王京
时间:2024-04-06 01:38 来源: 作者: 点击:次
综合介绍 General Introduction 王京博士（https://www.scopus.com/authid/detail.uri?authorId=57200917883）曾跟随无创产前诊断之父、卢煜明院士从事重大疾病相关无创基因诊断技术的原创研究。课题组聚焦传染疾病诊断相关领域的研究热点及前沿问题，针对肿瘤等重大疾病的防治难题，开展基于CRISPR/Cas技术和纳米材料的可视化分析方法的研究，探索具有临床应用潜力的无创诊断技术。在CRISPR基因检测平台建设、新探针开发与核酸扩增新方法探索等方面取得了阶段性进展，开发了一系列肿瘤可视化筛查平台，在Biosensors and Bioelectronics、Analytical Chemistry等高水平期刊上发表论文30余篇，申请中国专利15项，授权10项。 个人相册 教育教学个人经历 personal experience 工作经历 教育经历 2019/08–至今 西北工业大学医学研究院 副教授2020/01–2021/01 香港中文大学 博士后 导师：卢煜明 院士 2016/09–2019/06 中山大学 分析化学 理学博士 导师：凌连生 教授 2012/09–2015/06 西南科技大学 化学 理学硕士 导师：林晓艳 教授 荣誉获奖教育教学 Education and teaching 招生信息 招生专业：硕士研究生：药学、生物与医药研究方向：A. 基于CRISPR/Cas技术新诊断方法的建立与应用研究；B. 纳米材料在疾病诊断领域的应用研究；C. 新一代核酸诊断肿瘤技术的开发。硕士期间，课题组提供海外交流机会，硕士期间表现优秀者，可推荐至海外高校攻读博士。联系方式：jwang0321@nwpu.edu.cn 科学研究获奖信息 The winning information （1）课题组获得2023年中国分析测试协会科学技术二等奖；（2）课题组学生刘建华获得国家奖学金；（3）课题组学生杨锡芳获得西北工业大学“自强之星”荣誉称号（全校仅10名）；（4）课题组学生多次获得西北工业大学一等学业奖学金；（5）课题组多名毕业生被评为西北工业大学优秀毕业生。 学术成果学术成果 Academic Achievements 代表性论文：[1] SZ Jing, X. Wu, D. Niu, J. Wang, C.-H. Leung*, W. Wang*. “Recent Advances in Organometallic NIR Iridium(III) Complexes for Detection and Therapy” Molecules, 2024, 29, 256. (Impact factor: 4.6，化学二区)[2] X. Yang, S.-C. Nao, C. Lin, L. Kong, J. Wang, C.-N. Ko, J. Liu*, D.-L. Ma, C.-H. Leung*, W. Wang*. “A cell-impermeable luminogenic probe for near-infrared imaging of prostate-specific membrane antigen in prostate cancer microenvironments” Eur. J. Med. Chem., 2023, 259, 115659. (Impact factor: 6.7，药学一区)[3] L. Wang, J. Liu, F. Chen, G. Li, J. Wang, D. S-H Chan, C.-Y. Wong*, W. Wang*, C.-H. Leung*. “A Switch-On Affinity-Based Iridium(III) Conjugate Probe for Imaging Mitochondrial Glutathione S-Transferase in Breast Cancer Cells” Bioconjugate Chem., 2023, 34, 1727. (Impact factor: 4.7，化学二区)[4] X. Wang, S. Jing, W. Wang*, J. Wang*. “Direct and noninvasive fluorescence analysis of an RNA-protein interaction based on a CRISPR/Cas12a-powered assay” Spectrochim. Acta A Mol. Biomol. Spectrosc., 2023, 299, 122884. (Impact factor: 4.3，化学二区)[5]W. Wang*, J. Liu, L. Kong, L. Wang, D. Niu, J. Wang*, C.-H. Leung*. “Synthesis and luminescence monitoring of iridium(III) complex？functionalized gold nanoparticles and their application for determination of gold(III) ions” Microchim. Acta, 2023, 190, 171 (Impact factor: 5.7, 化学二区)[6] C. Lin, X. Wang, S.-C. Nao, J. Wang, J. Liu*, D.-L. Ma, W.-G. Zhu, C.-H. Leung*, W. Wang*, “A labile iridium(III) complex-based luminogenic probe for the ratiometric detection of dithiocarbamate compounds in living system” Sens. Actuator B-Chem., 2023, 377, 133006. (Impact factor: 8.4, 化学一区)[7] Jingqi Liu, Xueliang Wang, Jing Wang* , Chung-Hang Leung*, Wanhe Wang*,Imaging mitochondrial palladium species in living cells with a NIR iridium (III) complex, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 288 (2023) 122188. （IF: 4.831, 化学二区）[8] Wanhe Wang*, Jianhua Liu, Sang-Cuo Nao, Dik-Lung Ma, Jing Wang* and Chung-Hang Leung*, Affinity-Based Luminescent Iridium(III) Complexes for the Detection of Disease-Related Proteins, Inorganics, 10 (2022), 178. (Invited, IF: 3.149, 化学三区) [9] Jing Wang*, Xifang Yang, Xueliang Wang and Wanhe Wang*, Recent Advances in CRISPR/Cas-Based Biosensors for Protein Detection, Bioengineering, 9 (2022) 512. (Invited, IF: 5.046)[10] Jing Wang*, Xueliang Wang, Kai Yang, Sijun Hu and Wanhe Wang*, Self-Assembly of Small Organic Molecules into Luminophores for Cancer Theranostic Applications, Biosensors, 12 (2022) 683. (Invited, IF: 5.519, 分析化学二区) [11] Wanhe Wang, Xueliang Wang,Jingqi Liu, Chuankai Lin, Jianhua Liu, Jing Wang*, The integration of gold nanoparticles with polymerase chain reaction for constructing colorimetric sensing platforms for detection of health-related DNA and proteins, Biosensors, 12 (2022) 421. (Invited, IF: 5.519, 分析化学二区)[12] ChuankaiLin1, JingWang1, KaiYang, JinbiaoLiu, Dik-LungMa, Chung-HangLeung, WanheWang, Development of a NIR iridium(III) complex for self-calibrated and luminogenic detection of boron trifluoride, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 282 (2022) 121658. （IF: 4.831, 化学二区）[13] Wanhe Wang, Jingqi Liu, Xiaoxia Li, Chuankai Lin, Xueliang Wang, Jianhua Liu, Liansheng Ling, Jing Wang*. CRISPR/Cas12a-based biosensor for colorimetric detection of serum prostate-specific antigen by taking nonenzymatic and isothermal amplification, Sensors and Actuators B: Chemical, 354 (2022),131228. (IF: 9.221, 分析化学一区)[14] Wanhe Wang, Jianhua Liu, Li-An Wu, Chung-Nga Ko, Xueliang Wang, Chuankai Lin, Jingqi Liu, Liansheng Ling, Jing Wang*. Nicking enzyme-free strand displacement ampli？cation-assisted CRISPR-Cas-based colorimetric detection of prostate-specific antigen in serum samples, Analytica Chimica Acta, 1195(2022), 339479. (IF: 6.911, 化学二区)[15] Jing Wang, Ji Zhang, Tingting Li, Ruidi Shen, Gongke Li, Liansheng Ling, Strand displacement amplification-coupled dynamic light scattering method to detect urinary telomerase for non-invasive detection of bladder cancer, Biosensors and Bioelectronics, 131 (2019) 143-148. (IF: 12.545, 工程技术一区)[16] Jing Wang, Tingting Li, Ruidi Shen, Gongke Li, and Liansheng Ling*, Polymerase Chain Reaction-Dynamic Light Scattering sensor for DNA and protein by using both replication and cleavage properties of Taq polymerase, Analytical Chemistry, 91 (2019), 3429-3435. (IF: 8.008, 化学一区)[17] Jing Wang, Xiaoyan Lin, Xuegang Luo, Yufeng Long, A sorbent of carboxymethyl cellulose loaded with zirconium for the removal of fluoride from aqueous solution, Chemical Engineering Journal, 252 (2014) 415-422. (IF: 16.744, 工程技术一区)[18] Jing Wang, Tingting Li, Haigang Li, Gongke Li, Shixin Wu, Liansheng Ling, A universal colorimetric PCR biosensor based upon triplex formation with the aid of Ru(phen)2dppx2+, Sensors and Actuators B: Chemical, 278 (2019) 39-45. (IF: 9.221, 分析化学一区)[19] Jing Wang, Haigang Li, Tingting Li, Liansheng Ling, Determination of bacterial DNA based on catalytic oxidation of cysteine by G-quadruplex DNAzyme generated from asymmetric PCR: Application to the colorimetric detection of Staphylococcus aureus, Microchimica Acta, 185 (2018) 410-418. (IF: 6.408, 化学二区)[20] Jing Wang, Xiaoyan Lin, Xuegang Luo, Wenhui Yao, Preparation and characterization of the linked lanthanum carboxymethylcellulose microsphere adsorbent for removal of fluoride from aqueous solutions，Royal Society of Chemistry Advances, 5(2015) 59273-59285. (IF: 4.036, 化学三区)[21] Jing Wang, Haigang Li, Tingting Li, Ji Zhang, Liansheng Ling, An efficient template-independent polymerase chain displacement reaction for the detection of Salmonella typhimurium, Analytical Methods, 10(2018)4229-4232. (IF: 3.532, 光谱学二区)[22] Jing Wang, Xiaoyan Lin, Heng Zhu, Xuegang Luo, Jianping Zhang, Preparation, Characterization, and Adsorption Properties of Amino-Alky Cellulose for 2, 4, 6-Trinitrotoluene, Polycyclic Aromatic Compounds, 34 (2014) 372-387. (IF: 2.195, 化学三区) [23] Xiaoting Guo, Jing Wang(co-first author), Zhifang Zhu, Manjun Zhang, Haigang Li, Jianmin Liu,Liansheng Ling, A colorimetric method for the sequence-specific recognition of double-stranded DNA on the surface of silver-coated glass, Canadian Journal of Chemistry, 96 (2018) 466-470. (IF: 1.054，化学四区) [24] Li Zou, Ruimin Li, Manjun Zhang, Yanwei Luo, Nian Zhou, Jing Wang and Liansheng Ling, A colorimetric sensing platform based upon recognizing hybridization chain reaction products with oligonucleotide modified gold nanoparticles through triplex formation, Nanoscale, 9 (2017) 1986. (IF: 8.307，化学二区) [25] Ruimin Li, Yue Zhou, Li Zou, Shumu Li, Jing Wang, Chunying Shu, Chunru Wang, Jiechao Ge, Liansheng Ling, In situ growth of gold nanoparticles on hydrogen-bondsupramolecular structures with high peroxidase-like activity at neutral pH and their application to one-pot blood glucose, sensing, Sensors and Actuators B: Chemical, 245 (2017) 656. (IF: 9.221, 分析化学一区)[26] Qiusheng Zhou, Xiaoyan Lin, Jing Qian, Jing Wang, Xuegang Luo, Porous zirconium alginate beads adsorbent for fluoride adsorption from aqueous solutions, Royal Society of Chemistry Advances, 5 (2015) 2100. (IF: 4.036, 化学三区)[27] Youli Zong, Yongde Zhang, Xiaoyan Lin, Dong Ye, Xuegang Luo, Jing Wang, Preparation of a novel microsphere adsorbent of prussian blue capsulated in carboxymethyl cellulose sodium for Cs(I) removal from contaminated water, Journal of Radioanalytical and Nuclear Chemistry, 311(2017) 1577. (IF: 1.754，化学三区) [28] Manjun Zhang, Ruimin Li, Jing Wang, Liansheng Ling, Sequence-specific recognition of HIV-1 DNA based upon nicking-assisted strand displacement amplification and triplex DNA, Science China Chemistry, 11 (2017) 1. (IF: 10.138，化学一区) [29] Yanwei Luo, Ruimin Li, Jing Wang, Manjun Zhang, Li Zou, Liansheng Ling, An Ag + -stabilized triplex DNA molecular switch controlled hybridization chain reaction, Science China Chemistry, 12 (2017) :1. (IF: 10.138，化学一区) 代表性专利：[1] 一种基于CRISPR/Cas12a与链置换扩增反应的PSA检测方法，王万河，王京（CN113667723A）。[2] 一种超灵敏检测前列腺特异性抗原（PSA）的方法，王京，王万河（CN112301095A）。[3] 基于链替换反应和DNA修饰的金纳米粒子检测尿液中端粒酶活性的方法，凌连生，王京，李婷婷，沈瑞迪（ZL201811359762.5）。[4] 一种多倍PCR扩增方法，凌连生，李海刚，王京. （ZL201710591161.6）。[5] 基于杂交链式反应和动态光散射检测尿液中端粒酶活性的方法，凌连生，李婷婷，王京（CN109182456A）。 [6] 浓香型白酒酒体的流变学表征，陈彦，王京，张海涛，罗惠波，饶家权，卢中明，林晓艳（ZL201210219687.9）。基金：[1] 陕西省重点研发计划（一般项目），主持，2024.01-2025.12；[2] 陕西基础科学（化学、生物学）研究院科学研究计划青年项目（22JHQ082），主持，2023.01-2024.12;[3] 研究生教育教学改革项目（2021AG51），主持，2021.01-2022.12;[4] 上海市“科技创新行动计划”扬帆计划项目，主持，2021.05-2024.04；[5] 广东省基础与应用基础研究基金，主持，2021.10-2024.09；[6] 陕西省自然科学基金青年项目，主持，2021.01-2022.12；[7] 海南省重点研发计划社发领域项目，联合主持，2021.12-2023.12；[8] 中央高校基本业务资助项目，主持，2020.01-2021.12。 综合介绍 |