教师主页移动版

个人简介 副教授，硕士生导师。2006年获得武汉大学理学硕士学位，2009年进入浙江大学化学系攻读博士学位并与2013年3月获得理学博士学位。2013年6月进入新加坡国立大学化学与生物分子工程系化学与生物分子工程系从事博士后研究工作（刘斌教授课题组）。2015年加入浙江工业大学，主要研究方向是肿瘤纳米药物载体的构建，及其在肿瘤诊疗一体化和免疫治疗中的应用。通过高分子载体材料携载基因，化疗药以及具有光响应性的功能有机分子，构建多功能脂质纳米粒，应用于细胞和动物模型中肿瘤治疗研究。特色工作是通过仿生化构建，探讨细菌和光热刺激在肿瘤免疫治疗中的作用，解决肿瘤治疗中转移的难题。以第一作者和共同通讯作者发表论文二十余篇，包括ACS Nano, Adv. Func. Mater., Angew. Chem.-Int. Edit., Biomaterials, Nano Letter, Appl. Mat. & Inter.,等。 教学与课程 主要课程： 分子生物学 生物化学实验 育人成果 1. 指导本科生获得全国大学生生命科学竞赛一等奖2项，二等奖一项；2. 指导本科生和研究生各获得浙江省新苗计划资助2项。 科研项目 1. 国家自然科学基金青年项目,功能型聚集诱导发光纳米粒的制备及在肿瘤光学免疫治疗中的应用(51603186), 项目负责人, 21万元。2. 浙江省自然科学基金，光热效应增敏纳米化疗药物输送协同治疗胰腺癌的研究（LY21E030011）,项目负责人，10万元。  科研成果 发表论文列表（1）Minjie Xu,  Ling Li  and  Qinglian Hu*, The recent progress in photothermal-triggered bacterial eradication, Biomater. Sci., 2021, 9（6）：‏ 1995-2008. （IF=6. 8）(2) Yuming Yang, Minjie Xu, zhe Wang, Yanqing Yang, Jie Liu*, Qinglian Hu*, Lin Li and Wei Huang*, Immune remodeling triggered by photothermal therapy with semiconducting polymer nanoparticles in combination with chemotherapy to inhibit metastatic cancers. J. Mater. Chem. B, 2021, 9 （11）：2613-2622 （IF=6.3）(3) Qinglian Hu, Zemin Huang, Yukun Duan, Zhengwei Fu*, Bin Liu* Reprogramming Tumor Microenvironment with Photothermal Therap. Bioconjug. Chem., 2020, 31(5):1268-1278. （IF=4.349）(4)   Yanqing Yang#, Xiaoxiao Fan#, Ling Li#, Yuming Yang, Alifu Nuernisha, Dingwei Xue, Chao He, Jun Qian*, Qinglian Hu*（共同通讯）, Hao Chen*, Jie Liu*, Wei Huang. Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared-II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence. ACS Nano. 2020, 14(2):2509-2521. (IF = 15.8, 高被引论文，JCR Q1, 中科院大类一区) (5)   Bing Guo#, Zemin Huang#, Qi Shi, Eshu Middha, Shidang Xu, Ling Li, Min Wu, Jianwen Jiang, Qinglian Hu*（共同通讯）, Zhengwei Fu*, Bin Liu* Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy, Adv. Funct. Mater., 2020, 30(5):1907093. (IF = 18.8, JCR Q1, 中科院大类一区)(6)   Zhe Wang#, Bing Guo#, Eshu Middha, Zemin Huang, Qinglian Hu*(共同通讯）, Zhengwei Fu*, Bin Liu*, Microfluidics-Prepared Uniform Conjugated Polymer Nanoparticles for Photo-Triggered Immune Microenvironment Modulation and Cancer Therapy. ACS App. Mater. Interfaces, 2019, 11(12): 11167-11176. (IF = 9.4, JCR Q1)(7 Qinglian Hu#, Min Wu#, Chun Fang, Changyong Cheng, Mengmeng Zhao, Weihuan Fang, Paul K. Chu, Yuan Ping*, Guping Tang*, Engineering nanoparticle-coated bacteria as oral DNA vaccines for cancer immunotherapy, Nano Letters, 2015, 8; 15(4):2732-2739. (IF = 11.189, JCR Q1, 中科院大类一区)(8) Qinglian Hu#, Meng Gao#, Guangxue Feng, Bin Liu*, Mitochondria-Targeted Cancer Therapy Using a Light-up Probe With Aggregation-induced Emission Characteristics, Angew. Chem.-Int. Edit., 2014, 53(51), 14225-14229. (IF = 15.336, 高被引论，JCR Q1, 中科院大类一区)(9) Qinglian Hu, Jinlei Wang, Jie She, Min Liu, Xue Jin, Guping Tang*, Paul K Chu*, Intracellular pathways and nuclear localization signal peptide-mediated gene transfection by cationic polymeric nanovectors, Biomaterials, 2012;33:1135-1145. ((IF = 12.475, JCR Q1, 中科院大类一区)(10) Q.L. Hu#, Q.Y. Jiang#, X. Jin, J. Shen, K. Wang, Y.B. Li, F.J. Xu*, G.P. Tang*, Z.H. Li, Cationic microRNA-delivering nanovectors with bifunctional peptides for efficient treatment of pancreatic cancers, Biomaterials, 2013; 34 (9):2265-2276. ((IF = 12.475, JCR Q1, 中科院大类一区)(11) Qinglian Hu#, Wen Li#, Xiurong Hu, Qida Hu, Jie Shen , Xue Jin , Jun Zhou , Guping Tang*, Paul K. Chu*, Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly. Biomaterials, 2012; 33: 6580-6591. (IF = 12.475, JCR Q1, 中科院大类一区) (12) Qinglian Hu#, Meng Gao#, Guangxue Feng, Xiaodong Chen, Bin Liu*, A Cell Apoptosis Probe Based on Fluorogen with Aggregation-induced emission Characteristics, ACS Appl. Mat. & Inter., 2015, 7(8), 4875–4882. ((IF = 9.4, JCR Q1)(13) Chongjing Zhang#, Qinglian Hu#, Guangxue Feng, Ruoyu Zhang, Youyong Yuan, Xianmao Lu, Bin Liu*,Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation induced emission characteristics. Chem. Sci.,2015，6 (8) ,4580-4586. (IF = 9.825, JCR Q1, 中科院大类一区)(14) Meng Gao#, Qinglian Hu#（共同一作）, Guangxue Feng, Nikodem Tomczak , Rongrong Liu, Bengang Xing, Ben Zhong Tang, Bin Liu*, A multifunctional probe with aggregation-Induced emission characteristics for selective fluorescence imaging and photodynamic killing of bacteria over mammalian cells, Adv. Healthc. Mat., 2015, 4(5):659-663. (IF = 6.27, JCR Q1)(15) Gao Meng#, Hu Qinglian#（共同一作）, Guangxue Feng，Benzhong Tang, Liu Bin. Fluorescentlight-up probe with “AIE + ESIPT” characteristics for specific detection of lysosomal esterase. Journal of Materials Chemistry B.  2014, 2, 3438.  (IF=6.3, JCR Q1，封面文章) 社会服务