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个人经历 personal experience 工作经历 教育经历 2020.10-2023.9    西北工业大学  生命学院   博士后   合作导师：杨慧 教授2023.9-至今          西北工业大学  生命学院   副教授 2014.09-2020.06    大连理工大学   应用化学   工学博士（硕博连读）

教育教学

科学研究 Scientific Research 主要从事代谢酶及生物小分子荧光探针的开发，并将其应用于复杂生物体系中酶活性原位检测、相关疾病预诊、代谢酶抑制剂和高表达菌群的高通量筛选等诸多实用领域。同时致力于开发具备优良光动力/光热效率的新型小分子光敏剂/光热转换剂，并结合肿瘤内高表达酶或生物小分子的反应特性，实现肿瘤部位可激活响应，建立肿瘤诊疗一体化系统。主持项目：     （1）中国博士后科学基金-面上项目，2021M692646，2021-01至2022-12，8万元     （2）国家自然科学基金-青年科学基金项目，32101202，2022-01至2024-12，30万元     （3）中央高校基本科研业务费资助项目（军工科研条件建设培育项目，D5000230153），2023-01至2023-12，30万元     （4）西北工业大学新进教师科研启动费，2023-09至2025-08，20万元参加项目：     （1）国家重点研发计划，2018YFC1603001，生鲜食品中混合污染物联合毒性效应评价及风险评估技术研究-基于联合效应的混合污染物广谱筛查与检测技术研究，2018-12至2021-12，115万元     （2）国家自然科学基金-面上项目，21572029，人源羧酸酯酶1亚型选择性荧光探针设计、合成与生物学应用，2016-01至2019-12，65万元

荣誉获奖

学术成果 Academic Achievements First author(1) Zhenhao Tian#; Fei Yan#; Xiangge Tian#; Lei Feng*; Jingnan Cui; Sa Deng; Baojing Zhang; Tian Xie*; Shanshan Huang; Xiaochi Ma*; A NIR fluorescent probe for Vanin-1 and its applications in imaging, kidney injury diagnosis, and the development of inhibitor, Acta Pharmaceutica Sinica B, 2022, 12(1): 316-325(2) Zhenhao Tian#; Jiayue Wang#; Yidan Gao#; Xiaokui Huo; Zhenlong Yu; Yan Wang; Chao Wang; Lei Feng*; Jingnan Cui; Xiangge Tian*; “Domain Directional Optimization” strategy for the development of UGT1A1-activated fluorescent probe and the application in living systems. Sensors and Actuators B: Chemical, 2022, 369: 132342 (3) Zhenhao Tian#; Lei Feng#; Lu Li; Xiangge Tian; Jingnan Cui; Houli Zhang; Chao Wang*; Huilian Huang; Baojing Zhang; Xiaochi Ma*; Visualized characterization of bacterial penicillin G acylase for the hydrolysis of β-lactams using an activatable NIR fluorescent probe, Sensors and Actuators B: Chemical, 2020, 310: 127872.(4) Zhenhao Tian#; Lele Ding#; Kun Li; Yunqing Song; Tongyi Dou; Jie Hou; Xiangge Tian; Lei Feng; Guangbo Ge*; Jingnan Cui*; Rational design of a long-wavelength fluorescent probe for highly selective sensing of carboxylesterase 1 in living systems, Analytical Chemistry, 2019, 91(9): 5638-5645.(5) Zhenhao Tian#; Qingsong Yan#; Lei Feng#; Sa Deng; Chao Wang*; Jingnan Cui; Chunjie Wang; Zhanjun Zhang; Tony D. James*; and Xiaochi Ma*; A far-red fluorescent probe for sensing laccase in fungi and its application in developing an effective biocatalyst for the biosynthesis of antituberculous dicoumarin, Chemical Communications, 2019, 55(27): 3951-3954.(6) Zhenhao Tian#; Xiangge Tian#; Lei Feng; Yan Tian; Xiaokui Huo; Baojing Zhang; Sa Deng; Xiaochi Ma*; Jingnan Cui*; A highly sensitive and selective two-photon fluorescent probe for glutathione S-transferase detection and imaging in living cells and tissues, Journal of Materials Chemistry B, 2019, 7(32): 4983-4989.Corresponding author(7) Mengru Sun#; Lilin Song#; Huizhen Wei; Jinhui Shi; Bei Zhao; Tian Tian; Yunqing Song*; Zhenhao Tian*; Guanghui Zhu*; Guangbo Ge*; Rational construction of a practical enzyme-activatable fluorogenic substrate for hNotum and its applications in functional imaging and inhibitor screening, Sensors and Actuators B: Chemical, 2023, 393: 134145.Co-first author(8) Rongjing He#; Zhenhao Tian#; Jian Huang; Mengru Sun; Feng Wei; Chunyu Li; Hairong Zeng; Feng Zhang; Xiaoqing Guan; Yan Feng; Xiangming Meng; Hui Yang*; and Guangbo Ge*; Rationally Engineered CYP3A4 Fluorogenic Substrates for Functional Imaging Analysis and Drug–Drug Interaction Studies, Journal of Medicinal Chemistry,2023, 66(10): 6743-6755.  (9) Jing Ning#; Zhenhao Tian#; Jiayue Wang#; Bo Wang; Xiangge Tian; Zhenlong Yu; Xiaokui Huo; Lei Feng*; Jingnan Cui; Tony D. James; Xiaochi Ma*; Rational Design of a Two-Photon Fluorescent Probe for Human Cytochrome P450 3A and the Visualization of Mechanism-Based Inactivation, Angewandte Chemie International Edition, 2022, 61(5): e202113191 (10) Fei Yan#; Zhenhao Tian#; Yonggang Yang; Xiangge Tian*; Xiuyan Han; Lei Feng*; Jingnan Cui; Xiaochi Ma*; Fluorescence-based visual analysis and inhibitor screening of Arylamine N-acetyltransferase 2, a key enzyme for tuberculosis, Sensors and Actuators B: Chemical, 2022, 373:132714 (11) Chao Wang#; Zhenhao Tian#; Ming Zhang; Ying Deng; Xiangge Tian; Lei Feng*; Jingnan Cui; Tony D. James*; Xiaochi Ma*; Visual identification of gut bacteria and determination of natural inhibitors using a fluorescent probe selective for PGP-1, Analytica Chimica Acta, 2022, 1191: 339280 (12) Mingyue Zhu#; Zhenhao Tian#; Lingling Jin; Xiaokui Huo; Chao Wang; Jingnan Cui; Yan Tian*; Xiangge Tian*; Lei Feng*; A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living cells and tissues, Frontiers of Chemical Science and Engineering, 2022, 16(1): 103-111 (13) Ming Zhang#; Zhenhao Tian#; Jiayue Wang#; Xiangge Tian; Chao Wang*; Jingnan Cui; Xiaokui Huo; Lei Feng*; Zhenlong Yu; and Xiaochi Ma*; Visual analysis and inhibitor screening of leucine aminopeptidase, a key virulence factor for pathogenic bacteria-associated infection, ACS Sensors, 2021, 6(10): 3604-3610 (14) Manman Tian#; Zhenhao Tian#; Dahong Yao#; Jing Ning; Sa Deng; Lei Feng*; Xiaokui Huo; Xiangge Tian*; Baojing Zhang; Chao Wang; Zhenlong Yu; Xiaochi Ma*; A NIR fluorescent probe for fatty acid amide hydrolase bioimaging and its application in development of inhibitors, Journal of Materials Chemistry B, 2021, 9(32): 6460-6465 (15) Lei Feng#; Zhenhao Tian#; Ming Zhang; Xin He; Xiangge Tian; Zhenlong Yu; Xiaochi Ma*; Chao Wang*; Real-time identification of gut microbiota with aminopeptidase N using an activable NIR fluorescent probe, Chinese Chemical Letters, 2021, 32(10): 3053-3056 (16) Qing Hu#; Zhenhao Tian#; Haonan Wang; Jian Huang; Fangyuan Wang; Bei Zhao; Rongjing He; Qiang Jin; Xudong Hou; Jie Hou; Shengquan Fang*; Ping Wang*; Guangbo Ge*; Rational design and development of a novel and highly specific near-infrared fluorogenic substrate for sensing and imaging of human pancreatic lipase in living systems, Sensors and Actuators B: Chemical, 2021, 341: 130033.(17) Chao Wang#; Zhenhao Tian#; Yifei Wang#; Ming Zhang; Baojing Zhang; Lei Feng*; Xiangge Tian; Huilian Huang; Jingnan Cui; Xiaochi Ma*; An enzyme-activated NIR fluorescent probe for detecting bacterial glutamyltranspeptidase (γ-GT) and high-throughput screening of its inhibitors, Sensors and Actuators B: Chemical, 2021, 329: 129225.(18) Yinzhu Jin#; Zhenhao Tian#; Xiangge Tian#; Lei Feng*; Jingnan Cui; Xiaochi Ma*; A highly selective fluorescent probe for real-time imaging of bacterial NAT2 and high-throughput screening of natural inhibitors for tuberculosis therapy, Materials Chemistry Frontiers, 2019, 3(1): 145-150.(19) Lele Ding#; Zhenhao Tian#; Jie Hou; Tongyi Dou; Qiang Jin; Dandan Wang; Liwei Zou; Yadi Zhu; Yunqing Song; Jingnan Cui*; Guangbo Ge*; Sensing carboxylesterase 1 in living systems by a practical and isoform-specific fluorescent probe, Chinese Chemical Letters, 2019, 30(3): 558-562.(20) Jing Ning#; Zhenhao Tian#; Bo Wang#; Guangbo Ge; Yue An; Jie Hou; Chao Wang; Xinyu Zhao; Yannan Li; Xiangge Tian; Zhenlong Yu; Xiaokui Huo; Chengpeng Sun; Lei Feng*; Jingnan Cui; Xiaochi Ma*; A highly sensitive and selective two-photon fluorescent probe for real-time sensing of cytochrome P450 1A1 in living systems, Materials Chemistry Frontiers, 2018, 2(11): 2013-2020.(21) Xiangge Tian#; Zhenhao Tian#; Yan Wang#; Jie Hou; Lei Feng; Liang Song; Jingnan Cui; Xiaokui Huo; Xinyu Zhao; Dayong Zhou*; Chao Wang; Chengpeng Sun; Jing Ning; Xiaochi Ma*; A highly selective fluorescent probe for detecting glutathione transferases to reveal anticancer-activity sensitivity of cisplatin in cancer cells and tumor tissues, Sensors and Actuators B: Chemical, 2018, 277: 423-430.

科学研究

学术成果

综合介绍