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个人简介 李彤彤，博士，主要从事肠道微生物与宿主免疫、代谢及疾病关系的研究，并致力于从微生物群落和抗生素抗性基因组的角度来研究环境污染物的毒性效应和作用机制。目前已在Journal of Hazardous Materials, Science of The Total Environment, Environmental Toxicology, FEMS Microbiol Ecol, Appl Microbiol Biot, Microb Ecol,Water Res, Front Microbial， International Biodeterioration & Biodegradation 等国际期刊共发表SCI论文20余篇。主持国家自然科学基金青年科学基金1项，浙江省自然科学基金1项。 教学与课程 本科生生物化学、生物化学实验、微生物学实验、病毒学 育人成果 科研项目 主要研究项目 1.  国家自然科学基金青年科学基金项目（22006133），2021/01-2023/12，24万元，主持 2.  浙江省自然科学基金/探索项目/探索青年（LQ21B070003），2021/01-2023/12，10万元，主持 3.  国家自然科学基金青年科学基金项目（31800118），2019/01-2021/12，25万元，参与4. 浙江省自然科学基金/公益项目/社会发展（GF22E067508），2022/01-2025/12，10万元，参与 科研成果 近五年代表性论文1. Li T, Xu B, Chen H, Shi Y, Li J, Yu M, Xia S, Wu S. Gut toxicity of polystyrene microplastics and polychlorinated biphenyls to Eisenia fetida: Single and co-exposure effects with a focus on links between gut bacteria and bacterial translocation stemming from gut barrier damage. Sci Total Environ. 2024 Jan 15;908:168254. doi: 10.1016/j.scitotenv.2023.168254. 2. Li T, Chen H, Xu B, Yu M, Li J, Shi Y, Xia S, Wu S. Deciphering the interplay between LPS/TLR4 pathways, neurotransmitter, and deltamethrin-induced depressive-like behavior: Perspectives from the gut-brain axis. Pestic Biochem Physiol. 2023 Dec;197:105697. doi: 10.1016/j.pestbp.2023.105697.3. Qiu L, Li C, Fu Y, Wang Y, Zhang Z, Zuo Z, Chen R, Yin X, Li T, Wu S. Biodegradation of phthalate isomers by newly isolated Klebsiella variico SY1 and its functional genomic analysis, International Biodeterioration & Biodegradation, 2023, 178 105557,4.  Yu Q, Han Q, Li T, Kou Y, Zhang X, Wang Y, Li G, Zhou H, Qu J, Li H. Metagenomics reveals the self-recovery and risk of antibiotic resistomes during carcass decomposition of wild mammals. Environ Res. 2023 Dec 1;238(Pt 2):117222. doi: 10.1016/j.envres.2023.117222. Epub 2023 Sep 30. PMID: 37778601.5. Li T, Tian D, Lu M, Wang B, Li J, Xu B, Chen H, Wu S. Gut microbiota dysbiosis induced by polychlorinated biphenyl 126 contributes to increased brain proinflammatory cytokines: Landscapes from the gut-brain axis and fecal microbiota transplantation. Ecotoxicol Environ Saf. 2022 Aug;241:113726. doi: 10.1016/j.ecoenv.2022.113726. Epub 2022 Jun 9. PMID: 35691195.6. Li T, Lu M, Xu B, Chen H, Li J, Zhu Z, Yu M, Zheng J, Peng P, Wu S. Multiple perspectives reveal the gut toxicity of polystyrene microplastics on Eisenia fetida: Insights into community signatures of gut bacteria and their translocation. Sci Total Environ. 2022 Sep 10;838(Pt 4):156352. doi: 10.1016/j.scitotenv.2022.156352. Epub 2022 May 30. PMID: 35654182.7. Su W, Li T, Yu Q, Feng T, Yang J, Qu J, Li X, Li H. Animal corpse degradation enriches antibiotic resistance genes but remains recalcitrant in drinking water microcosm, INTERNATIONAL BIODETERIORATION & BIODEGRADATION.2022, 1688. Yu Q, Yang J, Su W, Li T, Feng T, Li H. Heavy metals and microbiome are negligible drivers than mobile genetic elements in determining particle-attached and free-living resistomes in the Yellow River. J Hazard Mater. 2022 Feb 15;424(Pt C):127564. doi: 10.1016/j.jhazmat.2021.127564. Epub 2021 Oct 20. PMID: 34736202.9. Yang J, Li T, Feng T, Yu Q, Su W, Zhou R, Li X, Li H. Water volume influences antibiotic resistomes and microbiomes during fish corpse decomposition. Sci Total Environ. 2021 Oct 1;789:147977. doi: 10.1016/j.scitotenv.2021.147977. Epub 2021 May 24. PMID: 34052485.10. Zhou R, Yu Q, Li T, Long M, Wang Y, Feng T, Su W, Yang J, Li H. Carcass decomposition influences the metabolic profiles and enriches noxious metabolites in different water types by widely targeted metabolomics. Chemosphere. 2021 Apr;269:129400. doi: 10.1016/j.chemosphere.2020.129400. Epub 2020 Dec 22. PMID: 33383254.11. Li H, Yu Q, Li T, Shao L, Su M, Zhou H, Qu J. Rumen Microbiome and Metabolome of Tibetan Sheep (Ovis aries) Reflect Animal Age and Nutritional Requirement. Front Vet Sci. 2020 Sep 2;7:609. doi: 10.3389/fvets.2020.00609. PMID: 32984417; PMCID: PMC7492597.12. Wu S, Wu M, Tian D, Qiu L, Li T. Effects of polystyrene microbeads on cytotoxicity and transcriptomic profiles in human Caco-2 cells. Environ Toxicol. 2020 Apr;35(4):495-506. doi: 10.1002/tox.22885. Epub 2019 Dec 3. PMID: 31797534.专利(1) 李爱华; 李彤彤; 王谢昊 ; 一种防治水产养殖动物真菌病的中药制剂及制备方法, 2016-5-25, 中国,ZL201410113318.0 (专利)(2) 吴石金; 邱乐泉; 张嘉琳; 钟卫鸿; 李彤彤 ; 短乳杆菌ZJ401及其应用, 2020-08-21, 中国, ZL201811630743.1 (专利)(3) 吴石金; 李彤彤; 邱乐泉; 钟莉; 陈昌盛 ; 质粒pRC12及其在微生物降解卤代烃污染物中的应用, 2021-06-04, 中国, ZL201811631926.5 (专利) 社会服务