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个人资料 单位： 膜分离与水科学技术研究院 单位： 膜分离与水科学技术研究院 职务： 院长助理 研究方向： 生物化工，生物材料，环境化工 {"data":[{"fieldValue":"生物化工，生物材料，环境化工"}]} 联系电话： 电子邮箱： shenchong@zjut.edu.cn 办公地址： 莫干山高等研究院B507,个人资料 单位： 膜分离与水科学技术研究院 单位： 膜分离与水科学技术研究院 职务： 院长助理 研究方向： 生物化工，生物材料，环境化工 {"data":[{"fieldValue":"生物化工，生物材料，环境化工"}]} 联系电话： 电子邮箱： shenchong@zjut.edu.cn 办公地址： 莫干山高等研究院B507,个人简介 教育经历： (1) 2006-03 至 2009-03, 浙江大学, 生物化工, 博士 (2) 2002-09 至 2005-03, 浙江大学, 生物化工, 硕士  (3) 1998-09 至 2002-06, 浙江大学, 生物化工, 学士 (4) 2006-06 至 2006-09,2007-07至2007-10，德国莱比锡大学，学术交流生 博士后工作经历： (1) 2009-05 至 2011-09, 浙江大学 科研与学术工作经历： (1) 2021-12 至 今, 浙江工业大学, 膜分离与水科学技术研究院, 朝晖特聘研究员(2) 2011-09 至 2021-11, 浙江大学, 化工学院, 副研究员(3) 2014-04 至 2015-04, 美国哥伦比亚大学, 生物医学工程系, 访问学者 科研项目 主持项目1. 模块组装法构建水凝胶器官芯片的方法学研究，国家自然科学基金面上项目，2021.1-2024.122. 面向微流控组织工程反应器的高机械性能仿生水凝胶研究，国家自然科学基金面上项目，2015.1-2016.123. 面向组织工程反应器构建的上皮细胞高分化功能的微环境调控研究，国家自然科学基金面上项目，2013.1-2016.124. 面向药物体外研究的 PEG 接枝改性膜及抗吸附规律研究，国家自然科学基金青年基金项目，2011.1-2013.15. 可调节硬度与剪切力的水凝胶微流控血管芯片构建，浙江省自然科学基金探索项目，2020.1-2022.126. 生态环保产业技术联合研发中心共建，浙江卓锦环保科技有限公司, 2022.09-2024.12, 100万元7. 鼠李糖脂分离纯化技术及产品应用，湖州紫金生物科技有限公司, 2023.06-2024.12, 21.5万元 8. 单兵深层创口水凝胶敷料的设计与应用基础研究，浙江大学“以民促军”基础培育计划，2017.5-2018.59. 血管微流控评价评价中国白酒的心血管健康性，北京工商大学重点实验室开放课题，2018.1-2018.1210. 面向体外药物肝毒性预测的肝细胞中空纤维反应器的 PEG 改性，博士后基金一等资助，2009.9-2011.1111. PEG 改性膜促进肝细胞自组装的机理研究，博士后基金特别资助，2010.6-2011.11参与项目1. 双氧水制备中失效再生剂的绿色活化工艺研究，浙江大学-恒逸全球未来先进技术研究院，2019.5-2020.52. 食用香料香精和配料绿色制造关键技术研究（任务 4 微生物发酵法生产鼠李糖），国家重点研发计划，2016.7-2020.123. 生物表面活性剂鼠李糖脂的双相发酵技术，国家高技术研究发展计划(863 计划)，2014.1-2016.124. 基于不溶胀水凝胶的器官芯片构建方法学研究，国家自然科学基金面上项目，2020.1-2023.125. 拟组织化培养人肝细胞用于预测体内药物代谢，罗氏研发合作项目，2007 科研成果 发表论文代表作：1. Chong Shen; Yizeng Li; Gang Lu; Qin Meng ; Electrodialysis treatment of rhamnolipids hydrolysate and its waste water for use as water-soluble fertilizer,  Bioresource Technology ,2024, 393: 1300802. Chong Shen; Huiming Yang; Wenqi She; Qin Meng ; A microfluidic lung-on-a-chip based on biomimetic hydrogel membrane,  Biotechnology & Bioengineering , 2023, 120: 2027-2038 3. Chong Shen; Yingjun Li; Wenqi She; Qin Meng ; Layer‐by‐layer adhesion of hydrogels for constructing heterogeneous microfluidic chips,  AIChE Journal , 2023, 70: e18277 4.Meng, Q; Wang, Y; Li, Y; Shen, C*. Hydrogel microfluidic-based liver-on-a-chip: Mimicking the mass transfer and structural features of liver. Biotechnology & Bioengineering, 2020, DOI:10.1002/bit.275895.Shen, C; Li, Y; Wang, Y; Meng, Q*. Non-swelling hydrogel-based microfluidic chips. Lab on a Chip. 2019, 7;19(23):3962-3973.6.Shen, C; Zhang, G; Wang, Q; Meng, Q*. Fabrication of Collagen Gel Hollow Fibers by Covalent Cross-Linking for Construction of Bioengineering Renal Tubules. ACS Applied Material & Interfaces. 2015, 7(35):19789-97.7.Shen, C; Meng, Q*; Zhang, G. Increased curvature of hollow fiber membranes could up-regulate differential functions of renal tubular cell layers. Biotechnology & Bioengineering. 2013. 110:2173-2183.8.Shen, C; Meng, Q*; Zhang, G*. Chemically modification of polysulfone membrane by polyethylene glycol for resisting drug adsorption and self-assembly of hepatocytes. Journal of Membrane Science. 2011. 369: 474-81.其他一作或通讯论文：1.Meng, Q; Wu, S; Shen, C* Polyethylenimine-Grafted-Corncob as a Multifunctional Biomaterial for Removing Heavy Metal Ions and Killing. Industrial & Engineering Chemistry Research. 2020, 59, 39, 17476–174822.Shen, C; Jiang, L; Long, X; Dahl, KN; Meng, Q*. Cells with higher cortical membrane tension are more sensitive to lysis by biosurfactant di-rhamnolipids. ACS Biomaterials Science & Engineering, 2020, 6, 1, 352–3573.Shen, C; Tang, S; Meng, Q*; Cadmium removal from rice protein via synergistic treatment of rhamnolipids and F127/PAA hydrogels, Colloids and Surfaces B: Biointerfaces , 2019, 181:734–7394.Meng, Q; Li, Y; Shen, C*, Antibacterial coatings of biomedical surfaces by polydextran aldehyde/polyethyle-nimine nanofibers, ACS Applied Bio Materials, 2019, 2: 562–5695.Meng, Q; Shen, C*, Construction of low contracted 3D skin equivalents by genipin cross-linking, Experimental Dermatology , 2018.10, 27(10): 1098~11036.Meng, Q; Peng, B; Shen, C*, Synthesis of F127/PAA hydrogels for removal of heavy metal ions from organic wastewater, Colloids and Surfaces B: Biointerfaces , 2018, 167: 176~1827.Shen, C; Peng, B; Wang, Y; Meng, Q*, Pb 2+ and Hg 2+ removal from polluted milk by di-acrylated Pluronic P123 hydrogels, Food Chemistry , 2018, 30;258:331-336.8.Meng, Q; Wang, Y; Li, Y; Wang, H; Shen, C*; Sun, J*, Fabrication of Hydrogel Tubes with Vascular Mimicked Stiffness for Construction of in Vitro Vascular Models, ACS Applied Bio Materials , 2018, 1, 237–2459.Shen, C; Li, Y; Wang, H; Meng, Q*. Mechanically strong interpenetrating network hydrogels for differential cellular adhesion. RSC Advances , 2017,7, 18046-1805310.Shen, C; Meng, Q*; Zhang G. Design of 3D printed insert for hanging culture of Caco-2 cells. Biofabrication. 2014, 7(1):015003.11.Shen, C; Meng, Q*; Zhang G. Species-specific toxicity of troglitazone on rats and human by gel entrapped hepatocytes. Toxicology & Applied Pharmacology. 2012,258: 19-25.12.Shen, C; Zhang, L; Zhang, G; Meng, Q*. Polymer membrane and cell models for drug discovery. Combinatorial Chemistry & High Throughput Screening : 2012,15(1):3-14.13.Shen, C; Meng, Q*. Prediction of CYP 450 mediated drug-drug interactions by three-dimensional cultured hepatocytes. Mini Reviews in Medicinal Chemistry . 2012,1;12(10):1028-36.14.Shen, C, Zhang, G; Meng, Q* Enhancement of the predicted drug hepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethylene glycol) modified hollow fiber. Toxicology & Applied Pharmacology. 2010 249(2): 140-7.15.Shen, C; Zhang, G; Meng, Q*. Evaluation of amiodarone-induced phospholipidosis by in vitro system of 3D cultured rat hepatocytes in gel entrapment. Biochemical Engineering Journal. 2010, 49(3): 308-16.16.Shen, C; Meng, Q*, Schmelzer, E; Bader, A. Gel entrapment culture of rat hepatocytes for investigation of tetracycline-induced toxicity. Toxicology & Applied Pharmacology. 2009,15(238):178-87.17.Shen, C; Cheng, X; Li, D; Meng, Q*. Investigation of rifampicin-induced hepatotoxicity in rat hepatocytes maintained in gel entrapment culture. Cell Biol Toxicol. 2009. 25:265-74.18.Shen, C; Meng, Q*; Zhang, G; Hu, W. Rifampicin exacerbates isoniazid-induced toxicity in human but not in rat hepatocytes in tissue-like cultures. British Journal of Pharmacology. 2008.153:784-91.19.Shen, C; Zhang, G; Meng, Q* An in vitro model for long-term hepatotoxicity testing utilizing rat hepatocytes entrapped in micro-hollow fiber reactor. Biochemical Engineering Journal. (2007) 34:267-72.20.Shen, C; Zhang, G; Qiu, H; Meng, Q* Acetaminophen-induced hepatotoxicity of gel entrapped rat hepatocytes in hollow fibers. Chemico-Biological Interactions. 2006,162:53-61.21.Shen, C; Zhang, H; Zhang, G; Meng, Q* Isoniazid-induced hepatotoxicity in rat hepatocytes of gel entrapment culture. Toxicology Letters. 2006,167:66-74.部分合作发表论文：1.Li, Y; Wang, Y; Shen, C; Meng, Q* Non-swellable F127-DA hydrogel with concave microwells for formation of uniform-sized vascular spheroids. RSC Advances , 2020, DOI:10.1039/D0RA06188C2.Long, X; Zhang, G; Shen, C; Sun, G; Wang, R; Yin, L; Meng, Q*; Application of rhamnolipid as a novel biodemulsifier for destabilizing waste crude oil. Bioresource Technology , 131, 2013, Pages 1-53.Lu, Y, Zhang, G, Shen C, Uygun, K; Yarmush, ML; Meng, Q* A novel 3D liver organoid system for elucidation of hepatic glucose metabolism. Biotechnology & Bioengineering .2012, 109:595–604.发明专利1.一种动物细胞的超低温保存溶液及保存方法；200710067090.6.2.一种鼠李糖脂在制备抗纤维化药物制剂中的用途；201510843516.7.3.磺基甜菜碱甲基丙烯酸酯接枝的聚砜共聚物及其制备方法与用途， 201310115859.2. 4.一种生物农药与植物生长调节复合剂及制备方法，202010064440.9. 5.PEG接枝的聚砜或聚醚砜中空纤维膜及其制备方法与用途，200910097050.5.国际会议1.Shen, C; Meng, Q. Bio-Microfluidics Based on Non-Swelling Hydrogels, AIChE meeting, Orlando, FL, USA, 11. 9-14; 20192.Wu, S; Meng, Q; Shen, C; Polyethylenimine functionalized corncob for portable water purification 生物质利用技术国际研讨会 浙江杭州 11.22-25, 20193.Shen, C; Long, X; Meng, Q. Rhamnolipids, useful biosurfactants in petroleum industry and agriculture. ACS National Meeting & Exposition, San Francisco, CA. 8.10-14, 2014 教学与课程     开设 研究生课程 海洋生化工程 一门。海洋生化工程包含海洋相关的生物化学、微生物学、生物反应工程和环境科学等多学科内容，所涉及的专业领域非常广泛。本课程主要介绍上述学科中与海洋相关的基础知识，重点阐述海洋生物化学和微生物学的内容。通过本课程的学习，使化工背景的研究生具备一定的生物学知识，有助于其在研究生阶段开展生物相关的研究，也可为其将来从事海洋生物学和生物化工的相关工作奠定专业基础。