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个人简介Personal Profile 【教育及工作经历】 2022.10 ~ 至今，西北大学，医学院，副教授 2022.05 ~ 2022.09，西北大学，医学院，讲师 2018.08 ~ 2022.04，西北大学，生命科学与医学部，师资博士后（生物学流动站） 2012.09 ~ 2017.12，中山大学，生命科学学院，理学博士学位（功能基因组与生物信息学方向） 2008.09 ~ 2012.07，延安大学，生命科学学院，理学学士学位（生物科学专业） 【主持及参与科研项目】 国家自然科学基金青年基金，31900443，基于新方法开发的长非编码 RNA DANCR 在基因转录调控和骨肉瘤发病中的作用及分子机制研究，2020.01-2022-12，24万元，西北大学，已结题，主持。 中国博士后科学基金第66批面上项目二等资助，2019M663799，lncRNA DANCR在骨肉瘤发病过程中的作用及分子机制研究，2019.11-2021-08，8万元，西北大学，已结题，主持。 国家自然科学基金面上项目，32270634，对CTCF结合位点附近染色质DNA去甲基化分子机制的研究，2023.01-2026.12，54万，西北大学，在研，参与。 国家自然科学基金面上项目，32070596，开发新方法研究内源逆转录病毒HERV-H在胚胎发育中调控染色质高级结构的分子机理，2021.01-2024-12，58万元，西北大学，在研，参与。 国家自然科学基金重大研究计划培育项目，91440110，长链非编码RNA与RNA结合蛋白的互作调控网络和功能研究，2015.01-2017.12，100万元，中山大学，已结题，参与。 【主要科研成果】 Shaorong Fan#, Wenju Sun#, Ligang Fan#, Nan Wu, Wei Sun, Haiqian Ma, Siyuan Chen,Zitong Li, Yu Li, Jilin Zhang, Jian Yan*. The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity. Computational and Structural Biotechnology Journal, 2022, 20: 5040-4. Tingting Wang#, Wenju Sun#, Ligang Fan#, Canfeng Hua#, Nan Wu, Shaorong Fan, Jilin Zhang, Xin Deng*, Jian Yan*. An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence. Elife, 2021, 10:e61885. Ligang Fan#, Tingting Wang#, Canfeng Hua#, Wenju Sun#, Xiaoyu Li, Lucas Grunwald, Jingui Liu, Nan Wu, Xiaolong Shao, Yimeng Yin, Jian Yan*, Xin Deng*. A compendium of DNA-binding specificities of transcription factors in Pseudomonas syringae. Nat Commun., 2020, 11, 4947. Wenkai Yi#, Jingyu Li#, Xiaoxuan Zhu#, Xi Wang#, Ligang Fan, Wenju Sun, Linbu Liao, Jilin Zhang, Xiaoyu Li, Jing Ye, Fulin Chen, Jussi Taipale, Kui Ming Chan*, Liang Zhang* & Jian Yan*: CRISPR-assisted detection of RNA-protein interactions in living cells. Nat Methods, 2020, 17(7):685-688. Huilin Huang#, Hengyou Weng#, Keren Zhou#, Tong Wu#, Boxuan Simen Zhao#, Mingli Sun, Zhenhua Chen, Xiaolan Deng, Gang Xiao, Franziska Auer, Lars Klemm, Huizhe Wu, Zhixiang Zuo, Xi Qin, Yunzhu Dong, Yile Zhou, Hanjun Qin, Shu tao, Juan Du, Jun Liu, Zhike Lu, Hang Yin, Ana Mesquita, Celvie L. Yuan, Yueh-Chiang Hu, Wenju Sun, rui Su, Lei Dong, Chao Shen, Chenying Li, Ying Qing, Xi Jiang, Xiwei Wu, Miao Sun, Jun-Lin Guan, Lianghu Qu, Minjie Wei, Markus Müschen, Gang Huang*, Chuan He*, Jianhua Yang* & Jianjun Chen*, Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature, 2019, 567(7748): 414. Huilin Huang#, Hengyou Weng#, Wenju Sun#, Xi Qin#, Hailing Shi#, Boxuan Simen Zhao, Ana Mesquita, Celvie L. Yuan, Yueh-Chiang Hu, Stefan Hüttelmaier, Jennifer Strong, Rui Su, Lei Dong, Sun Miao, Li Chenying, Nachtergaele Sigrid, Wang Yungui, Hu Chao, Ferchen Kyle, Greis Kenneth D., Jiang Xi, Wei Minjie , Lianghu Qu, Jun-Lin Guan, Chuan He*, Jianhua Yang*, Jianjun Chen*. Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability. Nat. Cell Biol., 2018, 20(3): 285-295. Jia-Jia Xuan, Wen-Ju Sun, Peng-Hui Lin, Ke-Ren Zhou, Shun Liu, Ling-Ling Zheng, Liang-Hu Qu*, Jian-Hua Yang*. RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data. Nucleic Acids Res. 2018, 46(D1): D327-D334. Ke-Ren Zhou, Shun Liu, Wen-Ju Sun, Ling-Ling Zheng, Hui Zhou, Jian-Hua Yang*, and Liang-Hu Qu*. ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data. Nucleic Acids Res. 2017 Jan 4; 45: D43–D50. Wen-Ju Sun, Jun-Hao Li, Shun Liu, Jie Wu, Hui Zhou, Liang-Hu Qu*, and Jian-Hua Yang*.  RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data. Nucleic Acids Res. 2016, 44(D1): D259-65. Ling-Ling Zheng#, Jun-Hao Li#, Jie Wu, Wen-Ju Sun, Shun Liu, Ze-Lin Wang, Hui Zhou, Jian-Hua Yang*, and Liang-Hu Qu*. deepBase v2.0: identification, expression, evolution and function of small RNAs, LncRNAs and circular RNAs fromdeep-sequencing data. Nucleic Acids Res. 2016, 44(D1): D196-202.