教师主页移动版

基本信息 代晓霞，博士毕业于华中农业大学生命科学技术学院，随后进入美国加州大学河滨分校化学系开展博士后研究工作，目前任职于湖南大学化学化工学院。主要研究方向为化学生物学，涉及生物质谱分析、核酸化学修饰及药物化学生物学等方面的研究。至今已在国际主流学术期刊上发表SCI论文30余篇，其中以第一作者或通讯作者在Analytical Chemistry、Molecular & Cellular Proteomics、Analytica Chimica Acta、ACS Chemical Biology和 Journal of Proteome Research等本领域权威期刊发表多篇研究论文。联系方式: xiaoxiad@hnu.edu.cn

教育背景

科研项目 国家自然科学基金青年项目，主持，2020-2022 湖南省自然科学基金青年项目，主持，2020-2021 湖南省自然科学基金面上项目，主持，2023-2025 化学生物传感与计量学国家重点实验室交叉学科前沿研究项目，主持，2020-2022

工作履历

学术成果   代表性论文 (*Corresponding author) Wang, Z., Qu, M., Chang, S., Dai, X.*, You, C.*. Human RNA-binding protein HNRNPD interacts with and regulates the repair of deoxyribouridine in DNA. International Journal of Biological Macromolecules, 2024, 262: 129951. Sun, Y., Dai, H., Dai, X., Yin, J., Cui, Y., Liu, X., Gonzalez, G., Yuan, J., Tang, F., Wang, N., Perlegos, A.E., Bonini, N.M., Yang, X.W., Gu, W., Wang, Y. *. m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration. Nature, 2023, 623: 580-587. Zhou, M., Liu, Q,. Pan, M,. Yang, Y,. Dai, X.*, You, C.*. STRAP binds to and promotes the repair of N1-methyldeoxyadenosine in DNA. Chinese Chemical Letters, 2023, 35: 108673. Zheng, X., Chang, S,. Liu, Y,. Dai, X.*, You, C.*. Human mitochondrial protein HSPD1 binds to and regulates the repair of deoxyinosine in DNA. Journal of Proteome Research, 2023, 22: 1339-1346. Zheng, X., Chen, D,. Zhao, Y,. Dai, X.*, You, C.*. Development of endonuclease V-assisted analytical method for sequencing analysis of deoxyinosine in DNA. Analytical Chemistry, 2022, 94: 11627-11632. Yang, Y., Wang, Z,. Wang, J,. Dai, X.*, You, C.*. Next-generation sequencing-based analysis of the effects of N1- and N6-methyldeoxyadenosine adducts on DNA transcription. Analytical Chemistry, 2022, 94: 11248-11254. Liu, Y., Zhu, X,. Wang, Z,. Dai, X.*, You, C.*. Next-generation sequencing-based analysis of the roles of DNA polymerases ν and θ in the replicative bypass of 8-oxo-7,8-dihydroguanine in human cells. ACS Chemical Biology, 2022, 17: 2315-2319. Kong, W., Ji, Y,. Zhu, X., Dai, X.*, You, C.*. Development and application of a chemical labeling‐based biosensing assay for rapid detection of 8‐oxoguanine and its repair in vitro and in human cells. Chinese Journal of Chemistry, 2022, 40: 2329-2334. Wang, J., Sheng, Y., Yang, Y., Dai, X.*, You, C.*. Next-generation sequencing-based analysis of the effect of N6-methyldeoxyadenosine modification on DNA replication in human cells. Chinese Chemical Letters, 2022, 33: 2077-2080. Sheng, Y., Zhou, M., You, C.*, Dai, X.*. Dynamics and biological relevance of epigenetic N6-methyladenine DNA modification in eukaryotic cells. Chinese Chemical Letters, 2022, 33: 2253-2258. Liu, Y., Qu, M,. Pan, M., Zheng, X., Sheng, Y., Ji, Y., You, C.*, Dai, X.*. Chemical proteomic profiling of UTP-binding proteins in human cells. Analytica Chimica Acta, 2021, 1168: 338607. Pan, M., Liu, Y., Zheng, X., Zhou, M., You, C.*, Dai, X.*. Comprehensive profiling of CTP-binding proteins using a biotinylated CTP probe. Chinese Chemical Letters, 2021, 32: 3479-3482. Dai, X., Gonzalez, G., Li, L., Li, J., You, C., Miao, W., Hu, J., Fu, L., Zhao, Y., Li, R., Li, L., Chen, X., Xu, Y., Gu, W., Wang, Y. YTHDF2 binds to 5-methylcytosine in RNA and modulates the maturation of ribosomal RNA. Analytical Chemistry, 2020, 92: 1346-1354. Dai, X., Wang, T., Gonzalez, G., Wang, Y. Identification of YTH domain-containing proteins as the readers for N1-methyladenosine in RNA. Analytical Chemistry, 2018, 90: 6380-6384. Dai, X., You, C., Wang, Y. The functions of serine 687 phosphorylation of human DNA polymerase η in UV damage tolerance. Molecular & Cellular Proteomics, 2016, 15: 1913-1920. Dai, X., Rulten, S., You, C., Caldecott, K., Wang, Y. Identification and functional characterizations of N-terminal α-N-methylation and phosphorylation of serine 461 in human poly(ADP-ribose) polymerase 3. Journal of Proteome Research, 2015, 14: 2575-2582. Dai, X., Otake, K.,You, C., Cai, Q., Wang, Z., Masumoto, H., Wang, Y. Identification of novel α-N-methylation of CENP-B that regulates its binding to the centromeric DNA. Journal of Proteome Research, 2013, 12: 4167-4175.

研究领域

学术成果