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个人简介Personal Profile 2024年入选“三秦英才”引进计划创新人才，主要从事钙离子调控相关心脑血管疾病机制和干预策略的研究。发表SCI论文28篇，总影响因子近300，IF>20期刊论文5篇，中科院TOP论文18篇，包括Nature、Circulation Research (3篇)、JAMA Cardiology、Science Translational Medicine等国际高水平期刊，被Nature、Science、Nature Reviews Cardiology、Circulation Research等高水平期刊引用700余次。目前主持国家自然科学基金面上项目、陕西省重点研发计划等8项科研项目。曾主持/参与完成加拿大博士后创新基金、国家自然科学基金面上项目、加拿大CIHR、美国NIH、加拿大HSC、加拿大AIHS、欧盟E-Rare跨国联合项目等16项科研项目。 主要学术成果（*共同第一作者, #通讯作者） 1. Jinhong Wei#, Wenting Guo, John Paul Estillore, Ruiwu Wang, Darrell Belke, Yong-Xiang Chen, Alexander Vallmitjana, Raul Benitez, Leif Hove-Madsen, and S.R. Wayne Chen#. RyR2 Serine-2030 PKA Site Governs Ca2+ Release Termination and Ca2+ Alternans. Circulation Research  2023. 132 (2), e59-e77. (IF:23.2, # 通讯作者) 2. Jinhong Wei, Jinjing Yao, Darrell Belke, Wenting Guo, Xiaowei Zhong, Bo Sun, Ruiwu Wang, John Paul Estillore, Vallmitjana Alexander, Raul Benitez, Leif Hove-Madsen, Enrique Alvarez-Lacalle, Blas Echebarria, and S.R. Wayne Chen#. Ca2+- CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart. Circulation Research 2021. 128 (4), e63-e83. (IF:23.2) 3. Deshun Gong*, Ximin Chi*, Jinhong Wei*, Gewei Zhou, Gaoxingyu Huang, Lin Zhang, Ruiwu Wang, Jianlin Lei, S. R. Wayne Chen#, and Nieng Yan#. Modulation of Cardiac Ryanodine Receptor 2 by Calmodulin. Nature 2019. 572 (7769), 347-351. (IF:69.5, * 共同第一作者) 4. Thomas M. Roston*, Jinhong Wei*, Wenting Guo, Yanhui Li, Xiaowei Zhong, Ruiwu Wang, John Paul Estillore, Puck J Peltenburg,  Ferran Rosés I Noguer, Jan Till, Lee L Eckhardt, Kate M Orland, Robert Hamilton, Martin J LaPage, Andrew D Krahn, Rafik Tadros, Jeffrey M Vinocur, Dania Kallas, Sonia Franciosi, Jason D Roberts, Arthur AM Wilde, Henrik K Jensen, Shubhayan Sanatani, and S. R. Wayne Chen#. Clinical and Functional Characterization of Ryanodine Receptor Variants Implicated in Calcium Release Deficiency Syndrome.  JAMA Cardiology 2022. 7(1), 84-92. (IF:30.2, * 共同第一作者) 5. Jinhong Wei, Jie Tong, Liying Yu, Jianbao Zhang#. EMF protects cardiomyocytes against hypoxia-induced injury via heat shock protein 70 activation. Chemico-Biological Interactions 2016. 248,8-17. (IF:5.2 医学二区) 6. Jinhong Wei, Hao Xu, Liang Shi, Jie Tong, Jianbao Zhang#. Trimetazidine protects cardiomyocytes against hypoxia induced injury through ameliorates calcium homeostasis. Chemico-Biological Interactions 2015. 236: 47-56. (IF:5.2，医学二区) 7. Jinhong Wei, Junqing Sun, Hao Xu, Liang Shi, Lijun Sun, Jianbao Zhang#. Effects of extremely low frequency electromagnetic fields on intracellular calcium transients in cardiomyocytes. Electromagnetic Biology and Medicine 2015. 34(1):77-84 (IF:2.9) 8. Mingke Ni, Yanhui Li, Jinhong Wei, Zhenpeng Song, Hui Wang, Jinjing Yao, Yong-Xiang Chen, Darrell Belke, John Estillore, Ruiwu Wang, Vallmina Alexander, Raul Benítez, Leif Hove-Madsen, Wei Feng, Ju Chen, Thomas Roston, Shub Sanatani, Anna Lehman, S. R. Wayne Chen#. Increased Ca2+ Transient Underlies RyR2-Related Left Ventricular Noncompaction. Circulation Research 2023. 133 (2). (IF:23.2) 9. Shanshan Tian, Xiaowei Zhong, Hui Wang, Jinhong Wei, Wenting Guo, Ruiwu Wang, John Paul Estillore, Carlo Napolitano, Henry Duff, Erkan llhan, Linda M. Knight, Michael S. Lloyd, Jason D. Roberts, Silvia G. Priori, and S. R. Wayne Chen#. RyR2 C-terminal Truncating Variants Identified in Patients with Arrhythmic Phenotypes Exert a Dominant Negative Effect throughFormation of Wildtype-truncation Heteromers. Biochemical Journal 2023. 480 (17), 1379-1395. (IF: 4.1) 10. Julian Ormerod, Elizabeth Ormondroyd, Yanhui Li, John Taylor, Jinhong Wei, Wenting Guo, Ruiwu Wang, Caroline Sarton, Karen McGuire, Helene M.P. Dreau, Jenny C. Taylor, Matthew R. Ginks, Kim Rajappan, S.R. Wayne Chen#, Hugh Watkins#. Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome. Circulation: Genomic and Precision Medicine 2022.15(1), e003589. (IF:7.7) 11. Bo Sun, Jinjing Yao, Mingke Ni, Jinhong Wei, Xiaowei Zhong, Wenting Guo, Lin Zhang, Ruiwu Wang, Darrell Belke, Yong-Xiang Chen, Krystien V.V. Lieve, Anders K. Broendberg, Thomas M. Roston, Ivan Blankoff, Janneke A. Kammeraad, Johannes C. von Alvensleben, Julieta Lazarte, Alexander Vallmitjana, Loryn J. Bohne, Robert A. Rose, Raul Benitez, Leif Hove-Madsen, Carlo Napolitano, Robert A. Hegele, Michael Fill, Shubhayan Sanatani, Arthur A.M. Wilde, Jason D. Roberts, Silvia G. Priori, Henrik K. Jensen and S. R. Wayne Chen#. Cardiac ryanodine receptor calcium release deficiency syndrome.Science Translational Medicine 2021.13(579). (IF:19.3) 12. Yanhui Li, Jinhong Wei, Wenting Guo, Bo Sun, John Paul Estillore, Ruiwu Wang, Ayhan Yoruk, Thomas M. Roston, Shubhayan Sanatani6, Arthur A.M. Wilde, Michael H. Gollob, Jason D. Roberts, Zian H. Tseng, Henrik K. Jensen, S.R. Wayne Chen#. Human RyR2 (Ryanodine Receptor 2) Loss-of-Function Mutations. Circulation: Arrhythmia and Electrophysiology 2021.14(9), e010013. (IF:8.4) 13. Wenting Guo, Jinhong Wei, John Paul Estillore, Lin Zhang, Ruiwu Wang, Bo Sun, and S. R. Wayne Chen#. RyR2 Disease Mutations at the C-terminal Domain Inter-subunit Interface Alter Closed state Stability and Channel Activation. Journal of Biological Chemistry 2021. 297 (1), 100808. (IF:5.5) 14. Ayelet Shauer#, Oded Shor, Jinhong Wei, Yair Elitzur, Nataly Kucherenko, Ruiwu Wang, S. R. Wayne Chen, Yulia Einav, David Luria. A Novel RyR2 Mutation (G3118R) is Associated with Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional and Computational Analysis. Journal of the American Heart Association 2021. 10 (6), e017128. (IF:6.1) 15. Xiaowei Zhong, Wenting Guo, Jinhong Wei, Yijun Tang, Yingjie Liu, Joe Z Zhang, Vern Hsen Tan, Lin Zhang, Ruiwu Wang, Peter P Jones, Carlo Napolitano, Silvia G Priori, S. R. Wayne Chen#. Identification of Loss-of-function RyR2 Mutations Associated with Idiopathic Ventricular Fibrillation and Sudden Death. Bioscience Reports 2021. 41 (4), BSR20210209. (IF:4) 16. Yajing Liu, Jinjing Yao, Zhenpeng Song, Wenting Guo, Bo Sun, Jinhong Wei, John Paul Estillore, Thomas G. Back, and S. R. Wayne Chen#. Limiting RyR2 Open Time Prevents Alzheimer's Disease-related Deficits in the 3xTG-AD Mouse Model. Journal of Neuroscience Research 2021. 99 (11), 2906-2921. (IF:4.4) 17. Malene Brohus, Todor Arsov, David A Wallace, Helene Halkjær Jensen, Mette Nyegaard, Lia Crotti, Marcin Adamski, Yafei Zhang, Matt A Field, Vicki Athanasopoulos, Isabelle Baró, Flavien Charpentier, Hariharan Raju, Deborah Disilvestre, Jinhong Wei, Ruiwu Wang, Haloom Rafehi, Antony Kaspi, Melanie Bahlo, Ivy Dick, S. R. Wayne Chen, Matthew C Cook, Carola G Vinuesa, Michael Toft Overgaard, Peter J Schwartz#. Infanticide vs. inherited cardiac arrhythmias. Europace 2020. 23 (3), 441-450. (IF:6.1) 18. Mads T Søndergaard, Yingjie Liu, Wenting Guo, Jinhong Wei, Ruiwu Wang, Malene Brohus, Michael T Overgaard, S. R. Wayne Chen#. Role of cardiac ryanodine receptor calmodulin‐binding domains in mediating the action of arrhythmogenic calmodulin N‐domain mutation N54I. The FEBS Journal 2020. 287: 2256-2280 (IF:5.6) 19. Krystien VV Lieve, Judith MA Verhagen, Jinhong Wei, J Martijn Bos, Christian van der Werf, Ferran Rosés i Noguer, Grazia MS Mancini, Wenting Guo, Ruiwu Wang, Freek van den Heuvel, Ingrid ME Frohn-Mulder, Wataru Shimizu, Akihiko Nogami, Hitoshi Horigome, Jaso Roberts, Antoine Leenhardt, Harry JG Crijns, Andreas C Blank, Takeshi Aiba, Ans CP Wiesfeld, Nico A Blom, Naokata Sumitomo, Jan Till, Michael J Ackerman, S. R. Wayne Chen, Ingrid MBH van de Laar, Arthur AM Wilde#. Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia. Heart rhythm 2019.16 (2), 220-228. (IF:6.8) 20. Bo Sun, Jinhong Wei, Xiaowei Zhong, Wenting Guo, Jinjing Yao, Ruiwu Wang, Alexander Vallmitjana, Raul Benitez, Leif Hove-Madsen, S. R. Wayne Chen#. The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts. Journal of Biological Chemistry 2018. 293 (35), 13650-13661. (IF: 5.5) 21. Xiaowei Zhong, Alexander Vallmitjana, Bo Sun, Zhichao Xiao, Wenting Guo, Jinhong Wei, Mingke Ni, Yongxiang Chen, Edward R O'Brien, Anne M Gillis, Masahiko Hoshijima, Hiroshi Takeshima, Leif Hove-Madsen, Raul Benitez, Darrell Belke, S. R. Wayne Chen#. Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans. Biochemical Journal 2018. 475 (1), 169-183. (IF: 4.1) 22. Yingjie Liu, Jinhong Wei, Siobhan MW King Yuen, Bo Sun, Yijun Tang, Ruiwu Wang, Filip Van Petegem, S. R. Wayne Chen#. CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca2+ release termination and diminishes protein expression. PloS One 2017. 12 (9). (IF:3.8) 23. Wenqian Chen, Andrea Koop, Yingjie Liu, Wenting Guo, Jinhong Wei, Ruiwu Wang, David H MacLennan, Robert T Dirksen, S. R. Wayne Chen#. Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease. Biochemical Journal 2017. 474 (16), 2749-2761. (IF: 4.1) 24. Zhichao Xiao, Wenting Guo, Bo Sun, Donald J Hunt, Jinhong Wei, Yingjie Liu, Yundi Wang, Ruiwu Wang, Peter P Jones, Thomas G Back, S. R. Wayne Chen#. Enhanced cytosolic Ca2+ activation underlies a common defect of central domain cardiac ryanodine receptor mutations linked to arrhythmias. Journal of Biological Chemistry 2016. 291 (47), 24528-24537. (IF: 5.5) 25. Zhen Tan, Zhichao Xiao, Jinhong Wei, Jingqun Zhang, Qiang Zhou, Chris D Smith, Alma Nani, Guogen Wu, Long-Sheng Song, Thomas G Back, Michael Fill, S. R. Wayne Chen#. Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia. Biochemical Journal 2016. 473 (22), 4159-4172. (IF:4.1) 26. Liang Shi, Hao Xu, Jinhong Wei, Xingfeng Ma, Jianbao Zhang#. Caffeine induces cardiomyocyte hypertrophy via p300 and CaMKII pathways. Chemico-Biological Interactions 2014. 221, 35-41. (IF:5.2) 27. Lijun Sun, Haoyu Wang, Hao Xu, Jinhong Wei, Liang Shi, Jianbao Zhang#. Effects of fluid shear stress and ciglitazone on osteoblasts. Journal of Mechanics in Medicine and Biology 2012. 12 (04), 125. (IF:0.9) 28. Hao Xu, Yali Zhang, Junqing Sun, Jinhong Wei, Lijun Sun, Jianbao Zhang#. Effect of distinct sources Ca2+ on hypertrophy in cardiomyocytes. Experimental Biology and Medicine 2012. 237 (3), 271-278. (IF:4.1)