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谭安江 教授 生物技术学院 蚕业研究所 个人邮箱： atan@just.edu.cn 办公地点： 生物技术学院 通讯地址： 江苏省镇江市长晖路 邮政编码： 212100 传真： 0511-85616595 您是第7080 位访问者 个人简介 谭安江，博士研究生导师，农业农村部蚕桑遗传改良重点实验室主任。长期从事昆虫生理生化和分子生物学研究，近年来以鳞翅目模式昆虫家蚕为主要研究对象，建立了稳定高效的遗传操作体系，拓展了基因编辑等功能遗传学研究手段，在家蚕发育和性别的调控、食性决定、抗病机制、新素材创建等方面取得了一系列的研究成果，在Cell Research，PNAS，PLoS Biology，PLoS Genetics，RNA Biology, Journal of Virology等刊物发表研究论文50余篇。获得了国家杰出青年科学基金、国家自然科学基金联合基金、973计划子课题等项目资助。 研究方向 昆虫是地球上种类和数量最为丰富的生物类群，呈现出高度多样性的生命特征。挖掘昆虫发育变态、性别决定、环境适应、食物选择等多种生物学过程中的重要调控因子，阐明其分子作用机制，是现代昆虫科学的核心课题。栽桑养蚕起源于我国，有着悠久的历史，至今仍在国民经济的发展中发挥着重要作用。家蚕既是一种重要的经济动物，也成为生命科学研究中不可或缺的鳞翅目模式昆虫。昆虫功能遗传学课题组长期致力于创建和优化以家蚕为代表的昆虫遗传操作和基因编辑体系，在此基础上结合多种分子生物学方法开展昆虫发育和性别的遗传调控、昆虫食性调控的分子机制、创建生物新素材等多项研究。我们的研究工作旨在探索昆虫生物学中若干重要科学问题的同时，紧密结合生产实践，助力我国现代蚕桑产业的可持续发展和创新。 教育经历 教育经历：1998.10-2003.03，日本岩手大学，农学博士，昆虫学1995.09-1998.08，安徽农业大学，农学硕士，蚕学1991.09-1995.07，安徽农业大学，农学学士，蚕学工作经历：2021.01至今，  江苏科技大学生物技术学院/中国农科院蚕业研究所，研究员2014.11-2020.12，中国科学院分子植物科学卓越创新中心，研究员2010.02-2014.10，中国科学院上海植物生理生态研究所，副研究员2008.06-2010.01，美国圣母大学生物科学系，博士后2006.01-2008.05，美国肯塔基大学昆虫学系，博士后2003.06-2005.12，日本农业生物资源研究所，博士后***************************************************************************************欢迎咨询报考本课题组研究生，让我们一起探索自然奥秘，发现科学之美！本课题组接收071000生物学、090500畜牧学、095133畜牧方向研究生，原则上不接收095132资源利用与植物保护、095135食品加工与安全方向研究生。 课程教学 科研项目 主持科研项目：1.国家杰出青年科学基金（31925007），昆虫生理生化，2020.01-2024.12。2.科技创新特区培育项目（17-163-12-ZT-003-081-01），基于基因替换的超天然蜘蛛丝高效表达系统研究，2018.1-2021.12。3.国家自然科学基金联合基金项目（U1738110），空间环境对家蚕胚胎发育的影响及变异机理的研究，2018.01-2020.12。4.国家自然科学基金面上项目（31572330），Doublesex基因在家蚕性别调控通路中的作用机制研究，2016.01-2019.12。5.中国科学院重点部署项目子课题（KJZD-EW-L12），家蚕高效表达系统的建立，2015.05-2017.12。6.国家自然科学基金面上项目（31272037），胚胎期致死基因pdp-1在亚洲玉米螟遗传控制中的应用研究，2013.01-2016.12。7.国家重点基础研究发展计划子课题（973计划，2012CB114101），害虫发育与变态的遗传机制，2012.01-2016.08。 专利成果 科研团队 获奖动态 教学随笔 论文著作 发表论文（#第一作者，*通讯作者）：1.Li Zhiqian, You Lang, Zhang Qichao, Yu Ye, Tan Anjiang*. A Targeted In-Fusion Expression System for Recombinant Protein Production in Bombyx mori. Frontiers in Genetics. doi: 10.3389/fgene.2021.816075. 20222.You Lang, Li Zhiqian, Zhang Zhongjie, Hu Bo, Yu Ye, Yang Fangying, Tan Anjiang*. Two dehydroecdysone reductases act as fat body-specific 20E catalyzers in Bombyx mori. Insect Science. doi: 10.1111/1744-7917.12928. 20213.Yang Fangying, Zhang Zhongjie, Hu Bo, Yu Ye, Tan Anjiang*. A CCCH zinc finger gene regulates doublesex alternative splicing and male development in Bombyx mori. Insect Science. doi: 10.1111/1744-7917.12876. 20214.Zhang Ru, Zhang Zhongjie, Huang Yongping, Qian Airong, Tan Anjiang*. A single ortholog of teashirt and tiptop regulates larval pigmentation and adult appendage patterning in Bombyx mori. Insect Biochemistry and Molecular Biology. doi: 10.1016/j.ibmb.2020.103369.  20205.Sun Lili, Zhang Zhongjie, Zhang Ru, Yu Ye, Yang Fangying, Tan Anjiang*.Molecular disruption of ion transport peptide receptor results in impaired water homeostasis and developmental defects in Bombyx mori. Frontiers in Physiology. doi.org/10.3389/fphys.2020.00424. 20206.Zhang Zhongjie#, Zhang Shuaishuai#, Niu Baolong#, Ji Dongfeng, Liu Xiaojing, Li Muwang, Bai Hua, Palli Subba, Wang Chengzhu, Tan Anjiang*. A determining factor for insect feeding preference in the silkworm, Bombyx mori, PLoS Biology, 17(2):e3000162. 20197.Xu Jun#, Dong Qinglin#, Yu Ye, Niu Baolong, Ji Dongfeng, Li Muwang, Huang Yongping, Chen Xin, Tan Anjiang*. Mass spider silk production through targeted gene replacement in Bombyx mori. PNAS. 115(35): 8757-8762. 20188.Zhang Zhongjie#, Niu Baolong#, Ji Dongfeng, Li Muwang, Li Kai, James Anthony A*, Tan Anjiang*, Huang Yongping*. Silkworm genetic sexing through W chromosome-linked, targeted gene integration. PNAS. 115(35): 8752-8756. 20189.Li Zhiqian, You Lang, Yan Dong, James Anthony A, Huang Yongping, Tan Anjiang*. Bombyx mori histone methyltransferase BmAsh2 is essential for silkworm piRNA-mediated sex determination. PLoS Genetics. 14(2):e1007245. 201810.Liu Zulian, Ling Lin, Xu Jun, Zeng Baosheng, Huang Yongping, Shang Peng, Tan Anjiang*. MicroRNA-14 regulates larval development time in Bombyx mori. Insect Biochemistry and Molecular Biology. 93: 57-65. 201811.Xu Jun, Chen Shuqing, Zeng Baosheng, James Anthony A, Tan Anjiang*, Huang Yongping*. Bombyx mori P-element somatic inhibitor (BmPSI) is a key auxiliary factor for silkworm male sex determination. PLoS Genetics 13(1): e1006576. 201712.Chen Shuqing#, Hou Chengxiang#, Bi Honglun, Wang Yueqiang, Xu Jun, Li Muwang, James Anthony A, Huang Yongping*, Tan Anjiang*. Transgenic clustered regularly interspaced short palindromic repeat/Cas9-mediated viral gene targeting for antiviral therapy of Bombyx mori Nucleopolyhedrovirus. Journal of Virology 91(8): e02465-16. 201713.Zeng Baosheng, Huang Yuping, Xu Jun, Shiotsuki Takahiro, Bai Hua, Palli Subba Reddy, Huang Yongping,Tan Anjiang*. FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, Bombyx mori. Journal of Biological Chemistry. 292(28):11659-11669. 201714.Zhang Zhongjie, Liu Xiaojing, Shiotsuki Takahiro, Wang Zhisheng, Xu Xia, Huang Yongping, Li Muwang, Li Kai*, Tan Anjiang*. Depletion of juvenile hormone esterase extends larval growth in Bombyx mori. Insect Biochemistry and Molecular Biology 81: 72-79. 201715.Zeng Baosheng, Zhan Shuai, Wang Yueqiang, Huang Yuping, Xu Jun, Liu Qun, Li Zhiqian, Huang Yongping*, Tan Anjiang*. Expansion of CRISPR targeting sites in Bombyx mori. Insect Biochemistry and Molecular Biology. 72: 31-40. 201616.Li Zhiqian, You Lang, Zeng Baosheng, Ling Lin, Xu Jun, Chen Xu, Zhang Zhongjie, Subba Reddy Palli, Huang Yongping*, Tan Anjiang*. Ectopic expression of the ecdysone oxidase impairs tissue degeneration in Bombyx mori. Proceedings of the Royal Society of Lodon B: Biological Sciences282(1809): 20150513. 201517.Ling Lin, Ge Xie, Li Zhiqian, Zeng Baosheng, Xu Jun, Shang Peng, Anthony A. James, Huang Yongping*, Tan Anjiang*. MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori. RNA Biology 12: 742-748. 201518.Zhang Zhongjie, Abu F.M Aslam, Liu Xiaojing, Li Muwang, Huang Yongping, Tan Anjiang*. Functional analysis of Bombyx Wnt1 during embryogenesis using the CRISPR/Cas9 system.Journal of Insect Physiology. 79:73-9. 201519.Xu Jun, Bi Honglun, Chen Rongmei, AF Aslam, Li Zhiqian, Ling Lin, Zeng Baosheng, Huang Yongping, and Tan Anjiang*. Transgenic characterization of two testis-specific promoters in the silkworm, Bombyx mori.Insect Molecular Biology. 24(2):183-90. 201520.Li Zhiqian, Zeng Baosheng, Ling Lin, Xu Jun, You Lang, Abu F. M. Aslam, Tan Anjiang*, Huang Yongping*. Enhancement of larval RNAi efficiency by over-expressing the Argonaute 2 in Bombyx mori. International Journal of Biological Sciences. 11(2): 176-185. 201521.Xu Jun, Wang Yueqiang, Li Zhiqian, Ling Lin, Zeng Baosheng, Anthony A James, Tan Anjiang*, Huang Yongping*. Transcription activator-like effector nuclease (TALEN)-mediated female-specific sterility in the silkworm, Bombyx mori. Insect Molecular Biology.23(6): 800-7. 201422.Xu Jun, Wang Yueqiang, Li Zhiqian, Ling Lin, Zeng Baosheng, You Lang, Chen Yazhou, AF Aslam, Huang Yongping, Tan Anjiang*. Functional characterization of the vitellogenin promoter in the silkworm, Bombyx mori. Insect Molecular Biology. 23(5):550-7. 201423.Chen Yazhou, Li Muwang, Iftakher Islam, You Lang, Wang Yueqiang, Li Zhiqian, Ling Lin, Zeng Baosheng, Xu Jun, Huang Yongping, Tan Anjiang*. Allelic-specific expression in relation to Bombyx mori resistance to Bt toxin.Insect Biochemistry and Molecular Biology. 54: 53-60.201424.Ling Lin, Ge Xie, Li Zhiqian, Zeng Baosheng, Xu Jun, AF Aslam, Song Qisheng, Shang Peng, Huang Yongping*, Tan Anjiang*. MicroRNA Let-7 regulates molting and metamorphosis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology. 53:13-21.201425.Li Zhiqian, Ge Xie, Ling Lin, Zeng Baosheng, Xu Jun, AF Aslam, You Lang, Subba Reddy Palli, Huang Yongping*, Tan Anjiang*. CYP18A1 regulates tissue-specific steroid hormone inactivation inBombyxmori. Insect Biochemistry and Molecular Biology. 54: 33-41.201426.Li Zhiqian, Jiang Jianhao, Chen Yazhou, You Lang, Niu Baolong, Meng Zhiqi, Huang Yongping, Tan Anjiang*. PDP1 regulates energy metabolism through the IIS-TOR pathway in the red flour beetle, Tribolium castaneum. Archive of Insect Biochemistry and Physiology 85(3):127-36. 201427.Wang Yueqiang, Li Zhiqian, Xu Jun, Zeng Baosheng, Ling Lin, You Lang, Chen Yazhou, Huang Yongping*, Tan Anjiang*. The CRISPR/Cas System mediates efficient genome engineering in Bombyx mori. Cell Research 23(12):1414-6. 201328.Tan Anjiang#, Fu Guoliang#, Jin Li, Guo Qiuhong, Li Zhiqian, Niu Baolong, Meng Zhiqi, Neil I. Morrison, Alphey Luke*, Huang Yongping*. Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori. PNAS 110(17): 6766-70. 201329.Ge Xie, Zhang Yong, Jiang Jianhao, Yang Xiaonan, Li Zhiqian, Huang Yongping, Tan Anjiang*. Identification of microRNAs in Helicoverpa armigera and Spodoptera litura based on deep sequencing and homology analysis. International Journal of Biological Sciences 9(1): 1-15. 201330.Liu Dan, Yan Shangchun*, Huang Yongping, Tan Anjiang*, David W. Stanley, Song Qisheng. Genetic transformation mediated by piggyBac in the Asian corn borer, Ostrinia furnacalis (Lepidoptera: Crambidae). Archive of Insect Biochemistry and Physiology 80(3): 140-50.201231.Tan Anjiang, Subba Reddy Palli. Identification and characterization of nuclear receptors from the red flour beetle, Tribolium castaneum. Insect Biochemistry and Molecular Biology 38(4): 430-9. 200832.Tan Anjiang, Subba Reddy Palli. Ecdysone receptor isoforms play distinct roles in controlling molting and metamorphosis in the red flour beetle, Tribolium castaneum. Molecular and cellular Endocrinology 291(1-2): 42-9. 200833.Tan Anjiang, Hiromasa Tanaka, Toshiki Tamura, Takahiro Shiotsuki. Precocious metamorphosis in transgenic silkworms overexpressing juvenile hormone esterase. PNAS 102(33): 11751-6. 2005