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综合介绍 General Introduction 个人相册

教育教学

个人经历 personal experience 工作经历 教育经历 2019.11 – 至今 西北工业大学 医学研究院 副教授 硕士生导师2017.10 – 2019.10 西安交通大学 前沿科学技术研究院 李鹏飞教授课题组 博士后 2012.09 - 2017.06  四川大学 生物治疗国家重点实验室 药物化学  理学博士  导师： 陈元伟教授， 钮大文教授2008.09 - 2012.07  四川大学 化学学院 化学类 理学学士

荣誉获奖

教育教学 Education and teaching 招生信息 招生专业：硕士研究生：药物化学，有机化学研究方向：抗肿瘤小分子药物设计与合成；有机合成方法学*欢迎对有机化学和药物化学感兴趣的同学咨询和报考，同时也欢迎想参加早期科研训练的本科同学。

科学研究

获奖信息 The winning information 2019-2020 年度 Bentham Ambassador

学术成果

科学研究 Scientific Research 有机硼化学：手性有机硼化合物作为有机合成的重要中间体，可以应用于Suzuki反应等，也可以转化为O、N、F等官能团，在药物和天然产物的合成中发挥着重要作用，同时，这类化合物的生物活性也受到越来越多的关注（例如Velcade、Crisaborole等），高选择性地合成有机硼类化合物具有重要的意义。团队致力于开发新型、高效的有机硼化合物合成方法。抗肿瘤小分子药物设计与合成：癌症严重威胁着人类的健康，而在中国，癌症已经成为最主要的死亡原因之一。癌症已经成为一个重要的公共卫生问题，其治疗措施一直是科学家研究的重点 。团队致力于开发含硼类抗肿瘤小分子化合物。

综合介绍

学术成果 Academic Achievements 论文发表：18. Jinhui Han, Xirong Liu, Hao Jin, Panchi Guo, Liang Xu, Pengfei Li* and Miao Zhan*, Iridium-catalyzed doubly stereoconvergent allylic alkylation of racemic α-boryl organozinc reagents, Chem Catal. (IF:10.8), 2024, 4, 100858. https://doi.org/10.1016/j.checat.2023.100858 17. Hao Jin, Jinhui Han, Xirong Liu, Chao Feng, and Miao Zhan*, Access to Diverse Organoborons by α-Deprotonation and Functionalization of Benzylboronates, Org. Lett. 2023, 25, 22, 4168–4172. https://doi.org/10.1021/acs.orglett.3c01465 (Highlighted by Org. Process Res. Dev. 2023, 27, 10, 1827–1840）16. Panchi Guo, Hao Jin, Jinhui Han, Liang Xu, Pengfei Li*, and Miao Zhan*, Nickel-Catalyzed Negishi Cross-Coupling of Alkyl Halides, Including Unactivated Tertiary Halides, with a Boron-Stabilized Organozinc Reagent, Org. Lett. 2023, 25, 8, 1268–1273. https://doi.org/10.1021/acs.orglett.3c0005115. Panchi Guo and Miao Zhan*, Iridium-Catalyzed Enantioconvergent Allylation of a Boron-Stabilized Organozinc Reagent, J. Org. Chem. 2021, 86, 14, 9905–9913. https://doi.org/10.1021/acs.joc.1c01076Before NWPU14. M. Zhan, P. Song, J. Jiao, P. Li, Novel Chiral Ligands‐Enabled Transition‐Metal‐Catalyzed Asymmetric C–H Borylation, Chin. J. Chem. 2020, 38, 665-667.https://doi.org/10.1002/cjoc.20200002313. M. Zhan, Z. Ding, S. Du, H. Chen, C. Feng, M. Xu, Z. Liu, M. Zhang, C. Wu, Y. Lan*, P. Li*, A unified approach for divergent synthesis of contiguous stereodiads employing a small boronyl group，Nat. Commun., 2020, 11, 792. (IF: 11.87) https://doi.org/10.1038/s41467-020-14592-712. M. Zhan, X. Pu, B. He, D. Niu, X. Zhang*, “Intramolecular Umpolung Allylation of Imines” Org. Lett. 2018, 20, 5857-5860. (IF: 6.49) https://doi.org/10.1021/acs.orglett.8b0253611. M. Zhan, Y. Deng, L. Zhao*, G. Yan, F. Wang, Y. Tian, L. Zhang, H. Jiang, Y. Chen*, “Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors” J. Med. Chem. 2017, 60, 4023-4035. (IF: 6.25) https://doi.org/10.1021/acs.jmedchem.7b0035710. M. Zhan, R.-Z. Li, Z.-D. Mou, C.-G. Cao, J. Liu*, Y.-W. Chen*, D. Niu*, “Silver-Assisted, Iridium-Catalyzed Allylation of Bis[(pinacolato)boryl]methane Allows the Synthesis of Enantioenriched Homoallylic Organoboronic Esters” ACS Catal., 2016, 6, 3381 -3386. (IF: 11.38) https://doi.org/10.1021/acscatal.6b007199. M. Zhan, R. Xu, Y. Tian, H. Jiang, L. Zhao, Y. Xie*, Y. Chen*, “A Simple and Cost-Effective Method for the Regioselective Deuteration of Phenols” Eur. J. Org. Chem. 2015, 3370–3373.（ IF: 2.88）https://doi.org/10.1002/ejoc.201500192 8. M. Zhan, H. Jiang, X. Pang, T. Zhang, R. Xu, L. Zhao, Y. Liu, Y. Gong, Y. Chen* “A convenient method for the Ru(0)-catalyzed regioselective deuteration of N-alkyl-substituted anilines” Tetrahedron Lett. 2014, 55, 5070-5073.（ IF: 2.1 2）https://doi.org/10.1016/j.tetlet.2014.07.0717. M. Zhan, T. Zhang, H. Huang, Y. Xie*, Y. Chen* “A simple method for α-position deuterated carbonyl compounds with pyrrolidine as catalyst” J. Label Compd. Radiopharm. 2014, 57, 533–539.（ IF: 1.42）https://doi.org/10.1002/jlcr.32106. Ruixue Xu, Ye Tian, Shenzhen Huang, Jiang Yu, Yufang Deng, Miao Zhan, Tao Zhang, Fangying Wang, Lifeng Zhao, Yuanwei Chen*， Synthesis and evaluation of novel thiazole‐based derivatives as selective inhibitors of DNA‐binding domain of the androgen receptor, Chem Biol Drug Des. 2018;91:172–180. https://doi.org/10.1111/cbdd.130685. Shiwei Guo, Xuehai Pang, Lingling Peng, Miao Zhan, Lei Fan, Yu Gong, Fanyuan Kang, Yuanwei Chen*, Design, synthesis and biological evaluation of deuterated Tivozanib for improving pharmacokinetic properties, Bioorg. Med. Chem. Lett. 2015, 2425–2428. https://doi.org/10.1016/j.bmcl.2015.03.0884. Ruixue Xu, Miao Zhan, Lingling Peng, Xuehai Pang, Jun Yang, Tao Zhang, Hongxia Jiang, Lifeng Zhao, Yuanwei Chen*, Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties, J. Label Compd. Radiopharm, 2015, 58, 308–312. https://doi.org/10.1002/jlcr.32993. Yizhao Ouyang, Miao Zhan, Jing Zhou, Jiao Jiao, Hao Hu, Yoichi M. A. Yamada, Pengfei Li, Z‐bpy, a New C2‐Symmetric Bipyridine Ligand and Its Application in Enantioselective Copper(I)‐Catalyzed Cyclopropanation of Olefins, Chin. J. Chem. 2019, 37, 807－810. https://doi.org/10.1002/cjoc.2019001412. Hongbao Sun, Xiaoyan Wang, Miao Zhan, Jie Liu, Yongmei Xie, Facile synthesis of novel tetrasubstituted 1-pyrazolines from Baylis–Hillman adducts and acyl diazomethanes, Tetrahedron Letters, 2013, 3846–3850. https://doi.org/10.1016/j.tetlet.2013.05.0411. Fangying Wang, Hongxia Jiang, Yufang Deng, Jiang Yu, Miao Zhan*, Lifeng Zhao*, Yuanwei Chen*, Design, synthesis and biological evaluation of deuterated Vismodegib for improving pharmacokinetic properties, Bioorganic & Medicinal Chemistry Letters, 2018, 2399–2402. https://doi.org/10.1016/j.bmcl.2018.06.025主持基金项目：陕西省重点研发（一般项目）广东省面上国家自然科学基金（青年）西北工业大学新进教师科研启动经费博士后面上基金