刘峰帆
时间:2024-04-27 21:07 来源: 作者: 点击:次
个人简介 刘峰帆博士毕业于东南大学-江苏省生物药物高技术研究重点实验室(江苏豪森药业股份联合实验室),博士后出站于2019年08月入职浙江工业大学绿色制药协同创新中心浙江省特聘专家团队。主要从事智能化绿色制药技术研究和抗肿瘤铂类药物,从事药物中间体和精细化工品的连续流反应技术研究及产业化推广应用。博士后期间主持国家自然科学基金、中国博士后基金面上一等资助、浙江省博士后基金和药学院、中心青年英才项目各1 项。入职后主持浙江省科技计划项目-院士专项子课题,参与浙江省重点研发项目、浙江省重点联合基金和国家重点研发计划各1 项,累计科研到款共166 万。以第一作者发表论文7 篇,其中发表药学Top(ZJUT TOP100)期刊1 篇,中国科技期刊卓越行动计划高起点新刊1 篇。研究方向:1.智能化绿色制药技术研究;2.靶向抗肿瘤铂类药物。 教学与课程 辅讲研究生课程《药物化学研究进展》辅讲研究生课程《制药伦理学》辅讲研究生课程《制药设备与车间设计》 育人成果 入职至今,指导、协助指导硕士研究生12人(其中1 位学生硕博连读)。指导的班级获2022 年校级“示范班级”等荣誉称号。 科研成果 Scheme 1 抗肿瘤铂类药物的系列研究1. Fengfan, Liu; Weiwei, Hu; Lei, Fang; Shaohua, Gou*,Synthesis and biological evaluatino of water soluble trans-[bicycle[2.2.2]octant-7R, 8R-diamine] platinum(II) complexes with linear or branched alkoxyacetates as leaving groups, Journal of coordination chemistry, 2016, 69: 1284~1292. (IF: 2.0)2. Fengfan, Liu; Shaohua, Gou*; Feihong, Chen; Lei, Fang*; Jian, Zhao, Study on antitumor platinum(II) complexes of chiral diamines with dicyclic species as steric hindrance, Journal of Medicinal Chemistry, 2015, 58: 6368~6377(IF: 6.25; 药学一区)3. Fengfan, Liu; Zhiping, Zhou; Shaohua, Gou*; Jian, Zhao; Feihong, Chen, Synthesis and antiproliferative activity of (1R,2R)-N-(2-butyl)-1,2-cyclohexanediamine platinum(II) complexes with malonate derivatives, Journal of Coordination Chemistry, 2014, 67: 2858~2866. (IF: 2.0)4. Jian, Zhao; Shaohua, Gou*; Fengfan, Liu. Potent anticancer activity and possible low toxicity of platinum(II) complexes with functionalized 1,1-cyclobutane dicarboxylate as a leaving ligand, Chemistry-A European Journal, 2014, 20: 1~11. (IF: 5.16)5. Fengfan Liu; Xiaomei Dong; Qiwen Shi; Jianli Chen; Weike Su*. Improving the anticancer activity of platinum (IV) prodrugs using a dual-targeting strategy with dichloroacetate axial ligand. RSC Adv.,2019, 9: 22240-22247.6. Fengfan Liu, Xiaomei Dong, Weike Su*. Antitumor platinum(II) complexes of trans-bicyclo[2.2.2]-octane-7R,8R-diamine with functionalized cyclobutane-1,1-dicarboxylates as leaving ligands. Nanosci Nanotech Let., 2019, 11, 998-1014.7. Fengfan Liu, WeiKe Su*. Progress in the development of functional antitumor platinum complexes, Chinese Journal of Pharmaceuticals, 2019, 823-833. 社会服务 |