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个人简介 教育经历2012/09-2017/12    大连理工大学制药科学与技术学院      药物工程专业        博士Ø  研究方向：导向天然产物及药物的有机合成方法学，不对称催化           王保民教授     Ø  毕业论文：吡唑啉酮的不对称官能团化2008/09-2012/06    大连理工大学制药科学与技术学院      制药工程专业        学士Ø  毕业论文：基于D-甘露醇骨架的手性胍催化剂的合成                   王保民教授工作经历2019/9-至今        浙江工业大学绿色制药协同创新中心                    校聘副教授Ø  研究方向：不对称合成方法学，海洋天然产物的合成与结构改造   2018/3-2019/07      法国国家科研中心（CNRS）iSM 2研究所                 博士后Ø  研究方向：轴手性化合物的构筑以及磷手性中心磷酸的合成及应用，不对称催化     合作导师      Dr. Damien Bonne (HDR, Associate professor) & Prof. Jean Rodriguez          2013/07-2013/08     三菱化学科学技术研究所（日本横滨）(MCRC)主要工作：研究X射线荧光光谱分析方法在测定分子筛中Si/Al含量比的应用    教学与课程 主要参与《天然药物化学》、《海洋药物学》和《实验室安全与伦理》课程的教学工作。 育人成果 科研项目 科研成果 (1)        Yang Yang,†  Xingyue Wang,†  Xinyi Ye, Baomin Wang, Xiaoze Bao* and Hong Wang*, Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles, Org. Biomol. Chem., 2021, 19, 4610-4621.(2)        Xing-Kai Qian, Jing Zhang, Pei-Fang Song, Yi-Su Zhao, Hong-Ying Ma, Qiang Jin, Dan-Dan Wang, Xiao-Qing Guan, Shi-Yang Li, XiaoZe Bao*, Li-Wei Zou*, Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells, Bioorg. Med. Chem., 2021, 40, 116187.(3)        Jing Zhang, Yang Yang, Xing-Kai Qian, Pei-Fang Song, Yi-Shu Zhao, Dr. Xiao-Qing Guan*, Li-Wei Zou*, Xiaoze Bao*, Hong Wang, Design, synthesis, and structure-activity relationship study of pyrazolones as potent inhibitors of pancreatic lipase, ChemMedChem, 2021, 16, 1600-1604.(4)        Xiaoze Bao*, Jean Rodriguez, Damien Bonne*. Enantioselective synthesis of atropisomers with multiple stereogenic axes, Angew. Chem. Int. Ed., 2020, 59,12623-12634.(5)        Xiaoze Bao*, Jinhui Ren, Yang Yang, Xinyi Ye, Baomin Wang, Hong Wang *, 2-activated 1,3-enynes in enantioselective synthesis, Org. Biomol. Chem., 2020, 18, 7977-7986.(6)        Xiaoze Bao, Jean Rodriguez*, Damien Bonne*. Bidirectional enantioselective synthesis of bisbenzofuran atropisomeric oligoarenes featuring two distal C-C stereogenic axes, Chem. Sci., 2020, 11, 403-408.(7)        Xiaoze Bao, Shiqiang Wei, Xiangkai Qian, Jingping Qu, Baomin Wang*, Liwei Zou*, Guangbo Ge. Asymmetric construction of a multi-pharmacophore-containing dispirotriheterocyclic scaffold and identification of a human carboxylesterase 1 inhibitor, Org. Lett., 2018, 20, 3394-3398.(8)        Xiaoze Bao, Shiqiang Wei, Jingping Qu, Baomin Wang*. C6’ steric bulk of cinchona alkaloid enables anenantioselective Michael addition/annulationsequence toward pyranopyrazoles, Chem. Commun., 2018, 54, 2028-2031.(9)        Xiaoze Bao, Shiqiang Wei, Liwei Zou, Yuli He, Fuzhao Xue, Jingping Qu, Baomin Wang*. Asymmetric chlorination of 4-substituted pyrazolones catalyzed by natural cinchona alkaloid, Chem. Commun., 2016, 52, 11426-11429. (10)      Xiaoze Bao, Shiqiang Wei, Liwei Zou, Yuming Song, Jingping Qu, Baomin Wang*. Asymmetric fluorination of 4-substituted pyrazolones catalyzed by quinine, Tetrahedron: Asymmetry, 2016, 27, 436-441. (11)      Xiaoze Bao, Baomin Wang*, Longchen Cui, Guodong Zhu, Yuli He, Jingping Qu, Yuming Song. An organocatalytic asymmetric Friedel-Crafts addition/fluorination sequence: construction of oxindole-pyrazolone conjugates bearing vicinal tetrasubstituted stereocenters, Org. Lett., 2015, 17, 5168-5171.(大连市优秀科技成果奖一等奖) (12)      Fuzhao Xue†,Xiaoze Bao†, Liwei Zou, Jingping Qu, Baomin Wang*. Asymmetric hydroxylation of 4-substituted pyrazolones catalyzed by natural cinchona alkaloids. Adv. Synth. Catal., 2016, 358, 3971-3976. (†共同第一作者). (13)      Peng Liu, Xiaoze Bao, Jean-Valère Naubron, Sara Chentouf, Stéphane Humbel, Nicolas Marion Jean, Laurent Giordano, Jean Rodriguez,* Damien Bonne*. Simultaneous control of central and helical chiralities: Expedient helicoselective synthesis of dioxa[6]helicenes, J. Am. Chem. Soc., 2020, 142, 16199-16204.(14)      Shiqaing Wei, Xiaoze Bao, Wenyao Wang, Shah Nawaz, Qimin Dai, Jingping Qu, Baomin Wang.* Enantioselective construction of dispirotriheterocycles featuring a 4-amino- pyrazolone motif through a cascade Michael/cyclization process, Chem. Commun., 2020, 56, 10690-10693. (15)      Siyuan Liu, Xiaoze Bao, Baomin Wang*. Pyrazolone: a powerful synthon for asymmetricdiverse derivatizations, Chem. Commun., 2018, 54, 11515-11529. (16)      Liyuan Zhao, Xiaoze Bao, Qingtao Hu, Baomin Wang*, Anhui Lu*. Porous Carbon Nanosheet-Supported Chiral Squaramide for Highly Enantioselective Friedel–Crafts Reaction, ChemCatChem., 2018, 10, 1248-1252. (17)      Kai Yang, Xiaoze Bao, Ye Yao, Jingping Qu, Baomin Wang*. Iodine-mediated cross-dehydrogenative couplingof pyrazolones and alkenes, Org. Biomol. Chem., 2018, 16, 6275-6283. (18)      Kai Yang, Xiaoze Bao, Siyuan Liu, Jingnan Xu, Jingping Qu, Baomin Wang*. Asymmetric Addition of Pyrazolones to Allenamides Catalyzedby a Chiral Phosphoric Acid, Eur. J. Org. Chem., 2018, 6469-6473. (19)      Longchen Cui, Guodong Zhu, Siyuan Liu, Xiaoze Bao, Xiangyu Zhao, Jingping Qu, Baomin Wang*. Construction of indolenine-substituted spiro[pyrrolidine-2,3’-oxindoles] from 2-alkenylindolenines and isatin-derived azomethineylides, Tetrahedron, 2018, 74, 2369-2375. (20)      Guodong Zhu, Shiqi Wu, Xiaoze Bao, Longchen Cui, Yanpeng Zhang, Jingping Qu, Hongbo Chen, Baomin Wang*. Asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides with α,β-ynones: a straightforward approach to spirooxindoles incorporating 2,5-dihydropyrroles and pyrroles, Chem. Commun., 2017, 53, 4714-4717. (21)      Yuli He, Xiaoze Bao, Jingping Qu, Baomin Wang*. Asymmetric tandem Michael addition/oxidation of pyrazolones with p-benzoquinone catalyzed by cinchona alkaloids, Tetrahedron: Asymmetry, 2015, 26, 1382-1387. (22)      Guodong Zhu, Baomin Wang*, Xiaoze Bao, Huanrui Zhang, Qian Wei, Jingping Qu. Catalytic asymmetric construction ofspiro[pyrrolidine-2,3,0-oxindole] scaffolds through chiral phosphoric acid-catalyzed 1,3-dipolar cycloaddition involving 3-amino oxindoles, Chem. Commun., 2015, 51, 11510-15513. (23)      Huanrui Zhang, Baomin Wang*, Longchen Cui, Xiaoze Bao, Jingping Qu, Yumin Song. Organocatalytic Asymmetric Fluorination of 4-Substituted Isoxazolinones, Eur. J. Org. Chem., 2015, 2143-2147. (24)      Hailei Zhang, Xiaoze Bao, Yuming Song, Jingping Qu, Baomin Wang*. Iodine-catalysed versatile sulfenylation of indoles with thiophenols:controllable synthesis of mono- and bis-arylthioindoles, Tetrahedron, 2015, 71, 8885-8891. (25)      Liwei Zou, Xiaoze Bao, Yuanyuan Ma, Yuming Song, Jingping Qu, Baomin Wang*. Novel tartrate-derived guanidine-catalyzed highly enantio- and diastereoselective Michael additionof 3-substituted oxindoles to nitroolefins, Chem. Commun., 2014, 50, 5760-5762. 社会服务