汤恒
时间:2024-04-27 21:07 来源: 作者: 点击:次
个人简介 汤恒，浙江工业大学生物工程学院讲师，美国明尼苏达大学访问学者，江南大学博士，美国晶体协会会员，主要从事酶工程及生物物理学领域，特别关注关键酶系挖掘、蛋白质高效改造策略构建和蛋白质晶体结构解析等方面。近五年主要在精细化工品生物制造和生物合成方面开展系列研究，对于酶挖掘和酶改造积累了较好的研究基础。主持国家自然科学基金项目（项目编号：3210160254），并获中国博士后科学基金第二批特别资助(2020TQ0125)；授权国家发明专利4件；在Journal of Biological Chemistry（入选Nature Index）和Applied Microbiology and Biotechnology Top杂志等上发表论文多篇。 教学与课程 育人成果 科研项目 科研成果 1. Heng Tang, Özlem Demir, Fredy Kurniawan, William L. Brown, Ke Shi,Nicholas H. Moeller, Michael A. Carpenter, Christopher Belica, Kayo Orellana, Guocheng Du, Aaron M. LeBeau, Rommie E. Amaro , Reuben S. Harris , and Hideki Aihara. Structural Characterization of a Minimal Antibody against Human APOBEC3B[J]. Viruses, 2021, 13(4): 663.1. IF=5.0482. Heng Tang, Ke Shi, Cheng Shi, Hideki Aihara, Juan Zhang and Guocheng Du. Enhancing subtilisin thermostability through a modified normalized B-factor analysis and loop-grafting strategy[J]. The Journal of Biological Chemistry.2019, 294(48): 18398-18407.IF=5.157.3. Xudong Feng, Heng Tang, Beijia Han, Liang Zhang, Bo Lv, Chun Li. Engineering the thermostability of β-glucuronidase from Penicillium purpurogenum Li-3 by loop transplant[J]. Applied microbiology and biotechnology, 2016, 100(23): 9955-9966. IF=4.813 (共同一作)4. Heng Tang, Juan Zhang, Ke Shi, Hideki Aihara, Guocheng Du. Insight into subtilisin E-S7 cleavage pattern based on crystal structure and hydrolysates peptide analysis[J]. Biochemical and biophysical research communications, 2019, 512(3): 623-628.IF=3.575.5. H.Tang, B.Wei, S.Huang, M.S.Ahmed, H.Yang, K.Lou, Y.Shi, X.Feng and C.Li. Effect of Glycosylation of β-Glucuronidase on its Catalytic Properties in Ionic Liquids[J]. Chemical and biochemical engineering quarterly, 2015, 29(4): 559-566. IF=1.582.6. Feng, X., Tang, H., Han, B., Lv, B., & Li, C. Enhancing the Thermostability of β-Glucuronidase by rationally redesigning the catalytic domain based on sequence alignment strategy[J]. Industrial & Engineering Chemistry Research, 2016, 55(19), 5474-5483.F=3.375.7. 理性设计提高β-葡萄糖醛酸苷酶的热稳定性[J].化工学报, 2015.8. 高效降解牛奶过敏原蛋白酶菌种筛选及其重组植物过氧化氢酶的功能验证[J].食品与生物技术学报, 2019.9. 多酶催化体系在医药化学品合成中的应用[J]. 合成生物学, 2021. 社会服务 |