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导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名： 蓝平 部门： 药学院 直属机构： 药学系 性别： 男 职务： 先进与应用化学合成研究院副院长 职称： 副研究员 学位： 博士 毕业院校： 澳大利亚国立大学 联系电话： 02085221367 电子邮箱： ping.lan@jnu.edu.cn 办公地址： 药学院312 通讯地址： 广州市天河区黄埔大道西601号 邮编： 510632 联系方式 个人简介 蓝平，博士，副研究员，硕士生导师。现任暨南大学先进与应用化学合成研究院副院长。主要研究方向为有机合成化学：包括天然产物全合成以及新型功能配料的研发与制备。目前主持科研项目包括国家自然科学基金青年项目1项，教育部海外名师项目1项，广东省自然科学基金面上项目1项，中央高校科研培育与创新基金1项，广州市企业横向项目3项。截止2019年9月，共发表SCI收录论文52篇，英文专著2篇，其中第一作者/通讯作者论文28篇，主要发表在Organic Letters, Journal of Organic Chemistry, Journal of Natural Products（天然产物全合成研究成果）和Journal of Colloid and Interface Science, Journal of Agricultural and Food Chemistry（功能配料研究成果）等专业TOP期刊上。 学习经历 2011.10-2015.01 澳大利亚国立大学化学研究院哲学（有机化学）博士              导师：Martin G. Banwell教授（澳大利亚科学院院士）              研究方向为天然产物全合成2008.09-2011.06 暨南大学药学院医学硕士（药物化学专业）              导师：陈卫民教授              研究方向为天然产物的结构修饰2004.09-2008.06 中南民族大学生命科学学院理学学士（药学专业） 工作经历 2019.09至今    暨南大学药学院 副高（绿色通道）2018.11至今    暨南大学先进与应用化学合成研究院 副院长2016.12-2019.07 暨南大学理工学院食品科学与工程系 副高（绿色通道）2015.10-2016.12 澳大利亚沃尔特伊丽莎医学研究所（The Walter and Eliza Hall Institute of Medical Research）博士后研究员              合作导师：Peter M. Colman教授（澳大利亚科学院院士）              Guillaume Lessene 副教授及Peter Czabotar副教授              研究方向为化学生物学2015.02-2015.10 澳大利亚国立大学化学研究院 博士后研究员              合作导师：Lewis N. Mander教授（澳大利亚科学院院士）              研究方向为天然产物全合成 主要论文 53.Lan, P.; Ye, S.; Banwell, M. G.* The application of dioxygenase-based   chemoenzymatic processes to the total synthesis of natural products. Chem.   Asian J. published online DOI: 10.1002/asia.2019009889影响因子（3.698）引用次数（0）52.Li, X.; Hai, Y. W.; Ma, D.; Chen, J.; Banwell, M.   G.; Lan, P.* Fatty acid ester surfactants   derived from raffinose: synthesis, characterization and structure-property profiles.   J. Colloid Interf. Sci. 2019,   556, 616–627.影响因子（6.361）引用次数（0）A1二区51.Chen, Y.; Chen, W. N.; Hu, N.; Banwell, M. G.; Ma,   C.;Gardiner, M.; Lan, P.* Anticarcinogenic and anti-inflammatory properties of   apigenin-derived isolaxifolin. J. Nat.   Prod. 2019, 82, 2451–2459.影响因子（4.257）引用次数（0）A1二区50.Sheng, B.; Vo, Y.; Lan, P.; Gardiner M. G.; Banwell, M.   G.*, Sun, P.* The direct and metal-catalyzed photochemical dimerization of   the phthalide (Z)-ligustilide   leading to both [2+2] and [4+2] cycloadducts: application to total syntheses   of tokinolides A-C and riligustilide. Org.   Lett. 2019, 21, 6295–6299.影响因子（6.555）引用次数（0） A1一区49.Lan, P.;   Banwell, M. G.*; Willis, A. C. Application of electrocyclic ring-opening and   desymmetrizing nucleophilic trappings of meso-6,6-dibromobicyclo[3.1.0]hexanes   to total syntheses of crinine and haemanthamine alkaloids. J. Org. Chem. 2019, 84,   3431–3466.影响因子（4.849）引用次数（0） A1二区48.Zhang, Z.; Liu, Y.; Chen, Y.*; Li, L.; Lan, P.; He, D.; Song, J.*; Zhang,   Y.* Transdermal delivery of 5-aminolevulinic acid by nanoethosome gels for   photodynamic therapy of hypertrophic scars. ACS Appl. Mater. Inter. 2019,   11, 3704–3714.影响因子（8.097）引用次数（0） A1一区47.Mikusek, J.; Nugent, J.; Lan, P.; Banwell, M. G.* A chemical synthesis study establishes   the true structure of the potent anti-inflammatory agent myrsinoic acid F. J. Nat. Prod. 2019, 82, 96–100.影响因子（4.257）引用次数（0） A1二区46.Benoit, B.; Tang, F.; Lan, P., Willis, A. C.; Banwell, M. G.* Synthetic studies on the   marine-derived sesquiterpene (+)-viridianol: divergent behaviour of two   structurally related, ring-fused cyclopropanes under the same hydrogenolytic   conditions. Aust. J. Chem.2019, 72, 305–310.影响因子（1.558）引用次数（0） A2四区45.Lan, P.;   Banwell, M. G.* Diastereoselective alkylation, allylation and benzylation   reactions (of derived amides). Encyclopedia   of Reagents for Organic Synthesis (e-EROS) 2019, In press著作章节44.Tang, F.; Lan,   P.; Benoit, B.; Banwell, M. G.*; Willis, A. C. Total   synthesis of (+)-viridianol, a marine-derived sesquiterpene embodying the decahydrocyclobuta[d]indene framework. J. Org. Chem. 2018,   83, 14049–14056.影响因子（4.849）引用次数（3） A1二区43.Yao, N.; Wang, C.; Hu, N.; Li, Y.; Liu, M.;   Lei, Y.; Chen, M.; Chen, L.; Chen, C.; Lan,   P.; Chen, W. M.; Chen, Z.; Fu, D.; Ye, W. C.; Zhang, D. M.* Inhibition of   PINK1/Parkin-dependent mitophagy sensitizes ultidrug-resistant cancer cells   to B5G1, a new betulinic acid analog. Cell  Death Dis. 2019, 10, 232.影响因子（5.638）引用次数（0）A1二区42.Liang, M. Y.; Banwell, M. G.; Wang, Y.*; Lan, P.* Effect of variations in the fatty acid residue of   lactose monoesters on their emulsifying properties and biological activities.   J. Agric. Food Chem. 2018, 66, 12594–12603.影响因子（3.412）引用次数（1）A1一区41.Qiu, Y.; Dlugosch, M.; Liu, X.; Khan, F.; Ward, J. S.; Lan, P.; Banwell, M. G.* The   reductive cyclisation of o-nitroarylated-α,β-unsaturated   aldehydes and ketones with TiCl3/HCl or Fe/HCl leading to   1,2,3,9-tetrahydro-4H-carbazol-4-ones   and related heterocycles. J. Org. Chem.2018, 83, 12023–12033.影响因子（4.849）引用次数（0）A1二区40.Moujalled, D.; Pomilio, G.; Ghiurau, C.; Ivery, A.; Salmon, J.; Rijal,   S.; Macraild, S.; Zhang, L.; Teh, T. C.; Tiong, I. S.; Lan, P.; Chanrion, M.; Claperon, A.; Rocchetti, F.; Zichi, A.;   Kraus-Berthier, L.; Wang, Y.; Halilovic, E.; Morris, E.; Colland, F.; Segal,   D.; Huang, D.; Roberts, A. W.; Maragno, A. L.; Lessene, G.; Geneste, O.; Wei.   A.* Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity   in pre-clinical models of acute myeloid leukemia. Leukemia2019, 33, 905–917.影响因子（13.164）引用次数（12）A1一区39.Ma, Y. R.; Banwell, M. G.; Yan, R.*; Lan, P.* Comparative study of the emulsifying properties of a   homologous series of long-chain 6ʹ-O-acylmaltose   esters. J. Agric. Food Chem. 2018, 66, 8832–8840.影响因子（3.412）引用次数（1）A1一区38.Lan, P.; Banwell, M. G.*; Willis, A. C. Total synthesis of (±)-crinane from   6,6-dibromobicyclo[3.1.0]hexane and using a 5-exo-trig radical   cyclisation reaction to assemble the requisite C3a-arylated perhydroindole. J. Org. Chem. 2018, 83, 8493–8498.影响因子（4.849）引用次数（2）A1二区37.Bon, D. J.-Y. D.; Mander, L. N.*; Lan,   P.*Syntheses of gibberellins A15 and A24, the key   metabolites in gibberellin biosynthesis. J.   Org. Chem. 2018,83,   6566–6572.影响因子（4.849）引用次数（0）A1二区36.Xiang, L.; Chen, J.; Yang, Y.; Xie, D.; Li, Y.; Liu, F.; Ma, H.; Wu,   F.; Chen, K.;* Wu, H.; Lan, P.;   Yuan, G.; Li, S.; Wang, Y.; Liu, J.; Zhu, J. Enhanced high permittivity and   lowed dielectric loss in cellulose-fibre framework polymer microcomposites. Polym. Composite. 2019, 40, 1526–1535.影响因子（2.324）引用次数（0）A2三区35.Liang, M. Y.; Chen, Y.; Banwell, M. G.; Wang, Y.*; Lan, P.* Enzymatic preparation of a   homologous series of long-chain 6-O-acylglucose   esters and their evaluation as emulsifiers. J. Agric. Food Chem. 2018,   66, 3949–3956.影响因子（3.412）引用次数（3）A1一区34.Chen, Y.; Lan, P.* Total Syntheses and   biological evaluation of the Ganoderma lucidum   alkaloids lucidimines B and C.   ACS Omega 2018, 3,3471–3481.影响因子（2.584）引用次数（1）新期刊，暂无分区33.Lan, P.*;   Herlt, A. J.; Willis, A. C.; Taylor, W. C.; Mander, L. N.* Structures of New   Alkaloids from rain forest trees Galbulimima belgraveana and Galbulimima baccata in Papua New Guinea, Indonesia and Northern   Australia. ACS Omega 2018,   3, 1912–1921.影响因子（2.584）引用次数（1）新期刊，暂无分区32.Taher, E. S.;   Banwell, M. G.*; Buckler, J. N.; Yan, Q.; Lan, P. The exploitation of enzymatically-derived cis-1,2-dihydrocatechols and related   compounds in the synthesis of biologically active natural products. Chem. Rec. 2018, 18, 239–264.影响因子（3.855）引用次数（9）A1二区31.Jian, J.; Fan,   J.; Yang, H.; Lan, P.; Li, M.;   Liu, P.; Gao, H.*; Sun, P. H.* Total synthesis   of the flavonoid natural   product Houttuynoid A fromhouttuynia   cordata. J. Nat. Prod. 2018, 81, 371–377. 影响因子（3.798）引用次数（2）A1二区30.Zhao, Q.; Zou, Y.; Huang, C.; Lan,   P.; Zheng, J.; Ou, S.* Formation of a hydroxymethylfurfural-cysteine   adduct and its absorption and cytotoxicity in Caco-2 cells. J. Agric. Food Chem. 2017, 65, 9902–9908.影响因子（3.412）引用次数（4）A1一区29.Brouwer, J. M.; Lan, P.; Cowan, A. D.; Bernardini, J.   P.; Birkinshaw, R. W.; van Delft, M. F.; Sleebs, B. E.; Robin, A. Y.; Wardad,   A.; Tan, I. K.; Reljic, B.; Lee, E. F.; Fairlie, W. D.; Call, M. J.; Smith,   B. J.; Dewson, G.; Lessene, G.; Colman, P. M.; Czabotar, P. E.* Conversion of   Bim-BH3 from activator to inhibitor of Bak through structure-based design. Mol. Cell 2017,68, 659–672.影响因子（14.713）引用次数（6）A1一区28.Banwell, M. G.;   Bolte, B.; Buckler, J. N.; Chang, E. L.; Lan,   P.; Taher, E. S.; White, L. V.; Willis, A. C. Chemoenzymatic pathways for   the synthesis of biologically active natural products. Journal and Proceedings of the Royal Society of New South Wales 2016, 149, 34–50. 影响因子（1.124）引用次数（9）A2四区27.Chang, E. L.; Benoit,   B.; Lan, P.; Willis, A. C.;   Banwell, M. G.* Chemoenzymatic total syntheses   of the enantiomers of the protoilludanes 8-deoxydihydrotsugicoline and radudiol.   J. Org. Chem. 2016, 81, 2078–2086.影响因子（4.849）引用次数（12）A1二区26.Lan, P.; White, L. E.;Taher,   E. S.;Guest, P. E.; Banwell, M.   G.*; Willis, A. C. Chemoenzymatic synthesis of (+)-asperpentyn and the   enantiomer of the structure assigned to aspergillusol A. J. Nat. Prod. 2015, 78, 1963–1968. 影响因子（3.798）引用次数（12）A1二区25.Lan, P.; Banwell, M. G.*; Willis, A. C. Chemoenzymatic synthesis of the   enantiomer of 4,12-dihydroxysterpurene, the structure assigned to a   metabolite isolated from the culture broth of Stereum purpureum.Org. Lett. 2015, 17, 166–169.影响因子（6.579）引用次数（12）A1一区24.Crisp,   A. L.; Li, J.; Lan, P.; Nugent,   J.; Matousova, E.; Banwell, M. G.* The Palladium-catalysed intramolecular   Alder-ene (IMAE) reactions of certain heteroatom-linked 1,6-enynes: the   formation of hexahydro-indoles and –benzofurans. Aust. J. Chem.2 015, 68, 1183–1189. 影响因子（1.558）引用次数（8）A2四区23.White,   L. V.; Lan, P.; Schwartz, B. D.;   Willis, A. C.; Banwell, M. G.* New, homochiral synthons obtained through   simple manipulations of enzymatically-derived 3-halo-cis-1,2-dihydrocatechols. Aust.   J. Chem. 2015, 68, 1467–1471.影响因子（1.558）引用次数（5）A2四区22.Banwell,   M. G.*; Buckler, J.; Jackson, C. J.; Lan,   P.; Ma, X.; Matousova, E.; Nugent, J. Devising new syntheses of the   alkaloid galanthamine, a potent and clinically deployed inhibitor of   acetylcholine esterase. Strategies   and Tactics in Organic Synthesis 2015, 11, 29–50.著作章节，引用次数（3）21.Yao, N.; Li, Y. J.; Zhang, D. M.; Liu, D. L.;   Tang, M. K.; Yiu, A.; Li, Y.; Chen, W. M.; Lan, P.; Yao, Z.; Chen, Z. S.; Ye,   W. C.* B4G2 induces mitochondrial apoptosis by the ROS-mediated opening of Ca2+-dependent   permeability transition pores. Cell.   Physiol. Biochem. 2015, 37, 838–852.影响因子（2.875）引用次数（9）A1二区20.Lan, P.;Jackson,C. J.;Banwell, M.   G.*; Willis, A. C. Synthesis of a D-ring isomer of galanthamine via a radical-based Smiles rearrangement reaction. J. Org. Chem. 2014, 79, 6759–6764.影响因子（4.849）引用次数（15）A1二区19.Lan, P.; Banwell,   M. G.*; Willis, A. C. Chemoenzymatic total   syntheses of ribisins A, B and D, polyoxygenated benzofuran derivatives   displaying NGF-potentiating properties. J.   Org. Chem.2014,   79, 2829–2842.•被选为重点推荐论文影响因子（4.849）引用次数（26）A1二区18.Lan, P.; Banwell,   M. G.*; Ward, J. S.; Willis, A. C. Chemoenzymatic total   synthesis and reassignment of the absolute configuration of ribisin C. Org. Lett. 2014, 16, 228–231.影响因子（6.579）引用次数（9）A1一区17.Zhang,   D. M.; Li, Y. J.; Shu, C.; Ruan, Z. X.; Chen, W. M.; Yiu, A.; Peng, Y. H;   Wang, J.; Lan, P.; Yao, Z.; Fung,   K. P.; Fu, L. W.; Chen, Z. S.*; Ye, W. C.* Bipiperidinyl derivatives of   23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells.   Anti-Cancer Drugs 2013, 24, 441–454.影响因子（1.784）引用次数（8）A2三区16.Lan, P.;Wu, Z. W.; Chen, W. N.; Sun, P. H.; Chen, W. M.* Molecular   modeling studies on phosphonic acid-containing thiazole derivatives: design   for fructose-1,6-bisphosphatase inhibitors. J. Mol. Model. 2012, 18, 973–990.影响因子（1.736）引用次数（3）A2四区15.Zhang, D. M.; Shu, C.; Chen, J. J.; Sodani, K.;   Wang, J.; Bhatnagar, J.; Lan, P.;   Ruan, Z. X.; Xiao, Z. J.; Ambudkar, S. V.; Chen, W. M.; Chen, Z. S.*; Ye, W.   C.* BBA, a derivative of 23-hydroxybetulinic acid, potently reverses   ABCB1-mediated drug resistance in vitro   and in vivo. Mol. Pharmaceut.2012, 9, 3147–3159.影响因子（4.384）引用次数（39）A1二区14.Lan, P.;Wang, J.; Zhang, D. M.; Shu, C.;   Cao, H. H.; Sun, P. H.; Wu, X. M.; Ye, W. C.*; Chen, W. M.* Synthesis andantiproliferative evaluation of 23-hydroxybetulinic acid   derivatives. Eur. J. Med. Chem. 2011, 46, 2490–2502.影响因子（4.816）引用次数（24）A1二区13.Lan, P.;Chen, W. N.; Chen, W. M.* Molecular modeling studies on   imidazo[4,5-b]pyridine derivatives as Aurora A kinase inhibitors using   3D-QSAR and docking approaches. Eur. J.   Med. Chem. 2011, 46, 77–94.    影响因子（4.816）引用次数（38）A1二区12.Lan, P.;Chen, W. N.; Huang, Z. J.; Sun, P.   H.; Chen, W. M.* Understanding the structure-activity relationship   of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and   docking. J. Mol. Model.2011, 17, 1643–1659.影响因子（1.736）引用次数（17）A2四区11.Lan, P.;Sun, J. R.; Chen, W. N.; Sun, P. H.; Chen, W. M.* Molecular   modeling studies on d-annulated   benzazepinones as VEGF-R2 kinase inhibitors using docking and 3D-QSAR. J. Enzym. Inhib. Med. Chem.2011, 26, 367–377.影响因子（3.638）引用次数（8）A1二区10.Lan, P.;Chen, W. N.; Sun, P. H.; Chen, W. M.* 3D-QSAR and molecular   docking studies of azaindole derivatives as Aurora B kinase inhibitors. J. Mol. Model.2011, 17, 1191–1205.影响因子（1.736）引用次数（11）A2四区9.Lan, P.;Chen, W. N.; Sun, P. H.; Chen, W. M.* 3D-QSAR studies on   betulinic acid and betulin derivatives as anti-HIV-1 agents using CoMFA and   CoMSIA. Med. Chem. Res.2011, 20,1247–1259.影响因子（1.402）引用次数（4）A2四区8.Sun, J. R.; Lan, P.; Sun, P. H.; Chen, W. M.* 3D-QSAR   and docking studies on pyrrolopyrimidine derivatives as LIM-Kinase 2 inhibitors.   Lett. Drug Des. Discov.2011, 8, 229–240.影响因子（1.170）引用次数（8）A2四区7.Huang, Z. J.; Zeng, Y.; Lan, P.; Sun, P. H.;   Chen, W. M.* Advances in structural modifications and biological activities   of berberine: an active compound in traditional Chinese medicine. Mini-Rev. Med. Chem.2011, 11, 1122–1129. 影响因子（2.645）引用次数（45）A2三区6.Song, Q. L.; Guo, B. Q.; Zhang, W.; Lan, P.;Sun, P. H.; Chen,   W. M.* Design, synthesis and antibacterial activity of novel ketolides   bearing an aryltetrazolyl-substituted alkyl side chain. J. Antibiot.2011, 64, 571–581.影响因子（2.150）引用次数（6）A2三区5.Wu, X.; Lan,   P.; Liu, Z.; Ruan, Z. X.; Wang, H.; Wang, G. C.; Ye, W. C.; Li, Y. L.   3D-QSAR studies of natural steroidal saponins as anticancer agents in human   nasopharyngeal carcinoma epithelial cells. Lett. Drug Des. Discov. 2013, 10,   245–252.影响因子（1.170）引用次数（1）A2四区4.Lan, P.;Xie, M. Q.; Yao, Y. M.; Chen, W. N.; Chen, W. M.* 3D-QSAR   studies and molecular docking on [5-(4-Amino-1H-benzoimidazol-2-yl)-furan-2-yl]-phosphonic acid derivatives as   fructose-1, 6-biphophatase inhibitors. J.   Comput. Aided Mol. Des.2010, 24, 993–1008.影响因子（2.990）引用次数（11）A2三区3.Lan, P.;Chen, W. N.; Xiao, G. K.; Sun, P. H.; Chen, W. M.* 3D-QSAR and docking   studies on pyrazolo[4,3-h]quinazoline-3-carboxamides as cyclin-dependent   kinase 2 (CDK2) inhibitors. Bioorg.   Med. Chem. Lett. 2010, 20, 6764–6772.影响因子（2.420）引用次数（36）A2三区2.Lan, P.;Huang, Z. J.; Sun, J. R.; Chen, W. M.* 3D-QSAR and molecular   docking studies on fused pyrazoles as p38α mitogen-activated protein kinase   inhibitors. Int. J. Mol. Sci.2010, 11, 3357–3374.影响因子（2.862）引用次数（27）A2三区1.Hu, L.; Lan,   P.;Song, Q. L.; Huang, Z. J.; Sun, P. H.; Zhuo, C.; Wang, Y.; Xiao,   S.; Chen, W. M.* Synthesis and antibacterial activity of C-12 pyrazolinyl   spiro ketolides. Eur. J. Med. Chem.2010, 45, 5943–5949.影响因子（3.447）引用次数（12）A1二区 承担课题 7.基于稠环偕二卤代环丙烷开环反应的活性天然产物全合成研究，广东省自然科学基金面上项目，2019-2022，10万，主持，编号：2019A15150112816.TBHQ的新型合成工艺研究，横向课题，广东广业清怡食品科技有限公司，2019-2021，30万，主持5.基于稠环偕二卤代环丙烷不对称开环反应的天然产物全合成研究，国家自然科学基金（青年项目），2019-2021，25万，主持，编号：218010944.“功能性食品配料绿色合成研究”，教育部海外名师项目， 2018-2023，100万，主持，编号：2018-HWMS0013.Fissitungfine   A的全合成与抗增殖活性研究，科研培育与创新基金，2017-2020，15万，主持，编号：216173272.高纯度蔗糖脂肪酸单酯绿色制备研究，横向课题，广州嘉德乐生化科技有限公司，2018-2021，10万，主持1.山苍子精油绿色萃取及综合利用技术开发与产业化示范，广东省“扬帆计划”引进创新创业团队，2017-2022，300万，参与   发明专利 3.蓝平，海耀文，李璇。6-O-酰基棉子糖单酯及其合成方法。中国专利申请：201910520028.0，2019-06-17.（已受理）2.蓝平，汪勇，滕英来，杜木香. 提高木酚素油溶性的改性方法[P]. 中国专利申请：201910547527.9,   2019-06-24. （已受理）1.叶文才，陈卫民，蓝平，张冬梅，王娇，舒畅，曹惠惠，于淼。23-羟基白桦酸衍生物及其制备方法和用途。中国发明专利 (公开号CN102108092A)   讲授课程