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个人简介Personal Profile         刘晶，西北大学，生命科学与医学部教授，博士生导师，课题组长。主要基于纳米材料的生物学效应与机制，针对肿瘤和感染等重大疾病的诊断和治疗设计智能纳米药物。近年来，在纳米生物医药领域以第一/通讯作者在Angew Chem Int Ed, Adv Mater, Adv Drug Deliv Rev, ACS Nano, Nano Today, Biomaterials, Small等学术期刊发表论文30余篇，4篇入选ISI web of knowledge-ESI统计的“近十年高引频论文（Highly cited papers: last 10 years）”，2篇热点论文，1篇VIP 论文，H因子28。授权发明专利3项。主持国家及省部级项目10项，包括国家自然科学基金2项，北京市自然科学基金重点项1项，北京市科技新星，中科院先导B、先导C项目骨干等。先后入选“陕西省青年千人计划”（2017）；受邀参加 68 届林岛诺贝尔奖获得者大会（全国全学科20名）；入选“中国科协青年人才托举”工程项目（2018）；获“中国毒理学家”资格认证（2019），入选中国科学院“百人计划”（2020），入选北京市科技新星（2022）。兼任中国药学会纳米药物专业委员会青年委员，中国环境诱变剂学会生物标志物专业委员会青年委员，Rare Metals客座编辑，Frontiers in Bioengineering and Biotechnology客座副主编，Nanoscience编委。长期担任ACS Nano, Nano Today, Biomaterials, Science Bulletin, Journal of Nanobiotechnology, Exploration, Nanoscale 等国际主流期刊审稿人。受邀在MIMIT国际分子影像与微创治疗，ASIATOX亚洲毒理学大会等国际学术会议做邀请报告，获得PACIFICHEM环太平洋国际化学大会优秀报告奖。    研究领域： 肿瘤与感染性疾病纳米药物的设计与应用 微生物纳米药物 纳米材料的免疫学效应   代表论著： (1) Wang, Longwei#; Zhang, Xiaodi#; You, Zhen#; Yang, Zhongwei; Guo, Mengyu; Guo, Jiawei; Liu, He; Zhang, Xiaoyu; Wang, Zhuo; Wang, Aizhu; Lv, Yawei*; Zhang, Jian; Yu, Xin*, Liu, Jing*; Chen, Chunying*. A Molybdenum Disulfide Nanozyme with Charges-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis. Angewandte Chemie International Edition, 2023, DOI: 10.1002/anie.202217448. (2) Wang, Longwei#; Yang, Zhongwei#; Song, Guoxin; You, Zhen; Zhang, Xiaoyu; Liu, Lin; Zhang, Jian; Ding, Longhua; Ren, Na; Wang, Aizhu*; Liu, Jing*; Liu, Hong; Yu, Xin*. Construction of S-N-C Bond for Boosting Bacteria-Killing by Synergistic Effect of Photocatalysis and Nanozyme. Applied Catalysis B: Environmental, 2023, DOI: 10.1016/j.apcatb.2022.122345. (3) Cheng, Wenting#; Zhang, Wanjun#; Xia, Xiaowen#; Zhang, Jianzhong; Wang, Mingyue; Li, Yanting; Li, Xin; Zheng, Yuxin; Liu, Jing*; Zhang, Rong*; Tang, Jinglong*.  The domino effect in inhanled carbon black nanoparticles triggers blood-brain barrier disruption via altering circulatory inflammation. Nano Today, 2023, 101721. (4) Wang, Longwei#; Tang, Xiaowen#; Yang, Zhongwei#; Guo, Jiawei; You, Zhen; Cai, Yu; Niu, Xiaochen; Zhang, Xiaoyu; Zhang, Liwei; Zhang, Jian; Wang, Aizhu; Liu, Jing*; Liu, Hong; Yu, Xin*. Regulation of functional groups enable the metal-free PDINH/GO advisable antibacterial photocatalytic therapy. Chemical Engineering Journal, 2023, 451, 139007. (5) Liu, Jing#; Guo,Mengyu#; Chen, Chunying*, Nano-bio interactions: A major principle in the dynamic biological processes of nano-assemblies. Advanced Drug Delivery Reviews, 2022,186,114318. (6) Xiao, Yating#; Li, Xun#; Mao, Jiahui; Zheng, Hong; Ji, Rui; Wang, Zhice; Guo, Mengyu; Yuan, Hui; Anwar, Arfidin; Chen, Chunying; Liu, Xingjun*, Liu, Jing*. Reverse anti-breast cancer drug resistance effects by a novel two-step assembled nano-celastrol medicine. Nanoscale, 2022, 14, 7856. (7) Guo, Mengyu#; Liu, Jing#; Chen, Xi; You, Zhen; Gao, Fene; Liu, Tao; Ren, Jiayu; Liu, Jiaming; Xiong, Zecheng; Liu, Ying; Wang, Yaling; Liu, Huibiao; Chang, Xueling; Cai, Rong; Chen, Chunying. Graphdiyne oxide nanosheets reprogram immunosuppressive macrophage for cancer immunotherapy. Nano Today, 2022, 101543. (8) Liu, Shihui; Wang, QingZhen; Liu, Tao; Bai, Ru; Ma, Manman; Liu, QiaoLin; Zhou, Huige*; Liu, Jing*; Wang, Mei*. Enhanced Glioblastoma Selectivity of Harmine via the Albumin Carrier. Journal of Biomedical Nanotechnology, 2022, 18, 1052-1063. (9) Liu, Jiaming#; Wang, Aizhu#; Liu, Shihui#; Yang, Ruiqi; Wang, Longwei; Gao, Fene; Zhou, Huige; Yu, Xin*; Liu, Jing*; Chen, Chunying*, Titanium nitride nanozyme for pH-responsive and irradiation enhanced cascade catalytic tumor therapy. Angewandte Chemie International Edition, 2021, 60, 2-12. (10) Wang, Longwei#; Li, Bo#; You, Zhen; Wang, Aizhu; Chen, Xuanyu; Song, Gaojing; Yang, Ling; Chen, Dan; Yu, Xin*; Liu, Jing*; Chen, Chunying*, Heterojunction of vertically arrayed MoS2 nanosheet/N-doped reduced graphene oxide enabling a nanozyme for sensitive biomolecule monitoring. Analytical Chemistry, 2021, 93, 11123. (11) Guo, Jin-Cheng#; An, Qiao#; Guo, Mengyu#; Xiao, Yating; Li, Bo; Gao, Fene; Wang, Yuqi; Li, Jiayang; Wang, Yaling; Liu, Ying; Meng, Huan; Guo, Jia; Liu, Jing*, Oxygen-independent free radical generation mediated by core-shell magnetic nanocomposites synergizes with immune checkpoint blockade for effective primary and metastatic tumor treatment, Nano Today, 2021, 36, 101024. (12) Wang, Longwei#; Gao, Fene#; Wang, Aizhu; Chen, Xuanyu; Li, Hao; Zhang, Xiao; Zheng, Hong; Ji, Rui; Li, Bo; Yu, Xin*; Liu, Jing*; Gu, Zhanjun; Chen, Fulin; Chen, Chunying*, Defect-rich adhesive molybdenum disulfide/rGO vertical heterostructures with enhanced nanozyme activity for smart bacterial killing application, Advanced Materials, 2020, 2005423. (13) Guo, Mengyu#; Zhang, Xiao#; Liu, Jing*; Gao, Fene; Zhang, Xiaolei; Hu, Xuhao; Li, Bo; Zhang, Xu; Zhou, Huige; Bai, Ru; Wang, Yaling; Li, Jiayang; Liu, Ying; Gu, Zhanjun; Chen, Chunying, Few-layer bismuthene for checkpoint knockdown enhanced cancer immunotherapy with rapid clearance and sequentially triggered one-for-all strategy, ACS Nano, 2020, 14, 15700-15713. (14) Longwei Wang#; Xiao Zhang#; Xin Yu*; Fene Gao; Ziyi Shen; Xiaolei Zhang; Shenguang Ge; Jing Liu*; Zhanjun Gu; Chunying Chen*, An All-Organic Semiconductor C3N4/PDINH Heterostructure with Advanced Antibacterial Photocatalytic Therapy Activity, Advanced Materials, 2019, 1901965. (15) Liu, Jing#; Zheng, Xiaopeng#; Yan, Liang; Zhou, Liangjun; Tian, Gan; Yin, Wenyan;Wang, Liming; Liu, Ying; Hu, Zhongbo; Gu, Zhanjun*; Chen, Chunying*; Zhao, Yuliang*, Bismuth Sulfide  Nanorods as a Precision Nanomedicine for in Vivo Multimodal Imaging-Guided Photothermal Therapy of Tumor, ACS Nano, 2015, 696-707.  (16) Liu, Jing; Wang, Pengyang; Zhang, Xiao; Wang, Liming*; Wang, Dongliang; Gu, Zhanjun; Tang, Jinglong; Guo, Mengyu; Cao, Mingjing; Zhou, Huige; Liu, Ying*; Chen, Chunying*, Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo, ACS Nano, 2016.4, 10, 4587-4598. (17) Liu, Jing#; Kang, Seung-gu#; Wang, Peng; Wang, Yue; Lv, Xiaonan; Liu, Ying; Wang, Fei; Gu, Zonglin; Yang, Zaixing; Weber, Jeffrey K.; Tao, Ning; Qin, Zhihai; Miao, Qing; Chen, Chunying*; Zhou, Ruhong*; Zhao, Yuliang*, Molecular mechanism of Gd@C82(OH)(22) increasing collagen expression: Implication for encaging tumor, Biomaterials, 2018, 152, 24-36. (18) Wang, Jing#; Liu, Jing#; Liu, Ying; Wang, Liming; Cao, Mingjing; Ji, Yinglu; Wu, Xiaochun; Xu, Yingying; Bai, Bing; Miao, Qing; Chen, Chunying; Zhao, Yuliang*, Gd-Hybridized Plasmonic Au-Nanocomposites Enhanced Tumor-Interior Drug Permeability in Multimodal Imaging-Guided Therapy, Advanced Materials, 2016, 28, 8950-8958. (19) Liu, Jing#; Feng, Xiaoyan#; Chen, Zhiyun; Yang, Xiqin; Shen, Ziyi; Guo, Mengyu; Deng, Fangling; Liu, Ying*; Zhang, Heqiu*; Chen, Chunying*, The adjuvant effect of C60(OH)22 nanoparticles promoting both humoral and cellular immune responses to HCV recombinant proteins, Materials Science & Engineering C, 2019, 97, 753~759. (20) Xu, Mengzhen#; Zhang, Can Yang#; Wu, Junguang; Zhou, Huige; Bai, Ru; Shen, Ziyi; Deng, Fangling; Liu, Ying*; Liu, Jing*, PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release, ACS Applied Materials & Interfaces, 2019, 11, 5701-5713. (21) Guo, Mengyu#; Zhao, Lina#; Liu, Jing#; Wang, Xiaofeng; Yao, Haodong; Chang, Xueling; Liu, Ying; Liu, Jiaming; You, Min; Ren, Jiayu; Wang, Fuhui; Wang, Liming; Wang, Yaling; Liu, Huibiao; Zhao, Yuliang; Cai, Rong; Chen, Chunying, The underlying function and structureal organization of the intracellular protein corona on graphdiyne oxide nanosheet forlocal immunomodulation. Nano Letters, 2021, 21, 6005-6013. (22) An, Qiao#; Liu, Jing#; Yu, Meng; Wan, Jiaxun; Li, Dian; Wang, Changchun; Chen, Chunying*; Guo, Jia*, Multifunctional Magnetic Gd3+-Based Coordination Polymer Nanoparticles: Combination of Magnetic Resonance and Multispectral Optoacoustic Detections for Tumor-Targeted Imaging in vivo, Small, 2015, 11, 5675~5686. (23) Xu, Shuai#; Liu, Jing#; Li, Dian; Wang, Liming; Guo, Jia*; Wang, Changchun; Chen, Chunying*, Fe-salphen complexes from intracellular pH-triggered degradation of Fe3O4@Salphen-In-III CPPs for selectively killing cancer cells, Biomaterials, 2014, 35, 1676-1685. (24) Huang, Sheng#; Liu, Jing#; He, Qian; Chen, Hongli; Cui, Jiabin; Xu, Suying; Zhao, Yuliang; Chen, Chunying*; Wang, Leyu*, Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release, Nano Research, 2015, 8, 4038-4047. (25) Xiao, Yating#; Liu, Jing#; Guo, Mengyu; Zhou, Huige; Jin, Jun; Liu, Jiaming; Liu, Ying; Zhang, Zhanjun*; Chen, Chunying*, Synergistic Combination Chemotherapy of Carrier-free Celastrol and Doxorubicin Nanocrystals for Overcoming Drug Resistance, Nanoscale, 2018, 10, 12639.   (26) Yu, Xin*; Zhao, Zhenhuan*; Ren, Na; Liu, Jing*; Sun, Dehui; Ding, Longhua; Liu, Hong*, Top or Bottom, Assembling Modules Determine the Photocatalytic Property of the Sheetlike Nanostructured Hybrid Photocatalyst Composed with Sn3O4 and rGO (GQD), ACS Sustainable Chemistry and Engineering, 2018, 6:11775-11782. (27) Wang, Song#; Zhang, Jianhua#; Wang, Huan; Yang, Lu; Hong, Shuai; Yu, Bo; Guo, Jincheng; Liu, Jing*; Zhu, Yanbing*, A novel multidimensional signature predicts prognosis in hepatocellular carcinoma patients, Journal of Cellular Physiology, 2018, 1-10.