinone derivatives with nitrogen heterocycle moieties as new anti-HBV agents. Eur J Med Chem. 2024;268:116280.2023年1. Ai C#, Wang Z#, Li P, Wang M, Zhang W, Song H, Cai X, Lv K*, Chen X* and Zheng Z*. Discovery and pharmacological characterization of a novel benzimidazole TRPV4 antagonist with cyanocyclobutyl moiety. Eur J Med Chem. 2023;249:115137.2. Zhang W, Wang M, Lv W, White FA, Chen X* and Obukhov AG*. Long-Term Treatment with Gadopentetic Acid or Gadodiamide Increases TRPC5 Expression and Decreases Adriamycin Nuclear Accumulation in Breast Cancer Cells. Cells. 2023;12.3. Li X, Hu H, Liu W, Zhang Q, Wang Y, Chen X, Zhu Y, Hu Z, Wang M, Ma J and Leng L. SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts. Stem Cell Res Ther. 2023;14:361.5. Wang M, Zhang X, Guo J, Yang S, Yang F and Chen X*. TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury. Int J Mol Sci. 2023;24.6. Song M#, Cao R#, Chen X#, Wang C, Xing X, Li W, Li Y, Liao Y, Zhong W*, Li Q* and Liu Z*. Amplified Targeted Drug Delivery Independent of Target Number through Alternative Administration of Two Matched Nanoparticles. ACS Nano. 2023;17:23359-23373.7. Chen X#, Yan Y#, Song H, Wang Z, Wang A, Yang J, Zhou R, Xu S, Yang S, Li W, Qin X, Dai Q, Liu M, Lv K*, Cao R* and Zhong W*. Investigation of novel 5'-amino adenosine derivatives with potential anti-Zika virus activity. Eur J Med Chem. 2023;261:115852.8. Wang Z, Yang S, Dai Q, Guo X, Li Y, Li W, Yang X, Yang J, Yan X, Tao H, Luo C, Li S, Chen X*, Cao R* and Zhong W*. In vitro and in vivo efficacy of Molnupiravir against Zika virus infections. Virol Sin. 2023;38:639-642.2022年及以前1. Wu H, Sun Q, Yuan S, Wang J, Li F, Gao H, Chen X, Yang R and Xu J*. AT1 Receptors: Their Actions from Hypertension to Cognitive Impairment. Cardiovasc Toxicol. 2022;22:311-325.2. Lv W, Wang Z, Wu H, Zhang W, Xu J and Chen X*. mTBI-Induced Systemic Vascular Dysfunction in a Mouse mTBI Model. Brain Sci. 2022;12.3. Li Y, Liu M, Yan Y, Wang Z, Dai Q, Yang X, Guo X, Li W, Chen X, Cao R and Zhong W*. Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo. Viruses. 2022;14.4. Hao Y, Wang Z, Frimpong F and Chen X*. Calcium-Permeable Channels and Endothelial Dysfunction in Acute Lung Injury. Curr Issues Mol Biol. 2022;44:2217-2229.5. Yan Y, Yang J, Xiao D, Yin J, Song M, Xu Y, Zhao L, Dai Q, Li Y, Wang C, Wang Z, Ren X, Yang X, Ni J, Liu M, Guo X, Li W, Chen X, Liu Z, Cao R* and Zhong W*. Nafamostat mesylate as a broad-spectrum candidate for the treatment of flavivirus infections by targeting envelope proteins. Antiviral Res. 2022;202:105325.6. Wang Z, Yan Y, Dai Q, Xu Y, Yin J, Li W, Li Y, Yang X, Guo X, Liu M, Chen X*, Cao R* and Zhong W*. Azelnidipine Exhibits In Vitro and In Vivo Antiviral Effects against Flavivirus Infections by Targeting the Viral RdRp. Viruses. 2022;14.7. Chen X, Sooch G, Demaree IS, White FA and Obukhov AG*. Transient Receptor Potential Canonical (TRPC) Channels: Then and Now. Cells. 2020;9.8. Liang KL, Bursova JO, Lam F, Chen X and Obukhov AG*. Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis. J Vis Exp. 2019.9. Chelvanambi S, Gupta SK, Chen X, Ellis BW, Maier BF, Colbert TM, Kuriakose J, Zorlutuna P, Jolicoeur P, Obukhov AG and Clauss M*. HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction Implications for Statin Treatment in HIV Patients. Circ Res. 2019;125:805-820.10. Chen X, Duan Y, Riley AM, Welch MA, White FA, Grant MB and Obukhov AG*. Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons. Molecules. 2019;24:775.11. Chen X, Taylor-Nguyen NN, Riley AM, Herring BP, White FA and Obukhov AG*. The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction. J Neuroinflammation. 2019;16:21.12. Ma W, Chen X, Cerne R, Syed SK, Ficorilli JV, Cabrera O, Obukhov AG and Efanov AM*. Catechol estrogens stimulate insulin secretion in pancreatic beta-cells via activation of the transient receptor potential A1 (TRPA1) channel. J Biol Chem. 2019;294:2935-2946.13. Li S, Hundal KS, Chen X, Choi M, Ogando DG, Obukhov AG and Bonanno JA*. R125H, W240S, C386R, and V507I SLC4A11 mutations associated with corneal endothelial dystrophy affect the transporter function but not trafficking in PS120 cells. Exp Eye Res. 2019;180:86-91.14. Chen X, Cao R and Zhong W*. Host Calcium Channels and Pumps in Viral Infections. Cells. 2019;9.15. Chen X#, Liu D#, Zhou D, Si Y, Xu D, Stamatkin CW, Ghozayel MK, Ripsch MS, Obukhov AG#, White FA# and Meroueh SO#. Small-molecule CaValpha1CaVbeta antagonist suppresses neuronal voltage-gated calcium-channel trafficking. Proc Natl Acad Sci U S A. 2018;115:E10566-E10575.16. Chen X, Meroueh M, Mazur G, Rouse E, Hundal KS, Stamatkin CW and Obukhov AG*. Phenylephrine, a common cold remedy active ingredient, suppresses uterine contractions through cAMP signalling. Sci Rep. 2018;8:11666.17. Zhang J, Chen X, Xue Y, Gamper N and Zhang X*. Beyond voltage-gated ion channels: Voltage-operated membrane proteins and cellular processes. J Cell Physiol. 2018;233:6377-6385.18. Li W#, Chen X#, Riley AM, Hiett SC, Temm CJ, Beli E, Long X, Chakraborty S, Alloosh M, White FA, Grant MB, Sturek M and Obukhov AG*. Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs. Basic Res Cardiol. 2017;112:54.19. Chen X, Qian S, Hoggatt A, Tang H, Hacker TA, Obukhov AG, Herring PB and Seye CI*. Endothelial Cell-Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice. Arterioscler Thromb Vasc Biol. 2017;37:75-83.20. Chen X, Li W, Riley AM, Soliman M, Chakraborty S, Stamatkin CW and Obukhov AG*. Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel. J Biol Chem. 2017;292:898-911.21. Chen X, Li W, Hiett SC and Obukhov AG. Novel Roles for Kv7 Channels in Shaping Histamine-Induced Contractions and Bradykinin-Dependent Relaxations in Pig Coronary Arteries. PLoS One. 2016;11:e0148569.22. Luo N, Conwell MD, Chen X, Kettenhofen CI, Westlake CJ, Cantor LB, Wells CD, Weinreb RN, Corson TW, Spandau DF, Joos KM, Iomini C, Obukhov AG and Sun Y*. Primary cilia signaling mediates intraocular pressure sensation. Proc Natl Acad Sci U S A. 2014;111:12871-6.23.  Hiett SC#, Owen MK#, Li W#, Chen X#, Riley A, Noblet J, Flores S, Sturek M, Tune JD and Obukhov AG*. Mechanisms underlying capsaicin effects in canine coronary artery: implications for coronary spasm. Cardiovasc Res. 2014;103:607-18.24.  Chen X, Sun W, Gianaris NG, Riley AM, Cummins TR, Fehrenbacher JC and Obukhov AG*. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel. J Biol Chem. 2014;289:9600-10.25. Guan B, Chen X and Zhang H. Two-electrode voltage clamp. Methods Mol Biol. 2013;998:79-89.26. Gao H, Chen X, Du X, Guan B, Liu Y and Zhang H*. EGF enhances the migration of cancer cells by up-regulation of TRPM7. Cell Calcium. 2011;50:559-68.27. Chen X#, Zhang X#, Jia C, Xu J, Gao H, Zhang G, Du X and Zhang H*. Membrane depolarization increases membrane PtdIns(4,5)P2 levels through mechanisms involving PKC betaII and PI4 kinase. J Biol Chem. 2011;286:39760-7.28.  Zhang X#, Chen X#, Jia C, Geng X, Du X and Zhang H*. Depolarization increases phosphatidylinositol (PI) 4,5-bisphosphate level and KCNQ currents through PI 4-kinase mechanisms. J Biol Chem. 2010;285:9402-9.

学术成果

综合介绍