柯淼林
时间:2024-04-27 21:06 来源: 作者: 点击:次
个人简介 柯淼林，博士，浙江工业大学绿色制药协同创新中心助理研究员，硕士生导师。2021.01 博士毕业于复旦大学有机化学专业；2021.01-2022.12 浙江工业大学从事博士后工作。2023.03 加入浙江工业大学绿色制药协同创新中心从事科研工作。主要从事药物合成及不对称催化方法学研究。近五年来，主持横向一项，参与国家自然科学基金2项。以第一作者或通讯作者在Org. Lett、Green. Synth. Catal、Chem. Commun、Org. Chem. Front、Adv. Synth. Catal等发表学术论文13篇。 科研项目 横向项目：1. 右美沙芬的全连续公斤级合成，横向，主持，100万。2. NQYE合成技术研究，横向，参与，200万。3.三唑类药物手性中间体的生物技术开发，横向，参与，300万。 科研成果 发表论文：15. Ke, M.; Li, X.; Zong, J .; Wang, B.; Zheng, J.; Zhang, S.; Chen, J.; Chen, F*. Asymmetric Construction of Carbon−Fluorine Quaternary Stereogenic Centers via Synergistic Pd/Cu Catalysis. Org. Lett. 2024, 26, 1201-1206.14. Wang,B.; Sun, L.; Cao, Q .; Li, X.; Chen, J.; Wang, S*.; Ke, M*.; Chen, F*.Cu-catalyzed three-component C-S-P coupling for the synthesis of trisubstituted allenyl phosphorothioates. Chin. Chem. Lett. 2024, https://doi.org/10.1016/j.cclet.2024.109617.13. Ke, M.; Yu, Y.; Sun, L .; Li, X.; Cao, Q.; Xiao, X*.; Chen, F*. Regio- and Stereoselective Syntheses of Chiral α-Quaternary (Z)-Trisubstituted Allylic Acids via Synergistic Palladium/Copper Catalysis.Chem. Commun. 2023, 59，2632-2635.12. Yu, C.; Yu, Y.; Sun, L.; Li, X.; Liu, Z.; Ke, M*.; Chen, F*. Highly Diastereo- and Enantioselective Synthesis of Multisubstituted Allylic Amino Acid Derivatives by Allylic Alkylation of A Chiral Glycine-Based Nickel Complex and Vinylethylene Carbonates. Org. Biomol. Chem. 2022, 20, 4894-4899.11. Ke, M.; Qiao, B.; Yu, Y.; Li, X.; Xiao, X.; Li, S.; Lan, Y*.; Chen, F*. Palladium-Catalyzed Asymmetric [3 + 2] Annulation of Vinylethylene Carbonates with Alkenes Installed on Cyclic N-Sulfonyl Imines: Highly Enantio- and Diastereoselective Construction of Chiral Tetrahydrofuran Scaffolds Bearing Three Vicinal and Quaternary Stereocenters. J. Org. Chem. 2022, 87, 5166-5177.10. Ke, M.; Yu, Y.; Zhang, K.; Zuo, S.; Liu, Z.; Xiao, X.; Chen, F*.Synergistic Pd/Cu Catalyzed Allylation of Cyclic Ketimine Esters with Vinylethylene Carbonates: Enantioselective Construction of Trisubstituted Allylic 2H-Pyrrole Derivatives. Adv. Synth. Catal. 2022, 364, 1849-1854.9. Liu, D#.; Ke, M#.; Ru, T.; Ning, Y*.; Chen, F*. Room-Temperature Pd-Catalyzed Methoxycarbonylation of Terminal Alkynes with High Branched Selectivity Enabled by Bisphosphine-Picolinamide Ligand. Chem. Commun. 2022, 58, 1041-1044.（共一）8. Ke, M.; Liu, Z.; Zhang, K.; Zuo, S.; Chen, F*. Synergistic Pd/Cu Catalysis for Stereoselective Allylation of Vinylethylene Carbonates with Glycine Iminoesters: Enantioselective Access to Diverse Trisubstituted Allylic Amino Acid Derivatives. Green. Synth. Catal. 2021, 2, 228-232.7. Liu, Z#.; Ke, M.#; Zhang, K.; Wang, Z.; Ye, B*.; Chen, F*. Palladium-Catalyzed Allylation of Vinylethylene Carbonates with β-Ketophosphonates: Stereoselective Synthesis of (Z)-Homoallylic Phosphonates. ChemCatChem.2021, 13, 1753-1762.（共一）6. Ke, M.; Liu, Z.; Huang, G.; Wang, J.; Tao, Y.; Chen, F*. Palladium-Catalyzed Regio- and Stereoselective Cross-Coupling of Vinylethylene Carbonates with Ketimine Esters to Generate (Z)-Tri- and Tetra-Substituted Allylic Amino Acid Derivatives. Org. Lett. 2020, 22, 4135-4140.5. Ke, M.; Huang, G.; Ding, L.; Fang, J.; Chen, F*. Direct Synthesis of Substituted (Z)-Allylic Sulfones by Palladium-Catalyzed Sulfonylation of Vinylethylene Carbonates with Sodium Sulfinates. ChemCatChem.2019, 11, 4720-4724.4. Ke, M.; Song, Q*.Copper-Catalyzed 1, 6-Hydrodifluoroacetylation of para-Quinone Methides at Ambient Temperature with Bis(pinacolato)diboron as Reductant. Adv. Synth. Catal. 2017, 359, 384-389.3. Ke, M.; Song, Q*.Copper/B2pin2-Catalyzed C-H Difluoroacetylation-Cycloamidation of Anilines Leading to the Formation of 3, 3-Difluoro-2-oxindoles. Chem. Commun. 2017, 53, 2222-2225.2. Ke, M.; Feng, Q.; Yang, K.; Song, Q*. Cu-Catalyzed Hydrofluoroacetylation of Alkynes or Alkynyl Carboxylic Acids Leading Highly Stereoselectively to Fluoroacetylated Alkenes. Org. Chem. Front., 2016, 3, 150-155.1. Ke, M.; Song, Q*.Copper-Catalyzed C(sp2)-H Difluoroalkylation of Aldehyde Derived Hydrazones with Diboron as Reductant.J. Org. Chem. 2016, 81, 3654-3664. 教学与课程 育人成果 1.在读研究生2023级：宗加颐、王薇、吴澄宇2022级：王波文、张树佳、刘辉智，商鹏翔、郑金英2021级：李心志、孙龙武2.已毕业研究生2020级：俞钰燕，曹乾乾2019级：俞超（福州大学联培） 社会服务 |