原续波
时间:2024-04-06 22:39 来源: 作者: 点击:次
原续波 教师名称：原续波 教师拼音名称：Yuan Xubo 出生日期：1967-02-09 性别：男 职称：教授 其他联系方式 移动电话：022-87401832 邮箱：xbyuan@tju.edu.cn 基本信息 研究方向 获奖情况 论文成果 Areas of research interest- Synthesis of biodegradable polymers, Preparation of nanoparticles for drug delivery, Surface functionalization of nanoparticles and their interaction with the biomembranes, in vivo biodistribution and tumor-targeted drug delivery using nanoparticles, nanoparticle-mediated gene therapy in combination with chemotherapy for cancer research.TeachingModern Research Methods of Materials; Frontier Development of Materials; Polymer PhysicsHonors and awards2009, National Second Prize for Teaching AchievementsResearch projects2011~2013, National Science Foundation of China, Iinhibition of malignant glioma by Hyperbranched star polymer single micelles mediated co-delivery of paclitaxel and as-miR-212010-2012, Project Foundation from New Century Excellent Talents Program, Functional nanoparticles mediated chemotherapeutic sensitization of gene therapy2006~2008, National Science Foundation of China, Multi-biofunctional nonoparticles mediated biological of glioma-targeted drug release across blood-brain barrier2006~2009, Key Project Foundation from Tianjin Science and Technology Research Program, Industrial Research of Stereotactic injection stained release chemotherapeutic agents in cancer therapy2006~2007, Crosswise Cooperation Project between school and enterprise, Research on Biodegradable drug-coating coronary stent2003~2005, Science Foundation of Tianjin, Key Research on Chemical Synthesis of Biodegradable PHB2002~2004, National Science Youth Foundation of China, Surface Functional Modification and Drug Delivery Targeted Glioma of NanoparticlesSelected publications(Journal articles, patents and books)Wei-hua Ren, Jiang Chang, Cheng-hu Yan, Xiao-min Qian�ALi-xia Long, Bin He, Xu-bo Yuan, Chun-sheng Kang, Didier Betbeder, Jing Sheng, Pei-yu Pu, Development of transferrin functionalized poly(ethylene-glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma, J Mater Sci: Mater Med, 2010, 21:2673�V2681.Yu Ren, Xuan Zhou, Mei Mei, Xu-bo Yuan*, Lei Han, Guang-Xiu Wang, Zhi-fan Jia, Peng Xu, Pei-yu Pu, Chun-sheng Kang*, MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to toxal, BMC Cancer, 2010,10:27.ChunSheng Kang, XuBo Yuan*, Fei L,PeiYu Pu, Shizhu Yu,Guang-Xiu Wang, ChangHong Shen, Jin Chang. Evaluation of folate-PAMAM as an efficient carrier for antisense oligonucleotides delivery in rat C6 glioma cell: in vitro and in vivo. J Biomed Mater Res A. 2009, 93A: 585�V594.Yu Ren, Chun-Sheng Kang*, Xu-bo Yuan*, Xuan Zhou, Peng Xu, Lei Han, Guang Xiu Wang, Zhifan Jia, Yue Zhong, Shizhu Yu, Jing Sheng, Pei-yu Pu .Co-delivery of As-miR-21 and 5-Fu by poly(amidoamine) dendrimer attenuate human glioma cell growth in vitro. J Biomater Sci Polym Ed ( DOI:10.1163/156856209X415828 ,in press). Kang CS, Yuan XB*, Zhong Yue, Pu PY,Y Guo YS, Albadany A, Zhang ZY, Li YH, Chang J, Sheng J.Growth inhibition against intracranial C6 gliomas by stereotactic delivery of BCNU from controlled release poly(D,L-lactic acid) nanoparticles. Technol Cancer Res Treat.2009,8:61-70. Xu-bo Yuan, Yan-bo Yuan, Wei Jiang, et al. Preparation of rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 349(1-2): 241-248.MQ Gu, XB Yuan*, CS Kang, YH Zhao, NJ Tian, PY Pu, J Sheng. Surface biofunctionalization of PLA nanoparticles through amphiphilic polysaccharide coating and gliand coupling: Evaluation of biofunctionalization and drug releasing behavior. Carbohyd Polym, 2007,67417-426.Wen-jie Ma, Xu-bo Yuan*, Chun-sheng Kang, et al, Evaluation of blood circulation of polysaccharide surface-decorated PLA nanoparticles, CARBOHYDRATE POLYMERS, 2008, 72(1):75-81.Xu-bo Yuan, Hong Li, Yan-bo Yuan, Preparation of cholesterol-modified chitosan self-aggregated nanoparticles for delivery of drugs to ocular surface, Carbohydrate Polymer, 2006, 65(3):337-345.Xu-Bo Yuan, Hong Li, Xiao-Xia Zhu, Hee-Gweon Woo, Self-aggregated nanoparticles composed of periodate-oxidized dextran and cholic acid: preparation, stabilization and in-vitro drug release, Journal of Chemical Technology & Biotechnology, 2006, 81(5):746�V754.Yan, Cheng-hu, Yuan, Xu-bo, Kang, Chunsheng, Zhao, Yun-Hei, Liu, Jie, Guo, Yanshuang, Lu, Jian, Pu, Peiyu, Sheng, Jing, Preparation of carmustine-loaded PLA ultrasmall-nanoparticles by adjusting micellar behavior of surfactants, Journal of Applied Polymer Science, 110(4), pp 2446-2452.Xu-bo Yuan, Chun-sheng Kang, Yun-hui Zhao, Ming-qi Gu, Pei-yu Pu, Neng-jiang Tian and Jing Sheng, Surface Multi-Functionalization of Poly(lactic acid) Nanoparticles and C6 Glioma Cell Targeting IN VIVO, Chinese Journal of Polymer Science, 2009, 27(2):1-9.Social AppointmentsVice secretary general of National Association of Materials Experimental Teaching Research Synthesis of biodegradable polymers 暂无内容 暂无内容 教育经历 1985.9-1989.6 Beijing Institute of Technology Department of Chemical Engineering 学士 1992.9-1995.6 Tianjin University Department of Materials Science and Technology 硕士 1998.9-2001.6 Tianjin University Department of Materials 博士 工作经历 1989.7 -1992.8 |Huifeng Co. Ltd.|Engineer 1997.8 -2001.12 |School of Materials Science and Engineering|Tianjin University|Assistant professor 2002.8 -2009.8 |School of Materials Science and Engineering|Tianjin University|Associate professor 1995.8 -1997.8 |School of Materials Science and Engineering|Tianjin University|Lecturer 2009.8 -2019.12 |School of Materials Science and Engineering|Tianjin University|Professor |