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王智文 教师名称：王智文 教师拼音名称：wang Zhi Wen 出生日期：1981-01-02 性别：男 职称：副教授 其他联系方式 通讯/办公地址：Peiyang 54E256, Tianjin University. 移动电话：022-85356617 邮箱：zww@tju.edu.cn 基本信息 研究方向 获奖情况 论文成果 姓名：王智文（Zhiwen Wang）现任职称/职务：Associate Professor （Ph. D Supervisor）通讯地址：Peiyang 54E256, Tianjin University.电子邮箱：zww@tju.edu.cn办公电话：022-85356617；010-88225053；qq:2845245149 研究方向：Construction of genome editing system in microorganism.Microbial cell factory costruction by metabolic engineering and synthetic biology for production of biochemical, medicine and bioenergy using renewable resources.Development of regulatory element for synthetic biology.Improvement of strain robustness by genome wide regulator engineering.Evolutionary engineering.讲授课程：Classes for undergraduate：Microbiological experiment, Metabolic engineering and synthetic biology.Classes for master and Ph. D candidate: Syetems metabolic engineering and synthetic biology 学术兼职：Peer reviewer of journals, like Biotechnology and Bioengineering, Biotechnology for Biofuels, Microbiology Cell Factories，Molecular BioSystems、Bioresource Technology、Applied Microbiology and Biotechnology, PloS One, World Journal of Microbiology and Biotechnology, Bioresources and Bioprocessing, Biotechnology Letter, Chinese Journal of Biotechnology and Chemical Industry and Engineering Progress. Member of AIChE and IMES. 学术成就：Over 30 papers were published;About 10 national invention patent were applied and authorized. 科研项目：PI of five programs, including National Natural Science Foundation of China and National High-tech R&D Program of China. PI of one program from Natural Science Foundation of Tianjin. PI of three programs from the Innovation Foundation of Tianjin University; 论著专利：12. Jing Fu, Zhiwen Wang(Co-first author), Tao Chen*, et al.. NADH Plays the vital role for chiral pure D-(-)-2,3-butanediol production in Bacillus subtilis under limited oxygen, Biotechnology and Bioengineering, 2014, Doi: 10.1002/bit.25265.11. Ting Shi, Yongcheng Wang, Zhiwen Wang*, Guanglu Wang, Dingyu Liu, Jing Fu, Tao Chen, Xueming Zhao. Deregulation of purine pathway in Bacillus subtilis and its use in riboflavin biosynthesis, Microbial Cell Factories, 2014,13:101. 10. Zhenquan Lin,Zhibo Xu,Yifan Li, Zhiwen Wang*,Tao Chen*, Xueming Zhao. Metabolic engineering of Escherichia coli for the production of riboflavin, Microbial Cell Factories, 2014,13:104.9. Xianghui Ma, Xinbo Zhang, Baiyun Wang, Yufeng Mao, Zhiwen Wang*,Tao Chen*, Xueming Zhao. Engineering microorganisms based on molecular evolutionary analysis: a succinate production case study, Evolutionary Applications, 2014,doi:10.1111/eva.12186.8. Guanglu Wang, Ling Bai, Zhiwen Wang*, Ting Shi, Tao Chen, Xueming Zhao. Enhancement of riboflavin production by deregulating gluconeogenesis in Bacillus subtilis, World J Microbiol Biotechnol, 2014, 30:1893–1900.7. Yang, J., Z. Wang(Co-first author), N. Zhu, B. Wang, T. Chen*, X. Zhao. Metabolic engineering of Escherichia coli and in silico comparing of carboxylation pathways for high succinate, Microbiological Research, 2014, 169:432-40.6. Wenwen Ma, Xiaoyue Wang, Yufeng Mao, Zhiwen Wang*, Tao Chen, Xueming Zhao. Development of a markerless gene replacement system in Corynebacterium glutamicum using upp as a counter-selection marker, Biotechnology Letters, 2014,DOI: 10.1007/s10529-014-1718-8.5. Ting Shi, Guanglu Wang, Zhiwen Wang*, et al.. Establishment of a markerless mutation delivery system in Bacillus subtilisstimulated by a double-strand break in the chromosome, PloS One, 2013, 8(11):e81370.3. Zhiwen Wang, Tao Chen*, Xianghui Ma, et al.. Enhancement of riboflavin production with Bacillus subtilis by expression and site-directed mutagenesis of zwf and gnd gene from Corynebacterium glutamicum, Bioresource Technology, 2011, 102(4): 3934-3940.2. Xianghui Ma*, Zhiwen Wang. Anticancer drug discovery in the future: an evolutionary perspective, Drug Discovery Today, 2009, 14(23):1136-1142.1. Zhiwen Wang, Xunli Liu*. Medium optimization for antifungal active substances production from a newly isolated Paenibacillus sp. using response surface methodology, Bioresource Technology, 2008, 99(17):8245-8251. 合作交流：Member of group: Professor Xueming Zhao, Tao Chen Improvement of strain robustness by genome wide regulator engineering.Evolutionary engineering. Construction of genome editing system in microorganism.Microbial cell factory costruction by metabolic engineering and synthetic biology for production of biochemical, medicine and bioenergy using renewable resources.Development of regulatory element for synthetic biology. 暂无内容 暂无内容