赵嫚
时间:2024-04-27 21:08 来源: 作者: 点击:次
个人简介 赵嫚，副教授，硕导。本科，安徽师范大学生命科学学院；博士：中国科学院大学植物研究所；英国John Innes Centre，访问学者。主持国家自然基金青年基金、省重点研发项目、省青年基金、省一般项目，企业横向项目等7项。以第一或通讯作者在GBE, BMC Plant Biology, JSE, IJMS, PloS ONE等期刊上发表SCI 论文10余篇。申请授权国家发明专利7项。获浙江省第九届青年教师教学技能大赛特等奖；浙江工业大学“十佳”青年教师称号。ISW国际认证引导员。研究方向：1、功能性天然产物的开发与生物合成，主要涉及，植物天然产物罗汉果苷、甜菊糖苷等萜类化合物，和黄酮类、酚酸类化合物的生物合成；医美功能性产品的生物合成，包括肽类、抗氧化化合物的生物催化与合成生物学；2、重要酶类催化机理的解析与分子改造；3、微生物合成底盘细胞的搭建和代谢途径分子调控机制研究。Email：mzhao@zjut.edu.cn 科研项目 主持项目：横向项目：1.2021.09-2024.08 冬虫夏草的人工侵染技术，企业横向，300万元，在研；2. 2019.01-2021.12 多酶体系泛酸的生物合成，企业横向，100万元，在研；纵向项目：1. 2021.01-2025.12 浙江省新品种选育重大科技专项子课题，2021C02064-5-4，45万元，在研；2. 2021.01-2023.12 中药半枝莲新克罗烷型二萜的合成途径研究，LY21H280009，10万元，在研；3. 2017.01-2019.12 国家自然科学基金青年基金，31600181，20万元 ，已结题；4. 2016.01-2020.12 浙江省新品种选育重大科技专项子课题，2016C02050-10-3，22.5万元，已结题；5. 2016.01-2018 .12 浙江省自然科学基金青年基金，LQ16C020003 ，5万元 ，已结题；部分参与项目：1. 2016.01-2019.12 国家自然科学基金面上项目，典型人工纳米材料干扰拟南芥生长繁殖及其与除草剂的复合毒理，21577128，78万元，结题，已结题；2. 2017.01-2019.12 浙江省自然科学基金面上项目，LY17B020012，8万元，已结题；3. 2016.03-2018.12 泛酸手性中间体不对称合成关键技术的研究开发，企业横向，100万元，已结题。 科研成果 部分科研成果：2022-Zhao M, Zhou B, Jia X, Wang M, Liu Z, Zheng Y. 2023. Increasing catalytic efficiency of SceCPR by semi-rational engineering towards the asymmetric reduction of D-pantolactone. J Biotech. 373:34-41. Zhao M, Wang M, Peng L, Liu W, Song X, Liu Z*, Zheng Y. 2022. Determination of three sites involved in the divergence of L-aspartate-α-decarboxylase self-cleavage in bacteria. Enzyme Microb Technol. 158:110048.Zhao M, Song X, Liu W, Qi F, Zhao T, Xia K, Liu Z*, Zheng Y. 2022. Whole-cell biotransformation for large scale production of carcinine in Escherichia coli. J Biotechnol.354:45-52. Tomlinson ML, Zhao M, Barclay EJ, …… Martin C. Diterpenoids from Scutellaria barbata induce tumour-selective cytotoxicity by taking the brakes off apoptosis. Medicinal Plant Biology. 2022, 1(3) .2021年以前：Peng L, Qian L, Wang M, Liu W, Song X, Cheng H, Yuan F, Zhao M*; Comparative transcriptome analysis during seeds development between two soybean cultivars, PeerJ, 2021. 9: e10772.Zhao M*, Wang W, Wei L, Chen P, Peng L, Qin Z, Yuan F, Wang Z, Ying X*. 2019. The evolution and biocatalysis of FAD2 indicate its correlation to the content of seed oil in plants. International Journal of Molecular Sciences 20(4):849.Zhao M*, Wang W, Wei L, Chen P, Yuan F, Wang Z, Ying X*. 2018. Molecular evolution and expression divergence of three key Met biosynthetic genes in plants: CGS, HMT and MMT. PeerJ 6:e6023.Zhao M*, Wang W, Wei L, Chen P, Yuan F, Zhu D, Wang Z, Ying X*. 2018. Molecular evolution and expression divergence of HMT gene family in plants. International Journal Molecular Science 19:1248Zhao M*, Ying X, Sun J, Zhao W. 2017. Molecular evolution of Coq1 gene family in eukaryotes. Journal of Systematics and Evolution 55(5):417-425.Zhao M, Gao L, Zhang L, Bai Y, Chen L, Yu M, Cheng F, Sun J, Wang Z, Ying X. 2017. Asymmetric reduction of ketopantolactone using a strictly (R)-stereoselective carbonyl reductase through efficient NADPH regeneration and the substrate constant-feeding strategy. Biotechnology Letters 39:1741-1746.Zhao M, Gu Y, He L, Chen Q and He CY. 2015. Sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans. BMC Plant Biology 15:120.Zhao M, He LL, Gu Y, Wang Y, Chen QS and He CY. 2014. Genome-wide analyses of a plant-specific LIM-domain gene family implicate its evolutionary role in plant diversification. Genome Biology and Evolution 6(4):1000-1012.Gong PC#, Zhao M# and He CY. 2014. Slow co-evolution of the MAGO and Y14 protein families is required for the maintenance of their obligate heterodimerization mode. PLoS ONE 9(1), e84842. (#Co-first author)He LL, Zhao M, Wang Y, Gai JY and He CY. 2013. Phylogeny, structural evolution and functional diversification of the plant PHOSPHATE1 gene family: a focus on Glycine max. BMC Evolutionary Biology 13, 103.Zhao J#, Tian Y#, Zhang JS, Zhao M, Gong PC, Riss S, Saedler R and He CY. 2013. The euAP1 protein MPF3 represses MPF2 to specify floral calyx identity and displays crucial roles in “Chinese lantern” development in Physalis. The Plant Cell 25, 2002-2021. (#Co-first author)He LL, Zhao J, Zhao M and He CY. 2011. Current development and application of soybean genomics. Frontiers in Biology 6(4), 337-348.Zhang JS#, Li Z#, Zhao J, Zhang S, Quan H, Zhao M and He CY. 2014. Deciphering the Physalis double-layered-lantern 1 mutant provides insights into functional divergence of the GLOBOSA duplicates within the Solanaceae. Plant Physiology 164, 748-764. (#Co-first author)赵嫚，彭莉，成浩，应向贤，汪钊. 2020. 微生物甲硫氨酸合成调控的综合研究进展与展望. 食品与发酵工业. 10.13995/j.cnki.11-1802/ts.024785. 教学与课程 教学上包括对本科生和研究生的培养，以及教师发展的研究教学内容：本科生课程：植物生物技术；生物学实验；生命科学探秘（通识课）研究生课程：基因工程II教师发展：ISW国际认证引导员，参与和组织校内外教师培训3期以上，涉及对教师教学设计、教学理念和教学方法的引导与培训。教学改革：获得校级课堂教学改革项目1项；获得校级课程思政建设项目1项；发表教改论文1篇《植物生物技术》课程思政案例获得学校课程思政示范案例 育人成果 育人：指导浙江省优秀毕业生1名指导第十五届“挑战杯”全国大学生课外学术科技作品竞赛，国家级，三等奖 社会服务 浙江省植物学会青年理事ISW国际认证引导员 |