叶青
时间:2024-04-27 21:06 来源: 作者: 点击:次
个人简介 叶青联系电话：13958144238 E-mail: yeqing1975121@zjut.edu.cn教育与工作经历2005.09至2009.12：浙江大学，博士学位2010.01至今: 浙江工业大学，副教授，硕士生导师主要从事药物活性小分子的设计合成和医药中间体的绿色合成工艺研究，目前已主持新药研究国家重点实验室开放研究课题1项，浙江省自然科学基金项目2项，中国博士后基金一等资助1项，在EJMC、BMC等药物化学核心期刊上发表论文10余篇，申请中国发明专利10余项。负责重大企业横向多个，具有较为丰富的产品工艺开发和产业化经验。 教学与课程 精细化学品化学，基础有机实验 育人成果 科研项目 1. 新型IDH1/R132H抑制剂的设计、合成及抗肿瘤活性研究 NO. LY18H300009 浙江省自然科学基金项目（负责）2. 糖原合成酶激酶-3β（GSK-3β）新型抑制剂的开发及脑缺血神经保护作用评价NO. LY14H300003 浙江省自然科学基金项目（负责）3. GSK-3β新型抑制剂设计、合成及其抗缺血性脑卒中作用评价NO. 2014M550256中国博士后基金一等资助（负责）4. 新型太阳能电池有机光敏染料合成及结构与性能NO. 2012R10018-1浙江省重点科技创新团队项目（负责）5. 新型IDH1/132H 抑制剂的设计、合成及抗肿瘤活性评价NO. SIMM1601KF-04新药研究国家重点实验室开放研究课题 (负责）6. 新型太阳能电池有机光敏染料及结构与性能研究NO.C10111632 国家基金面上项目（参与）7. 基于金属螯合作用的多靶点抗阿尔茨海默化合物设计、合成及生物活性研究NO.C10114237国家基金青年项目（参与）8. 成药性小分子化合物的合成 NO. KYY-HX-20180643 校企合作项目（负责）9. 苯并三氮唑绿色合成工艺研究NO.KYY-HX-20170271校企合作项目（负责）10. 杀菌剂BIT绿色生产工程工艺技术研究NO.HG-[2014]029校企合作项目（负责）11. 兰索拉唑原料药合成工艺开发NO.HG-[2014]035@ 校企合作项目（负责）12. 抗倒酯合成工艺优化NO. HG-[2013]072@ 校企合作项目（负责）13. 偶氮染料连续管道化反应合成技术开发NO.HG-[2014]006@ 校企合作项目（负责） 科研成果 发表文章：1.Yuanyuan, Hu, Anhui, Gao, Honghui, Liao, Mengmeng Zhang, Gaoya Xu, Lixin Gao, Lei Xu, Yubo Zhou, Jianrong Gao, Qing Ye*, Jia Li, 3-(7-Azaindolyl)-4-indolylmaleimides as a novel class of mutant isocitrate dehydrogenase-1 inhibitors: Design, synthesis, and biological evaluationArchiv der Pharmazie, 2018, 351,1-122. Boye Zhu, Meng Xu, Chunxia Qian, Liang Han, Jianrong Gao, Qing Ye*, Yujin Li,Synthesis and fluorescence characteristics of selective ratiometric fluorescent sensors for silver ions based on 3-indolyl-4-indazolyl maleimide derivatives.RESEARCH ON CHEMICAL INTERMEDIATES, 2018, 44, 3985-3999.3. Yuanyuan Hu, Wenchen Ruan, Anhui Gao, Yubo Zhou, Lixin Gao, Meng Xu, Jianrong Gao, Qing Ye*, Jia Li, Tao Pang,Synthesis and biological evaluation of novel 4,5-bisindolyl-1,2,4-triazol-3-ones as glycogen synthase kinase-3 beta inhibitors and neuroprotective agents. PHARMAZIE, 2017, 72, 707-713.4. Boye Zhu, Liang Han, YuJin Li, Jianrong Gao,Qing Ye*, The AIEE properties and solid state fluorescence of 3-indolyl-4-indazolyl maleimide compounds: Synthesis and fluorescence characteristics. TETRAHEDRON, 2017,73, 1602-1610.5. Tao Pang, Yunjie Wang, Yuanxue Gao, Yuan Xu, Qiu Li, Yubo Zhou, Lei Xu, Zhangjian Huang, Hong Liao, Luyong Zhang, Jianrong Gao,Qing Ye*,Jia Li. A novel GSK-3 beta inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway. ACTA PHARMACOLOGICA SINICA, 2016, 37, 741-752.6. Qing Ye, Qiu Li, Yubo Zhou, Lei Xu, Weili Mao, Yuanxue Gao, Chenhui Li, Yuan Xu, Yazhou Xu, Hong Liao, Luyong Zhang, Jianrong Gao, Jia Li,and Tao Pang. Synthesis and Evaluation of 3-(furo[2,3-b]pyridin-3-yl)-4-(1H-indol-3-yl)-maleimides as Novel GSK-3β Inhibitorsand Anti-Ischemic Agents. Chem Biol Drug Des 2015, 86: 746-752.7. Qing Ye, Weili Mao, yubo Zhou, Lei Xu, Qiu Li, Yuanxue Gao, Jing Wang, Chenhui Li, Yazhou Xu, Jianrong Gao, Jia Li, Tao Pang. Synthesis and biological evaluation of 3-([1,2,4]triazolo [4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3 beta inhibitors and neuroprotective agents. Bioorg. Med. Chem. 2015, 23: 1179-1188.8. Synthesis and Biological Evaluation of 3-Benzisoxazolyl -4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β. Molecules 2013, 18 (5), 5498-5516. 9. Qing Ye, Yanhong Shen, Yubo Zhou, Dan Lv, Jianrong Gao, Jia Li, Yongzhou Hu. Design, synthesis and evaluation of 7-azaindazolyl-indolylmaleimides as glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.2013, 68， 361-371.10. Qing Ye, Meng Li, Yubo Zhou, Jian-rong Gao, Yong-Zhou Hu, Jia Li. Design, Synthesis, and Evaluation of 3-Aryl-4-pyrrolyl-maleimides as Glycogen Synthase Kinase-3 beta Inhibitors.. Archiv der Pharmazie, 2013, 346, 349-358.11. Qing Ye, Xiaobo Zhu, Kai Gu, Jianrong Gao, Weirong Miao. Synthesis and Herbicidal Activity of N-Aryl-2-heteroaryloxy-N-isopropyl acetamide. Synthesis and Herbicidal Activity of N-Aryl-2-heteroaryloxy–N -isopropyl acetamide,Asian Journal of Chemistry, 2013, 25 (12), 6931-6934 .12.Qing Ye, Ji Cao, Xinglu Zhou, Dan Lv, Qiaojun He, Bo Yang, Yongzhou Hu. Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β（GSK-3β）inhibitors.Bioorg. Med. Chem.2009, 17, 4302-4312.13. Qing Ye, Guiqing Xu, Dan Lv, Zhe Cheng, Jia Li, Yongzhou Hu. Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors. Bioorg. Med. Chem. 2009, 17, 4763-4772.授权专利：1.叶青, 李佳, 周宇波, 高安慧, 高立信, 胡圆圆, 励雪, 高建荣。一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用CN 201610270132.5 2.叶青, 许萌, 朱博也, 韩亮, 李郁锦, 高建荣。3-吲哚-4-吲唑马来酰亚胺类化合物及其制备方法和应用201611167253.33. 叶青, 朱博也, 许萌, 韩亮, 李郁锦, 高建荣。3-吲哚-4-（5-氮杂吲哚）马来酰亚胺类化合物及其制备方法和应用CN 201611166792.54. 叶青, 高建荣, 顾凯, 张力。一种奥拉西坦关键中间体2-（2,4-二氧代吡咯烷-1-基）乙酸乙酯的合成新方法CN 201510132423.35. 叶青, 李佳, 庞涛, 高建荣, 周宇波, 许磊, 毛伟丽。3-（1,2,4-三氮唑并[4,3-a]吡啶-3-基）-4-（1H-吲哚-3-基）马来酰亚胺类衍生物及其制备方法和应用 CN 201410763064.76. 叶青, 高建荣, 任锋, 李郁锦, 韩亮, 顾凯, 钟健。一种奥拉西坦关键中间体2-（2,4-二氧代吡咯烷-1-基）-乙酰胺的合成新工艺CN 201410473452.1 7. 叶青, 李佳, 高建荣, 李萌, 周宇波, 许磊。一种3-苯并异恶唑-4-吲哚马来酰亚胺衍生物及其用途CN 201310083721.9 社会服务 |