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导航 个人简介 学习经历 工作经历 研究方向 主要论文 主要著作 承担课题,个人信息 姓名： 何留民 部门： 生命科学技术学院 直属机构： 生物医学工程系 性别： 男 职称： 副研究员 学位： 博士 毕业院校： 中山大学 电子邮箱： tlmhe@jnu.edu.cn 邮编： 510632 荣誉奖励： 省级青年人才 联系方式 个人简介 长期专注于神经组织工程，在利用纳米医学先进技术构建神经再生适宜微环境及调控神经再生方面具有深厚的研究积累。主要研究成果包括：1）仿生型组织工程支架构建利用静电纺丝技术制备纳米纤维支架，并在纤维表面装载活性多糖/蛋白质（碳纳米管）纳米多层膜，在结构和生物化学性质上同时模仿天然细胞外基质，显著促进细胞粘附、迁移和神经元轴突生长。2）基质物理化学性质调控细胞生长通过支架的拓扑结构和物理化学性质协同调控细胞生长行为，获得特异性的细胞生长，促进组织再生。3）分子设计活性自组装短肽纳米水凝胶促进神经再生设计活性短肽自组装纳米水凝胶，能够负载并长效缓释活性因子，与传统材料相比更接近体内生理环境；支持神经细胞3D生长和分化。该纳米支架能够支持并促进神经轴突再生和内源性神经干细胞向支架内迁移、分化并与再生神经形成功能性突触联系，在大鼠脑、脊髓、坐骨神经损伤模型中均取得了良好促神经再生效果。  在上述领域主持国家自然科学基金2项、973子课题、广东省重大科技专项、广州市珠江科技新星专项和中国博士后科学基金一等资助等项目，获批经费累积超过500万元。先后入选“广东特支计划”科技创新青年拔尖人才计划、广州市珠江科技新星、广东省高等学校优秀青年教师培养计划和香江学者计划等人才计划。在包括Biomaterials、J Mater Chem、ACS Applied Materials & Interfaces、Acta Biomater等高水平学术期刊上发表了SCI论文40余篇。申请中国发明专利8项，授权3项。连续两次（2015年/2017年）受邀在全国生物材料大会担任分会主席并做邀请报告。   学习经历 联合培养博士：新加坡国立大学  2007.4-2008.4   专业：生物医学工程博士：中山大学       2004.9-2009.6   专业：高分子化学与物理学士：郑州大学       2000.9-2004.6   专业：高分子材料与工程 主要论文 2018年1 Reddy S, Archana G, He LM*, Ramakrishana S* CNTs-COOH paste electrode for detection of temozolomide Iranian Journal of Chemistry and Chemical Engineering In press2 Zhao YY#, Zhu R#, Guo T, Wu D, Song L, Ramakrishna S, He LM* Assembly pathway selection of designer SAP and application in fabricating hierarchical hybrid scaffolds for nerve regenerationACS Applied Materials & Interfaces 2018, 10(31):26128-26141，A1-1区，IF:8.0973 ReddyS, Kang LX, Zhang J, He LM* and RamakrishnaS.Preparation of Mo2C- carbon nanomaterials for hydrogen evolution reaction. Carbon Letters In pressA2区，IF:1.4324 Xiang ZQ, Bao YQ, Zhang J, Liu C, Xu D, Liu F, Chen H, He LM, Ramakrishna S, Zhang ZJ, Vardi N, Xu Y*, Inhibition of non-NMDA ionotropic glutamate receptors delays the retinal degeneration in rd10 mouse Neuropharmacology 2018, 139:137-1495 Wang J, Tian LL, He LM, Chen N, Ramakrishna S, So KF*, Mo XM* Lycium barbarum polysaccharide encapsulated Poly lactic-co-glycolic acid Nanofbers: cost efective herbal medicine for potential application in peripheral nerve tissue engineering Scientific Reports 2018,8:8669 6 Shao H#, Li TT#, Zhu R#, Xu XT, Chen SF, Yu JD, Song L, Zhou LB, Wu WT, So KF, Ramakrishna S, Ruan YW*, He LM* Carbon nanotube multilayered nanocomposites for promoting differentiation and function of neural stem cells Biomaterials2018, 175:93-109. A1-1区，IF：8.8067 Wu DN#, Zhang YN#, Guo T, Xu XT, Xie DM, Zhu R, Chen SF, Ramakrishna S, He LM*. RGD/TAT-functionalized chitosan-graft-PEI-PEG gene nanovector for sustained delivery of NT-3 for neural regenerationActa Biomaterialia 2018, 72:266-277.A1-1区，IF:6.3838 Wu DN, Zhang SY, Zhao YY, Ao NJ, Ramakrishna S, He LM* The effects of motif net charge and amphiphilicity on the self-assembly of functionally designer RADA16-I peptidesBiomedical Materials 2018, 13(3):035011.A1-2区，IF:2.8979 Reddy S, He LM*, Ramakrishna S*. Miniaturized-electroneurostimulators and self-powered/rechargeable implanted devices for electrical-stimulation therapy. Biomedical Signal Processing & Control, 2018, 41:255-263.A2区，IF:2.78310 Reddy S, Xu XT, Guo T, Zhu R,  He LM*, Ramakrishana1S* Allotropic carbon (graphene oxide and reduced  graphene oxide) based biomaterials for neural  regeneration Current Opinion in Biomedical Engineering 2018, 6:120-129 2017年1 Sun X, Shao H, Yan Y, Yu X, Li DS, Zhou LB, Wu WT, So KF, Ramakrishna S, Li A*, He LM*Poly(dopamine)-modified carbon nanotube multilayered film and its effects on macrophagesCarbon 2017, 113:176-191. A1-1区，IF:7.0822 Wu XL#, He LM#, Li W, Li H, Wong WM, Wu WT* Functional self assembling peptide nanofiber hydrogel for peripheral nerve regenerationRegenerative Biomaterials,2017, 4(1):21-30.共同一作3 Ke Y, Zhang XY, Ramakrishna S, He LM*, Wu G* Reactive blends based on polyhydroxyalkanoates: Preparation and biomedical applicationMaterials Science and Engineering C 2017, 70(Pt 2):1107-1119 . A1-2区，IF:5.084 Li J, Chen SX, Zhao ZK, Luo YH,  Hou YH, Li H, He LM, Zhou LB, Wu WT Effect of VEGF on inflammatory regulation, neural survival and functional improvement in rats following a complete spinal cord transection. Frontiers in Cellular Neuroscience, 2017, 11:381. A1-2区，IF:4.35 Liu Y, Xiong Y, Xing F, Gao H, Wang X, He LM, Ren C, Liu L, So KF, Xiao J*. Precise Regulation of miR-210 Is Critical for the Cellular Homeostasis Maintenance and Transplantation Efficacy Enhancement of Mesenchymal Stem Cells in Acute Liver Failure Therapy. Cell Transplantation. 2017, 26(5):805-820. A2区，IF:2.8852016年1 Sun YQ#, Zhang YN#, Tian LL, Zhao YY, Wu DN, Xue W, Ramakrishna S, Wu WT, He LM*Self-assembly Behavior of Molecular Designer Functional RADA 16-I Peptides: The Influence of Motifs, pH and Assembly Time. Biomedical Materials 2016, 12(1):015007. A1-2区，IF:2.8972 Shao H, Zhao PP, Su L, Zhang YN, Sun YQ, Yue S, Ramakrishna S, Xue W, He LM* Fabrication of carbon nanotube nanocomposites via layer-by-layer assembly and evaluation in biomedical applicationNanomedicine (Lond.) 2016, 11(23):3087-3101. A1-2区，IF:5.0053 Sun YQ, Li W, Wu XL, Zhang N, Zhang YN, Ouyang SY, Song XY, Fang XY, Ramakrishna S, He LM*, Wu WT* Functional self-assembling peptide nanofiber hydrogels designed for nerve degeneration ACS Applied Materials & Interfaces2016, 8(3):2348-59.A1-1区，IF:8.0974 Zhao PP, Chen LS, Shao H, Zhang YN, Sun YQ, Ke Y, Ramakrishna S, He LM*, Xue W* Cytotoxic and adhesion-associated response of NIH-3T3 fibroblasts to COOH-functionalized multi-walled carbon nanotubes Biomedical Materials 11 (2016) 015021. A1-2区，IF:2.8975 He LM,Tian LL,Sun YQ, Xue W,So KF,Ramakrishna S*,Wu WT*Nano-engineeredenvironmentfornerveregeneration:scaffolds,functionalmoleculesandstemcells.CurrStemCell Res Ther2016, 11:605-617. A2区，IF

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