教师主页移动版

个人经历 personal experience 工作经历 教育经历 2020/04 –   至今，       西北工业大学，柔性电子研究院，教授2017/10 – 2019/10，  纽约州立大学布法罗分校，激光、光子学、生物光子学研究中心，博士后2016/07 – 2017/09，  南京工业大学，先进材料研究院，博士后 2011/09 – 2012/03，新加坡南洋理工大学，生物工程学院，联培博士2010/09 – 2016/07，南京邮电大学，材料科学与工程学院，博士2006/09 – 2010/06，河南工业大学，化学与化工学院，学士

教育教学

教育教学 Education and teaching 教育教学 招生信息 本科生课程《柔性电子---生物电子学》                 《有机电子学导论》研究生课程《生物医学光子学》 每年招收具有化学、光学、材料、医学背景的硕士研究生2-3名，博士研究生1-2名。课题组经费充足、实验条件完善，鼓励和支持各种形式的联合培养和交流合作，热忱欢迎具有化学、材料、光学、生物光子学、有机光电器件等研究背景的硕士、博士研究生或博士后加盟！

荣誉获奖

科学研究 Scientific Research      本课题组主要从事超快生物光子学研究，针对光敏剂激发态动力学行为调控的关键问题，从激发态行为量化方法（新技术）、调控策略（新机制）到精准诊疗（新应用）三个层面展开研究，取得如下创新成果：（1）利用飞秒瞬态光谱技术，突破长期困扰光敏剂激发态行为探测与量化的难题，为激发态行为研究提供关键工具和理论基础；（2）将激发态行为参数融入传统构效关系分析，阐明构型变化对激发态行为调控的关键作用，提出构型调控机制，实现激发态系间窜越效率几乎从0到100%的巨大提升；提出激发态再吸收机制，开启近红外光声成像新模式，降低所需激光强度至少6个量级；（3）依据构型调控新机制，构建系间窜越可逆开关的光敏剂，实现光诊疗性能的精准调控，为解决光敏剂在体内滞留所导致的光毒性难题提供新方案。上述研究沿着“分子结构-激发态动力学行为-光学性能”这一研究主线，从微观分子角度深入认识材料激发态动力学行为，实现高性能医学光功能材料的理性设计及功能强化。近五年以第一作者或通讯作者在Adv.  Mater., J. Am. Chem. Soc., Acc. Chem. Res., Angew. Chem. Int. Ed. (5篇), Adv. Funct. Mater.等期刊发表SCI论文20余篇，其中5篇文章为ESI高被引论文。主持国家级项目2项，省部级项目5项。任中国光学学会“生物医学光子学专业委员会”青年委员，卓越计划高起点BMEMat 期刊青年编委，中国激光杂志社和《中国激光》期刊青年编委。主持项目1、国家自然科学基金面上项目，2022-2025，主持2、西北工业大学“翱翔新星”，2023-2024,  主持3、西北工业大学基础研究创新能力专项项目，2022-2023,  主持4、宁波市自然科学基金重点项目，2021-2024,  主持5、国家自然科学基金青年项目，2021-2023，主持

科学研究

社会兼职 Social Appointments 1、中国光学学会“生物医学光子学专业委员会”青年委员2、中国感光学会“光学传感与诊疗”专业委员会委员3、卓越计划高起点BMEMat 期刊青年编委4、卓越计划高起点VIEW期刊青年编委5、中国激光杂志社和《中国激光》期刊青年编委

学术成果

学术成果 Academic Achievements 近期研究成果入职西北工业大学后成果1.    Near-infrared-II-excited Triplet Fusion Upconversion with Anti-Stokes Shift Approaching the Theoretical Limit. J. Am. Chem. Soc. 2024, Accepted2.    Shedding Light on Imaging Safety: Decoding the Origin of Photocytotoxicity in RhB-Assisted Fluorescence Imaging.  Journal of Biophotonics 2024, Accepted3.    Minghui Li, Guojing Chen, Mingxuan Jia, Jie Zhang, Xiaofei Miao, Weiyun Yao, Yibo Fan, Yajie Lu, Xin Xiao, Fan Quli,  Wenbo Hu*, Jing Li*, Tailoring the Dynamics of Excited-State Charge Transfer through Conformational Engineering to Improve Second Near-Infrared Fluorescence for High-Resolution Osteosarcoma Imaging. Small Structures 2024, 2300483.4.   Hui Zhao, Mubin He, Tingchao He, Zizi Wu, Yonghui Pan, Jia Gao, Xiaofei Miao, Junzi Li,  Huang Wei, Huili Ma*, Wenbo Hu*, Fan Quli*, Insights into the Excited State Dynamics of Donor–Acceptor Organic Photosensitizer for Precise Deep-Brain Two-Photon Photodynamic Therapy. Laser Photonics Rev. 2024, 2300917.5.     Xiaoming Hu, Zhuting Fang, Fengwei Sun, Caijun Zhu, Mingxuan Jia, Xiaofei Miao, Lingting Huang, Wenbo Hu*, Quli Fan*,  Zhen Yang*,  Wei Huang*, Deciphering Oxygen-Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron-Hole Pairs. Angew. Chem. Int. Ed. 2024, 63, e202401036.6.     Xiaofei Miao, Weiyun Yao, Ruizhe Chen, Mingxuan Jia, Can Ren, Hui Zhao, Tingchao He*, Quli Fan*, Wenbo Hu*, Excimer‐Mediated Ultrafast Intermolecular Nonradiative Decay Enables Giant Photothermal Performance for Optimized Phototheranostic. Adv. Mater. 2023, e2301739.7.     Yishen Liu, Meijia Gu, Qihang Ding, Zhiyun Zhang, Wanxia Gong, Yuan, Yuncong Yuan, Xiaofei Miao, Huili Ma, Xuechuang Hong, Wenbo Hu*, Yuling Xiao*, Highly Twisted Conformation Thiopyrylium Photosensitizers for in vivo Near Infrared-II Imaging and Rapid Inactivation of Coronavirus. Angew. Chem. Int. Ed. 2023, 62, e202214875. (Front Cover)8.     Shangyu Chen, Yonghui Pan, Chen, Kai Chen, Chen, Pengfei Chen, Shen, Qingming Shen, Sun, Pengfei Sun*, Wenbo Hu*,  Quli Fan*, Increasing Molecular Planarity through Donor/Side-Chain Engineering for Improved NIR-IIa Fluorescence Imaging and NIR-II Photothermal Therapy under 1064 nm. Angew. Chem., Int. Ed. 2023, 62, e202215372.9.     Ruizhe Chen, Yonghui Pan, Zizi Wu, Mingxuan Jia, Xiaofei Miao, Xiaomei Lu*, Quli Fan, and Wenbo Hu*, Photostable Organic Two-Photon Dyes with Ultrahigh Brightness for Long-Term Fluorescence Imaging, Chem.--Asian J., 2023, e202300351.10.     Weiyun Yao, Man Xu, Jie Li, Wenbo Hu*, Wei Huang*, Revealing Excited-State Dynamics of Type I Zinc Phthalocyanine Photosensitizer for Photodynamic Therapy. SCIENTIA SINICA Chimica 2022, 52, 1384-1392. (Front Cover)11.     Keyue Liao, Yonghui Pan, Zizi Wu, Weiyun Yao, Miao, Xiaomei Lu*, Quli Fan, Wenbo Hu*, Viscosity Effects on Excited-State Dynamics of Indocyanine Green for Phototheranostic. Chem.--Asian J. 2022, 17, e202200112.12.     Chao Yin, Hua Zhang, Bo Sun, Shangyu Chen, Xinyue Jiang, Xiaofei Miao, Pengfei Sun*, Wenbo Hu*,  Quli Fan*, Wei Huang, Remarkable Suppression of Vibrational Relaxation in Organic Semiconducting Polymers by Introducing a Weak Electron Donor for Improved NIR‐II Phototheranostics. Adv. Funct. Mater. 2021, 31, 2106575.13.      Wenbo Hu*,  Paras N. Prasad*, Wei Huang*, Manipulating the Dynamics of Dark Excited States in Organic Materials for Phototheranostics. Acc. Chem. Res. 2021, 54, 697. (Cover)14.      Zhenxiong Shi, Xu Han, Wenbo Hu*, Hua Bai, Bo Peng, Lei Ji, Quli Fan, Lin Li*, Wei Huang*, Bioapplications of Small Molecule Aza-BODIPY: From Rational Structural Design to in vivo Investigations. Chem. Soc. Rev. 2020, 49, 7533. (Front Cover)15.     Wenbo Hu, Huijuan Zhang, Guang S. He, Alexander Baev, Jun Xia*, Wei Huang*, Paras N. Prasad*, Organic NIR-II Photoacoustic Agent Utilizing Combined Two-Photon and Excited State Absorption at 1064 nm. ACS Photonics 2020, 7, 3161.16.      Xiaofei Miao, Haojie Tao, Wenbo Hu*, Yonghui Pan, Quli Fan*, Wei Huang, Elucidating the Excited-State Dynamics Behavior in Near-Infrared BODIPY Dye and Aggregates Toward Biophotonics, Sci. China Chem. 2020, 63, 1075.入职西北工业大学前成果1.     Wenbo Hu, Tingchao He, Hui Zhao, Haojie Tao, Runfeng Chen, Lu Jin, Junzi Li, Quli Fan*, Wei Huang*, Alexander Baev, Paras N. Prasad*, Stimuli Responsive Reversible Switching of Intersystem Crossing in Pure Organic Material for Smart Photodynamic Therapy, Angew. Chem. Int. Ed. 2019, 58, 11105. (Hot paper)2.      Wenbo Hu#, Xiaofei Miao#, Haojie Tao, Alexander Baev, Can Ren, Quli Fan*, Tingchao He*, Wei Huang, Paras N. Prasad*, Manipulating Nonradiative Decay Channel by Intermolecular Charge Transfer for Exceptionally-Improved Photothermal Conversion, ACS Nano. 2019, 13, 12006.3.      Zhongzheng Yu#, Wenbo Hu#, Hui Zhao, Xiaofei Miao, Yan Guan, Weizheng Cai, Zhiping Zeng, Quli Fan*, Timothy Thatt Yang Tan*, Generating New Cross Relaxation Pathways by Coating Prussian Blue on NaNdF4 for Enhanced Photothermal Agents. Angew. Chem., Int. Ed. 2019. 58, 8536.4.      Xiaofei Miao#, Wenbo Hu#, Tingchao He, Haojie Tao, Qi Wang, Run-Feng Chen, Lu Jin, Hui Zhao, Xiaomei Lu, Quli Fan*, and Wei Huang. Deciphering the Intersystem Crossing in Near-Infrared Bodipy Photosensitizer for Highly-Efficient Photodynamic Therapy. Chem. Sci. 2019, 10, 3096.5.      Tingchao He, Can Ren, Yu Luo, Qi Wang, Junzi Li, Xiaodong Lin, Chuangxiang Ye, Wenbo Hu*, and Junmin Zhang*. Water-Soluble Chiral Tetrazine Derivatives: Towards the Application of Circularly Polarized Luminescence from Upper-Excited States to Photodynamic Therapy. Chem. Sci.,2019, 10, 4163. (Inside Cover)

综合介绍