党刘毅
时间:2024-05-11 17:33 来源: 作者: 点击:次
个人简介Personal Profile 应用生物科学博士，硕士研究生导师。主要从事蛋白糖基化分析及其与疾病关系研究。先后主持国家自然科学基金青年项目、中国博士后基金、陕西省自然科学基金项目等科研项目；在糖蛋白质组学和糖生物学领域发表SCI论文20余篇，授权国家发明专利1项。 科研项目 （1）陕西省自然科学基础研究计划面上项目，高通量糖基转移酶受体筛选新方法及其在岩藻糖基化分析中的应用（2023-JC-YB-164），2023.01-2024.12，在研，主持。 （2）国家自然科学基金青年项目，大鼠5/6肾切除慢性肾衰竭模型中完整N-糖肽的定量组学分析（81800655），2019.01-2021.12，已结题，主持。 （3）中国博士后科学基金面上项目，完整糖肽上平分型 N-糖链的质谱鉴定新方法及其应用（2019M653715），2019-2021，已结题，主持。 （4）比利时根特大学特别研究基金，Study of the expression and biological activity of chimeric carbohydrate-binding proteins containing an amaranthin or a ricin domain in cucumber，2013.3-2017.2，已结题，主持。 学术论文 (1) Liuyi Dang, Pengfei Li, Wei Dan, Huanhuan Liu, Jiechen Shen, Bojing Zhu, Li Jia, Shisheng Sun. Glycoproteomic analysis of regulatory effects of bisecting N-glycans on N-glycan biosynthesis and protein expressions in human HK-2 cells. Carbohydrate Research, 2023, 531, 108894 (2) Jiechen Shen#, Li Jia#, Liuyi Dang#, Yuanjie Su#, Jie Zhang, Yintai Xu, Bojing Zhu, Zexuan Chen, Jingyu Wu, Rongxia Lan, Zhifang Hao, Chen Ma, Ting Zhao, Ni Gao, Jieyun Bai, Yuan Zhi, Jun Li, Junying Zhang, Shisheng Sun. StrucGP: de novo structural sequencing of site-specific N-glycan on glycoproteins using a modularization strategy. Nature Methods. 2021, 18: 921-929. (Co-first author) (3) Liuyi Dang, Li, Jia, Yuan Zhi, Pengfei Li, Ting Zhao, Bojing Zhu, Rongxian Lan, Yingwei Hu, Hui Zhang, Shisheng Sun. Mapping human N-linked glycoproteins and glycosylation sites using mass spectrometry. Trends in Analytical Chemistry, 2019, 114：143-150. (4) Liuyi Dang, Jiechen Shen, Ting Zhao, Fei Zhao, Li Jia, Bojing Zhu, Chen Ma, Danqian Chen, Yingyong Zhao, and Shisheng Sun. Recognition of bisecting N-glycans on intact glycopeptides by two characteristic ions in tandem mass spectra. Analytical Chemistry, 2019, 91: 5478-5482. (5) Liuyi Dang, Pierre Rouge, Els J M Van Damme. Amaranthin-like proteins with aerolysin domains in plants. Frontiers in Plant Science, 2017, 8: 1368. (6) Liuyi Dang, Pierre Rougé, Els J M Van Damme. Expression analysis of ribosome-inactivating proteins from cucumber. Progress in Biochemistry and Biophysics, 2017, 10:929-941. (7) Liuyi Dang, Els J M Van Damme. Genome-wide identification and domain organization of lectin domains in cucumber. Plant Physiology and Biochemistry, 2016, 108: 165-176. (8) Liuyi Dang, Els J M Van Damme. Toxic proteins in plants. Phytochemistry, 2015, 117: 51-64. (9) Hanjie Yu, Mingxiu Li, Jian Shu, Liuyi Dang, Xin Wu, Yuzi Wang, Xuan Wang, Xin Chang, Xiaojuan Bao, Bojing Zhu, Xiameng Ren, Wentian Chen, Yi Li. Characterization of aberrant glycosylation associated with osteoarthritis based on integrated glycomics methods. Arthritis Research & Therapy, 2023, 25, 102. (10) Pengfei Li, Chen Ma, Jing Li, Shanshan You, Liuyi Dang, Jingyu Wu, Zhifang Hao, Jun Li, Yuan Zhi, Lin Chen, Shisheng Sun. Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells. Journal of Zhejiang University-SCIENCE B, 2022, 23, 407–422. (11) Jian Shu, Hanjie Yu, Xiameng Ren, Yan Wang, Kun Zhang, Zhen Tang, Liuyi Dang, Wentian Chen, Baozhen Li, Hailong Xie, Zheng Li. Role of salivary glycopatterns for oral microbiota associated with gastric cancer. International Journal of Biological Macromolecules, 2022, 209, 1368-1378. (12) Wei Dan, Cheng Li, Jun Li, Pengfei Li, Miaomiao Xin, Zexuan Chen, Liuyi Dang, Zihao Yu, Jing Li, Jiechen Shen, Liangshuo Hu, Shisheng Sun. Glycoproteomic analysis reveals the effects of bisecting GlcNAc in intrahepatic cholangiocarcinoma. Glycoconjugate Journal, 2022, 39, 737–745. (13) Miaomiao Xin, Shanshan You, Jingyu Wu, Yintai Xu, Cheng Li, Bojing Zhu, Jiechen Shen, Zexuan Chen, Liuyi Dang, Wei Dan, Xinwen Zhang, Shisheng Sun. Evaluation of absorbent cotton for glycopeptide enrichment. Analytical and Bioanalytical Chemistry, 2022, 414, 8245-8253. (14) Jun Li, Ting Zhao, Jing Li, Jiechen Shen, Li Jia, Bojing Zhu, Liuyi Dang, Chen Ma, Didi Liu, Fan Mu, Liangshuo Hu, Shisheng Sun. Precision N-glycoproteomics reveals elevated LacdiNAc as a novel signature of intrahepatic cholangiocarcinoma. Molecular Oncology. 2022, 16, 2135–2152 (15) Xilong Wang, Lixin Yue, Liuyi Dang, Jiajun Yang, Zhuo Chen, Xiurong Wang, Jian Shu & Zheng Li. Role of sialylated glycans on bovine lactoferrin against influenza virus. Glycoconjugate Journal. Glycoconjugate Journal, 2021, 38, 689–696. (16) Li Jia, Jun Li, Pengfei Li, Didi Liu, Jing Li, Jiechen Shen, Bojing Zhu, Chen Ma, Ting Zhao, Rongxia Lan, Liuyi Dang, Wang Li, Shisheng Sun. Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT. Theranostics. 2021, 11 (14): 6905-6921 (17) Pengfei Li, Zhifang Hao, Huanhuan Liu, Bojing Zhu, Liuyi Dang, Chen Ma, Yintai Xu, Yiyan Zhang, Daidi Fan, Shisheng Sun. Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets. Biology. 2021, 10 (3): 250. (18) Rongxia Lan, Miaomiao Xin, Zhifang Hao, Shanshan You, Yintai Xu, Jingyu Wu, Liuyi Dang, Xinwen Zhang, Shisheng Sun. Biological functions and large-scale profiling of protein glycosylation in human semen. Journal of Proteome Research, 2020, 19, 10, 3877–3889. (19) Jingyu Wu, Zhifang Hao, Chen Ma, Pengfei Li, Liuyi Dang, Shisheng Sun. Comparative proteogenomics profiling of non-small and small lung carcinoma cell lines using mass spectrometry. PeerJ, 2020., 8: e8779. (20) Ting Zhao, Li Jia, Jun Li, Chen Ma, Jingyu Wu, Jiechen Shen, Liuyi Dang, Bojing Zhu, Pengfei Li, Yuan Zhi, Rongxia Lan, Yintai Xu, Zhifang Hao, Yichao Chai, Qingshan Li, Liangshuo Hu, Shisheng Sun. Heterogeneities of site-specific N-glycosylation in HCC tumors with low and high afp concentrations. Frontiers in Oncology, 2020, 10: 496. (21) Jian Shu, Liuyi Dang, Dandan Zhang, Punit Shah, Lijun Chen, Hui Zhang, Shisheng Sun. Dynamic analysis of proteomic alterations in response to N‐linked glycosylation inhibition in a drug-resistant ovarian carcinoma cell line. FEBS Journal, 2019, 286(8): 1594-1605. (22) Jingchao Li, Zhonghua Li, Xiaotao Duan, Ke Qin, Liuyi Dang, Shisheng Sun, Li Cai, Linda C. Hsieh-Wilson, Liming Wu, Wen Yi. An isotope-coded photocleavable probe for quantitative profiling of protein O-GlcNAcylation" ACS Chemical Biology, 2019, 14, 4-10. (23) Bojing Zhu, Jiechen Shen, Ting Zhao, Haihai Jiang, Tianran Ma, Jie Zhang, Liuyi Dang, Ni Gao, Yingwei Hu, Yi Shi, Shisheng Sun. Intact glycopeptide analysis of influenza A/H1N1/09 neuraminidase revealing the effects of host and glycosite location on site‐specific glycan structures. Proteomics, 2019, 1800202. (24) Sofie Van Holle, Kristof De Schutter, Lore Eggermont, Mariya Tsaneva, Liuyi Dang, Els J M Van Damme. Comparative study of lectin domains in model species: New insights into evolutionary dynamics. International Journal of Molecular Sciences, 2017.18(6): 1136. (25) Yaogang Zhong, Yannan Qin, Liuyi Dang, Liyuan Jia, Zhiwei Zhang, Haoxiang Wu, Jihong Cui, Huijie Bian, Zheng Li. Alteration and localization of glycan-binding proteins in human hepatic stellate cells during liver fibrosis. Proteomics, 2015,15: 3283-3295. (26) Yaogang Zhong, Xinmin Qin, Haoqi Du, Liuyi Dang, Zheng Li. Altered expression of glycan-binding proteins in hepatocellular carcinoma cell lines. Progress in Biochemistry and Biophysics, 2014, 41, 1173-1181. (27) Yannan Qin, Yaogang Zhong, Minzhi Zhu, Liuyi Dang, Hanjie Yu, Zhuo Chen, Wentian Chen, Xiurong Wang, Hua Zhang, Zheng Li. Age- and sex-associated differences in the glycopatterns of human salivary glycoproteins and their roles against influenza A virus. Journal of Proteome Research, 2013, 12, 2742-2754. (28) Ganglong Yang, Wei Chu, Hua Zhang, Xiuxuan Sun, Tanxi Cai, Liuyi Dang, Qinzhe Wang, Hanjie Yu, Yaogang Zhong, Zhuo Chen, Fuquan Yang, Zheng Li. Isolation and identification of mannose-binding proteins and estimation of their abundance in sera from hepatocellular carcinoma patients. Proteomics, 2013, 13, 878-892. (29) Yannan Qin, Yaogang Zhong, Liuyi Dang, Minzhi Zhu, Hanjie Yu, Wentian Chen, Jihong Cui, Huijie Bian, Zheng Li. Alteration of protein glycosylation in human hepatic stellate cells activated with transforming growth factor-beta 1. Journal of Proteomics, 2012, 75, 4114-4123. (30) 赵菲, 党刘毅, 赵璇, 李可. 补体系统及其糖基化. 生物化学与生物物理进展, 2017, 44(10): 888-897. (31) Chenjing Shang, Liuyi Dang, Els J M Van Damme, 2017. Plant AB toxins with lectin domains. In: Gopalakrishnakone P, Carlini R, Ligabue-Braun, R (Eds.), Plant toxins. Springer Netherlands, Dordrecht, pp. 1-14. 详情请见：Researchgate：https://www.researchgate.net/profile/Liuyi-Dang |